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The map label for this gene is trm1

Identifier: 15921533

GI number: 15921533

Start: 1268622

End: 1269746

Strand: Direct

Name: trm1

Synonym: ST1269

Alternate gene names: 15921533

Gene position: 1268622-1269746 (Clockwise)

Preceding gene: 15921532

Following gene: 15921537

Centisome position: 47.08

GC content: 30.04

Gene sequence:

>1125_bases
ATGAATTTGATTGAAATAAGAGAAGGTAAGGCTTCTTTACTAATTCCTAATCCTAAAGATTATGAGAAAGAAGGGAGATA
TGATCCCAGTTGGTCTCCAGTTTTCTACAATCCTAAGATGAGATTAAATAGAGATATTAGTGTTTTAGCCTTAAGTGTAA
TAAAGCCTAAAAGTGTTGTCGATGCTCTATCTGCCTCTGGAGTCAGAGGGATAAGATATTATACTGAAATTGGAGGGATA
GAAAAATTGATATTAAATGATAAAAATCCTATAGCAACAGAATTAATAAAGAAAAATGCAGAGAAGAACTATGTGAATGC
TCGAATAACAACAAAGGACGCAAATTCTTTATTATATGAGATTAAAGCAGATTTTGTAGATATAGATCCTTTTGGTTCTC
CAGCCCCTTTTATCTTGTCAGCCATAAACGCTACAATAAACAAAGGCTATGTAGCTTTTACTGCAACTGATTTATCAGCC
CTAGAATGTTCTTCAAAATTTTCTGCTAGAAGAAAATACGACTTGATATGCGAAAGATTAAGTTTTTCCAAAGAATTAGG
AATTAGAGGTTTAATTGCCAAGGTAATAAGAGAAGGTGCTATTATAGAAAAAGCTGCATATCCTATATTTTCATTTTATT
TTGATTATTATTATAGAGTATTCTTTAGAATAGAAAATGGCGCTAAAAAAGTTGATAAATTACTTGAGAAACAAGGGTAT
TATTATGAGTGTTCTAAATGTGGGTATCGTGAGGTCGATTATTATGCAGAAAGAAAAATATGTCCTAGATGTGGTATCGA
GATGAGAAGATATGGTCCAGCATGGACAGGGGAACTATGGAATAGAGAGTTTTTGTTAAGTATGAAAGAGAATCTAAAGA
ATTTCACATACTTTGATACTTTCATGCAAGTAAATAAGTTGTTAAATATATTAGTAGAAGAGTCAAAGTATGTATCACCT
TATTTTAGACTAGATTTTATAGCATCCTTAATAAAAAGAAATATACCAAAAAGAGAAAAAATGTTAGAATGTTTAAAAGA
AGCTTCAATAACTCACTTTGATTATAGAGGTATAAAAACTAATAAAGAAATAGATGAAATAGTAAATTGTATAAAAATTA
ACTAG

Upstream 100 bases:

>100_bases
ATAAAAGCAAGTCTTATTGTGGTTGTGAAAGAGAGCAAAAATAAAAAAATATATGAAAAAGAGGATTTTAATACAATAAG
TGAAAACGAAATTATGAACT

Downstream 100 bases:

>100_bases
CTGATTTAGCATTAGTTAGTAAGTATCTAGATAATTGTGGACACGTCGAAGGAGAAATATAGCTACCATTTCCGCATTTT
TTGAGAATTTTACAAGTATA

Product: N(2),N(2)-dimethylguanosine tRNA methyltransferase

Products: NA

Alternate protein names: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNLIEIREGKASLLIPNPKDYEKEGRYDPSWSPVFYNPKMRLNRDISVLALSVIKPKSVVDALSASGVRGIRYYTEIGGI
EKLILNDKNPIATELIKKNAEKNYVNARITTKDANSLLYEIKADFVDIDPFGSPAPFILSAINATINKGYVAFTATDLSA
LECSSKFSARRKYDLICERLSFSKELGIRGLIAKVIREGAIIEKAAYPIFSFYFDYYYRVFFRIENGAKKVDKLLEKQGY
YYECSKCGYREVDYYAERKICPRCGIEMRRYGPAWTGELWNREFLLSMKENLKNFTYFDTFMQVNKLLNILVEESKYVSP
YFRLDFIASLIKRNIPKREKMLECLKEASITHFDYRGIKTNKEIDEIVNCIKIN

Sequences:

>Translated_374_residues
MNLIEIREGKASLLIPNPKDYEKEGRYDPSWSPVFYNPKMRLNRDISVLALSVIKPKSVVDALSASGVRGIRYYTEIGGI
EKLILNDKNPIATELIKKNAEKNYVNARITTKDANSLLYEIKADFVDIDPFGSPAPFILSAINATINKGYVAFTATDLSA
LECSSKFSARRKYDLICERLSFSKELGIRGLIAKVIREGAIIEKAAYPIFSFYFDYYYRVFFRIENGAKKVDKLLEKQGY
YYECSKCGYREVDYYAERKICPRCGIEMRRYGPAWTGELWNREFLLSMKENLKNFTYFDTFMQVNKLLNILVEESKYVSP
YFRLDFIASLIKRNIPKREKMLECLKEASITHFDYRGIKTNKEIDEIVNCIKIN
>Mature_374_residues
MNLIEIREGKASLLIPNPKDYEKEGRYDPSWSPVFYNPKMRLNRDISVLALSVIKPKSVVDALSASGVRGIRYYTEIGGI
EKLILNDKNPIATELIKKNAEKNYVNARITTKDANSLLYEIKADFVDIDPFGSPAPFILSAINATINKGYVAFTATDLSA
LECSSKFSARRKYDLICERLSFSKELGIRGLIAKVIREGAIIEKAAYPIFSFYFDYYYRVFFRIENGAKKVDKLLEKQGY
YYECSKCGYREVDYYAERKICPRCGIEMRRYGPAWTGELWNREFLLSMKENLKNFTYFDTFMQVNKLLNILVEESKYVSP
YFRLDFIASLIKRNIPKREKMLECLKEASITHFDYRGIKTNKEIDEIVNCIKIN

Specific function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

COG id: COG1867

COG function: function code J; N2,N2-dimethylguanosine tRNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TRM1 family

Homologues:

Organism=Homo sapiens, GI8923219, Length=334, Percent_Identity=26.0479041916168, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI209862871, Length=334, Percent_Identity=26.0479041916168, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI216548445, Length=315, Percent_Identity=26.984126984127, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI163792194, Length=323, Percent_Identity=27.5541795665635, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17564890, Length=398, Percent_Identity=24.8743718592965, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320325, Length=456, Percent_Identity=25.4385964912281, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19921190, Length=441, Percent_Identity=24.0362811791383, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRM1_SULTO (Q971V9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377202.1
- ProteinModelPortal:   Q971V9
- SMR:   Q971V9
- GeneID:   1459269
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1269
- NMPDR:   fig|273063.1.peg.1370
- HOGENOM:   HBG577872
- OMA:   FHEDANV
- ProtClustDB:   PRK04338
- BioCyc:   STOK273063:ST1269-MONOMER
- BRENDA:   2.1.1.32
- HAMAP:   MF_00290
- InterPro:   IPR022923
- InterPro:   IPR002905
- PANTHER:   PTHR10631

Pfam domain/function: PF02005 TRM

EC number: =2.1.1.32

Molecular weight: Translated: 43334; Mature: 43334

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIEIREGKASLLIPNPKDYEKEGRYDPSWSPVFYNPKMRLNRDISVLALSVIKPKSVV
CCCEEEECCCCEEECCCCCCHHHCCCCCCCCCCEEECCCCCCCCCHHHHHEECCCCHHHH
DALSASGVRGIRYYTEIGGIEKLILNDKNPIATELIKKNAEKNYVNARITTKDANSLLYE
HHHHHCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHE
IKADFVDIDPFGSPAPFILSAINATINKGYVAFTATDLSALECSSKFSARRKYDLICERL
EECCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
SFSKELGIRGLIAKVIREGAIIEKAAYPIFSFYFDYYYRVFFRIENGAKKVDKLLEKQGY
HHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCC
YYECSKCGYREVDYYAERKICPRCGIEMRRYGPAWTGELWNREFLLSMKENLKNFTYFDT
EEECCCCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHCCHHHHHHHHHHHCCCHHHHH
FMQVNKLLNILVEESKYVSPYFRLDFIASLIKRNIPKREKMLECLKEASITHFDYRGIKT
HHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCC
NKEIDEIVNCIKIN
CHHHHHHHHHHCCC
>Mature Secondary Structure
MNLIEIREGKASLLIPNPKDYEKEGRYDPSWSPVFYNPKMRLNRDISVLALSVIKPKSVV
CCCEEEECCCCEEECCCCCCHHHCCCCCCCCCCEEECCCCCCCCCHHHHHEECCCCHHHH
DALSASGVRGIRYYTEIGGIEKLILNDKNPIATELIKKNAEKNYVNARITTKDANSLLYE
HHHHHCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHE
IKADFVDIDPFGSPAPFILSAINATINKGYVAFTATDLSALECSSKFSARRKYDLICERL
EECCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
SFSKELGIRGLIAKVIREGAIIEKAAYPIFSFYFDYYYRVFFRIENGAKKVDKLLEKQGY
HHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCC
YYECSKCGYREVDYYAERKICPRCGIEMRRYGPAWTGELWNREFLLSMKENLKNFTYFDT
EEECCCCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHCCHHHHHHHHHHHCCCHHHHH
FMQVNKLLNILVEESKYVSPYFRLDFIASLIKRNIPKREKMLECLKEASITHFDYRGIKT
HHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCC
NKEIDEIVNCIKIN
CHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479