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The map label for this gene is pdhA [H]

Identifier: 159184757

GI number: 159184757

Start: 1423772

End: 1424692

Strand: Direct

Name: pdhA [H]

Synonym: Atu1429

Alternate gene names: 159184757

Gene position: 1423772-1424692 (Clockwise)

Preceding gene: 159184756

Following gene: 15888755

Centisome position: 50.1

GC content: 59.17

Gene sequence:

>921_bases
ATGCTTTTGATCCGCCGTTTCGAGGAAAAGGCAGGCCAGCTTTACGGTATGGGCTTTATAGGTGGTTTCTGTCACCTCTA
CATCGGCCAGGAAGCCGTTGTTGTCGGCATGCAGATGTCACAGAAGGAAGGCGATCAGGTCATCACCGCTTACCGTGACC
ATGGCCACATGCTTGCTTTGGGCATGAGCGCGCGTGGCGTCATGGCCGAGTTGACCGGTCGCAAGGGCGGCCTGTCGAAA
GGCAAGGGCGGCTCCATGCACATGTTCTCCAAGGAGAAGCATTTTTACGGCGGCCACGGCATCGTTGGTGCGCAGGTTTC
GCTTGGAACCGGTCTCGCCTTCGCCAACCGCTATCGCGGCAATGACAATGTCTCCGTGACCTATTTTGGTGACGGCGCCG
CCAACCAGGGCCAGGTCTACGAGAGCTTCAACATGGCTGCTCTCTGGAAGTTGCCGATCATCTATATCGTCGAGAATAAC
CGTTACGCCATGGGCACCTCGACCGCCCGCGCCACCGCCCAGTCGAACTACTCGCTGCGCGGCCAGTCCTTCGGCATCCC
CGGCGTTCAGGTGGATGGCATGGATGTGCGCGCCGTGAAGGCTGCCGCTGACCAGGCGCTGGAGCATTGCCGTTCCGGCA
AGGGCCCGATCATTCTGGAAATGCTGACCTACCGTTACCGTGGCCACTCCATGTCGGACCCGGCGAAATACCGCTCCAAG
GATGAAGTGCAGAAGATGCGCTCCGAACATGACCCGATCGAACAGGTCAAGGCACGGCTTCTGGACCATGGTTGGGCAAG
CGAAGACGAATTGAAGGCCATCGACAAGGATGTCCGTGATATCGTCGCCGACAGCGCCGACTTCGCCCAGAACGACCCCG
AGCCGGATGTATCCGAGCTCTACACCGACATTCTGCTCTGA

Upstream 100 bases:

>100_bases
CGTATCCGGCCGCAAGACAACGGCAAAGGCTGCAACCGAATTCACCGGTAAGAACAGCCCGGACTTTTCGAAGGACGAAG
AGCTTCACGCCTATCGTGAA

Downstream 100 bases:

>100_bases
TCGGGAAAGGGAAACCCATGCCTGTAGAAATTCTTATGCCCGCCCTTTCCCCGACCATGGAGGAAGGCACGCTTTCCAAA
TGGCTTAAAAAGGAAGGCGA

Product: pyruvate dehydrogenase alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQMSQKEGDQVITAYRDHGHMLALGMSARGVMAELTGRKGGLSK
GKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRGNDNVSVTYFGDGAANQGQVYESFNMAALWKLPIIYIVENN
RYAMGTSTARATAQSNYSLRGQSFGIPGVQVDGMDVRAVKAAADQALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSK
DEVQKMRSEHDPIEQVKARLLDHGWASEDELKAIDKDVRDIVADSADFAQNDPEPDVSELYTDILL

Sequences:

>Translated_306_residues
MLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQMSQKEGDQVITAYRDHGHMLALGMSARGVMAELTGRKGGLSK
GKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRGNDNVSVTYFGDGAANQGQVYESFNMAALWKLPIIYIVENN
RYAMGTSTARATAQSNYSLRGQSFGIPGVQVDGMDVRAVKAAADQALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSK
DEVQKMRSEHDPIEQVKARLLDHGWASEDELKAIDKDVRDIVADSADFAQNDPEPDVSELYTDILL
>Mature_306_residues
MLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQMSQKEGDQVITAYRDHGHMLALGMSARGVMAELTGRKGGLSK
GKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRGNDNVSVTYFGDGAANQGQVYESFNMAALWKLPIIYIVENN
RYAMGTSTARATAQSNYSLRGQSFGIPGVQVDGMDVRAVKAAADQALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSK
DEVQKMRSEHDPIEQVKARLLDHGWASEDELKAIDKDVRDIVADSADFAQNDPEPDVSELYTDILL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=301, Percent_Identity=55.4817275747508, Blast_Score=345, Evalue=2e-95,
Organism=Homo sapiens, GI4505685, Length=301, Percent_Identity=56.1461794019934, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI291084742, Length=301, Percent_Identity=56.1461794019934, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI291084744, Length=308, Percent_Identity=54.8701298701299, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI291084757, Length=301, Percent_Identity=50.1661129568106, Blast_Score=269, Evalue=2e-72,
Organism=Homo sapiens, GI11386135, Length=277, Percent_Identity=32.4909747292419, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI258645172, Length=277, Percent_Identity=32.4909747292419, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=305, Percent_Identity=52.7868852459016, Blast_Score=321, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17536047, Length=305, Percent_Identity=52.7868852459016, Blast_Score=320, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI86563355, Length=285, Percent_Identity=30.5263157894737, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI86563357, Length=285, Percent_Identity=30.5263157894737, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321026, Length=309, Percent_Identity=50.8090614886731, Blast_Score=317, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24639744, Length=305, Percent_Identity=50.4918032786885, Blast_Score=318, Evalue=3e-87,
Organism=Drosophila melanogaster, GI28571106, Length=305, Percent_Identity=50.4918032786885, Blast_Score=318, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24639740, Length=305, Percent_Identity=50.4918032786885, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=50.4918032786885, Blast_Score=317, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24639748, Length=305, Percent_Identity=52.1311475409836, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI21355903, Length=277, Percent_Identity=29.2418772563177, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 33617; Mature: 33617

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQMSQKEGDQVITAYRDHGHMLAL
CCCHHHHHHHHCCEEEEHHHHHEEHEEECCCEEEEEEHHCCCCCCEEEEEEECCCCEEEE
GMSARGVMAELTGRKGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRG
CCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCEECCCCEEEEEEECCCCHHHHHHCCC
NDNVSVTYFGDGAANQGQVYESFNMAALWKLPIIYIVENNRYAMGTSTARATAQSNYSLR
CCCEEEEEECCCCCCCCCEECCCCEEEEEECCEEEEEECCEEEECCCHHHHHHCCCCEEC
GQSFGIPGVQVDGMDVRAVKAAADQALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSK
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCHHHCCH
DEVQKMRSEHDPIEQVKARLLDHGWASEDELKAIDKDVRDIVADSADFAQNDPEPDVSEL
HHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHH
YTDILL
HHHHCC
>Mature Secondary Structure
MLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQMSQKEGDQVITAYRDHGHMLAL
CCCHHHHHHHHCCEEEEHHHHHEEHEEECCCEEEEEEHHCCCCCCEEEEEEECCCCEEEE
GMSARGVMAELTGRKGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRG
CCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCEECCCCEEEEEEECCCCHHHHHHCCC
NDNVSVTYFGDGAANQGQVYESFNMAALWKLPIIYIVENNRYAMGTSTARATAQSNYSLR
CCCEEEEEECCCCCCCCCEECCCCEEEEEECCEEEEEECCEEEECCCHHHHHHCCCCEEC
GQSFGIPGVQVDGMDVRAVKAAADQALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSK
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCHHHCCH
DEVQKMRSEHDPIEQVKARLLDHGWASEDELKAIDKDVRDIVADSADFAQNDPEPDVSEL
HHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHH
YTDILL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]