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The map label for this gene is ndk [H]

Identifier: 15920470

GI number: 15920470

Start: 298742

End: 299188

Strand: Reverse

Name: ndk [H]

Synonym: ST0280

Alternate gene names: 15920470

Gene position: 299188-298742 (Counterclockwise)

Preceding gene: 15920471

Following gene: 15920468

Centisome position: 11.1

GC content: 33.78

Gene sequence:

>447_bases
GTGATGAGTATCCAAAGAACTTTTGTTATGATAAAACCAGATGGTGTAAGAAGAAATCTTATTGGCGAAATAATTTCTAG
ATTTGAAAAAAGAGGTCTTAAAATTATAGGCTTAAAAATGGTTAAAATAGATAGACCTACTGCAGAAAGACTTTATGAAG
AGCATAAAGGTAAATCATTCTTTGAGGAGTTAATTAGCTATATAACTTCTGGTCCAGTAGTGTGTATGGTAATCGAAGGA
GATGAAGCTGTTAGTGTTGTTAGAAAAATGATAGGAAACACTGACCCTAAAGAGGCTCCACCAGGTACAATAAGAGGTGA
TTATGCCTTAAGTAAAGCAGAAAATGTTATACACGCTTCAGATAGTGAAGAAAAGGCAAAAAGAGAAATGAGTATATTTT
TCAAAGAAGAAGAGCTAGTTACACCTTTAGCCCAAGTGCATATGTAG

Upstream 100 bases:

>100_bases
GTATATTATGGTTCTGTTCAAATAAATGTAAAAAATCAATGTTGAAGCTACATAGAGATCCTAAAAAGTTGAAATGGACA
AAATCATATATAGGTGGTAA

Downstream 100 bases:

>100_bases
GGTCATTAACTCTTTTTATATTAATTATTTCCTTTATAACTTCTTTCATATCATCTGTGATTATATCTTTATATTTGGTT
AATAGTATCTCTAAATCTTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MMSIQRTFVMIKPDGVRRNLIGEIISRFEKRGLKIIGLKMVKIDRPTAERLYEEHKGKSFFEELISYITSGPVVCMVIEG
DEAVSVVRKMIGNTDPKEAPPGTIRGDYALSKAENVIHASDSEEKAKREMSIFFKEEELVTPLAQVHM

Sequences:

>Translated_148_residues
MMSIQRTFVMIKPDGVRRNLIGEIISRFEKRGLKIIGLKMVKIDRPTAERLYEEHKGKSFFEELISYITSGPVVCMVIEG
DEAVSVVRKMIGNTDPKEAPPGTIRGDYALSKAENVIHASDSEEKAKREMSIFFKEEELVTPLAQVHM
>Mature_148_residues
MMSIQRTFVMIKPDGVRRNLIGEIISRFEKRGLKIIGLKMVKIDRPTAERLYEEHKGKSFFEELISYITSGPVVCMVIEG
DEAVSVVRKMIGNTDPKEAPPGTIRGDYALSKAENVIHASDSEEKAKREMSIFFKEEELVTPLAQVHM

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=48.9051094890511, Blast_Score=147, Evalue=2e-36,
Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=45.2554744525547, Blast_Score=145, Evalue=1e-35,
Organism=Homo sapiens, GI4557797, Length=147, Percent_Identity=46.2585034013605, Blast_Score=142, Evalue=9e-35,
Organism=Homo sapiens, GI38045913, Length=147, Percent_Identity=46.2585034013605, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI66392227, Length=147, Percent_Identity=44.2176870748299, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI66392205, Length=147, Percent_Identity=44.2176870748299, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI4505409, Length=147, Percent_Identity=44.2176870748299, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI66392192, Length=147, Percent_Identity=44.2176870748299, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI66392203, Length=147, Percent_Identity=44.2176870748299, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI7019465, Length=137, Percent_Identity=34.3065693430657, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI37574614, Length=137, Percent_Identity=34.3065693430657, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=28.9855072463768, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=29.9270072992701, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=27.8571428571429, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI30023828, Length=143, Percent_Identity=28.6713286713287, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=48.2014388489209, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=46.0431654676259, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71995094, Length=130, Percent_Identity=34.6153846153846, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=47.0588235294118, Blast_Score=146, Evalue=1e-36,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=45.985401459854, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=34.5864661654135, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24645457, Length=137, Percent_Identity=27.007299270073, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16756; Mature: 16756

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSIQRTFVMIKPDGVRRNLIGEIISRFEKRGLKIIGLKMVKIDRPTAERLYEEHKGKSF
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHCCHHH
FEELISYITSGPVVCMVIEGDEAVSVVRKMIGNTDPKEAPPGTIRGDYALSKAENVIHAS
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHEECC
DSEEKAKREMSIFFKEEELVTPLAQVHM
CCHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MMSIQRTFVMIKPDGVRRNLIGEIISRFEKRGLKIIGLKMVKIDRPTAERLYEEHKGKSF
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHCCHHH
FEELISYITSGPVVCMVIEGDEAVSVVRKMIGNTDPKEAPPGTIRGDYALSKAENVIHAS
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHEECC
DSEEKAKREMSIFFKEEELVTPLAQVHM
CCHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]