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The map label for this gene is uppS

Identifier: 15920367

GI number: 15920367

Start: 212515

End: 213303

Strand: Reverse

Name: uppS

Synonym: ST0189

Alternate gene names: 15920367

Gene position: 213303-212515 (Counterclockwise)

Preceding gene: 15920368

Following gene: 15920366

Centisome position: 7.92

GC content: 29.53

Gene sequence:

>789_bases
ATGTTTAAAGAAAAAGTAGGGAAGATTATACTATATCCAGTCTATAAGTTCTATGAAAAAATTTTATGGAATGAGATAAA
AAATGGTCCATTTCCTCAACATGTTGGAATTATTCCAGATGGGAATAGGAGATGGGCAAGAGCCAACAACTTAAGTATAA
ATGATGCATATTATAGTGGTTACAGAAAGTTAAAACAAGTGTTATTATGGTTACTAGAGATGGGTATAAAAAATATAACG
GTATTTGCACTTTCAACAGAAAATTGTGATAAGAGATCAAATCTTGAGCTTAATACAATATTTAACTACATTAAGGCAGG
ATTAGAAGAGTTACTCTATGGCGAAATAATTTATAAATATGAAGTTAAAGTAAGAGCAATAGGTCTAATATATAAACTTC
CCCTAGACCTATTAGAAGTACTAAATCAATTAAGTAAAAAAACTGAGAATTTTAACAAGAGGAAGCTTACTCTTGCAATC
TGTTATGGAGGAAGACAAGAAATAATTGATGCTACCAAAAAAATTATTGCAGATTACGAGAAAGGAAAAATAAAACTAGA
TGATATTAATGAAAATATATTTAGGCAATACCTTTATGATAAAGAGCTAGAAGACATAGATCTAGTAATTAGATCTTCTG
GTGAAATACGAATAAGTAATTTCCTTTTATGGCATATAGCGTATTCAGAACTCTTTTTTGTAGACACATATTGGCCAGAC
TTTAGAAAGATAGACTTATGGAGAGCAATAAGATCTTATCAAAAGAGGAAAAGAAATTTCGGTGCTTAA

Upstream 100 bases:

>100_bases
GACCTGGGAATTCTACGTTAGAACACACAAATAATGAAAAGATTTCTATCGATGAAATATTTATAGCTTTAACAACTTAT
ATCAATGCGATAGAAGAATT

Downstream 100 bases:

>100_bases
ATTTATAAGCTACCTCCTTAAATAAGTTTCGTATGGGATATTTTCAAGGTAATGATTTTAGGAAAATAACTGGTGGTAAA
AAAGGAAAACATAGAGATAA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MFKEKVGKIILYPVYKFYEKILWNEIKNGPFPQHVGIIPDGNRRWARANNLSINDAYYSGYRKLKQVLLWLLEMGIKNIT
VFALSTENCDKRSNLELNTIFNYIKAGLEELLYGEIIYKYEVKVRAIGLIYKLPLDLLEVLNQLSKKTENFNKRKLTLAI
CYGGRQEIIDATKKIIADYEKGKIKLDDINENIFRQYLYDKELEDIDLVIRSSGEIRISNFLLWHIAYSELFFVDTYWPD
FRKIDLWRAIRSYQKRKRNFGA

Sequences:

>Translated_262_residues
MFKEKVGKIILYPVYKFYEKILWNEIKNGPFPQHVGIIPDGNRRWARANNLSINDAYYSGYRKLKQVLLWLLEMGIKNIT
VFALSTENCDKRSNLELNTIFNYIKAGLEELLYGEIIYKYEVKVRAIGLIYKLPLDLLEVLNQLSKKTENFNKRKLTLAI
CYGGRQEIIDATKKIIADYEKGKIKLDDINENIFRQYLYDKELEDIDLVIRSSGEIRISNFLLWHIAYSELFFVDTYWPD
FRKIDLWRAIRSYQKRKRNFGA
>Mature_262_residues
MFKEKVGKIILYPVYKFYEKILWNEIKNGPFPQHVGIIPDGNRRWARANNLSINDAYYSGYRKLKQVLLWLLEMGIKNIT
VFALSTENCDKRSNLELNTIFNYIKAGLEELLYGEIIYKYEVKVRAIGLIYKLPLDLLEVLNQLSKKTENFNKRKLTLAI
CYGGRQEIIDATKKIIADYEKGKIKLDDINENIFRQYLYDKELEDIDLVIRSSGEIRISNFLLWHIAYSELFFVDTYWPD
FRKIDLWRAIRSYQKRKRNFGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=239, Percent_Identity=35.1464435146443, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI45580742, Length=239, Percent_Identity=35.1464435146443, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=32.1739130434783, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71993029, Length=233, Percent_Identity=33.0472103004292, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=35, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=26.431718061674, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18857969, Length=246, Percent_Identity=32.9268292682927, Blast_Score=138, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_SULTO (Q976K2)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376036.1
- ProteinModelPortal:   Q976K2
- GeneID:   1458073
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0189
- NMPDR:   fig|273063.1.peg.204
- HOGENOM:   HBG627837
- OMA:   HLYTSGQ
- ProtClustDB:   CLSK802588
- BioCyc:   STOK273063:ST0189-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 31136; Mature: 31136

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 40-40

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKEKVGKIILYPVYKFYEKILWNEIKNGPFPQHVGIIPDGNRRWARANNLSINDAYYSG
CCCHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHH
YRKLKQVLLWLLEMGIKNITVFALSTENCDKRSNLELNTIFNYIKAGLEELLYGEIIYKY
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
EVKVRAIGLIYKLPLDLLEVLNQLSKKTENFNKRKLTLAICYGGRQEIIDATKKIIADYE
EEEEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHC
KGKIKLDDINENIFRQYLYDKELEDIDLVIRSSGEIRISNFLLWHIAYSELFFVDTYWPD
CCEEEEECCCHHHHHHHHHCCCCCHHHHEEECCCCEEEHHEEEEEEHHHHEEEEECCCCC
FRKIDLWRAIRSYQKRKRNFGA
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFKEKVGKIILYPVYKFYEKILWNEIKNGPFPQHVGIIPDGNRRWARANNLSINDAYYSG
CCCHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHH
YRKLKQVLLWLLEMGIKNITVFALSTENCDKRSNLELNTIFNYIKAGLEELLYGEIIYKY
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
EVKVRAIGLIYKLPLDLLEVLNQLSKKTENFNKRKLTLAICYGGRQEIIDATKKIIADYE
EEEEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHC
KGKIKLDDINENIFRQYLYDKELEDIDLVIRSSGEIRISNFLLWHIAYSELFFVDTYWPD
CCEEEEECCCHHHHHHHHHCCCCCHHHHEEECCCCEEEHHEEEEEEHHHHEEEEECCCCC
FRKIDLWRAIRSYQKRKRNFGA
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479