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The map label for this gene is cueR [H]

Identifier: 159184539

GI number: 159184539

Start: 928267

End: 928644

Strand: Direct

Name: cueR [H]

Synonym: Atu0938

Alternate gene names: 159184539

Gene position: 928267-928644 (Clockwise)

Preceding gene: 159184538

Following gene: 159184540

Centisome position: 32.67

GC content: 60.58

Gene sequence:

>378_bases
ATGATCCGTTATTACGAGCAGATCGGCCTCATCACCCCCGCCGCCCGCACCGGCAATAATTACCGGGTCTATGGCGAGCA
GGATGTGCACAATCTGCGCTTCATCAAGCGGGCGCGTACGCTCGGTTTCTCGCTGGAAGAAACCGAGACTTTGCTGAAAC
TCTGGCAGGACAAGAGCCGCGAGAGTTCGGCGGTGAAGGAGATCGCGCTCGTCCATATCGCCGATCTCGAGCAGAAGATC
GCCGAGATGAAGAGCATGGTGAAGACGCTCTCCCATCTCGCCCATTGCTGCGGTGGCGACCACCGACCCGACTGCCCCAT
CCTCGACGATCTCGCGGGCGCCGACAAGACAGACGGCAAGCCCGCGAGAACCCACTGA

Upstream 100 bases:

>100_bases
TTGCCAATGCGCTGCGGTTGAAACGGGCAAAGGTTGTGCACAGGGAGGTGACGTCGTGAACATCGGCCAGGCATCGGAGG
CATCGGGCGTTTCCGCCAAG

Downstream 100 bases:

>100_bases
ACTGCAATATCAGCCGGCGCACAAATATCGTGCCGTTCAAAAGGAGAAAACCATGAGTGCAACCACCTTCCACATCCCTG
ATATGACCTGCGGCCATTGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MIRYYEQIGLITPAARTGNNYRVYGEQDVHNLRFIKRARTLGFSLEETETLLKLWQDKSRESSAVKEIALVHIADLEQKI
AEMKSMVKTLSHLAHCCGGDHRPDCPILDDLAGADKTDGKPARTH

Sequences:

>Translated_125_residues
MIRYYEQIGLITPAARTGNNYRVYGEQDVHNLRFIKRARTLGFSLEETETLLKLWQDKSRESSAVKEIALVHIADLEQKI
AEMKSMVKTLSHLAHCCGGDHRPDCPILDDLAGADKTDGKPARTH
>Mature_125_residues
MIRYYEQIGLITPAARTGNNYRVYGEQDVHNLRFIKRARTLGFSLEETETLLKLWQDKSRESSAVKEIALVHIADLEQKI
AEMKSMVKTLSHLAHCCGGDHRPDCPILDDLAGADKTDGKPARTH

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=112, Percent_Identity=42.8571428571429, Blast_Score=104, Evalue=1e-24,
Organism=Escherichia coli, GI1789687, Length=113, Percent_Identity=38.0530973451327, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14119; Mature: 14119

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRYYEQIGLITPAARTGNNYRVYGEQDVHNLRFIKRARTLGFSLEETETLLKLWQDKSR
CCCHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
ESSAVKEIALVHIADLEQKIAEMKSMVKTLSHLAHCCGGDHRPDCPILDDLAGADKTDGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCC
PARTH
CCCCC
>Mature Secondary Structure
MIRYYEQIGLITPAARTGNNYRVYGEQDVHNLRFIKRARTLGFSLEETETLLKLWQDKSR
CCCHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
ESSAVKEIALVHIADLEQKIAEMKSMVKTLSHLAHCCGGDHRPDCPILDDLAGADKTDGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCC
PARTH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]