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The map label for this gene is mdtA [H]

Identifier: 159185191

GI number: 159185191

Start: 2362835

End: 2364028

Strand: Direct

Name: mdtA [H]

Synonym: Atu2392

Alternate gene names: 159185191

Gene position: 2362835-2364028 (Clockwise)

Preceding gene: 15889662

Following gene: 15889664

Centisome position: 83.15

GC content: 61.31

Gene sequence:

>1194_bases
ATGCAGCATAAAGTCACGTTTAACCGCTTTGTTTTCCTTCTTCTTTCCGCAGCGGCGCTCCCCTTGTCCGCAGCCGCCGA
GGGAGAGGCGCAGGCACCGGTCAAACAGCAGAACCTGCCTTCCATCATCGTTGCGCATGCCGCAAAACGCGATCTCGTCG
ACCGCATCATCGCGACGGGCACCATCCGTCCGGTTGATGAAATCTATGTCCAGCCGCTGGTCGACGGCCTGTCGATCGAT
ACGCTGAACGTCGATATCGGTGACAGGGTCGAAGCAAATGCGATCCTTGCCGTCCTCTCCTCGGACAGTCTGATCCTTCA
GAAAAGCCAGCTTGAGGCCAACAAGGCCAAGGCGCAGGCTGCTGTCGCACAGGCCAAGGCACAGGTCCTGGAAGCGGAGG
CGAGCGCCAATGACGCGAACCGCCAGCGCGACCGCGCCGCAAAGCTCGGCCAGAGCGGCTCCGGCTCCGTCTCGCAGGTA
GAACAGACCCAGGCCCAGGCCGAAGTGGCCGCCGCCAAACTCAACGCCGCCCGCCAGGCCGTTTCCGCCGGCGAAGCCGA
CATCAAGGTGGTTGATGCGCAGATTGCCGATATCGATCTGAAGCTGACGCGCACGGGCGTGAAAACCCCGGTTGCCGGCA
TCGTTTCAGCCAAGAATGCGAAGGTCGGCGCGATTGCCAGCGGTGCCGGCAATCCGCTTTTCACCGTCATCAAGGATGGC
GCGATCGAACTCGTCGCCGATCTGTCCGAGACCGATATCCAGAAGGTGAAGATCGGCCAGAAAGCCTATTTGACGGTTGC
CGGCGGAGCTGAGAAAATAGAGGGCAAGGTGCGCCTCGTCTCGCCCACCGTCGATCCGACGACGCGCCTCGGTTCCGTGC
ATGTGGTGCTGCCCGAAAACAGCCCGGCGCGCTCAGGCATGTATGCCAGCGCGGCGATCATCGTCGAAGAGACGAATGCG
CTTGCTTTGCCGCTTTCGGCCGTTACCTCCGGGCGTGAAGGCTCGACCACCCGCAAGGTGGAAGGCGACGTCGTCAAGCA
GGTGAAGATCGAGACCGGCATAGAAGACAGTGGTTTCATCGAGATTGTCAGCGGTCTTGCCGCTGGAGACAAGGTTGTCG
AGAAGGCTGGAGCATTCGTGCGTGATGGTGACCGGATAAACCCGGTGGAAGCCCAGACGGCTGCGTCCAACTGA

Upstream 100 bases:

>100_bases
TATTGTGATCCCTTGTTTCACATTCGCCATCGCATGACCTTTTGAGACACGGCCCCGAGCCTGCAGGACATGTGAGCGGA
TATTGCGCGAGCCAAGACAC

Downstream 100 bases:

>100_bases
CTGAGGGAATGAAATGAACTTTTCCGCATGGTCAATCCGTAACCCGATTGCGCCGCTGCTCGGCTTCGCGCTTTTGATGA
TCCTCGGTATGCAGGCGTTC

Product: HlyD family secretion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQHKVTFNRFVFLLLSAAALPLSAAAEGEAQAPVKQQNLPSIIVAHAAKRDLVDRIIATGTIRPVDEIYVQPLVDGLSID
TLNVDIGDRVEANAILAVLSSDSLILQKSQLEANKAKAQAAVAQAKAQVLEAEASANDANRQRDRAAKLGQSGSGSVSQV
EQTQAQAEVAAAKLNAARQAVSAGEADIKVVDAQIADIDLKLTRTGVKTPVAGIVSAKNAKVGAIASGAGNPLFTVIKDG
AIELVADLSETDIQKVKIGQKAYLTVAGGAEKIEGKVRLVSPTVDPTTRLGSVHVVLPENSPARSGMYASAAIIVEETNA
LALPLSAVTSGREGSTTRKVEGDVVKQVKIETGIEDSGFIEIVSGLAAGDKVVEKAGAFVRDGDRINPVEAQTAASN

Sequences:

