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The map label for this gene is ung

Identifier: 159185223

GI number: 159185223

Start: 2426413

End: 2427126

Strand: Reverse

Name: ung

Synonym: Atu2455

Alternate gene names: 159185223

Gene position: 2427126-2426413 (Counterclockwise)

Preceding gene: 15889727

Following gene: 15889725

Centisome position: 85.41

GC content: 58.54

Gene sequence:

>714_bases
ATGGCAGAGGCAGGCGTCAAACTCGAAGACAGCTGGAAGCACGTTCTCTCGGGCGAATTCGCCAGCCCCTACATGCAGAA
GCTGAAAGAGTTCCTGCTTGCCGAAAAGACCGCCGGCAAGCGCATCTTTCCGAAGGGCGCGGAATATTTCCGCGCTCTCG
ACCTCACGCCTCTCGACGAGGTCAAGGTCGTCATTCTTGGCCAGGATCCCTACCATGGGCTCGGTCAGGCACATGGGCTC
TGCTTTTCGGTGCAGCCCGGGGTGCGCATTCCGCCCTCGCTCGTCAATATCTACAAGGAATTGCAGAGCGACCTCGGCAT
TCGCCCGGTCAAGCACGGTTTTCTGGAAAGCTGGGCAAAACAGGGCGTGTTGCTGCTCAACAGCGTGCTGACGGTGGAAG
AGGCGCGGGCCGCCTCGCATCAGGGGCAGGGCTGGGAAAAATTCACCGATGCGGTCATCCGCGCCGTGAACGACGAATGT
GACCATGTGGTCTTTCTGCTCTGGGGTTCCTATGCCCAGAAGAAGGCGGCCTTCGTGGACCAGCGCAAACATCTCGTGCT
GCGCTCGCCACACCCGTCACCCCTTTCAGCCCATAACGGGTTTTTCGGCAACGGCCATTTTTCTAAGGCCAACGCTTTCC
TCGTTTCGCATGGCCGTGATCCGATCGACTGGCAATTGCCTGACGTGGTGGAAGGCGACAAAAACCTTCTTTAA

Upstream 100 bases:

>100_bases
GCCTTTCGCAAAATACTTTTTCATCTGCGATCCGGATGGTTACAAGATCGAAGTGCTGCAGCGCGGCGACCGGTTCAAAT
AAGCTCTGATGGAGGCGGGC

Downstream 100 bases:

>100_bases
ATACTCATAAATACCTTTGCGCTTTGCCAGTCTCGGGGTTAAAGATAACCGGACTACAAAGTGAAGGATTATGCCCGTGT
CTCTCCTGTCCGCAGAAACC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAEAGVKLEDSWKHVLSGEFASPYMQKLKEFLLAEKTAGKRIFPKGAEYFRALDLTPLDEVKVVILGQDPYHGLGQAHGL
CFSVQPGVRIPPSLVNIYKELQSDLGIRPVKHGFLESWAKQGVLLLNSVLTVEEARAASHQGQGWEKFTDAVIRAVNDEC
DHVVFLLWGSYAQKKAAFVDQRKHLVLRSPHPSPLSAHNGFFGNGHFSKANAFLVSHGRDPIDWQLPDVVEGDKNLL

Sequences:

>Translated_237_residues
MAEAGVKLEDSWKHVLSGEFASPYMQKLKEFLLAEKTAGKRIFPKGAEYFRALDLTPLDEVKVVILGQDPYHGLGQAHGL
CFSVQPGVRIPPSLVNIYKELQSDLGIRPVKHGFLESWAKQGVLLLNSVLTVEEARAASHQGQGWEKFTDAVIRAVNDEC
DHVVFLLWGSYAQKKAAFVDQRKHLVLRSPHPSPLSAHNGFFGNGHFSKANAFLVSHGRDPIDWQLPDVVEGDKNLL
>Mature_236_residues
AEAGVKLEDSWKHVLSGEFASPYMQKLKEFLLAEKTAGKRIFPKGAEYFRALDLTPLDEVKVVILGQDPYHGLGQAHGLC
FSVQPGVRIPPSLVNIYKELQSDLGIRPVKHGFLESWAKQGVLLLNSVLTVEEARAASHQGQGWEKFTDAVIRAVNDECD
HVVFLLWGSYAQKKAAFVDQRKHLVLRSPHPSPLSAHNGFFGNGHFSKANAFLVSHGRDPIDWQLPDVVEGDKNLL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=222, Percent_Identity=54.0540540540541, Blast_Score=230, Evalue=8e-61,
Organism=Homo sapiens, GI6224979, Length=222, Percent_Identity=54.0540540540541, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=55.2995391705069, Blast_Score=244, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=48.8479262672811, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=44.4915254237288, Blast_Score=178, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_AGRT5 (Q8UCM8)

Other databases:

- EMBL:   AE007869
- PIR:   AE2878
- PIR:   G97654
- RefSeq:   NP_355407.2
- ProteinModelPortal:   Q8UCM8
- SMR:   Q8UCM8
- STRING:   Q8UCM8
- GeneID:   1134493
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2455
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q8UCM8
- ProtClustDB:   PRK05254
- BioCyc:   ATUM176299-1:ATU2455-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26330; Mature: 26199

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 73-73

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAGVKLEDSWKHVLSGEFASPYMQKLKEFLLAEKTAGKRIFPKGAEYFRALDLTPLDE
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCC
VKVVILGQDPYHGLGQAHGLCFSVQPGVRIPPSLVNIYKELQSDLGIRPVKHGFLESWAK
EEEEEECCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QGVLLLNSVLTVEEARAASHQGQGWEKFTDAVIRAVNDECDHVVFLLWGSYAQKKAAFVD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
QRKHLVLRSPHPSPLSAHNGFFGNGHFSKANAFLVSHGRDPIDWQLPDVVEGDKNLL
HHCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
AEAGVKLEDSWKHVLSGEFASPYMQKLKEFLLAEKTAGKRIFPKGAEYFRALDLTPLDE
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCC
VKVVILGQDPYHGLGQAHGLCFSVQPGVRIPPSLVNIYKELQSDLGIRPVKHGFLESWAK
EEEEEECCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QGVLLLNSVLTVEEARAASHQGQGWEKFTDAVIRAVNDECDHVVFLLWGSYAQKKAAFVD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
QRKHLVLRSPHPSPLSAHNGFFGNGHFSKANAFLVSHGRDPIDWQLPDVVEGDKNLL
HHCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194