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The map label for this gene is xdhB [H]

Identifier: 159185153

GI number: 159185153

Start: 2286728

End: 2288980

Strand: Direct

Name: xdhB [H]

Synonym: Atu2310

Alternate gene names: 159185153

Gene position: 2286728-2288980 (Clockwise)

Preceding gene: 15889586

Following gene: 15889588

Centisome position: 80.47

GC content: 61.52

Gene sequence:

>2253_bases
GTGACCGGCAGTGCCGAATATATCGATGACATTCCCGAACCCGCCGGCCTCGTCCACGGCGCACTCGGCCTTGCCGACCG
TGCCCATGCTGAAATCGTTTCGATGGACCTCTCCGAAGTGGAAGCTACACCGGGCGTGCTGTGGGTGATGGTGGGCAAGG
ATGTGCCCGGCGAAAACGATGTCTCGTCCGGCGGTCGTCACGACGAGCCGCTGCTAGCCGAAACGAAGGTTGAATTCCAC
GGCCAGCCGATCTTTGCGGTGTTTGCCGAAACCCGCGATATCGCCAGAAAGGCCGCGCGCAAGGCAAAGATCACTTACAG
AGACCTGCCGCATTTCACCGATATCGACACCGCGATTGAAAATGGCGGCGCGCTCGTCATCGATCCGATGACGCTGAAAC
GCGGCGATGCCAAGATTGAAATGGATGTCGCGCCCCGCCGCCTGACCGGCACGATGCGGATCGGCGGGCAGGAGCATTTT
TATCTCGAAAGCCACATCGCCATGGCCGTGCCGGGTGAGGATGACGAGGTGACGCTGTGGAGCTCCACTCAGCATCCCAG
CGAAATCCAGCATATCGTCAGCCACATTCTGCAGGTGCCGTCCAACGCCGTCACTGTACAGGTGCGCCGCATGGGCGGCG
GCTTCGGCGGCAAGGAAACCCAGGGCAACCAGTTTGCAGCACTCTGCGCCATCGCCGCCAAGAAGCTGAACCGGGCCGTG
AAAATCCGTCCCGACCGCGACGAGGACATGACGGCCACCGGCAAGCGCCATGATTTCCGTGTCGATTACGAACTTGGTTT
CGATGAGGAAGGCCGCATCCACGCTGTCGACGCCACCTATGCGGCACGCTGCGGTTTTTCCTCCGACCTGTCCGGCCCGG
TGACGGACCGCGCGCTGTTCCATGCCGATTCCAGCTATTTCTATCCGCATGTGCACCTGACTTCGCGACCGCTGAAAACC
CACACGGTCTCCAACACCGCCTTTCGCGGCTTCGGTGGCCCGCAGGGCATGCTGGGGGCCGAACGGTTCATCGAGGAAAT
CGCCTATGCGGTCGGCAAGGACCCGCTCGATATCCGCAAACTGAACTTTTACGGCGAGACCGGCTCGGGCCGCACCACGA
CGCCCTATCATCAGGAGGTCGAGGACAACATCATCGCCCGCGTCGTCGAGGAACTTGAGACATCCAGCGACTATCGCGCC
CGACGCGAGGCGATCATCGAATTCAACAGGACCAGCCCGATCATCCGCAAGGGCATCGCGCTCACTCCGGTGAAATTCGG
CATCTCCTTCACCATGACCGCCTTCAACCAGGCGGGCGCGCTGGTGCATATCTACAATGACGGATCGATCCACCTGAACC
ACGGCGGCACTGAAATGGGCCAGGGCCTCTACACCAAGGTGGCGCAGGTGGTGGCCGATGCCTTCCAGGTGGATATCGGC
CGGGTGAAGATAACGGCAACGACCACGGGCAAGGTGCCGAATACTTCGGCCACCGCCGCCTCATCCGGCACGGACCTGAA
CGGCATGGCCGCCTATGACGCCGCCCGTCAGATCCGCGAAAGGCTGGTGAAGTTCGCCGCTGAAAACTGGAATGTGCCGG
AAGAAGAAGTGGTCTTCCTGCCGAACCGGGTGCGCATCGGACTTGAGGAAATCGCCTTCAACGATTTCATCAAGAAGGCA
TATTTCGCCCGCGTGCAGCTTTCCGCCGCCGGTTTTTACAAGACGCCGAAAATCCACTGGGACCGCGCCGCCGGCCGTGG
CACGCCGTTTTATTATTTCGCCTATGGCGCGGCCTGTTCGGAAGTGTCGATCGATACGCTGACCGGCGAATATATGATGG
AACGCACCGATATCCTCCACGATGTCGGCAAGTCGCTGAACCCGGCCATCGACATCGGCCAGATCGAAGGCGCCTTCGTG
CAGGGCATGGGCTGGCTGACGACGGAGGAATTATGGTGGGACGGCAAGGGGCGGCTGCGCACCCACGCGCCCTCCACCTA
CAAGATCCCGCTCGCCTCCGATCGGCCGAAGAGCTTCAACGTCAAGCTGGCGGAATGGGCGGAAAATGCGGAACCCACCA
TCGGCCGCTCCAAGGCGGTCGGCGAACCGCCCTTCATGCTGGCGATCTCGGTTCTCGAAGCGCTCTCCATGGCGGTCGCC
TCCGTCGCCGATTACAAGGTCTGCCCGCGTCTCGATGCGCCGGCCACACCCGAACGGGTTTTGATGGCGGTGGAACGGTT
GAAAAAGGTGTGA

