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The map label for this gene is fabH [C]

Identifier: 15921634

GI number: 15921634

Start: 1357322

End: 1358368

Strand: Direct

Name: fabH [C]

Synonym: ST1349

Alternate gene names: 15921634

Gene position: 1357322-1358368 (Clockwise)

Preceding gene: 15921633

Following gene: 15921635

Centisome position: 50.37

GC content: 35.82

Gene sequence:

>1047_bases
ATGAGTTCTGGGATAGTAGGATGGGGAGCATATGTTCCTCGTTATAGATTAAATGTCCTAGAAATAGCTAAACTATGGGG
ATATGATGAAGGTGTTGTAAAAAGTTTGGGTTTGATGGAAAAAGCAGTTCCTTCTCACGATGAAGATTCAACAACAATGG
CATGGGAGGCAGCGAGAAATGCTTTAATGAGAGCAAAAATCGATCCTTCTGAAATCAAAGCCGTCTTATTTGGTTCTGAA
TCTAAAGTTTATGCAGTTAAACCTACTTCTACAATAATTATTGATTCTTTAGGTATATCACATGAAACTTTAAGTGCAGA
TTTAGAATTTGCTTGTAGGGCAGCATCAGTAGGTTTAAGGTTATTGTCTGGAATGGTTGAAGCAAATAGAATAAAATACG
GTTTAGTAATAGGAAGTGATGTAGCCCAATCTAATCCTGGTGATGTATTAGAATTAAGCTCTGCTGCCGCTTCTGTAGCA
TATATTGTTGGTCCAGCAGATGAATCTTCTGCAATAATAGAATATGCAACTTCATATACAACTGATATGCCAGATTTTTG
GAGAAGAGATGGAATGCCTTATCCACTTCATGGTGAGGCATTTACTGGTGAACCAGCTTATTTTGCCCATATTATATCTG
CTGTTCAACTTCTACTTAAAGAGGGTGGGTATTCAATATCTGATTTTGATTATTTTGTATTTCATCAACCTAATGGTAAA
TTCCCATTGCAAGTTGCTAAAAAGCTAGGCGTCCCATTAGAGAAAGTCAAAGAAGGATTAGTGTCCCCGTATATAGGAAA
TCCTTATAATGCGTCAGCATTATTAGGTTTAGCAAAGGTTTTAGATATTGCTAAGCCTGGACAAAGAATATTAGTTGCTC
CTTTTGGAAGTGGTGCTGGAAGTGATGCATTTAGTATCTTGGTTACAGATAAAATAGAAGAGAGGCAAAAACTTGCGCCA
AGAGTTGAAGATTATATTAATAATAAGAAAGTAATTTCATACTCTGTTTATGCAAAGACAACAAACAAATACAAGGTGTA
TGAGTAA

Upstream 100 bases:

>100_bases
TTTCCTAATTCCTTTTTAAAACTTATATTCGACAAAAGTCTATGAATCCATAGACAATTGTAGAAACTCTTTTTATTTAA
AAATGTTCTTATATTAGCCA

Downstream 100 bases:

>100_bases
TGGTTTCAATAGCTGAAGTTTCTTTCATAAAGATTGATCGCTATTATGAGTATTCTGAAAAAGATTTAGTTATAGAGGCT
TATAAGCAAATAGAAACTAA

Product: hypothetical protein

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSSGIVGWGAYVPRYRLNVLEIAKLWGYDEGVVKSLGLMEKAVPSHDEDSTTMAWEAARNALMRAKIDPSEIKAVLFGSE
SKVYAVKPTSTIIIDSLGISHETLSADLEFACRAASVGLRLLSGMVEANRIKYGLVIGSDVAQSNPGDVLELSSAAASVA
YIVGPADESSAIIEYATSYTTDMPDFWRRDGMPYPLHGEAFTGEPAYFAHIISAVQLLLKEGGYSISDFDYFVFHQPNGK
FPLQVAKKLGVPLEKVKEGLVSPYIGNPYNASALLGLAKVLDIAKPGQRILVAPFGSGAGSDAFSILVTDKIEERQKLAP
RVEDYINNKKVISYSVYAKTTNKYKVYE

Sequences:

