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The map label for this gene is guaA

Identifier: 15926092

GI number: 15926092

Start: 434505

End: 436046

Strand: Direct

Name: guaA

Synonym: SA0376

Alternate gene names: 15926092

Gene position: 434505-436046 (Clockwise)

Preceding gene: 15926091

Following gene: 15926099

Centisome position: 15.44

GC content: 37.29

Gene sequence:

>1542_bases
ATGGAAATGGCAAAAGAACAAGAGTTAATCCTTGTCTTAGACTTTGGTAGCCAATACAACCAATTAATTACACGCCGAAT
TCGTGAAATGGGCGTTTATAGTGAATTACACGATCATGAAATTTCAATTGAAGAAATTAAGAAAATGAATCCAAAAGGTA
TCATCTTATCAGGTGGTCCAAATTCAGTTTATGAAGAAGGTTCATTTACAATTGATCCGGAAATATATAATTTAGGAATT
CCAGTACTTGGTATTTGTTACGGCATGCAATTAACTACTAAATTATTAGGTGGTAAAGTTGAACGTGCCAATGAACGTGA
ATACGGTAAAGCAATCATTAATGCGAAGTCAGATGAGTTATTCGCTGGCTTACCAGCAGAACAAACTGTTTGGATGAGTC
ATTCTGATAAAGTTATTGAAATTCCAGAAGGCTTTGAAGTTATCGCTGATAGCCCAAGCACAGACTATGCAGCAATTGAA
GATAAGAAACGTCGCATTTATGGTGTGCAATTCCATCCAGAAGTACGTCATACAGAATATGGTAATGATTTATTAAACAA
CTTCGTACGTCGTGTTTGTGATTGTAAAGGACAATGGACGATGGAAAACTTTATCGAAATTGAAATTGAAAAGATTCGTC
AACGCGTAGGCGACCGTCGTGTATTATGTGCGATGAGTGGTGGCGTAGATTCATCTGTTGTTGCTGTATTATTGCATAAA
GCAATTGGGGATCAACTAACATGTATCTTTGTAGACCATGGCTTACTTCGTAAAGGTGAAGGCGACATGGTTATGGAACA
ATTCGGTGAAGGGTTCAACATGAATATTATTCGTGTTAATGCGAAAGATCGTTTTATGAATAAATTAAAAGGTGTTTCAG
ATCCTGAACAAAAACGTAAAATCATTGGTAATGAATTTGTATATGTATTTGATGATGAAGCATCAAAACTTAAAGGTGTA
GACTTCCTTGCGCAAGGAACACTATATACAGACGTCATCGAATCAGGTACTAAGACAGCACAAACAATCAAATCACACCA
CAATGTTGGTGGATTACCAGAAGACATGGAATTCGAATTAATCGAACCAATCAATACATTGTTTAAAGATGAAGTACGTA
AATTAGGTATTGAATTAGGTATTCCAGAACATTTAGTGTGGAGACAACCATTCCCAGGACCTGGTCTTGGTATTCGTGTA
CTTGGAGAAATTACTGAAGATAAACTAGAAATCGTTAGAGAATCAGACGCGATTTTACGCCAAGTGATTAGAGAAGAAGG
TCTTGAAAGAGAAATTTGGCAATACTTCACAGTGTTACCAAACATTCAATCAGTAGGTGTTATGGGAGACTACCGTACGT
ATGATCACACAGTAGGTATCCGTGCAGTAACATCTATCGACGGCATGACAAGTGACTTCGCACGCATCGATTGGGAAGTC
TTACAAAAGATTTCAAGTCGTATCGTAAACGAAGTAGACCACGTCAATCGCGTAGTCTATGACATTACATCAAAACCACC
AAGCACAATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GGGTCCTGCTGGTTTAGCAGAAAGCCATCCACATAATATTCAAATTACGAAAGAATCACCGAACTACTCATTCTAATTAA
GATAAAGGAGAACGACAAAT

Downstream 100 bases:

>100_bases
TTATATATAATAAAACCACCTGTTTGCACGGGTGGTTTTTAATTTGAGTAGTTGGAAAATTACAATAAGGACGGAAAAGG
GGTAAGGTGTTCTAAGTTTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGI
PVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIE
DKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHK
AIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGV
DFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRV
LGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEV
LQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE

Sequences:

>Translated_513_residues
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGI
PVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIE
DKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHK
AIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGV
DFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRV
LGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEV
LQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>Mature_513_residues
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGI
PVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIE
DKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHK
AIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGV
DFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRV
LGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEV
LQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=37.0909090909091, Blast_Score=305, Evalue=8e-83,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=50.968992248062, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1789760, Length=190, Percent_Identity=32.1052631578947, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=36.8695652173913, Blast_Score=310, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=37.0434782608696, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=37.0434782608696, Blast_Score=309, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=51.7441860465116, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322638, Length=153, Percent_Identity=32.0261437908497, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281365319, Length=544, Percent_Identity=36.0294117647059, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_STAA1 (A7WY93)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001440978.1
- ProteinModelPortal:   A7WY93
- SMR:   A7WY93
- STRING:   A7WY93
- EnsemblBacteria:   EBSTAT00000002911
- GeneID:   5560834
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0388
- eggNOG:   COG0519
- GeneTree:   EBGT00050000024834
- HOGENOM:   HBG391775
- OMA:   VVNAAHS
- ProtClustDB:   PRK00074
- BioCyc:   SAUR418127:SAHV_0388-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- InterPro:   IPR004506
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF03054 tRNA_Me_trans

EC number: =6.3.5.2

Molecular weight: Translated: 58203; Mature: 58203

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 172-172 ACT_SITE 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEECCC
NSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDEL
CCCCCCCCEEECCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCC
FAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEY
EECCCCCCEEEECCCCCEEECCCCCEEEECCCCCCCHHHCCCCCEEEEEEECCCCCCCCC
GNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHK
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRK
HHCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCHHHHHH
IIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFEL
HCCCCEEEEECCCCCHHCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
IEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILR
HHHHHHHHHHHHHHHCHHCCCCHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
QVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEV
HHHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCHHH
LQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC
>Mature Secondary Structure
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEECCC
NSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDEL
CCCCCCCCEEECCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCC
FAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEY
EECCCCCCEEEECCCCCEEECCCCCEEEECCCCCCCHHHCCCCCEEEEEEECCCCCCCCC
GNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHK
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRK
HHCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCHHHHHH
IIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFEL
HCCCCEEEEECCCCCHHCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
IEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILR
HHHHHHHHHHHHHHHCHHCCCCHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
QVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEV
HHHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCHHH
LQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA