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The map label for this gene is pth

Identifier: 15920389

GI number: 15920389

Start: 230298

End: 230663

Strand: Reverse

Name: pth

Synonym: ST0208

Alternate gene names: 15920389

Gene position: 230663-230298 (Counterclockwise)

Preceding gene: 15920400

Following gene: 15920388

Centisome position: 8.56

GC content: 33.06

Gene sequence:

>366_bases
ATGGCTACTAAAATGGTAATAGTCGTAAGGACAGATTTAGATATGGGAAAAGGTAAAATAGCTGCTCAAGTCGCTCATGC
AGCTGTTTCATTAGTTCTTGATATTCTAAATTCTAGTAATAGTCTTTGGAAAGAATGGTTATATAAATGGCTAGAAGAAG
GACAACCTAAAATAGTTGTTAAAGTTCCTAGCCTCGATGAATTAAATAAAAGATATGAAAAGGCTATAGAACTAAATTTA
CCAACAACTATAATACAAGATGCTGGAAAAACGCAGATAGAACCTGGAACAATAACTTGTATAGGAATTGGACCAGCCCC
TGTAGAATTAGTTGATAAGATAACTGGAGATCTAAAACTTCTTTAA

Upstream 100 bases:

>100_bases
AGCATACTGGTGGTTCAATCTCTTCTCTTAAACTTAATCTGAAATTTAGACTCATTGTATTACATAGTTTTTAATTTGGT
TTATAAATTCTCTCTTTTTG

Downstream 100 bases:

>100_bases
TTTTTTATTAATTAAAATTTTTAATTACTAGATAAAATCTGCTTGTTTATAATTAGAAATTATTGTAATAGTGTTTAAAT
GAAGTTTAGATATTCAGTAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 121; Mature: 120

Protein sequence:

>121_residues
MATKMVIVVRTDLDMGKGKIAAQVAHAAVSLVLDILNSSNSLWKEWLYKWLEEGQPKIVVKVPSLDELNKRYEKAIELNL
PTTIIQDAGKTQIEPGTITCIGIGPAPVELVDKITGDLKLL

Sequences:

>Translated_121_residues
MATKMVIVVRTDLDMGKGKIAAQVAHAAVSLVLDILNSSNSLWKEWLYKWLEEGQPKIVVKVPSLDELNKRYEKAIELNL
PTTIIQDAGKTQIEPGTITCIGIGPAPVELVDKITGDLKLL
>Mature_120_residues
ATKMVIVVRTDLDMGKGKIAAQVAHAAVSLVLDILNSSNSLWKEWLYKWLEEGQPKIVVKVPSLDELNKRYEKAIELNLP
TTIIQDAGKTQIEPGTITCIGIGPAPVELVDKITGDLKLL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family

Homologues:

Organism=Homo sapiens, GI7706351, Length=117, Percent_Identity=51.2820512820513, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17558188, Length=118, Percent_Identity=43.2203389830509, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319414, Length=119, Percent_Identity=45.3781512605042, Blast_Score=107, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24646438, Length=120, Percent_Identity=46.6666666666667, Blast_Score=111, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281376919, Length=118, Percent_Identity=44.9152542372881, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24644665, Length=118, Percent_Identity=44.9152542372881, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_SULTO (Q976I0)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376058.1
- ProteinModelPortal:   Q976I0
- SMR:   Q976I0
- GeneID:   1458097
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0208
- NMPDR:   fig|273063.1.peg.226
- HOGENOM:   HBG526257
- OMA:   IQRRNPE
- ProtClustDB:   PRK04322
- BioCyc:   STOK273063:ST0208-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00628
- InterPro:   IPR002833
- TIGRFAMs:   TIGR00283

Pfam domain/function: PF01981 PTH2

EC number: =3.1.1.29

Molecular weight: Translated: 13264; Mature: 13133

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKMVIVVRTDLDMGKGKIAAQVAHAAVSLVLDILNSSNSLWKEWLYKWLEEGQPKIVV
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
KVPSLDELNKRYEKAIELNLPTTIIQDAGKTQIEPGTITCIGIGPAPVELVDKITGDLKL
ECCCHHHHHHHHHHHEECCCCHHHHHCCCCCEECCCCEEEEECCCCHHHHHHHHCCCEEC
L
C
>Mature Secondary Structure 
ATKMVIVVRTDLDMGKGKIAAQVAHAAVSLVLDILNSSNSLWKEWLYKWLEEGQPKIVV
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
KVPSLDELNKRYEKAIELNLPTTIIQDAGKTQIEPGTITCIGIGPAPVELVDKITGDLKL
ECCCHHHHHHHHHHHEECCCCHHHHHCCCCCEECCCCEEEEECCCCHHHHHHHHCCCEEC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479