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The map label for this gene is xdhA [H]

Identifier: 15889586

GI number: 15889586

Start: 2284977

End: 2286446

Strand: Direct

Name: xdhA [H]

Synonym: Atu2309

Alternate gene names: 15889586

Gene position: 2284977-2286446 (Clockwise)

Preceding gene: 159185152

Following gene: 159185153

Centisome position: 80.41

GC content: 60.61

Gene sequence:

>1470_bases
ATGAAAGACGCGATCAGCTTCATCCTCAACAGCGAAACCATTTCGCTGAAGGATTTCGGACCGACGGACACGCTTCTCGA
TTACCTCCGCATCAGCAAGCGGTTGACCGGGACGAAGGAAGGCTGTGCGGAAGGTGACTGCGGCGCCTGCACGGTGTTGG
TCGGGCGACTGCTTGATGGTTCGCTGCGGTATGAAAGCGTCAATGCCTGCATCCGTTTTCTGGGCTCGCTGCACGGCACC
CATATCGTCACGGTGGAGCATCTGGCCGTCCGCGACGGCGCGCTGCATCCCGTGCAGCAGGCCATGGTGGATTTCCACGG
CTCGCAATGCGGTTTCTGTACGCCGGGTTTCATTATGTCGCTTTATGGCCTGTGGCTATCAAGCGAAACCCCCGGCCGCG
CCGACATCGAAAAGGCGCTGCAAGGCAATCTCTGTCGATGCACGGGTTATGAGCCGATCGTGAGGGCCGCCGAAAAAATC
GCCGCGGCCCGTCCGAGTGCGCTGTTCGACCCGCTGCAACGGGACCGCACCGATATCATGGCAAAGCTCTGGGCGGTCCG
CGAAAACGAGACGATCATCGTCACCCACGGCGAGGATCGCAGCATCATTCCGGCAACGCTTTCCGATTTGACCGAAATTT
ACGCCGCTGAACCGAAGGCCACCATCGTCGCCGGTTCCACCGATGTCGGCCTGTGGGTGACGAAGCAGATGCGGGCACTG
AACCCTGTCATCTTCATCAATAATCTCGGGGATTTGCAGACGATCACCGTGGGTGAAGACGGCATCACGCTGGGCGCCGG
TGTCACCTACAGCCAGGCCTTCAAGACCATCGCAGAGCACTTCCCGCCGCTTGCCCGACTGTTCGACCGGCTGGGCGGTG
AGCAGGTGCGCAATATGGGAACGATTGGCGGCAACATCGCCAATGGCTCGCCCATCGGCGACACGCCACCGGCGCTGATC
GCGCTGGGCGCGACGCTCACCCTGCGCTCGTCTTCCGGAGGCCGCAGCCTGCCGCTGGAAAGCTATTTCATCGACTACGG
CAAACAGGACCGGCTGAGCGGCGAATTCGTCGAAAAACTCTTCATTCCGTTCCAGAAGCCGGAAAGCCGTTACGCCGTCT
ACAAGATTTCCAAGCGGCGCGACGAAGATATCTCCGCGCTCTGCGCCGCCTTCAATCTGACGTTAGATGCCGAAGGCACC
GTCGAAGACATCCTCATCGCCTTCGGCGGCATGGCCGGCACGCCAAAACGGGCAACGCATCTGGAAGCGGCGCTTCTCGG
GAAAGAGTGGTCGCAGGAAACGATCGACGCCGCGCGCGATGCGCTGGATGAGGATTTCACCCCGCTGACGGATTGGCGTG
CAACCGCCGAATATCGCCAGTTGACGGCGAAGAACCTGCTGACACGATTCTTCCTGGAGACATCAGGGGAAAAGCAGGAA
CTCAGCCGTTTCTCGCTGGAGGAGGCGTGA

Upstream 100 bases:

>100_bases
GCCAAAACGGAAATCGATATACGCGCAAGGGCGTGCATAGATACACAGAGATAATCACAAGAAACCGGTTCGGCAGCCGG
ACAAAAAAGCAGGGCATTGC

Downstream 100 bases:

>100_bases
TGATGGCGATGGCGAAACCCGCACCCTCCCTCATTCCTGTGCTTGTCACAGGAATCCAGCCGACGCGCGTCTGCGCGGCC
AAAGACTCTTTTCAGCCCAA

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MKDAISFILNSETISLKDFGPTDTLLDYLRISKRLTGTKEGCAEGDCGACTVLVGRLLDGSLRYESVNACIRFLGSLHGT
HIVTVEHLAVRDGALHPVQQAMVDFHGSQCGFCTPGFIMSLYGLWLSSETPGRADIEKALQGNLCRCTGYEPIVRAAEKI
AAARPSALFDPLQRDRTDIMAKLWAVRENETIIVTHGEDRSIIPATLSDLTEIYAAEPKATIVAGSTDVGLWVTKQMRAL
NPVIFINNLGDLQTITVGEDGITLGAGVTYSQAFKTIAEHFPPLARLFDRLGGEQVRNMGTIGGNIANGSPIGDTPPALI
ALGATLTLRSSSGGRSLPLESYFIDYGKQDRLSGEFVEKLFIPFQKPESRYAVYKISKRRDEDISALCAAFNLTLDAEGT
VEDILIAFGGMAGTPKRATHLEAALLGKEWSQETIDAARDALDEDFTPLTDWRATAEYRQLTAKNLLTRFFLETSGEKQE
LSRFSLEEA

Sequences:

>Translated_489_residues
MKDAISFILNSETISLKDFGPTDTLLDYLRISKRLTGTKEGCAEGDCGACTVLVGRLLDGSLRYESVNACIRFLGSLHGT
HIVTVEHLAVRDGALHPVQQAMVDFHGSQCGFCTPGFIMSLYGLWLSSETPGRADIEKALQGNLCRCTGYEPIVRAAEKI
AAARPSALFDPLQRDRTDIMAKLWAVRENETIIVTHGEDRSIIPATLSDLTEIYAAEPKATIVAGSTDVGLWVTKQMRAL
NPVIFINNLGDLQTITVGEDGITLGAGVTYSQAFKTIAEHFPPLARLFDRLGGEQVRNMGTIGGNIANGSPIGDTPPALI
ALGATLTLRSSSGGRSLPLESYFIDYGKQDRLSGEFVEKLFIPFQKPESRYAVYKISKRRDEDISALCAAFNLTLDAEGT
VEDILIAFGGMAGTPKRATHLEAALLGKEWSQETIDAARDALDEDFTPLTDWRATAEYRQLTAKNLLTRFFLETSGEKQE
LSRFSLEEA
>Mature_489_residues
MKDAISFILNSETISLKDFGPTDTLLDYLRISKRLTGTKEGCAEGDCGACTVLVGRLLDGSLRYESVNACIRFLGSLHGT
HIVTVEHLAVRDGALHPVQQAMVDFHGSQCGFCTPGFIMSLYGLWLSSETPGRADIEKALQGNLCRCTGYEPIVRAAEKI
AAARPSALFDPLQRDRTDIMAKLWAVRENETIIVTHGEDRSIIPATLSDLTEIYAAEPKATIVAGSTDVGLWVTKQMRAL
NPVIFINNLGDLQTITVGEDGITLGAGVTYSQAFKTIAEHFPPLARLFDRLGGEQVRNMGTIGGNIANGSPIGDTPPALI
ALGATLTLRSSSGGRSLPLESYFIDYGKQDRLSGEFVEKLFIPFQKPESRYAVYKISKRRDEDISALCAAFNLTLDAEGT
VEDILIAFGGMAGTPKRATHLEAALLGKEWSQETIDAARDALDEDFTPLTDWRATAEYRQLTAKNLLTRFFLETSGEKQE
LSRFSLEEA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=535, Percent_Identity=29.7196261682243, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI71773480, Length=525, Percent_Identity=28.3809523809524, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1789231, Length=283, Percent_Identity=29.3286219081272, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786480, Length=154, Percent_Identity=40.2597402597403, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1789232, Length=136, Percent_Identity=41.1764705882353, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=552, Percent_Identity=29.7101449275362, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI32566215, Length=541, Percent_Identity=25.8780036968577, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=45.8064516129032, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17737937, Length=488, Percent_Identity=32.7868852459016, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24647201, Length=516, Percent_Identity=25.968992248062, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24647199, Length=501, Percent_Identity=26.9461077844311, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24647197, Length=507, Percent_Identity=26.8244575936884, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24647195, Length=502, Percent_Identity=24.9003984063745, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24647193, Length=509, Percent_Identity=25.5402750491159, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 53308; Mature: 53308

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDAISFILNSETISLKDFGPTDTLLDYLRISKRLTGTKEGCAEGDCGACTVLVGRLLDG
CCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
SLRYESVNACIRFLGSLHGTHIVTVEHLAVRDGALHPVQQAMVDFHGSQCGFCTPGFIMS
CCHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
LYGLWLSSETPGRADIEKALQGNLCRCTGYEPIVRAAEKIAAARPSALFDPLQRDRTDIM
HHHHHHCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AKLWAVRENETIIVTHGEDRSIIPATLSDLTEIYAAEPKATIVAGSTDVGLWVTKQMRAL
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHC
NPVIFINNLGDLQTITVGEDGITLGAGVTYSQAFKTIAEHFPPLARLFDRLGGEQVRNMG
CCEEEEECCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCHHHHHHCC
TIGGNIANGSPIGDTPPALIALGATLTLRSSSGGRSLPLESYFIDYGKQDRLSGEFVEKL
CCCCCCCCCCCCCCCCHHHEEECCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHH
FIPFQKPESRYAVYKISKRRDEDISALCAAFNLTLDAEGTVEDILIAFGGMAGTPKRATH
HCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCHHHH
LEAALLGKEWSQETIDAARDALDEDFTPLTDWRATAEYRQLTAKNLLTRFFLETSGEKQE
HHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LSRFSLEEA
HHHHHCCCC
>Mature Secondary Structure
MKDAISFILNSETISLKDFGPTDTLLDYLRISKRLTGTKEGCAEGDCGACTVLVGRLLDG
CCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
SLRYESVNACIRFLGSLHGTHIVTVEHLAVRDGALHPVQQAMVDFHGSQCGFCTPGFIMS
CCHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
LYGLWLSSETPGRADIEKALQGNLCRCTGYEPIVRAAEKIAAARPSALFDPLQRDRTDIM
HHHHHHCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AKLWAVRENETIIVTHGEDRSIIPATLSDLTEIYAAEPKATIVAGSTDVGLWVTKQMRAL
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHC
NPVIFINNLGDLQTITVGEDGITLGAGVTYSQAFKTIAEHFPPLARLFDRLGGEQVRNMG
CCEEEEECCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCHHHHHHCC
TIGGNIANGSPIGDTPPALIALGATLTLRSSSGGRSLPLESYFIDYGKQDRLSGEFVEKL
CCCCCCCCCCCCCCCCHHHEEECCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHH
FIPFQKPESRYAVYKISKRRDEDISALCAAFNLTLDAEGTVEDILIAFGGMAGTPKRATH
HCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCHHHH
LEAALLGKEWSQETIDAARDALDEDFTPLTDWRATAEYRQLTAKNLLTRFFLETSGEKQE
HHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LSRFSLEEA
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]