| Definition | Sulfolobus tokodaii str. 7 chromosome, complete genome. |
|---|---|
| Accession | NC_003106 |
| Length | 2,694,756 |
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The map label for this gene is nrdZ [H]
Identifier: 15921522
GI number: 15921522
Start: 1257903
End: 1260398
Strand: Direct
Name: nrdZ [H]
Synonym: ST1259
Alternate gene names: 15921522
Gene position: 1257903-1260398 (Clockwise)
Preceding gene: 15921521
Following gene: 15921523
Centisome position: 46.68
GC content: 35.94
Gene sequence:
>2496_bases ATGCAAAAAGCTGATATTACCATCCTCTCACTCTCAAAGCTTAAGGTTCTCAAAAGAAGTGGTAAGGTTGAAGAGTTTAA ATCTGATAAGATATTTTCAAAGCTAGGAATTATACCAGAAGACGTAATGGATGGAATACTTAATGATATAGCTCAAAATG CTAAAGATAATGCTATAGATACAAGAACTATAGCAGATATCGTCGAAAGGAACCTGATTGAGCACTCTTTGGATCATCCA GAATTAATGGATCTCGCAAAGAAGTATGTTTTAGCTAGGATTTATAATCATGTATTTGGTAAGGGCAATTGGAAAGGTTT TGATGAAAGAGATTTATTGTTAACATATAATGCGTTAAAAGTATTAGAAGCAAGGTATTTGTTAAAGGATCCAAACACTT TACGTTATATTGAAACACCACAGATGATGTTTAGGAGGGTAGCAAAACATTTGGCTAATGTAGAAAGACAATATGGTAGA TCTGAGAGTGAGGTTAAACAATTAGAGGAGAAGTTTTATAAAATAATGTCTGAGTTAAAGTTCTTACCAAATACACCAAC TCTAATGAATAGTGGTACAAGATTGGGAATTTTGTCTGCATGTTTTGTAATTCCAGTTAGGGATTCAATGATTACTCCAA ATGGTGAAGGTATATACGATGCATTAAGGGCTATGGCTGTTGTTCATCAACAAGGTGGAGGTACTGGATTTGACTTCTCC GAATTAAGACCTAAGGGGGATATTGTGGCTTCTACTGCAGGTGTAGCTTCAGGTCCAGTGTCATTTATGAGAATATTTGA TGTATCTACTGATGTTGTAAAGCAAGGAGGTAAGAGAAGAGGAGCAAATATGGGTGTTATGCATGTATGGCACCCTGATA TAGAGGAGTTTATTAAATCAAAGACTGGTCAATTAAAAGATACGCAATTACAGAACTTTAATATTTCAGTAGGAGTTTAT GATTATTTTATGCAAGCTGTAGAGAGAGGCGATGTTGTACCATTAATTAACCCTAGGAAGACTAAGATTGCTGATTGGGA TTATTACATGTCTAAGGCTAGAGGTTATATGAATGAGGAGTGGATACAAGAGGTTATATTGTCAGAATTGGAAGAGAAGG GCGGTACGGTTGATCTTGCTGAAAGTAAGATAATAACTATTGATGAGGCTTTAGTAATTGCTGAGAAAGAAAATGCTATA ACACAATGGGTTAATGCTAGGAATTTGTTCGATGAAATTGTAAAAGGTGCTTGGGACTCTGGTGATCCAGGATTACTATT CATAGACACAATAAATAGGCGCCACCCAGTGTGGTATTTAGGGAAGATAAACGCTACAAACCCATGTGGTGAGGAACCCT TATTACCCTGGGAAAGCTGTAATTTAGGTTCTATCAATTTAGAAAAATTTGTTGTGGATGGTAAGATTGATTGGGATGGT TTAGCTGAAACTATTCGTTATGCTGTTAGGCTTTTAGATAATGTAATAGATGCTAATCGTTATCCATTAAAGCAGATTGA GGAAGCTACTAAGAAGACTAGGAAAGTTGGCTTAGGTGTTATGGGTTTAGCTAGAATGTTAATTAAGCTAGGCATACCTT ATGACTCTGTTGATGCTGTGTACTTATCTTATCAACTAGCCAAGTTCATTTATTATCACGCTTTTAAGGAGTCAATTGAG ATTGCTAAAGAAAAAGGTTCATTCCCAGCTTATGATGCAAAACTGTACAAAGACATATGGGAGAGTGCAAAGGACTTTTA CGAAATACTTGAAATTATGGGTATTAAGGATAAGCCTAGCGATTATGTGAAGAAACTCACCTCAATTGTTGATAAATTAG ACTTTGATAAACTTAAGGAGGATAGGATAAAGTATGGATTAAGAAATGCTACTGTAGTCTCAGTAGCACCTACGGGCACA ATTTCAATTATTGCCGGTACTTCATCATCAATAGAGCCACTGTTTGCATTAGCATTCATAAGAAATGTTGCTGTAGGAAA GTTCATGGAAATTGACCCACTATTCCTAGATTACTTAAGGAAATATGAGCTAGATAATCCAGAGGTTGTCAAAAAAATAG CTGAGACTGGCATGATTGGTGATAATCCATTTATGCCAAAAAGTATGAGGAAAGTATTTAGGACTGCACATGAAGTATCA CCAGAGTATCATTTGCTGCATCAAGCTGCTTGGCAACAGTGGAACGATTCGGGTACTTCAAAGACAATAAACTTAAGGAG TGAGGAACCACCAGAAACTGTTGAAAGAGTATACATGTTGGCATGGAAGCTTGGAATTAAGGGCGTTACTGTATATAGGG ATAAATCTAAGAGCCAACAAGTAATTTACTTTGGAATAAAGAAAGAAAGGGAAGAAGTTAAGAAAGAAGAGGAAAAAAAG ATACAGCAATTATTACCATCTTCACTAAGAATCCAGAAAAAATTTGTTGAAGTAAGCGAGACATATGCCGGTGGATGCAA AACGTGTGAATTATAA
Upstream 100 bases:
>100_bases TGAACTTAGGTATTAGAAATTATTCTCTTTTTGGGGTAATACTATTCTAATTGGCGATACTGTATATATACTTCGAAATA TAATATTTAATGATTAGAAA
Downstream 100 bases:
>100_bases AAATTTTTATTTTTATTTTTCGATATTCCTATTGTAGTGTGTTTATTATGCAGTTAATCCTTCCTTGTGAGTATTCAGTT AAAGAGATTTTGCCAGCTAT
Product: ribonucleoside-diphosphate reductase large subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 831; Mature: 831
Protein sequence:
>831_residues MQKADITILSLSKLKVLKRSGKVEEFKSDKIFSKLGIIPEDVMDGILNDIAQNAKDNAIDTRTIADIVERNLIEHSLDHP ELMDLAKKYVLARIYNHVFGKGNWKGFDERDLLLTYNALKVLEARYLLKDPNTLRYIETPQMMFRRVAKHLANVERQYGR SESEVKQLEEKFYKIMSELKFLPNTPTLMNSGTRLGILSACFVIPVRDSMITPNGEGIYDALRAMAVVHQQGGGTGFDFS ELRPKGDIVASTAGVASGPVSFMRIFDVSTDVVKQGGKRRGANMGVMHVWHPDIEEFIKSKTGQLKDTQLQNFNISVGVY DYFMQAVERGDVVPLINPRKTKIADWDYYMSKARGYMNEEWIQEVILSELEEKGGTVDLAESKIITIDEALVIAEKENAI TQWVNARNLFDEIVKGAWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVVDGKIDWDG LAETIRYAVRLLDNVIDANRYPLKQIEEATKKTRKVGLGVMGLARMLIKLGIPYDSVDAVYLSYQLAKFIYYHAFKESIE IAKEKGSFPAYDAKLYKDIWESAKDFYEILEIMGIKDKPSDYVKKLTSIVDKLDFDKLKEDRIKYGLRNATVVSVAPTGT ISIIAGTSSSIEPLFALAFIRNVAVGKFMEIDPLFLDYLRKYELDNPEVVKKIAETGMIGDNPFMPKSMRKVFRTAHEVS PEYHLLHQAAWQQWNDSGTSKTINLRSEEPPETVERVYMLAWKLGIKGVTVYRDKSKSQQVIYFGIKKEREEVKKEEEKK IQQLLPSSLRIQKKFVEVSETYAGGCKTCEL
Sequences:
>Translated_831_residues MQKADITILSLSKLKVLKRSGKVEEFKSDKIFSKLGIIPEDVMDGILNDIAQNAKDNAIDTRTIADIVERNLIEHSLDHP ELMDLAKKYVLARIYNHVFGKGNWKGFDERDLLLTYNALKVLEARYLLKDPNTLRYIETPQMMFRRVAKHLANVERQYGR SESEVKQLEEKFYKIMSELKFLPNTPTLMNSGTRLGILSACFVIPVRDSMITPNGEGIYDALRAMAVVHQQGGGTGFDFS ELRPKGDIVASTAGVASGPVSFMRIFDVSTDVVKQGGKRRGANMGVMHVWHPDIEEFIKSKTGQLKDTQLQNFNISVGVY DYFMQAVERGDVVPLINPRKTKIADWDYYMSKARGYMNEEWIQEVILSELEEKGGTVDLAESKIITIDEALVIAEKENAI TQWVNARNLFDEIVKGAWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVVDGKIDWDG LAETIRYAVRLLDNVIDANRYPLKQIEEATKKTRKVGLGVMGLARMLIKLGIPYDSVDAVYLSYQLAKFIYYHAFKESIE IAKEKGSFPAYDAKLYKDIWESAKDFYEILEIMGIKDKPSDYVKKLTSIVDKLDFDKLKEDRIKYGLRNATVVSVAPTGT ISIIAGTSSSIEPLFALAFIRNVAVGKFMEIDPLFLDYLRKYELDNPEVVKKIAETGMIGDNPFMPKSMRKVFRTAHEVS PEYHLLHQAAWQQWNDSGTSKTINLRSEEPPETVERVYMLAWKLGIKGVTVYRDKSKSQQVIYFGIKKEREEVKKEEEKK IQQLLPSSLRIQKKFVEVSETYAGGCKTCEL >Mature_831_residues MQKADITILSLSKLKVLKRSGKVEEFKSDKIFSKLGIIPEDVMDGILNDIAQNAKDNAIDTRTIADIVERNLIEHSLDHP ELMDLAKKYVLARIYNHVFGKGNWKGFDERDLLLTYNALKVLEARYLLKDPNTLRYIETPQMMFRRVAKHLANVERQYGR SESEVKQLEEKFYKIMSELKFLPNTPTLMNSGTRLGILSACFVIPVRDSMITPNGEGIYDALRAMAVVHQQGGGTGFDFS ELRPKGDIVASTAGVASGPVSFMRIFDVSTDVVKQGGKRRGANMGVMHVWHPDIEEFIKSKTGQLKDTQLQNFNISVGVY DYFMQAVERGDVVPLINPRKTKIADWDYYMSKARGYMNEEWIQEVILSELEEKGGTVDLAESKIITIDEALVIAEKENAI TQWVNARNLFDEIVKGAWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVVDGKIDWDG LAETIRYAVRLLDNVIDANRYPLKQIEEATKKTRKVGLGVMGLARMLIKLGIPYDSVDAVYLSYQLAKFIYYHAFKESIE IAKEKGSFPAYDAKLYKDIWESAKDFYEILEIMGIKDKPSDYVKKLTSIVDKLDFDKLKEDRIKYGLRNATVVSVAPTGT ISIIAGTSSSIEPLFALAFIRNVAVGKFMEIDPLFLDYLRKYELDNPEVVKKIAETGMIGDNPFMPKSMRKVFRTAHEVS PEYHLLHQAAWQQWNDSGTSKTINLRSEEPPETVERVYMLAWKLGIKGVTVYRDKSKSQQVIYFGIKKEREEVKKEEEKK IQQLLPSSLRIQKKFVEVSETYAGGCKTCEL
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-cone domain [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=699, Percent_Identity=28.0400572246066, Blast_Score=250, Evalue=4e-66, Organism=Escherichia coli, GI1789030, Length=673, Percent_Identity=25.260029717682, Blast_Score=158, Evalue=1e-39, Organism=Escherichia coli, GI2367133, Length=721, Percent_Identity=23.7170596393897, Blast_Score=131, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17555242, Length=742, Percent_Identity=26.8194070080863, Blast_Score=234, Evalue=2e-61, Organism=Saccharomyces cerevisiae, GI6322123, Length=701, Percent_Identity=26.9614835948645, Blast_Score=223, Evalue=1e-58, Organism=Saccharomyces cerevisiae, GI6320914, Length=731, Percent_Identity=25.8549931600547, Blast_Score=214, Evalue=3e-56, Organism=Drosophila melanogaster, GI17352481, Length=843, Percent_Identity=25.5041518386714, Blast_Score=229, Evalue=4e-60,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013344 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 94467; Mature: 94467
Theoretical pI: Translated: 7.15; Mature: 7.15
Prosite motif: PS51161 ATP_CONE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQKADITILSLSKLKVLKRSGKVEEFKSDKIFSKLGIIPEDVMDGILNDIAQNAKDNAID CCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCH TRTIADIVERNLIEHSLDHPELMDLAKKYVLARIYNHVFGKGNWKGFDERDLLLTYNALK HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHH VLEARYLLKDPNTLRYIETPQMMFRRVAKHLANVERQYGRSESEVKQLEEKFYKIMSELK HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH FLPNTPTLMNSGTRLGILSACFVIPVRDSMITPNGEGIYDALRAMAVVHQQGGGTGFDFS CCCCCCHHHCCCCCHHHHHHHHHEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCHH ELRPKGDIVASTAGVASGPVSFMRIFDVSTDVVKQGGKRRGANMGVMHVWHPDIEEFIKS HCCCCCCEEEECCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEECCCHHHHHHH KTGQLKDTQLQNFNISVGVYDYFMQAVERGDVVPLINPRKTKIADWDYYMSKARGYMNEE CCCCCCCCEECCCEEEEHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCCHH WIQEVILSELEEKGGTVDLAESKIITIDEALVIAEKENAITQWVNARNLFDEIVKGAWDS HHHHHHHHHHHHCCCEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCC GDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVVDGKIDWDG CCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHEEECCCCCHHH LAETIRYAVRLLDNVIDANRYPLKQIEEATKKTRKVGLGVMGLARMLIKLGIPYDSVDAV HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH YLSYQLAKFIYYHAFKESIEIAKEKGSFPAYDAKLYKDIWESAKDFYEILEIMGIKDKPS HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH DYVKKLTSIVDKLDFDKLKEDRIKYGLRNATVVSVAPTGTISIIAGTSSSIEPLFALAFI HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHH RNVAVGKFMEIDPLFLDYLRKYELDNPEVVKKIAETGMIGDNPFMPKSMRKVFRTAHEVS HHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC PEYHLLHQAAWQQWNDSGTSKTINLRSEEPPETVERVYMLAWKLGIKGVTVYRDKSKSQQ CHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCE VIYFGIKKEREEVKKEEEKKIQQLLPSSLRIQKKFVEVSETYAGGCKTCEL EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC >Mature Secondary Structure MQKADITILSLSKLKVLKRSGKVEEFKSDKIFSKLGIIPEDVMDGILNDIAQNAKDNAID CCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCH TRTIADIVERNLIEHSLDHPELMDLAKKYVLARIYNHVFGKGNWKGFDERDLLLTYNALK HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHH VLEARYLLKDPNTLRYIETPQMMFRRVAKHLANVERQYGRSESEVKQLEEKFYKIMSELK HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH FLPNTPTLMNSGTRLGILSACFVIPVRDSMITPNGEGIYDALRAMAVVHQQGGGTGFDFS CCCCCCHHHCCCCCHHHHHHHHHEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCHH ELRPKGDIVASTAGVASGPVSFMRIFDVSTDVVKQGGKRRGANMGVMHVWHPDIEEFIKS HCCCCCCEEEECCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEECCCHHHHHHH KTGQLKDTQLQNFNISVGVYDYFMQAVERGDVVPLINPRKTKIADWDYYMSKARGYMNEE CCCCCCCCEECCCEEEEHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCCHH WIQEVILSELEEKGGTVDLAESKIITIDEALVIAEKENAITQWVNARNLFDEIVKGAWDS HHHHHHHHHHHHCCCEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCC GDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVVDGKIDWDG CCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHEEECCCCCHHH LAETIRYAVRLLDNVIDANRYPLKQIEEATKKTRKVGLGVMGLARMLIKLGIPYDSVDAV HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH YLSYQLAKFIYYHAFKESIEIAKEKGSFPAYDAKLYKDIWESAKDFYEILEIMGIKDKPS HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH DYVKKLTSIVDKLDFDKLKEDRIKYGLRNATVVSVAPTGTISIIAGTSSSIEPLFALAFI HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHH RNVAVGKFMEIDPLFLDYLRKYELDNPEVVKKIAETGMIGDNPFMPKSMRKVFRTAHEVS HHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC PEYHLLHQAAWQQWNDSGTSKTINLRSEEPPETVERVYMLAWKLGIKGVTVYRDKSKSQQ CHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCE VIYFGIKKEREEVKKEEEKKIQQLLPSSLRIQKKFVEVSETYAGGCKTCEL EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9634230; 12218036 [H]