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The map label for this gene is hisI

Identifier: 159184898

GI number: 159184898

Start: 1737056

End: 1737508

Strand: Direct

Name: hisI

Synonym: Atu1750

Alternate gene names: 159184898

Gene position: 1737056-1737508 (Clockwise)

Preceding gene: 15889053

Following gene: 159184899

Centisome position: 61.13

GC content: 58.06

Gene sequence:

>453_bases
ATGTCCATTCCCTTTCCGTCCGCGCCTGCGGACAAGGAAGCGCTCGAAAACGCAGGTCTCTTTTCGCCGAAATTCGATGC
CCACGGCCTCGTCACCGCCGTGGTTACCGATGCGCGCGATGGCGAATTGCTGATGGTCGCCCATATGAATGCGGAAGCTT
TGTCGCTGACGCTCGAGACCGGCATCGCGCATTATTACAGCCGCTCCCGCGACAAGATCTGGAAAAAGGGCGAAACCTCC
GGCAACCTGCAGACGGTGAAGGAATTCCGCACCGATTGCGATCAGGATGCCGTATGGCTGAAGGTCTCCGTTGCCGGCCA
TGATGCGACCTGCCATACCGGCCGCCGCTCATGCTTTTACCGCACTGTCGAGCTATCAAACGGCGATGCTGTGACGAAAA
TCACCGACGACACCCGCCATTTCGACCCGGCCACAACCTACTCCAATACATAA

Upstream 100 bases:

>100_bases
GTTTCCTGAAACCCGCTGCTCAGACAAAATTTTGGAGTGGCGGACTGATCCCATCGTCTCCGCCGCTTTGAAACCTTCCG
CTTTTCTCCCCGGGGTAGCC

Downstream 100 bases:

>100_bases
TCGGCCACCTTCCATCGGCCGCACCAATTTGCTACCAATATAGCAGGCTCCGGGGGTAAGGGCGGAACCTGAAAGGCAGG
CAGGGAGTGCGACAAATGTT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MSIPFPSAPADKEALENAGLFSPKFDAHGLVTAVVTDARDGELLMVAHMNAEALSLTLETGIAHYYSRSRDKIWKKGETS
GNLQTVKEFRTDCDQDAVWLKVSVAGHDATCHTGRRSCFYRTVELSNGDAVTKITDDTRHFDPATTYSNT

Sequences:

>Translated_150_residues
MSIPFPSAPADKEALENAGLFSPKFDAHGLVTAVVTDARDGELLMVAHMNAEALSLTLETGIAHYYSRSRDKIWKKGETS
GNLQTVKEFRTDCDQDAVWLKVSVAGHDATCHTGRRSCFYRTVELSNGDAVTKITDDTRHFDPATTYSNT
>Mature_149_residues
SIPFPSAPADKEALENAGLFSPKFDAHGLVTAVVTDARDGELLMVAHMNAEALSLTLETGIAHYYSRSRDKIWKKGETSG
NLQTVKEFRTDCDQDAVWLKVSVAGHDATCHTGRRSCFYRTVELSNGDAVTKITDDTRHFDPATTYSNT

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=121, Percent_Identity=37.1900826446281, Blast_Score=84, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319819, Length=92, Percent_Identity=40.2173913043478, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_AGRT5 (Q8UEK7)

Other databases:

- EMBL:   AE007869
- PIR:   AG2791
- PIR:   G97570
- RefSeq:   NP_354735.2
- STRING:   Q8UEK7
- GeneID:   1133788
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1750
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   CHVGYRS
- PhylomeDB:   Q8UEK7
- ProtClustDB:   PRK00051
- BioCyc:   ATUM176299-1:ATU1750-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 16483; Mature: 16352

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPFPSAPADKEALENAGLFSPKFDAHGLVTAVVTDARDGELLMVAHMNAEALSLTLET
CCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEEHHH
GIAHYYSRSRDKIWKKGETSGNLQTVKEFRTDCDQDAVWLKVSVAGHDATCHTGRRSCFY
HHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEE
RTVELSNGDAVTKITDDTRHFDPATTYSNT
EEEEECCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SIPFPSAPADKEALENAGLFSPKFDAHGLVTAVVTDARDGELLMVAHMNAEALSLTLET
CCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEEHHH
GIAHYYSRSRDKIWKKGETSGNLQTVKEFRTDCDQDAVWLKVSVAGHDATCHTGRRSCFY
HHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEE
RTVELSNGDAVTKITDDTRHFDPATTYSNT
EEEEECCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194