Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 159185024

GI number: 159185024

Start: 2001407

End: 2002951

Strand: Reverse

Name: degP [H]

Synonym: Atu2043

Alternate gene names: 159185024

Gene position: 2002951-2001407 (Counterclockwise)

Preceding gene: 15889331

Following gene: 15889329

Centisome position: 70.49

GC content: 60.78

Gene sequence:

>1545_bases
ATGGCCGTGACCCTTCTTTCGCCTTTTCGCAGCAGCATTGCCGCAGTTGCGGGCATCGCGCTTGTGGCGGGCAGCCTTTC
GGCGCCGGTTGCGGCAAGAGCGCAGAGCCATGGGCCGGAATCGGTGGCTGATCTTGCCGAGCCGCTGCTCGATGCGGTGG
TGAATATTTCCACGTCCCAGAACGTCAAGACCGAGGGCAAGGGTCCAGTTCCGCCGAAGCTGCCGGAAGGTTCGCCCTTC
CAGGAGTTCTTCAAGGATTATTTCGACAGCCAGAAGCCGGAAGGCGGCGAAAAGGTCAATTCGCTGGGGTCGGGTTTCGT
GATCGATCCGGCTGGCTATGTCGTGACCAACAACCACGTCATCGAGGGTGCTGATGCCATCGAGGTGATTTTCCCGAATG
GCTCGAAGCTCAAGGCGACGCTGGTCGGTACCGATACCAAGACCGACCTTTCGGTCCTGAAGGTGGAGCCGAAAACACCG
CTGAAGGCCGTGAAGTTCGGCGATTCGCGCAGCATGCGCATCGGCGACTGGGTGATGGCTGTCGGCAATCCGTTCGGGCT
TGGCGGATCGCTGACCGTGGGCGTCATTTCCGCGCGCGGCCGCAATATCAATGCCGGCCCCTATGACAATTTCATCCAGA
CGGATGCGGCCATCAACAAGGGTAACTCCGGTGGCCCGCTCTTCAACATGAAGGGTGAGGTGATCGGCATCAATACGGCG
ATCATTTCGCCGAGCGGCGGTTCGATCGGTATTGGTTTCGCCGTACCGACGGAGCTTGCCCAGAATATCGTGCAGCAGCT
CATCGAATTCGGCGAGACCCGCCGCGGCTGGCTCGGCGTTCGCGTTCAGCCTGTTACTGATGATGTGGCTGCGAGCCTCG
GCATGGACAGCGCCAAGGGCGCGCTGATATCAGGCGTGGCCAAGGGCGGCCCGGTGGAGAACGGCCCGATCCAGGCGGGT
GATGTCGTGCTGAAGTTCGACGGCAAGGATATCAATGAAATGCGCGACCTCTTGCGTATCGTGGCGGAAAGCCCTGTCGG
CAAGGAAGTCGATGTTGTCGTTTATCGCGACGGCAAGGAAGAGACCGTCAAGGTCAAGCTCGGGCAATTGCAGGATACGA
CCGACGAGAAGGCCTCGACCGACGACCCGCAGGGTGAAGACGGTGATGGCAGCATGGTCGCCCCCGACGATAAAGACGGT
GGCGACGATCAGGCGCAGGACCAGACACCTGAAGTGCGCGAAGCACCGCAGACCGTGCTCGGCATGAATCTCGTGGTGCT
GAGCAATGAGCTGCGCACGGAAAAGGGCATTGCCGAAAGCGTGGAAGGCGTGCTTGTCGCAAGCGTCGATCCCGGTTCTC
CCGCCGAACAGAAGGGCATGAAGGCCGGCGACGTCATCGTCGAGGTCGGGCAGGATTTCATGGAAGTTCCTGGCGACGTG
CTGGTACGTGTGAACGGCCTGAAGTCCGAAGGCCGCAAGAACGCGCATATGATGGTGGCGGATGCTCAGGGCAATCTGCG
CGTGGTGGCGTTGCCGCTGGAATAA

Upstream 100 bases:

>100_bases
TCCCCGCCTGTTCACGAAAAGGTATTTTTACACTTCATCATTCCGCCTTATGCTTTGACGATATAAGCAGGGCATGACGA
TTTGAAACGCGAGGACGCTT

Downstream 100 bases:

>100_bases
ACGCTTTTCGCCCGATCCGTCAGGAATCGGGTGGTTGCGGCACTGTCGGGTCCCTATCCCTTGGTCTCCATCAAACGGAG
GCCAAGGATATGAAATTACT

Product: htrA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MAVTLLSPFRSSIAAVAGIALVAGSLSAPVAARAQSHGPESVADLAEPLLDAVVNISTSQNVKTEGKGPVPPKLPEGSPF
QEFFKDYFDSQKPEGGEKVNSLGSGFVIDPAGYVVTNNHVIEGADAIEVIFPNGSKLKATLVGTDTKTDLSVLKVEPKTP
LKAVKFGDSRSMRIGDWVMAVGNPFGLGGSLTVGVISARGRNINAGPYDNFIQTDAAINKGNSGGPLFNMKGEVIGINTA
IISPSGGSIGIGFAVPTELAQNIVQQLIEFGETRRGWLGVRVQPVTDDVAASLGMDSAKGALISGVAKGGPVENGPIQAG
DVVLKFDGKDINEMRDLLRIVAESPVGKEVDVVVYRDGKEETVKVKLGQLQDTTDEKASTDDPQGEDGDGSMVAPDDKDG
GDDQAQDQTPEVREAPQTVLGMNLVVLSNELRTEKGIAESVEGVLVASVDPGSPAEQKGMKAGDVIVEVGQDFMEVPGDV
LVRVNGLKSEGRKNAHMMVADAQGNLRVVALPLE

Sequences:

>Translated_514_residues
MAVTLLSPFRSSIAAVAGIALVAGSLSAPVAARAQSHGPESVADLAEPLLDAVVNISTSQNVKTEGKGPVPPKLPEGSPF
QEFFKDYFDSQKPEGGEKVNSLGSGFVIDPAGYVVTNNHVIEGADAIEVIFPNGSKLKATLVGTDTKTDLSVLKVEPKTP
LKAVKFGDSRSMRIGDWVMAVGNPFGLGGSLTVGVISARGRNINAGPYDNFIQTDAAINKGNSGGPLFNMKGEVIGINTA
IISPSGGSIGIGFAVPTELAQNIVQQLIEFGETRRGWLGVRVQPVTDDVAASLGMDSAKGALISGVAKGGPVENGPIQAG
DVVLKFDGKDINEMRDLLRIVAESPVGKEVDVVVYRDGKEETVKVKLGQLQDTTDEKASTDDPQGEDGDGSMVAPDDKDG
GDDQAQDQTPEVREAPQTVLGMNLVVLSNELRTEKGIAESVEGVLVASVDPGSPAEQKGMKAGDVIVEVGQDFMEVPGDV
LVRVNGLKSEGRKNAHMMVADAQGNLRVVALPLE
>Mature_513_residues
AVTLLSPFRSSIAAVAGIALVAGSLSAPVAARAQSHGPESVADLAEPLLDAVVNISTSQNVKTEGKGPVPPKLPEGSPFQ
EFFKDYFDSQKPEGGEKVNSLGSGFVIDPAGYVVTNNHVIEGADAIEVIFPNGSKLKATLVGTDTKTDLSVLKVEPKTPL
KAVKFGDSRSMRIGDWVMAVGNPFGLGGSLTVGVISARGRNINAGPYDNFIQTDAAINKGNSGGPLFNMKGEVIGINTAI
ISPSGGSIGIGFAVPTELAQNIVQQLIEFGETRRGWLGVRVQPVTDDVAASLGMDSAKGALISGVAKGGPVENGPIQAGD
VVLKFDGKDINEMRDLLRIVAESPVGKEVDVVVYRDGKEETVKVKLGQLQDTTDEKASTDDPQGEDGDGSMVAPDDKDGG
DDQAQDQTPEVREAPQTVLGMNLVVLSNELRTEKGIAESVEGVLVASVDPGSPAEQKGMKAGDVIVEVGQDFMEVPGDVL
VRVNGLKSEGRKNAHMMVADAQGNLRVVALPLE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=272, Percent_Identity=34.1911764705882, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI24308541, Length=255, Percent_Identity=31.3725490196078, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4506141, Length=255, Percent_Identity=32.5490196078431, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI7019477, Length=278, Percent_Identity=31.294964028777, Blast_Score=123, Evalue=5e-28,
Organism=Escherichia coli, GI1786356, Length=465, Percent_Identity=35.2688172043011, Blast_Score=261, Evalue=9e-71,
Organism=Escherichia coli, GI1789629, Length=329, Percent_Identity=41.0334346504559, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=40.1459854014599, Blast_Score=185, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24646839, Length=308, Percent_Identity=30.5194805194805, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 53552; Mature: 53421

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTLLSPFRSSIAAVAGIALVAGSLSAPVAARAQSHGPESVADLAEPLLDAVVNISTSQ
CEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHEECCCCC
NVKTEGKGPVPPKLPEGSPFQEFFKDYFDSQKPEGGEKVNSLGSGFVIDPAGYVVTNNHV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCEEECCCCEEEECCEE
IEGADAIEVIFPNGSKLKATLVGTDTKTDLSVLKVEPKTPLKAVKFGDSRSMRIGDWVMA
ECCCCEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCEEECCEEEE
VGNPFGLGGSLTVGVISARGRNINAGPYDNFIQTDAAINKGNSGGPLFNMKGEVIGINTA
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHCCHHHCCCCCCCCEEECCCCEEEEEEE
IISPSGGSIGIGFAVPTELAQNIVQQLIEFGETRRGWLGVRVQPVTDDVAASLGMDSAKG
EECCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHCCCCCCCC
ALISGVAKGGPVENGPIQAGDVVLKFDGKDINEMRDLLRIVAESPVGKEVDVVVYRDGKE
HHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
ETVKVKLGQLQDTTDEKASTDDPQGEDGDGSMVAPDDKDGGDDQAQDQTPEVREAPQTVL
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHCCHHHH
GMNLVVLSNELRTEKGIAESVEGVLVASVDPGSPAEQKGMKAGDVIVEVGQDFMEVPGDV
CCEEEEEECHHHHHCCHHHCCCCEEEEECCCCCCHHHHCCCCCHHHHHHCHHHHHCCCEE
LVRVNGLKSEGRKNAHMMVADAQGNLRVVALPLE
EEEEECCCCCCCCCCEEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
AVTLLSPFRSSIAAVAGIALVAGSLSAPVAARAQSHGPESVADLAEPLLDAVVNISTSQ
EEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHEECCCCC
NVKTEGKGPVPPKLPEGSPFQEFFKDYFDSQKPEGGEKVNSLGSGFVIDPAGYVVTNNHV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCEEECCCCEEEECCEE
IEGADAIEVIFPNGSKLKATLVGTDTKTDLSVLKVEPKTPLKAVKFGDSRSMRIGDWVMA
ECCCCEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCEEECCEEEE
VGNPFGLGGSLTVGVISARGRNINAGPYDNFIQTDAAINKGNSGGPLFNMKGEVIGINTA
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHCCHHHCCCCCCCCEEECCCCEEEEEEE
IISPSGGSIGIGFAVPTELAQNIVQQLIEFGETRRGWLGVRVQPVTDDVAASLGMDSAKG
EECCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHCCCCCCCC
ALISGVAKGGPVENGPIQAGDVVLKFDGKDINEMRDLLRIVAESPVGKEVDVVVYRDGKE
HHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
ETVKVKLGQLQDTTDEKASTDDPQGEDGDGSMVAPDDKDGGDDQAQDQTPEVREAPQTVL
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHCCHHHH
GMNLVVLSNELRTEKGIAESVEGVLVASVDPGSPAEQKGMKAGDVIVEVGQDFMEVPGDV
CCEEEEEECHHHHHCCHHHCCCCEEEEECCCCCCHHHHCCCCCHHHHHHCHHHHHCCCEE
LVRVNGLKSEGRKNAHMMVADAQGNLRVVALPLE
EEEEECCCCCCCCCCEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]