>Translated_397_residues
MQHKVTFNRFVFLLLSAAALPLSAAAEGEAQAPVKQQNLPSIIVAHAAKRDLVDRIIATGTIRPVDEIYVQPLVDGLSID
TLNVDIGDRVEANAILAVLSSDSLILQKSQLEANKAKAQAAVAQAKAQVLEAEASANDANRQRDRAAKLGQSGSGSVSQV
EQTQAQAEVAAAKLNAARQAVSAGEADIKVVDAQIADIDLKLTRTGVKTPVAGIVSAKNAKVGAIASGAGNPLFTVIKDG
AIELVADLSETDIQKVKIGQKAYLTVAGGAEKIEGKVRLVSPTVDPTTRLGSVHVVLPENSPARSGMYASAAIIVEETNA
LALPLSAVTSGREGSTTRKVEGDVVKQVKIETGIEDSGFIEIVSGLAAGDKVVEKAGAFVRDGDRINPVEAQTAASN
>Mature_397_residues
MQHKVTFNRFVFLLLSAAALPLSAAAEGEAQAPVKQQNLPSIIVAHAAKRDLVDRIIATGTIRPVDEIYVQPLVDGLSID
TLNVDIGDRVEANAILAVLSSDSLILQKSQLEANKAKAQAAVAQAKAQVLEAEASANDANRQRDRAAKLGQSGSGSVSQV
EQTQAQAEVAAAKLNAARQAVSAGEADIKVVDAQIADIDLKLTRTGVKTPVAGIVSAKNAKVGAIASGAGNPLFTVIKDG
AIELVADLSETDIQKVKIGQKAYLTVAGGAEKIEGKVRLVSPTVDPTTRLGSVHVVLPENSPARSGMYASAAIIVEETNA
LALPLSAVTSGREGSTTRKVEGDVVKQVKIETGIEDSGFIEIVSGLAAGDKVVEKAGAFVRDGDRINPVEAQTAASN

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=351, Percent_Identity=28.2051282051282, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081796, Length=343, Percent_Identity=27.9883381924198, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41080; Mature: 41080

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHKVTFNRFVFLLLSAAALPLSAAAEGEAQAPVKQQNLPSIIVAHAAKRDLVDRIIATG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCC
TIRPVDEIYVQPLVDGLSIDTLNVDIGDRVEANAILAVLSSDSLILQKSQLEANKAKAQA
CCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHH
AVAQAKAQVLEAEASANDANRQRDRAAKLGQSGSGSVSQVEQTQAQAEVAAAKLNAARQA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VSAGEADIKVVDAQIADIDLKLTRTGVKTPVAGIVSAKNAKVGAIASGAGNPLFTVIKDG
HHCCCCCEEEEEEEEEEEEEEEECCCCCCCHHHHEECCCCCEEEEECCCCCCEEEEECCC
AIELVADLSETDIQKVKIGQKAYLTVAGGAEKIEGKVRLVSPTVDPTTRLGSVHVVLPEN
CEEEECCCCHHHHHHHCCCCEEEEEEECCHHHCCCEEEEEECCCCCCCCCCEEEEEECCC
SPARSGMYASAAIIVEETNALALPLSAVTSGREGSTTRKVEGDVVKQVKIETGIEDSGFI
CCCCCCCEEEEEEEEECCCCEEEEHHHHCCCCCCCCCEECCCHHHHEEEEECCCCCCCHH
EIVSGLAAGDKVVEKAGAFVRDGDRINPVEAQTAASN
HHHHHHCCCHHHHHHCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQHKVTFNRFVFLLLSAAALPLSAAAEGEAQAPVKQQNLPSIIVAHAAKRDLVDRIIATG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCC
TIRPVDEIYVQPLVDGLSIDTLNVDIGDRVEANAILAVLSSDSLILQKSQLEANKAKAQA
CCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHH
AVAQAKAQVLEAEASANDANRQRDRAAKLGQSGSGSVSQVEQTQAQAEVAAAKLNAARQA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VSAGEADIKVVDAQIADIDLKLTRTGVKTPVAGIVSAKNAKVGAIASGAGNPLFTVIKDG
HHCCCCCEEEEEEEEEEEEEEEECCCCCCCHHHHEECCCCCEEEEECCCCCCEEEEECCC
AIELVADLSETDIQKVKIGQKAYLTVAGGAEKIEGKVRLVSPTVDPTTRLGSVHVVLPEN
CEEEECCCCHHHHHHHCCCCEEEEEEECCHHHCCCEEEEEECCCCCCCCCCEEEEEECCC
SPARSGMYASAAIIVEETNALALPLSAVTSGREGSTTRKVEGDVVKQVKIETGIEDSGFI
CCCCCCCEEEEEEEEECCCCEEEEHHHHCCCCCCCCCEECCCHHHHEEEEECCCCCCCHH
EIVSGLAAGDKVVEKAGAFVRDGDRINPVEAQTAASN
HHHHHHCCCHHHHHHCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA