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The map label for this gene is rnd [H]

Identifier: 159184639

GI number: 159184639

Start: 1142006

End: 1143172

Strand: Reverse

Name: rnd [H]

Synonym: Atu1151

Alternate gene names: 159184639

Gene position: 1143172-1142006 (Counterclockwise)

Preceding gene: 15888490

Following gene: 15888488

Centisome position: 40.23

GC content: 60.5

Gene sequence:

>1167_bases
ATGATTGAAACGACTGCCGCCCTCGCCGAAGCCTGCACGGAACTGGCGAAATCGGAATTCATTACCATCGACACCGAATT
TTTGCGGGAAACAACCTTCTGGCCGGAACTGTGCCTCGTACAGATGGCGAGCCCGACGCTCGAAGTACTGGTTGATCCGC
TGGCCAAGGGTATCGATCTTACGCCGATGTTCGAACTAATGGCCAATCCAAACGTCGTGAAGGTTTTCCACGCCGCACGG
CAGGACATCGAAATCATCTATCATCTCGGCGGGCTCATTCCCCATCCGATCTTCGACACGCAGGTCGCCGCCATGGTGTG
CGGTTTCGGCGATTCGATCTCCTACGACCAGCTGGTCCAGAAGATCAAGAATGTGCAGATCGACAAATCCTCGCGTTTCA
CCGACTGGAGCCGCCGTCCGCTCACCGAAAAGCAGCTGGATTACGCGCTGGCCGACGTAACACATCTGCGCGATGTCTAT
CTCTCGCTCAAAGCGCAGCTGGAGCGCGAAGGCCGCTCCCTGTGGCTGACCGAAGAGATGAACATTCTGGAATCGCGCGA
CACCTATGACATGCATCCCGACGATGCGTGGCTGCGGCTGAAATCGCGCCTGCGCAAGCCGACGGAACTCGCCATCCTCA
AATTCGTCGCCGCCTGGCGCGAACGTGAAGCGCGGTCGCGCAACGTGCCACGCTCCCGCGTGTTGAAGGACGATGGGATC
TTCGAAATCGCCCAGCAGCAGCCGAAGGACGCCGAGGCGCTGTCGCGGCTTCGCACCATTCCCAAGGGCTGGGAACGGTC
CGCCTCCGGCACCGCCATCATCGAAACGGTGAATGCGGCGCTGGCGCTGCCGAAAGAAGAGATGCCGAAGGCACCGCGCC
ACAGCCACGCACCGGAAGGTTCCGGTGCTGCCGTGGAACTTTTGAAGGTTCTCCTGAAGCTGACGGCAGACAAGCACGGC
GTCGCGGCCAAGGTCATCGCCAACAGCGACGATCTGGACAAGATCGCGTCCGAAGGCGAAAACGCGACCGTTGCGGCGTT
GACCGGCTGGCGGCGCGAGCTGTTCGGCGATGTGGCGCTGAAACTCATCAATGGCGAAGTGGCCTTGCGTTTCGCCGGCA
AGAAGGTCGAGGCCGTGGAAGTTGAGGCGGCAGCGAGCGAGTCGTAA

Upstream 100 bases:

>100_bases
GAGAAAAACGATCCTTGAGGCCGGAAAAGCGGGCTTTGTATTGACATGCGCCCGGCAAAGGGAAAGTAAGACGGATAATT
TTCACGAGTGGCCATTTGCA

Downstream 100 bases:

>100_bases
CCGCCCGCCTTTCTCACCCCAATTTTGCCCGCATCGCGTCCCATTTCTCTACCGATGGTCATGCGATTTGAGGGTCTTGC
CATGAAAACTGCCCGCACTC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIETTAALAEACTELAKSEFITIDTEFLRETTFWPELCLVQMASPTLEVLVDPLAKGIDLTPMFELMANPNVVKVFHAAR
QDIEIIYHLGGLIPHPIFDTQVAAMVCGFGDSISYDQLVQKIKNVQIDKSSRFTDWSRRPLTEKQLDYALADVTHLRDVY
LSLKAQLEREGRSLWLTEEMNILESRDTYDMHPDDAWLRLKSRLRKPTELAILKFVAAWREREARSRNVPRSRVLKDDGI
FEIAQQQPKDAEALSRLRTIPKGWERSASGTAIIETVNAALALPKEEMPKAPRHSHAPEGSGAAVELLKVLLKLTADKHG
VAAKVIANSDDLDKIASEGENATVAALTGWRRELFGDVALKLINGEVALRFAGKKVEAVEVEAAASES

Sequences:

>Translated_388_residues
MIETTAALAEACTELAKSEFITIDTEFLRETTFWPELCLVQMASPTLEVLVDPLAKGIDLTPMFELMANPNVVKVFHAAR
QDIEIIYHLGGLIPHPIFDTQVAAMVCGFGDSISYDQLVQKIKNVQIDKSSRFTDWSRRPLTEKQLDYALADVTHLRDVY
LSLKAQLEREGRSLWLTEEMNILESRDTYDMHPDDAWLRLKSRLRKPTELAILKFVAAWREREARSRNVPRSRVLKDDGI
FEIAQQQPKDAEALSRLRTIPKGWERSASGTAIIETVNAALALPKEEMPKAPRHSHAPEGSGAAVELLKVLLKLTADKHG
VAAKVIANSDDLDKIASEGENATVAALTGWRRELFGDVALKLINGEVALRFAGKKVEAVEVEAAASES
>Mature_388_residues
MIETTAALAEACTELAKSEFITIDTEFLRETTFWPELCLVQMASPTLEVLVDPLAKGIDLTPMFELMANPNVVKVFHAAR
QDIEIIYHLGGLIPHPIFDTQVAAMVCGFGDSISYDQLVQKIKNVQIDKSSRFTDWSRRPLTEKQLDYALADVTHLRDVY
LSLKAQLEREGRSLWLTEEMNILESRDTYDMHPDDAWLRLKSRLRKPTELAILKFVAAWREREARSRNVPRSRVLKDDGI
FEIAQQQPKDAEALSRLRTIPKGWERSASGTAIIETVNAALALPKEEMPKAPRHSHAPEGSGAAVELLKVLLKLTADKHG
VAAKVIANSDDLDKIASEGENATVAALTGWRRELFGDVALKLINGEVALRFAGKKVEAVEVEAAASES

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=263, Percent_Identity=26.9961977186312, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI50301240, Length=263, Percent_Identity=26.9961977186312, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1788105, Length=374, Percent_Identity=29.6791443850267, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17531757, Length=168, Percent_Identity=27.3809523809524, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=193, Percent_Identity=29.0155440414508, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161078302, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43206; Mature: 43206

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETTAALAEACTELAKSEFITIDTEFLRETTFWPELCLVQMASPTLEVLVDPLAKGIDL
CCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
TPMFELMANPNVVKVFHAARQDIEIIYHLGGLIPHPIFDTQVAAMVCGFGDSISYDQLVQ
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
KIKNVQIDKSSRFTDWSRRPLTEKQLDYALADVTHLRDVYLSLKAQLEREGRSLWLTEEM
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
NILESRDTYDMHPDDAWLRLKSRLRKPTELAILKFVAAWREREARSRNVPRSRVLKDDGI
HHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCH
FEIAQQQPKDAEALSRLRTIPKGWERSASGTAIIETVNAALALPKEEMPKAPRHSHAPEG
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
SGAAVELLKVLLKLTADKHGVAAKVIANSDDLDKIASEGENATVAALTGWRRELFGDVAL
CCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
KLINGEVALRFAGKKVEAVEVEAAASES
HHHCCCEEEEECCCCEEEEEECCCCCCC
>Mature Secondary Structure
MIETTAALAEACTELAKSEFITIDTEFLRETTFWPELCLVQMASPTLEVLVDPLAKGIDL
CCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
TPMFELMANPNVVKVFHAARQDIEIIYHLGGLIPHPIFDTQVAAMVCGFGDSISYDQLVQ
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
KIKNVQIDKSSRFTDWSRRPLTEKQLDYALADVTHLRDVYLSLKAQLEREGRSLWLTEEM
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
NILESRDTYDMHPDDAWLRLKSRLRKPTELAILKFVAAWREREARSRNVPRSRVLKDDGI
HHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCH
FEIAQQQPKDAEALSRLRTIPKGWERSASGTAIIETVNAALALPKEEMPKAPRHSHAPEG
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
SGAAVELLKVLLKLTADKHGVAAKVIANSDDLDKIASEGENATVAALTGWRRELFGDVAL
CCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
KLINGEVALRFAGKKVEAVEVEAAASES
HHHCCCEEEEECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]