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The map label for this gene is uvrC

Identifier: 159184627

GI number: 159184627

Start: 1117423

End: 1119351

Strand: Reverse

Name: uvrC

Synonym: Atu1129

Alternate gene names: 159184627

Gene position: 1119351-1117423 (Counterclockwise)

Preceding gene: 159184628

Following gene: 15888465

Centisome position: 39.39

GC content: 60.55

Gene sequence:

>1929_bases
ATGGACTGGAATGCGGGCTGGAAGAACGAATCCGGCCTGAAGGGCATGGATCTCATCGGCGAATTCGTCAAACACCTGCC
GAATTCGCCGGGTGTCTACCGCATGTTCAACGAAGCGGGCGACGTTCTTTACGTCGGCAAGGCGCGTTCGCTGAAGAAGC
GCGTCGGCAATTACGCACAGGGTCGCGTGCATTCCAACCGCATCGCCCAGATGGTGCGTTTCACCACCCACATGGAATTC
GTCACCACCCGTACGGAGACTGAGGCGCTTCTCTTGGAAGCGAATCTGATCAAACGCTTACGGCCGCGCTTTAACGTGCT
TTTGCGTGACGACAAGTCGTTTCCCTATATTCTGATTACCGCGGATAATCGCGCACCGGCGATCTTCAAGCATCGCGGTG
CCCGGGCGCGGAAAGGCGATTATTTCGGGCCTTTTGCATCGGCCGGCGCCGTTGGCCGCACGATCAATTCGCTGCAACGC
GCCTTCCTGATCCGCACCTGCACCGACAGCGTGTTCGAGACCCGCACGCGTCCCTGTCTTCTCTACCAGATCAAGCGCTG
TTCCGGGCCCTGCACCCATGAGGTGAGCGACGAGGGTTATGCGGAACTCGTCAAGGAAGCCAAGGATTTCCTCTCCGGCA
AGAGCCAGGCCGTCAAGACCGCGATCGCGCGGCAGATGAACGAGGCATCAGAGGATCTCGATTTCGAGCGCGCTGCCATC
TATCGCGACCGGCTGGCGGCGCTCTCGCACGTCCAGAGCCATCAGGGCATCAATCCCGCCGGTATTGAGGAAGCGGATGT
CTTTGCCATTCACCATGAAGGCGGTATTTCCTGTATTCAGGTATTCTTTTTCCGCACCGGCCAGAACTGGGGCAACCGCG
CCTATTTCCCGAAGGCCGATCCATCCTTGCCCGGCTCGGAAATCCTCAACGCCTTCCTAGCACAGTTCTACGACGACAAG
CCGGTGCCGAAACAGATCCTGCTTTCCGAAACGGTTGAGGAACAGGAGCTGCTGGCCGCAGCACTTGGCGAGAAGGCGGG
CCATAAGGTGACGATCAGCGTGCCGCAGCGTGGCGAGAAGAAGGACATTACCGACCATGTTCTTGCCAATGCCCGCGAGG
CGCATGGCCGCAAGCTGGCGGAAACCTCGTCTCAGGCGCGACTGCTGAAAGGCTTTGCGGAGACCTTCAACCTGCCCTAT
GTGCCGCGCCGCATCGAGATTTACGATAACTCGCACATCATGGGCACCAATGCCGTGGGCGGCATGGTGGTGGCGGGGCC
GGAAGGTTTTGTGAAAAACCAGTATCGCAAGTTCAATATCAAATCGACCGACATCACCCCCGGCGACGACTTCGGCATGA
TGCGCGAGGTGATGACCCGTCGCTTCTCGCGCCTGTTGAAGGAAGAGGGCAAACCTGATCGCGCGCAGACGCCGACACCG
GAAGAAGCCGCCGACCTGCCCTTTCCCGCCTGGCCGGATGTAATCCTGATCGACGGCGGCCAGGGGCAGATGACCGCGGT
GCGGGCTATCCTCGACGAACTCGGCATTCGCGACTGCGTGACGGCCATCGGCGTGGCGAAGGGTGTGGACCGCGAGGCGG
GGCGCGAGCGCTTCTTTGCGGACGGGCGCAGCGATTTTTCCCTGCCGCCGCGCGATCCCGTGCTTTATTTCATTCAGCGC
ATGCGCGACGAGGCCCACCGCTTCGCCATCGGCTCGCACCGGGCGCGACGCAAGAAGGAAATGGTGCGCAATCCGCTGGA
TGAAATCTCGGGAATCGGGCCGGGGCGCAAGCGCTCCCTATTGCAACATTTCGGCACGGCCAAGGCGGTTTCCCGCGCCG
GCCTCAACGATCTGATGACTGTTACCGGCATTTCCGAGACGGTGGCGCGGCAAATTTACAATCACTTCCACGAGAGCGGC
AGCGATTGA

