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The map label for this gene is ipk

Identifier: 15926172

GI number: 15926172

Start: 524245

End: 525093

Strand: Direct

Name: ipk

Synonym: SA0453

Alternate gene names: 15926172

Gene position: 524245-525093 (Clockwise)

Preceding gene: 15926171

Following gene: 15926173

Centisome position: 18.62

GC content: 34.75

Gene sequence:

>849_bases
ATGATATATGAAACGGCACCAGCCAAAATTAATTTTACGCTCGATACACTTTTTAAAAGAAATGATGGCTATCATGAGAT
TGAAATGATAATGACAACAGTTGATTTAAATGATCGTTTAACTTTTCATAAAAGAAAAGATCGAAAGATAGTTGTTGAGA
TTGAACATAATTATGTGCCTTCTAATCATAAAAATCTCGCATATCGTGCAGCGCAACTATTTATTGAGCAATATCAACTA
AAGCAAGGTGTAACAATTTCTATCGATAAAGAAATACCTGTTTCTGCTGGCTTAGCTGGAGGTTCGGCTGATGCAGCAGC
AACGTTAAGAGGATTGAATCGACTTTTTGATATAGGGGCGAGTTTGGAAGAATTGGCTCTACTAGGCAGTAAAATTGGGA
CAGATATTCCGTTTTGTATTTATAATAAAACTGCACTATGTACTGGAAGAGGAGAGAAAATCGAGTTTTTAAATAAACCA
CCTTCAGCTTGGGTGATTCTTGCTAAACCAAACTTAGGCATATCATCACCAGATATATTTAAGTTGATCAATTTAGATAA
GCGTTACGACGTACATACGAAAATGTGTTATGAGGCCTTAGAAAATCGAGATTATCAACAATTATGTCAAAGTTTGTCTA
ATCGATTAGAGCCAATTTCTGTTTCAAAACACCCACAAATCGATAAATTAAAAAATAATATGTTGAAAAGTGGTGCAGAT
GGTGCGTTAATGAGTGGAAGCGGACCGACTGTGTATGGGCTAGCACGAAAAGAAAGCCAAGCAAAAAATATTTATAATGC
AGTTAACGGTTGTTGTAATGAAGTGTACTTAGTTAGACTATTAGGATAG

Upstream 100 bases:

>100_bases
TTTTTTATTAAAAAAACACTAAAAAACAAATTAAAATGTCAAATATTAATTCTCTTTATGTTAAAATCATCATATTAAGA
TAACGAAAAGAGGGCGGAAA

Downstream 100 bases:

>100_bases
AAGGGTTGAAAAGATGAGATATAAACGAAGCGAGAGAATTGTTTTTATGACGCAATATTTGATGAACCATCCGAATAAAT
TGATTCCATTAACTTTTTTT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQL
KQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKP
PSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGAD
GALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG

Sequences:

>Translated_282_residues
MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQL
KQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKP
PSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGAD
GALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG
>Mature_282_residues
MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQL
KQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKP
PSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGAD
GALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=270, Percent_Identity=30.3703703703704, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_STAA1 (A7WYP4)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441082.1
- ProteinModelPortal:   A7WYP4
- STRING:   A7WYP4
- EnsemblBacteria:   EBSTAT00000003045
- GeneID:   5561309
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0492
- eggNOG:   COG1947
- GeneTree:   EBGT00050000025469
- HOGENOM:   HBG734593
- OMA:   RIYNGLR
- ProtClustDB:   PRK00128
- BioCyc:   SAUR418127:SAHV_0492-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31443; Mature: 31443

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: ACT_SITE 9-9 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVP
CCCCCCCCEEEEEHHHHHHCCCCCEEEEEEEEEECCCCCEEEEECCCCEEEEEEECCCCC
SNHKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGA
CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
SLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPPSAWVILAKPNLGISSPDIF
CHHHHHHHHHHHCCCCCEEEECCEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCCHH
KLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGAD
HEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
GALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG
CCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure
MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVP
CCCCCCCCEEEEEHHHHHHCCCCCEEEEEEEEEECCCCCEEEEECCCCEEEEEEECCCCC
SNHKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGA
CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
SLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPPSAWVILAKPNLGISSPDIF
CHHHHHHHHHHHCCCCCEEEECCEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCCHH
KLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGAD
HEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
GALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG
CCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA