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The map label for this gene is hemN [H]

Identifier: 159184833

GI number: 159184833

Start: 1581975

End: 1583324

Strand: Reverse

Name: hemN [H]

Synonym: Atu1601

Alternate gene names: 159184833

Gene position: 1583324-1581975 (Counterclockwise)

Preceding gene: 15888916

Following gene: 159184832

Centisome position: 55.72

GC content: 57.85

Gene sequence:

>1350_bases
ATGAATACGGAACTTCTTCGCAAATATTCGGGTGCAGTGCCGCGTTACACCAGCTATCCGACCGCTCCGCATTTCCACGC
GGGAATCGATGACACGACCTATCGCGGCTGGCTCGGCGCGCTCAACCACAGGAACCGGATATCGCTTTACCTGCACATTC
CCTATTGTGACCGGCTCTGCTGGTTCTGTGCCTGTCACACCAAGCACACGCTGAAATACGAGCCGATTGCCGTTTATCTG
GAAGCACTTAAGCAGGAGATTGCTGCCGTTGGCGCACTTGTTTCGCCCGATGCGGTGGTGAGTGCCGTGCATTTCGGCGG
CGGCTCGCCCACCATGCTGAAGCCTGATGACATGGTCAGCCTGATGGACTGTCTGCGGCGCCATTTCACCTTCGGGCTAG
ACCCCGAAATCAGCGTTGAGATGGACCCGAACGATCTGGATGACAGCCGTTACGATGCGCTTGCCGCCGTCGGCATGTCG
CGGGCAAGCCTCGGTGTGCAGGACTTCGATGACAAAGTGCAAAAAACCATCAACCGCATCCAGTCCTTCCAACAGACGAA
ATCCGTCGTTGATGCGGTGCGGGCGAGGGGCGTGCACTCGGTCAATTGCGACATTCTTTATGGCCTGCCGTTCCAGACCT
GCGAGACATTGAAGAAGACGGTTGGTCAGATCGTCTCTCTCAATCCGGACCGGGTGGCGCTTTTCGGTTATGCCCATGTG
CCGTGGATGAAAAAACACCAGTCGCTGATCCCCGAACACGCGCTGCCTGATATTGCTGAGCGTTACCGCCAGATGACGAT
GGCGGGCGAGATGCTGAAGCAGGCGGGATATCGCGCAGTCGGCATCGACCACTTTGCCAAGCCGGCGGATACCTTATGCC
AGGCCGTCGAGGCCGGGGCCCTGCGGCGGAATTTCCAGGGCTATACCACCGATACGGCCGATGCGCTGATCGGGCTTGGT
GCATCATCCGTTGGTCGGTTGCCGCAGGGCTATGTGCAGAACATGGTGGCAACGCGCGAATATCAGCGCATGGTGGGTGA
AGGCGGTCTTGCCGCCGTGAAGGGTATAGAATTATCGCAGGACGATCATTTGCGCTCGCATGTCATCGAAAGGCTGATGT
GCGATTTCTCTATCGATCTTTCGGACATGCAGCACCGTTTCGGCAAGGTGAGCCATTCCGTGAGGGATCAGGCGCAACAG
TTTGCCGCAGGCGACAGGGATGGTGTGGTGCGTCTGGACGCCGATGTTTTTGCCGTGACCGAGGTCGGAAAACCCTTCGT
GCGTCATATCGCGGCAATCTTCGACACCTATCTCGGCAATGGACGCGGCCGTCATTCGGTTGCTGTTTAG

Upstream 100 bases:

>100_bases
ACTTATGGCGCAATTTGATTGAAGTCAAAGTTGCAAACTGTCGCAGCCGCTACTGAAAGGAAGGAAATCGACATTTTCTT
GATAAAAGGCAAATACGGTG

Downstream 100 bases:

>100_bases
GCAACAGTTTTGGGGCAAATTTCAAAGTTACGTCACGAAACCATTGGCTTTTTTGTGCGACTTGCCTATGTGGTGCGTCA
GAAAGAACAATTCATACGAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MNTELLRKYSGAVPRYTSYPTAPHFHAGIDDTTYRGWLGALNHRNRISLYLHIPYCDRLCWFCACHTKHTLKYEPIAVYL
EALKQEIAAVGALVSPDAVVSAVHFGGGSPTMLKPDDMVSLMDCLRRHFTFGLDPEISVEMDPNDLDDSRYDALAAVGMS
RASLGVQDFDDKVQKTINRIQSFQQTKSVVDAVRARGVHSVNCDILYGLPFQTCETLKKTVGQIVSLNPDRVALFGYAHV
PWMKKHQSLIPEHALPDIAERYRQMTMAGEMLKQAGYRAVGIDHFAKPADTLCQAVEAGALRRNFQGYTTDTADALIGLG
ASSVGRLPQGYVQNMVATREYQRMVGEGGLAAVKGIELSQDDHLRSHVIERLMCDFSIDLSDMQHRFGKVSHSVRDQAQQ
FAAGDRDGVVRLDADVFAVTEVGKPFVRHIAAIFDTYLGNGRGRHSVAV

Sequences:

>Translated_449_residues
MNTELLRKYSGAVPRYTSYPTAPHFHAGIDDTTYRGWLGALNHRNRISLYLHIPYCDRLCWFCACHTKHTLKYEPIAVYL
EALKQEIAAVGALVSPDAVVSAVHFGGGSPTMLKPDDMVSLMDCLRRHFTFGLDPEISVEMDPNDLDDSRYDALAAVGMS
RASLGVQDFDDKVQKTINRIQSFQQTKSVVDAVRARGVHSVNCDILYGLPFQTCETLKKTVGQIVSLNPDRVALFGYAHV
PWMKKHQSLIPEHALPDIAERYRQMTMAGEMLKQAGYRAVGIDHFAKPADTLCQAVEAGALRRNFQGYTTDTADALIGLG
ASSVGRLPQGYVQNMVATREYQRMVGEGGLAAVKGIELSQDDHLRSHVIERLMCDFSIDLSDMQHRFGKVSHSVRDQAQQ
FAAGDRDGVVRLDADVFAVTEVGKPFVRHIAAIFDTYLGNGRGRHSVAV
>Mature_449_residues
MNTELLRKYSGAVPRYTSYPTAPHFHAGIDDTTYRGWLGALNHRNRISLYLHIPYCDRLCWFCACHTKHTLKYEPIAVYL
EALKQEIAAVGALVSPDAVVSAVHFGGGSPTMLKPDDMVSLMDCLRRHFTFGLDPEISVEMDPNDLDDSRYDALAAVGMS
RASLGVQDFDDKVQKTINRIQSFQQTKSVVDAVRARGVHSVNCDILYGLPFQTCETLKKTVGQIVSLNPDRVALFGYAHV
PWMKKHQSLIPEHALPDIAERYRQMTMAGEMLKQAGYRAVGIDHFAKPADTLCQAVEAGALRRNFQGYTTDTADALIGLG
ASSVGRLPQGYVQNMVATREYQRMVGEGGLAAVKGIELSQDDHLRSHVIERLMCDFSIDLSDMQHRFGKVSHSVRDQAQQ
FAAGDRDGVVRLDADVFAVTEVGKPFVRHIAAIFDTYLGNGRGRHSVAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=295, Percent_Identity=24.0677966101695, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI87082341, Length=435, Percent_Identity=37.2413793103448, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1789325, Length=396, Percent_Identity=26.2626262626263, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49760; Mature: 49760

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTELLRKYSGAVPRYTSYPTAPHFHAGIDDTTYRGWLGALNHRNRISLYLHIPYCDRLC
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHH
WFCACHTKHTLKYEPIAVYLEALKQEIAAVGALVSPDAVVSAVHFGGGSPTMLKPDDMVS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHH
LMDCLRRHFTFGLDPEISVEMDPNDLDDSRYDALAAVGMSRASLGVQDFDDKVQKTINRI
HHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QSFQQTKSVVDAVRARGVHSVNCDILYGLPFQTCETLKKTVGQIVSLNPDRVALFGYAHV
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECC
PWMKKHQSLIPEHALPDIAERYRQMTMAGEMLKQAGYRAVGIDHFAKPADTLCQAVEAGA
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECHHHHCCCHHHHHHHHHHHH
LRRNFQGYTTDTADALIGLGASSVGRLPQGYVQNMVATREYQRMVGEGGLAAVKGIELSQ
HHHCCCCCCCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCC
DDHLRSHVIERLMCDFSIDLSDMQHRFGKVSHSVRDQAQQFAAGDRDGVVRLDADVFAVT
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
EVGKPFVRHIAAIFDTYLGNGRGRHSVAV
HCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNTELLRKYSGAVPRYTSYPTAPHFHAGIDDTTYRGWLGALNHRNRISLYLHIPYCDRLC
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHH
WFCACHTKHTLKYEPIAVYLEALKQEIAAVGALVSPDAVVSAVHFGGGSPTMLKPDDMVS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHH
LMDCLRRHFTFGLDPEISVEMDPNDLDDSRYDALAAVGMSRASLGVQDFDDKVQKTINRI
HHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QSFQQTKSVVDAVRARGVHSVNCDILYGLPFQTCETLKKTVGQIVSLNPDRVALFGYAHV
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECC
PWMKKHQSLIPEHALPDIAERYRQMTMAGEMLKQAGYRAVGIDHFAKPADTLCQAVEAGA
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECHHHHCCCHHHHHHHHHHHH
LRRNFQGYTTDTADALIGLGASSVGRLPQGYVQNMVATREYQRMVGEGGLAAVKGIELSQ
HHHCCCCCCCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCC
DDHLRSHVIERLMCDFSIDLSDMQHRFGKVSHSVRDQAQQFAAGDRDGVVRLDADVFAVT
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
EVGKPFVRHIAAIFDTYLGNGRGRHSVAV
HCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]