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The map label for this gene is tyrS

Identifier: 159184939

GI number: 159184939

Start: 1808346

End: 1809599

Strand: Direct

Name: tyrS

Synonym: Atu1828

Alternate gene names: 159184939

Gene position: 1808346-1809599 (Clockwise)

Preceding gene: 15889129

Following gene: 15889133

Centisome position: 63.64

GC content: 59.97

Gene sequence:

>1254_bases
ATGTCCAGGTTCAAGTCCGATTTCCTCCGCACGCTCGATGAGCGCGGCTTCATTCACCAGATCTCCGATGAGGCAGGTCT
CGACGAACTGTTCGCCAAGGAAACCGTGACCGCCTATATCGGCTATGACCCGACGGCCTCCAGCCTGCATGTCGGCCACC
TCACCCAGATCATGATGCTGCACTGGATGCAGAAGACCGGCCACCAGCCGATTTCTCTGATGGGCGGCGGCACCGGCATG
GTCGGCGATCCCTCTTTCAAGGAGGAGGCCCGCAAGCTAATGACGATCGACATGATCGAGGACAATATCACCTCGCTCAA
GCACGTCTTTGCGAATTACCTCGATTACGATCGTGCCGAGAACCCGGCATTGATGATCAACAATGCCGACTGGCTGCGTG
GTCTGAACTACCTCGAATTCCTGCGTGATGTCGGCCGCCATTTTTCGGTCAACCGCATGCTGTCCTTCGACAGCGTGAAG
ACGCGCCTCGACCGCGAGCAATCGCTGTCCTTCCTCGAATTCAACTACATGATCCTGCAGGCCTACGATTTCGTGGAGCT
GAACCAGCGCACGGGCTGCCGGCTGCAGATGGGCGGTTCGGACCAGTGGGGCAACATCATCAACGGCATCGACCTTGGTC
ACCGCATGGGGACACCGCAGCTTTACGCGCTGACCTCGCCGCTTCTGACCACCTCTTCCGGCGCGAAGATGGGCAAGTCC
GCATCTGGCGCGGTGTGGCTGAACAAGGACCTGCTGCCGGTCTATGATTTCTGGCAATACTGGCGCAACACCGAAGATGC
TGACGTGGTTCGCTTCGCGAAACTCTTCACCACCCTGCCGATGGATGAGATCGCCCGCATTGCCACGCTTGGCGGATCTG
AGATCAACGAAGCGAAGAAAATCCTCGCAACCGAAGTGACGGCGATCCTGCATGGCCGCGCTGCGGCGGAAGAAGCCGCC
GAAACGGCGCGCAAGACCTTCGAGGAAGGCGCGCTTGCCGAAAACCTGCCCTCCATCGAGGTTCCGACATCCGAACTCGA
TGCTGGTGTCGGCGTCCTGTCGCTCATCGTCCGCGCCGGCCTTGCGAGCTCGAATGGCGAAGCCCGCCGCCATGTTCAGG
GCGGCGCGGTGAAGATCAACGAACAGGGCGTTTCAGACGAGCGCCAGATAATCGGCACCGGCGAAGTGACCGGTGACGGC
GTCATCAAGCTGTCGGTCGGCAAGAAGAAGCACGTTCTGGTTCGCCCGGCGTAA

Upstream 100 bases:

>100_bases
TCATGGCCGAAACGGGTGCACATTTCAAAAAACAATGATAAAGCCCCGGCGTTCATTGGCTTTCAATGACGGAAAAGATC
AAACCAGAAAGTAAAAGGTT

Downstream 100 bases:

>100_bases
AACCAGCGCCAAACCTGCATCGAGGGCCGCGAAAGCGGCCCTTTTTATTGAAACTCGAAAATCTGCCGGAAGACACCCGG
CGCAATCAGCGACAGCGGGT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSRFKSDFLRTLDERGFIHQISDEAGLDELFAKETVTAYIGYDPTASSLHVGHLTQIMMLHWMQKTGHQPISLMGGGTGM
VGDPSFKEEARKLMTIDMIEDNITSLKHVFANYLDYDRAENPALMINNADWLRGLNYLEFLRDVGRHFSVNRMLSFDSVK
TRLDREQSLSFLEFNYMILQAYDFVELNQRTGCRLQMGGSDQWGNIINGIDLGHRMGTPQLYALTSPLLTTSSGAKMGKS
ASGAVWLNKDLLPVYDFWQYWRNTEDADVVRFAKLFTTLPMDEIARIATLGGSEINEAKKILATEVTAILHGRAAAEEAA
ETARKTFEEGALAENLPSIEVPTSELDAGVGVLSLIVRAGLASSNGEARRHVQGGAVKINEQGVSDERQIIGTGEVTGDG
VIKLSVGKKKHVLVRPA

Sequences:

>Translated_417_residues
MSRFKSDFLRTLDERGFIHQISDEAGLDELFAKETVTAYIGYDPTASSLHVGHLTQIMMLHWMQKTGHQPISLMGGGTGM
VGDPSFKEEARKLMTIDMIEDNITSLKHVFANYLDYDRAENPALMINNADWLRGLNYLEFLRDVGRHFSVNRMLSFDSVK
TRLDREQSLSFLEFNYMILQAYDFVELNQRTGCRLQMGGSDQWGNIINGIDLGHRMGTPQLYALTSPLLTTSSGAKMGKS
ASGAVWLNKDLLPVYDFWQYWRNTEDADVVRFAKLFTTLPMDEIARIATLGGSEINEAKKILATEVTAILHGRAAAEEAA
ETARKTFEEGALAENLPSIEVPTSELDAGVGVLSLIVRAGLASSNGEARRHVQGGAVKINEQGVSDERQIIGTGEVTGDG
VIKLSVGKKKHVLVRPA
>Mature_416_residues
SRFKSDFLRTLDERGFIHQISDEAGLDELFAKETVTAYIGYDPTASSLHVGHLTQIMMLHWMQKTGHQPISLMGGGTGMV
GDPSFKEEARKLMTIDMIEDNITSLKHVFANYLDYDRAENPALMINNADWLRGLNYLEFLRDVGRHFSVNRMLSFDSVKT
RLDREQSLSFLEFNYMILQAYDFVELNQRTGCRLQMGGSDQWGNIINGIDLGHRMGTPQLYALTSPLLTTSSGAKMGKSA
SGAVWLNKDLLPVYDFWQYWRNTEDADVVRFAKLFTTLPMDEIARIATLGGSEINEAKKILATEVTAILHGRAAAEEAAE
TARKTFEEGALAENLPSIEVPTSELDAGVGVLSLIVRAGLASSNGEARRHVQGGAVKINEQGVSDERQIIGTGEVTGDGV
IKLSVGKKKHVLVRPA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=429, Percent_Identity=34.4988344988345, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1787925, Length=422, Percent_Identity=40.2843601895735, Blast_Score=330, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI25145802, Length=394, Percent_Identity=30.7106598984772, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25145805, Length=310, Percent_Identity=29.0322580645161, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6325160, Length=438, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20130383, Length=435, Percent_Identity=34.0229885057471, Blast_Score=252, Evalue=4e-67,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_AGRT5 (Q8UED2)

Other databases:

- EMBL:   AE007869
- PIR:   AB2801
- PIR:   D97580
- RefSeq:   NP_354812.2
- ProteinModelPortal:   Q8UED2
- SMR:   Q8UED2
- STRING:   Q8UED2
- GeneID:   1133866
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1828
- eggNOG:   COG0162
- HOGENOM:   HBG288125
- OMA:   TFYIGFD
- PhylomeDB:   Q8UED2
- BioCyc:   ATUM176299-1:ATU1828-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02006
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 46118; Mature: 45987

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 39-39 BINDING 176-176 BINDING 180-180 BINDING 239-239

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFKSDFLRTLDERGFIHQISDEAGLDELFAKETVTAYIGYDPTASSLHVGHLTQIMML
CCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHEEEEECCCCCCCCEEHHHHHHHHHH
HWMQKTGHQPISLMGGGTGMVGDPSFKEEARKLMTIDMIEDNITSLKHVFANYLDYDRAE
HHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NPALMINNADWLRGLNYLEFLRDVGRHFSVNRMLSFDSVKTRLDREQSLSFLEFNYMILQ
CCEEEEECHHHHHHCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCHHHHHHEEEEE
AYDFVELNQRTGCRLQMGGSDQWGNIINGIDLGHRMGTPQLYALTSPLLTTSSGAKMGKS
EECCEEECCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCC
ASGAVWLNKDLLPVYDFWQYWRNTEDADVVRFAKLFTTLPMDEIARIATLGGSEINEAKK
CCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHH
ILATEVTAILHGRAAAEEAAETARKTFEEGALAENLPSIEVPTSELDAGVGVLSLIVRAG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
LASSNGEARRHVQGGAVKINEQGVSDERQIIGTGEVTGDGVIKLSVGKKKHVLVRPA
CCCCCCHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEECCCCCEEEEECC
>Mature Secondary Structure 
SRFKSDFLRTLDERGFIHQISDEAGLDELFAKETVTAYIGYDPTASSLHVGHLTQIMML
CHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHEEEEECCCCCCCCEEHHHHHHHHHH
HWMQKTGHQPISLMGGGTGMVGDPSFKEEARKLMTIDMIEDNITSLKHVFANYLDYDRAE
HHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NPALMINNADWLRGLNYLEFLRDVGRHFSVNRMLSFDSVKTRLDREQSLSFLEFNYMILQ
CCEEEEECHHHHHHCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCHHHHHHEEEEE
AYDFVELNQRTGCRLQMGGSDQWGNIINGIDLGHRMGTPQLYALTSPLLTTSSGAKMGKS
EECCEEECCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCC
ASGAVWLNKDLLPVYDFWQYWRNTEDADVVRFAKLFTTLPMDEIARIATLGGSEINEAKK
CCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHH
ILATEVTAILHGRAAAEEAAETARKTFEEGALAENLPSIEVPTSELDAGVGVLSLIVRAG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
LASSNGEARRHVQGGAVKINEQGVSDERQIIGTGEVTGDGVIKLSVGKKKHVLVRPA
CCCCCCHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194