>Translated_348_residues
MSSGIVGWGAYVPRYRLNVLEIAKLWGYDEGVVKSLGLMEKAVPSHDEDSTTMAWEAARNALMRAKIDPSEIKAVLFGSE
SKVYAVKPTSTIIIDSLGISHETLSADLEFACRAASVGLRLLSGMVEANRIKYGLVIGSDVAQSNPGDVLELSSAAASVA
YIVGPADESSAIIEYATSYTTDMPDFWRRDGMPYPLHGEAFTGEPAYFAHIISAVQLLLKEGGYSISDFDYFVFHQPNGK
FPLQVAKKLGVPLEKVKEGLVSPYIGNPYNASALLGLAKVLDIAKPGQRILVAPFGSGAGSDAFSILVTDKIEERQKLAP
RVEDYINNKKVISYSVYAKTTNKYKVYE
>Mature_347_residues
SSGIVGWGAYVPRYRLNVLEIAKLWGYDEGVVKSLGLMEKAVPSHDEDSTTMAWEAARNALMRAKIDPSEIKAVLFGSES
KVYAVKPTSTIIIDSLGISHETLSADLEFACRAASVGLRLLSGMVEANRIKYGLVIGSDVAQSNPGDVLELSSAAASVAY
IVGPADESSAIIEYATSYTTDMPDFWRRDGMPYPLHGEAFTGEPAYFAHIISAVQLLLKEGGYSISDFDYFVFHQPNGKF
PLQVAKKLGVPLEKVKEGLVSPYIGNPYNASALLGLAKVLDIAKPGQRILVAPFGSGAGSDAFSILVTDKIEERQKLAPR
VEDYINNKKVISYSVYAKTTNKYKVYE

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Catalyzes The First Condensation Reaction Which Initiates Fatty Acid Synthesis And May Therefore Play A Role In Governing The

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0219 family

Homologues:

Organism=Escherichia coli, GI1787333, Length=315, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1349_SULTO (Q971K8)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377303.1
- ProteinModelPortal:   Q971K8
- SMR:   Q971K8
- GeneID:   1459372
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1349
- NMPDR:   fig|273063.1.peg.1471
- HOGENOM:   HBG297330
- OMA:   ESKPYAV
- ProtClustDB:   PRK04262
- BioCyc:   STOK273063:ST1349-MONOMER
- HAMAP:   MF_01409
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004656
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00748

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: 2.3.1.41

Molecular weight: Translated: 37795; Mature: 37663

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGIVGWGAYVPRYRLNVLEIAKLWGYDEGVVKSLGLMEKAVPSHDEDSTTMAWEAARN
CCCCCEEHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ALMRAKIDPSEIKAVLFGSESKVYAVKPTSTIIIDSLGISHETLSADLEFACRAASVGLR
HHHCCCCCHHHEEEEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LLSGMVEANRIKYGLVIGSDVAQSNPGDVLELSSAAASVAYIVGPADESSAIIEYATSYT
HHHHHHHHCCEEEEEEECCHHCCCCCCCEEEHHHHHCEEEEEECCCCCCCHHHHHHHHCC
TDMPDFWRRDGMPYPLHGEAFTGEPAYFAHIISAVQLLLKEGGYSISDFDYFVFHQPNGK
CCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCC
FPLQVAKKLGVPLEKVKEGLVSPYIGNPYNASALLGLAKVLDIAKPGQRILVAPFGSGAG
CHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
SDAFSILVTDKIEERQKLAPRVEDYINNKKVISYSVYAKTTNKYKVYE
CCEEEEEEECCHHHHHHHCHHHHHHCCCCEEEEEEEEEECCCCEEECC
>Mature Secondary Structure 
SSGIVGWGAYVPRYRLNVLEIAKLWGYDEGVVKSLGLMEKAVPSHDEDSTTMAWEAARN
CCCCEEHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ALMRAKIDPSEIKAVLFGSESKVYAVKPTSTIIIDSLGISHETLSADLEFACRAASVGLR
HHHCCCCCHHHEEEEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LLSGMVEANRIKYGLVIGSDVAQSNPGDVLELSSAAASVAYIVGPADESSAIIEYATSYT
HHHHHHHHCCEEEEEEECCHHCCCCCCCEEEHHHHHCEEEEEECCCCCCCHHHHHHHHCC
TDMPDFWRRDGMPYPLHGEAFTGEPAYFAHIISAVQLLLKEGGYSISDFDYFVFHQPNGK
CCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCC
FPLQVAKKLGVPLEKVKEGLVSPYIGNPYNASALLGLAKVLDIAKPGQRILVAPFGSGAG
CHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
SDAFSILVTDKIEERQKLAPRVEDYINNKKVISYSVYAKTTNKYKVYE
CCEEEEEEECCHHHHHHHCHHHHHHCCCCEEEEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; DTT; EDTA [C]

Metal ions: Phosphate [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl -ACP-decarboxyl ation, [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479