Upstream 100 bases:

>100_bases
GCCTGATGGCGGTATTCTGTTCGATGAAACCGACGACGAAGACGACGATGCCAACCTTGCCGCAACCGACACGGCCGAGG
CATCGCGCAGCGTTGCCGGC

Downstream 100 bases:

>100_bases
CGCAGAACGGTAAGACCGATCTGCTAAAAAACCATAATAACGTGTTGACCCTATGCGTCAGGGACGGCATCAAAGCAGCT
TATCCAGACTGACAGGTTTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MDWNAGWKNESGLKGMDLIGEFVKHLPNSPGVYRMFNEAGDVLYVGKARSLKKRVGNYAQGRVHSNRIAQMVRFTTHMEF
VTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITADNRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQR
AFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDEGYAELVKEAKDFLSGKSQAVKTAIARQMNEASEDLDFERAAI
YRDRLAALSHVQSHQGINPAGIEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPSLPGSEILNAFLAQFYDDK
PVPKQILLSETVEEQELLAAALGEKAGHKVTISVPQRGEKKDITDHVLANAREAHGRKLAETSSQARLLKGFAETFNLPY
VPRRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTDITPGDDFGMMREVMTRRFSRLLKEEGKPDRAQTPTP
EEAADLPFPAWPDVILIDGGQGQMTAVRAILDELGIRDCVTAIGVAKGVDREAGRERFFADGRSDFSLPPRDPVLYFIQR
MRDEAHRFAIGSHRARRKKEMVRNPLDEISGIGPGRKRSLLQHFGTAKAVSRAGLNDLMTVTGISETVARQIYNHFHESG
SD

Sequences:

>Translated_642_residues
MDWNAGWKNESGLKGMDLIGEFVKHLPNSPGVYRMFNEAGDVLYVGKARSLKKRVGNYAQGRVHSNRIAQMVRFTTHMEF
VTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITADNRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQR
AFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDEGYAELVKEAKDFLSGKSQAVKTAIARQMNEASEDLDFERAAI
YRDRLAALSHVQSHQGINPAGIEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPSLPGSEILNAFLAQFYDDK
PVPKQILLSETVEEQELLAAALGEKAGHKVTISVPQRGEKKDITDHVLANAREAHGRKLAETSSQARLLKGFAETFNLPY
VPRRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTDITPGDDFGMMREVMTRRFSRLLKEEGKPDRAQTPTP
EEAADLPFPAWPDVILIDGGQGQMTAVRAILDELGIRDCVTAIGVAKGVDREAGRERFFADGRSDFSLPPRDPVLYFIQR
MRDEAHRFAIGSHRARRKKEMVRNPLDEISGIGPGRKRSLLQHFGTAKAVSRAGLNDLMTVTGISETVARQIYNHFHESG
SD
>Mature_642_residues
MDWNAGWKNESGLKGMDLIGEFVKHLPNSPGVYRMFNEAGDVLYVGKARSLKKRVGNYAQGRVHSNRIAQMVRFTTHMEF
VTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITADNRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQR
AFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDEGYAELVKEAKDFLSGKSQAVKTAIARQMNEASEDLDFERAAI
YRDRLAALSHVQSHQGINPAGIEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPSLPGSEILNAFLAQFYDDK
PVPKQILLSETVEEQELLAAALGEKAGHKVTISVPQRGEKKDITDHVLANAREAHGRKLAETSSQARLLKGFAETFNLPY
VPRRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTDITPGDDFGMMREVMTRRFSRLLKEEGKPDRAQTPTP
EEAADLPFPAWPDVILIDGGQGQMTAVRAILDELGIRDCVTAIGVAKGVDREAGRERFFADGRSDFSLPPRDPVLYFIQR
MRDEAHRFAIGSHRARRKKEMVRNPLDEISGIGPGRKRSLLQHFGTAKAVSRAGLNDLMTVTGISETVARQIYNHFHESG
SD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=621, Percent_Identity=39.1304347826087, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1788037, Length=206, Percent_Identity=27.6699029126214, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_AGRT5 (Q8UGA9)

Other databases:

- EMBL:   AE007869
- PIR:   AH2715
- PIR:   C97497
- RefSeq:   NP_354147.2
- HSSP:   Q9WYA3
- ProteinModelPortal:   Q8UGA9
- STRING:   Q8UGA9
- GeneID:   1133167
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1129
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q8UGA9
- ProtClustDB:   PRK00558
- BioCyc:   ATUM176299-1:ATU1129-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71711; Mature: 71711

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWNAGWKNESGLKGMDLIGEFVKHLPNSPGVYRMFNEAGDVLYVGKARSLKKRVGNYAQ
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCHHHHHHHHCCHHC
GRVHSNRIAQMVRFTTHMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILIT
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCEEEEE
ADNRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCL
CCCCCCHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LYQIKRCSGPCTHEVSDEGYAELVKEAKDFLSGKSQAVKTAIARQMNEASEDLDFERAAI
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
YRDRLAALSHVQSHQGINPAGIEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKAD
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCC
PSLPGSEILNAFLAQFYDDKPVPKQILLSETVEEQELLAAALGEKAGHKVTISVPQRGEK
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
KDITDHVLANAREAHGRKLAETSSQARLLKGFAETFNLPYVPRRIEIYDNSHIMGTNAVG
CCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCC
GMVVAGPEGFVKNQYRKFNIKSTDITPGDDFGMMREVMTRRFSRLLKEEGKPDRAQTPTP
CEEEECCCHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EEAADLPFPAWPDVILIDGGQGQMTAVRAILDELGIRDCVTAIGVAKGVDREAGRERFFA
CHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHC
DGRSDFSLPPRDPVLYFIQRMRDEAHRFAIGSHRARRKKEMVRNPLDEISGIGPGRKRSL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHH
LQHFGTAKAVSRAGLNDLMTVTGISETVARQIYNHFHESGSD
HHHHCHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDWNAGWKNESGLKGMDLIGEFVKHLPNSPGVYRMFNEAGDVLYVGKARSLKKRVGNYAQ
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCHHHHHHHHCCHHC
GRVHSNRIAQMVRFTTHMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILIT
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCEEEEE
ADNRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCL
CCCCCCHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LYQIKRCSGPCTHEVSDEGYAELVKEAKDFLSGKSQAVKTAIARQMNEASEDLDFERAAI
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
YRDRLAALSHVQSHQGINPAGIEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKAD
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCC
PSLPGSEILNAFLAQFYDDKPVPKQILLSETVEEQELLAAALGEKAGHKVTISVPQRGEK
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
KDITDHVLANAREAHGRKLAETSSQARLLKGFAETFNLPYVPRRIEIYDNSHIMGTNAVG
CCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCC
GMVVAGPEGFVKNQYRKFNIKSTDITPGDDFGMMREVMTRRFSRLLKEEGKPDRAQTPTP
CEEEECCCHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EEAADLPFPAWPDVILIDGGQGQMTAVRAILDELGIRDCVTAIGVAKGVDREAGRERFFA
CHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHC
DGRSDFSLPPRDPVLYFIQRMRDEAHRFAIGSHRARRKKEMVRNPLDEISGIGPGRKRSL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHH
LQHFGTAKAVSRAGLNDLMTVTGISETVARQIYNHFHESGSD
HHHHCHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194