Upstream 100 bases:

>100_bases
AGGAGCTTGAACCATGGACACTACAAGCTTCGACAAGACCAAGACCGAAATCGACGGCCCGATGCACACGTCGCTCCGGC
ACGATTCCGCGCATAAGCAT

Downstream 100 bases:

>100_bases
GAGGGCCAGCGCCAATGCCTGACACCTCCTTATCCACTTTCCTCGCCCGCCCCGCCCCCACAATCCTCGTGGAAATCGAG
GCGGTGAAAGGCTCATCACC

Product: xanthine dehydrogenase C-terminal subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MTGSAEYIDDIPEPAGLVHGALGLADRAHAEIVSMDLSEVEATPGVLWVMVGKDVPGENDVSSGGRHDEPLLAETKVEFH
GQPIFAVFAETRDIARKAARKAKITYRDLPHFTDIDTAIENGGALVIDPMTLKRGDAKIEMDVAPRRLTGTMRIGGQEHF
YLESHIAMAVPGEDDEVTLWSSTQHPSEIQHIVSHILQVPSNAVTVQVRRMGGGFGGKETQGNQFAALCAIAAKKLNRAV
KIRPDRDEDMTATGKRHDFRVDYELGFDEEGRIHAVDATYAARCGFSSDLSGPVTDRALFHADSSYFYPHVHLTSRPLKT
HTVSNTAFRGFGGPQGMLGAERFIEEIAYAVGKDPLDIRKLNFYGETGSGRTTTPYHQEVEDNIIARVVEELETSSDYRA
RREAIIEFNRTSPIIRKGIALTPVKFGISFTMTAFNQAGALVHIYNDGSIHLNHGGTEMGQGLYTKVAQVVADAFQVDIG
RVKITATTTGKVPNTSATAASSGTDLNGMAAYDAARQIRERLVKFAAENWNVPEEEVVFLPNRVRIGLEEIAFNDFIKKA
YFARVQLSAAGFYKTPKIHWDRAAGRGTPFYYFAYGAACSEVSIDTLTGEYMMERTDILHDVGKSLNPAIDIGQIEGAFV
QGMGWLTTEELWWDGKGRLRTHAPSTYKIPLASDRPKSFNVKLAEWAENAEPTIGRSKAVGEPPFMLAISVLEALSMAVA
SVADYKVCPRLDAPATPERVLMAVERLKKV

Sequences:

>Translated_750_residues
MTGSAEYIDDIPEPAGLVHGALGLADRAHAEIVSMDLSEVEATPGVLWVMVGKDVPGENDVSSGGRHDEPLLAETKVEFH
GQPIFAVFAETRDIARKAARKAKITYRDLPHFTDIDTAIENGGALVIDPMTLKRGDAKIEMDVAPRRLTGTMRIGGQEHF
YLESHIAMAVPGEDDEVTLWSSTQHPSEIQHIVSHILQVPSNAVTVQVRRMGGGFGGKETQGNQFAALCAIAAKKLNRAV
KIRPDRDEDMTATGKRHDFRVDYELGFDEEGRIHAVDATYAARCGFSSDLSGPVTDRALFHADSSYFYPHVHLTSRPLKT
HTVSNTAFRGFGGPQGMLGAERFIEEIAYAVGKDPLDIRKLNFYGETGSGRTTTPYHQEVEDNIIARVVEELETSSDYRA
RREAIIEFNRTSPIIRKGIALTPVKFGISFTMTAFNQAGALVHIYNDGSIHLNHGGTEMGQGLYTKVAQVVADAFQVDIG
RVKITATTTGKVPNTSATAASSGTDLNGMAAYDAARQIRERLVKFAAENWNVPEEEVVFLPNRVRIGLEEIAFNDFIKKA
YFARVQLSAAGFYKTPKIHWDRAAGRGTPFYYFAYGAACSEVSIDTLTGEYMMERTDILHDVGKSLNPAIDIGQIEGAFV
QGMGWLTTEELWWDGKGRLRTHAPSTYKIPLASDRPKSFNVKLAEWAENAEPTIGRSKAVGEPPFMLAISVLEALSMAVA
SVADYKVCPRLDAPATPERVLMAVERLKKV
>Mature_749_residues
TGSAEYIDDIPEPAGLVHGALGLADRAHAEIVSMDLSEVEATPGVLWVMVGKDVPGENDVSSGGRHDEPLLAETKVEFHG
QPIFAVFAETRDIARKAARKAKITYRDLPHFTDIDTAIENGGALVIDPMTLKRGDAKIEMDVAPRRLTGTMRIGGQEHFY
LESHIAMAVPGEDDEVTLWSSTQHPSEIQHIVSHILQVPSNAVTVQVRRMGGGFGGKETQGNQFAALCAIAAKKLNRAVK
IRPDRDEDMTATGKRHDFRVDYELGFDEEGRIHAVDATYAARCGFSSDLSGPVTDRALFHADSSYFYPHVHLTSRPLKTH
TVSNTAFRGFGGPQGMLGAERFIEEIAYAVGKDPLDIRKLNFYGETGSGRTTTPYHQEVEDNIIARVVEELETSSDYRAR
REAIIEFNRTSPIIRKGIALTPVKFGISFTMTAFNQAGALVHIYNDGSIHLNHGGTEMGQGLYTKVAQVVADAFQVDIGR
VKITATTTGKVPNTSATAASSGTDLNGMAAYDAARQIRERLVKFAAENWNVPEEEVVFLPNRVRIGLEEIAFNDFIKKAY
FARVQLSAAGFYKTPKIHWDRAAGRGTPFYYFAYGAACSEVSIDTLTGEYMMERTDILHDVGKSLNPAIDIGQIEGAFVQ
GMGWLTTEELWWDGKGRLRTHAPSTYKIPLASDRPKSFNVKLAEWAENAEPTIGRSKAVGEPPFMLAISVLEALSMAVAS
VADYKVCPRLDAPATPERVLMAVERLKKV

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=746, Percent_Identity=43.4316353887399, Blast_Score=580, Evalue=1e-165,
Organism=Homo sapiens, GI71773480, Length=757, Percent_Identity=38.7054161162484, Blast_Score=478, Evalue=1e-134,
Organism=Escherichia coli, GI1789230, Length=781, Percent_Identity=26.2483994878361, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI1789246, Length=790, Percent_Identity=25.4430379746835, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1786478, Length=754, Percent_Identity=23.6074270557029, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540638, Length=756, Percent_Identity=40.2116402116402, Blast_Score=510, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI32566215, Length=719, Percent_Identity=32.9624478442281, Blast_Score=350, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17539860, Length=729, Percent_Identity=31.9615912208505, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI17737937, Length=753, Percent_Identity=41.1686586985392, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24647199, Length=762, Percent_Identity=30.8398950131234, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24647193, Length=772, Percent_Identity=30.440414507772, Blast_Score=313, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24647201, Length=760, Percent_Identity=30.2631578947368, Blast_Score=302, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24647197, Length=762, Percent_Identity=28.740157480315, Blast_Score=279, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24647195, Length=762, Percent_Identity=28.6089238845144, Blast_Score=279, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 82249; Mature: 82118

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSAEYIDDIPEPAGLVHGALGLADRAHAEIVSMDLSEVEATPGVLWVMVGKDVPGEND
CCCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHEECCHHHHCCCCCEEEEEECCCCCCCCC
VSSGGRHDEPLLAETKVEFHGQPIFAVFAETRDIARKAARKAKITYRDLPHFTDIDTAIE
CCCCCCCCCCCEEECCCEECCCEEEEEEHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHH
NGGALVIDPMTLKRGDAKIEMDVAPRRLTGTMRIGGQEHFYLESHIAMAVPGEDDEVTLW
CCCEEEECCCEECCCCCEEEEECCCCEEEEEEEECCCCEEEEECCEEEEECCCCCCEEEE
SSTQHPSEIQHIVSHILQVPSNAVTVQVRRMGGGFGGKETQGNQFAALCAIAAKKLNRAV
ECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEE
KIRPDRDEDMTATGKRHDFRVDYELGFDEEGRIHAVDATYAARCGFSSDLSGPVTDRALF
EECCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEECCHHHHHCCCCCCCCCCCCCCEEE
HADSSYFYPHVHLTSRPLKTHTVSNTAFRGFGGPQGMLGAERFIEEIAYAVGKDPLDIRK
ECCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
LNFYGETGSGRTTTPYHQEVEDNIIARVVEELETSSDYRARREAIIEFNRTSPIIRKGIA
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCCHHHHCCCE
LTPVKFGISFTMTAFNQAGALVHIYNDGSIHLNHGGTEMGQGLYTKVAQVVADAFQVDIG
ECEEEECCEEEEEECCCCCCEEEEEECCEEEEECCCCHHCCHHHHHHHHHHHHHHHEEEC
RVKITATTTGKVPNTSATAASSGTDLNGMAAYDAARQIRERLVKFAAENWNVPEEEVVFL
EEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEC
PNRVRIGLEEIAFNDFIKKAYFARVQLSAAGFYKTPKIHWDRAAGRGTPFYYFAYGAACS
CCHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCCCEEEEEECCCCC
EVSIDTLTGEYMMERTDILHDVGKSLNPAIDIGQIEGAFVQGMGWLTTEELWWDGKGRLR
CCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCCEEEHHEEECCCCCEE
THAPSTYKIPLASDRPKSFNVKLAEWAENAEPTIGRSKAVGEPPFMLAISVLEALSMAVA
ECCCCEEEEECCCCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SVADYKVCPRLDAPATPERVLMAVERLKKV
HHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGSAEYIDDIPEPAGLVHGALGLADRAHAEIVSMDLSEVEATPGVLWVMVGKDVPGEND
CCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHEECCHHHHCCCCCEEEEEECCCCCCCCC
VSSGGRHDEPLLAETKVEFHGQPIFAVFAETRDIARKAARKAKITYRDLPHFTDIDTAIE
CCCCCCCCCCCEEECCCEECCCEEEEEEHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHH
NGGALVIDPMTLKRGDAKIEMDVAPRRLTGTMRIGGQEHFYLESHIAMAVPGEDDEVTLW
CCCEEEECCCEECCCCCEEEEECCCCEEEEEEEECCCCEEEEECCEEEEECCCCCCEEEE
SSTQHPSEIQHIVSHILQVPSNAVTVQVRRMGGGFGGKETQGNQFAALCAIAAKKLNRAV
ECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEE
KIRPDRDEDMTATGKRHDFRVDYELGFDEEGRIHAVDATYAARCGFSSDLSGPVTDRALF
EECCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEECCHHHHHCCCCCCCCCCCCCCEEE
HADSSYFYPHVHLTSRPLKTHTVSNTAFRGFGGPQGMLGAERFIEEIAYAVGKDPLDIRK
ECCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
LNFYGETGSGRTTTPYHQEVEDNIIARVVEELETSSDYRARREAIIEFNRTSPIIRKGIA
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCCHHHHCCCE
LTPVKFGISFTMTAFNQAGALVHIYNDGSIHLNHGGTEMGQGLYTKVAQVVADAFQVDIG
ECEEEECCEEEEEECCCCCCEEEEEECCEEEEECCCCHHCCHHHHHHHHHHHHHHHEEEC
RVKITATTTGKVPNTSATAASSGTDLNGMAAYDAARQIRERLVKFAAENWNVPEEEVVFL
EEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEC
PNRVRIGLEEIAFNDFIKKAYFARVQLSAAGFYKTPKIHWDRAAGRGTPFYYFAYGAACS
CCHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCCCEEEEEECCCCC
EVSIDTLTGEYMMERTDILHDVGKSLNPAIDIGQIEGAFVQGMGWLTTEELWWDGKGRLR
CCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCCEEEHHEEECCCCCEE
THAPSTYKIPLASDRPKSFNVKLAEWAENAEPTIGRSKAVGEPPFMLAISVLEALSMAVA
ECCCCEEEEECCCCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SVADYKVCPRLDAPATPERVLMAVERLKKV
HHHCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]