Click here to switch to the map view.

The map label for this gene is yqhM [H]

Identifier: 15921456

GI number: 15921456

Start: 1195563

End: 1196285

Strand: Direct

Name: yqhM [H]

Synonym: ST1193

Alternate gene names: 15921456

Gene position: 1195563-1196285 (Clockwise)

Preceding gene: 15921455

Following gene: 15921457

Centisome position: 44.37

GC content: 36.51

Gene sequence:

>723_bases
ATGAGACTTATAATTGAAGGTGGCGAACGTGGAGAGAGACAAATGGCTCTTGATGAGACTATGCTTCTGCTTCTTACTAA
GGATTTAATACCAGAAACCGTTAGGTTCTGGAATTTTAAACCTACAACTTTAACGCTAGGTAGATTTTTGGCAGTAAAGG
ATTGGGTTAATGAGGAAGAATTGAGACGTTTTAATTTCCCCTTAATAAGACGTTTTACCGGTGGTGGTCCGGCTTTACAT
GACGAAAATGGTGAAATTACTTGGAGTGTTGCTATCAAGGGTAATGATTTAATGAAGGCTTATCAAACTATTGCTAAAGC
GTTAATTAACGCTCTTTCTCATTTTGATTTGAAGGGAGAGTTTTCTCCGATAAATGATATTGTTGTTCAGGGTAAGAAGA
TTGTTGGAATGGCTGGGGCTATTAAGAGGAATTCTATTTTAGTTCATGGTACTTTTATGTATGCTACAAACCCAGAGTTT
ATGAGGGTCATTAAGTCTCCAAAGGTTAAGGAGGCTGAAAGAGGTGAGGCTAAGTCTAGAGTTACTACTGTTTCTTTACT
TTTGGGTTATAATATATCAAGGAGTGAGGCTTTAGAGGCTTTAATTGAGGGTTTTAAGTCTGTTTTTAATCTTGAGGATG
GTGAGTTAACTGACATAGAGAAGGAGTTTAGTGAATCATTAAGGTTTAAATATACTAATCCTCAATGGACTTATTTGAGA
TGA

Upstream 100 bases:

>100_bases
TAGATAAAAAAGTCTATTTATTCTATCACTAACTAAATAAAAACTCTTACAGCCTATTAAAATATGTTTTCTTATAAACC
CTTTATGAGTTTTTATTTTT

Downstream 100 bases:

>100_bases
TTTGTGAAAAGGTGTTTAGGTCTAGGGCCGGAAAGACTGTTATTTTGAGGGTCTATGATAATAATGTTGAGGTTACTGGT
GATTTCTTCACTACTGATGA

Product: hypothetical protein

Products: lipoyl-AMP; pyrophosphate; N6-lipoyl-lysine [C]

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MRLIIEGGERGERQMALDETMLLLLTKDLIPETVRFWNFKPTTLTLGRFLAVKDWVNEEELRRFNFPLIRRFTGGGPALH
DENGEITWSVAIKGNDLMKAYQTIAKALINALSHFDLKGEFSPINDIVVQGKKIVGMAGAIKRNSILVHGTFMYATNPEF
MRVIKSPKVKEAERGEAKSRVTTVSLLLGYNISRSEALEALIEGFKSVFNLEDGELTDIEKEFSESLRFKYTNPQWTYLR

Sequences:

>Translated_240_residues
MRLIIEGGERGERQMALDETMLLLLTKDLIPETVRFWNFKPTTLTLGRFLAVKDWVNEEELRRFNFPLIRRFTGGGPALH
DENGEITWSVAIKGNDLMKAYQTIAKALINALSHFDLKGEFSPINDIVVQGKKIVGMAGAIKRNSILVHGTFMYATNPEF
MRVIKSPKVKEAERGEAKSRVTTVSLLLGYNISRSEALEALIEGFKSVFNLEDGELTDIEKEFSESLRFKYTNPQWTYLR
>Mature_240_residues
MRLIIEGGERGERQMALDETMLLLLTKDLIPETVRFWNFKPTTLTLGRFLAVKDWVNEEELRRFNFPLIRRFTGGGPALH
DENGEITWSVAIKGNDLMKAYQTIAKALINALSHFDLKGEFSPINDIVVQGKKIVGMAGAIKRNSILVHGTFMYATNPEF
MRVIKSPKVKEAERGEAKSRVTTVSLLLGYNISRSEALEALIEGFKSVFNLEDGELTDIEKEFSESLRFKYTNPQWTYLR

Specific function: Catalyzes Both The ATP-Dependent Activation Of Exogenously Supplied Lipoate To Lipoyl-Amp And The Transfer Of The Activated Lipoyl On The Lipoate-Dependent Enzymes. Creates An Amide Linkage That Joins The Free Carboxyl Group Of Lipoic Acid To The Epsilon-

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 27335; Mature: 27335

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIIEGGERGERQMALDETMLLLLTKDLIPETVRFWNFKPTTLTLGRFLAVKDWVNEEE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
LRRFNFPLIRRFTGGGPALHDENGEITWSVAIKGNDLMKAYQTIAKALINALSHFDLKGE
HHHCCCHHHEEECCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC
FSPINDIVVQGKKIVGMAGAIKRNSILVHGTFMYATNPEFMRVIKSPKVKEAERGEAKSR
CCCHHHHHHCCCCEEEECCCEECCEEEEEEEEEEECCHHHHHHHCCCCCCCCCCCCHHHH
VTTVSLLLGYNISRSEALEALIEGFKSVFNLEDGELTDIEKEFSESLRFKYTNPQWTYLR
HHHEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCCEEEEC
>Mature Secondary Structure
MRLIIEGGERGERQMALDETMLLLLTKDLIPETVRFWNFKPTTLTLGRFLAVKDWVNEEE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
LRRFNFPLIRRFTGGGPALHDENGEITWSVAIKGNDLMKAYQTIAKALINALSHFDLKGE
HHHCCCHHHEEECCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC
FSPINDIVVQGKKIVGMAGAIKRNSILVHGTFMYATNPEFMRVIKSPKVKEAERGEAKSR
CCCHHHHHHCCCCEEEECCCEECCEEEEEEEEEEECCHHHHHHHCCCCCCCCCCCCHHHH
VTTVSLLLGYNISRSEALEALIEGFKSVFNLEDGELTDIEKEFSESLRFKYTNPQWTYLR
HHHEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lipoic acid; ATP [C]

Specific reaction: Catalyzes first the reaction of lipoic acid and ATP to form lipoyl-AMP and pyrophosphate, then the formation N6-lipoyl-lysine from a specific lysine residue in lipoate-dependent enzymes [C]

General reaction: Ligases; Forming Carbon-Nitrogen Bonds; Other Carbon-Nitrogen Ligases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]