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The map label for this gene is guaB [H]

Identifier: 159184394

GI number: 159184394

Start: 612499

End: 613872

Strand: Direct

Name: guaB [H]

Synonym: Atu0624

Alternate gene names: 159184394

Gene position: 612499-613872 (Clockwise)

Preceding gene: 159184393

Following gene: 15887966

Centisome position: 21.55

GC content: 63.25

Gene sequence:

>1374_bases
CTGAACCTGCCGATCCTCTCTTCCGCCATGGATACGGTCACCGAAGGCCGCCTCGCCATCGCCATGGCCCAGGCCGGCGG
CATCGGTGTCATTCACCGTAACCTTACCCCCATCGAGCAGGCCGAAGAAGTGCGGCAGGTGAAGAAGTTCGAAAGCGGCA
TGGTCGTCAATCCGGTCACCATCGGCCCCGACGCGACGCTTGCCGAAGCGCAGGCATTGATGAAGGCGCACGGCATTTCC
GGCATTCCGGTGGTCGAAAACGGCGGTGCCGGCGGCCACAAGAATGGCCGCCTCGTCGGCATTCTCACTAACCGCGACGT
GCGCTTCGCCTCCGATCCGCAGCAGAAGATCTACGAACTGATGACCCGCGAAAATCTGGTCACGGTCAAGGAAAGCAGCG
TCGATCAGCAGGAAGCGCGCCGCCTGCTGCACAAGCACCGCATTGAAAAGCTGCTGGTTGTGGACGGAAAGGGCAATTGC
GTCGGTCTCATCACCGTTAAGGATATTGAGAAGTCGCAGCTAAACCCCAATGCCACCAAGGATGCGCAGGGCCGCCTTCG
CGCCGCCGCCGCCATCAGCGTGGGTGCTGATGCCATCGAGCGCGCCGAACGCCTCATCGATGCCGGCGTTGACCTTCTGG
TCGTTGATACCGCGCATGGCCATTCGCAGCGGGTTCTCGATGCCGTGGCGCAGGTCAAGAAGATGTCGAACTCGGTTCGC
ATCATCGCCGGCAATGTCGCCACTGCCGACGGCACCAAGGCGCTGATCGATGCCGGTGCGGACGCCGTCAAGGTCGGTAT
CGGCCCCGGCTCCATCTGCACCACCCGTATCGTCGCCGGCGTTGGCGTTCCGCAGCTTGCCGCAGTCATGGCCGCAGTCG
AAGCGGCCAGCCTCGCCGATATTCCTGTCATCGCCGATGGCGGCATCAAGTTCTCGGGCGATCTGGCCAAGGCGATCGCC
GCCGGCGCTTCCGCCGTCATGATCGGCTCGCTGCTCGCCGGTACGGATGAAAGCCCGGGCGAAGTGTTCCTGTATCAGGG
CCGTTCCTTCAAGGCCTATCGCGGCATGGGTTCCGTTGGCGCCATGGCGCGCGGTTCCGCTGACCGTTATTTCCAGGCGG
AAGTGCGCGATACGCTGAAGCTCGTGCCTGAGGGTATCGAAGGTCAGGTGCCCTATAAGGGCCCAGTCTCCGGCGTCCTG
CACCAGCTGGCCGGCGGCCTCAAGGCTGCCATGGGTTATGTCGGTGGCAGCAACATCAAGGAATTCCAGGAGCGCGCCAC
CTTCGTGCGCATTTCCAGCGCCGGCCTGCGGGAAAGCCACGCCCATGACGTGACAATCACGCGTGAAAGCCCGAACTATC
CGGGCGCGGTTTGA

Upstream 100 bases:

>100_bases
GGACGCTCTCACATTTGACGATGTGTTGCTGCAACCCGGACATTCCGAAGTCATGCCGGGACAGACAAATATCGCCACCC
GCATTGCCCGCGATATCGAT

Downstream 100 bases:

>100_bases
TCTTTCGAGCCGAATCCGTAAAAAGATAGGCTAGATATTTGGCGCTCCCCGATCTCAAGCCGGATCGGGGAGCGTTTTCA
TGATGGGGGGAAAGCATGTC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNLPILSSAMDTVTEGRLAIAMAQAGGIGVIHRNLTPIEQAEEVRQVKKFESGMVVNPVTIGPDATLAEAQALMKAHGIS
GIPVVENGGAGGHKNGRLVGILTNRDVRFASDPQQKIYELMTRENLVTVKESSVDQQEARRLLHKHRIEKLLVVDGKGNC
VGLITVKDIEKSQLNPNATKDAQGRLRAAAAISVGADAIERAERLIDAGVDLLVVDTAHGHSQRVLDAVAQVKKMSNSVR
IIAGNVATADGTKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLAAVMAAVEAASLADIPVIADGGIKFSGDLAKAIA
AGASAVMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVL
HQLAGGLKAAMGYVGGSNIKEFQERATFVRISSAGLRESHAHDVTITRESPNYPGAV

Sequences:

>Translated_457_residues
MNLPILSSAMDTVTEGRLAIAMAQAGGIGVIHRNLTPIEQAEEVRQVKKFESGMVVNPVTIGPDATLAEAQALMKAHGIS
GIPVVENGGAGGHKNGRLVGILTNRDVRFASDPQQKIYELMTRENLVTVKESSVDQQEARRLLHKHRIEKLLVVDGKGNC
VGLITVKDIEKSQLNPNATKDAQGRLRAAAAISVGADAIERAERLIDAGVDLLVVDTAHGHSQRVLDAVAQVKKMSNSVR
IIAGNVATADGTKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLAAVMAAVEAASLADIPVIADGGIKFSGDLAKAIA
AGASAVMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVL
HQLAGGLKAAMGYVGGSNIKEFQERATFVRISSAGLRESHAHDVTITRESPNYPGAV
>Mature_457_residues
MNLPILSSAMDTVTEGRLAIAMAQAGGIGVIHRNLTPIEQAEEVRQVKKFESGMVVNPVTIGPDATLAEAQALMKAHGIS
GIPVVENGGAGGHKNGRLVGILTNRDVRFASDPQQKIYELMTRENLVTVKESSVDQQEARRLLHKHRIEKLLVVDGKGNC
VGLITVKDIEKSQLNPNATKDAQGRLRAAAAISVGADAIERAERLIDAGVDLLVVDTAHGHSQRVLDAVAQVKKMSNSVR
IIAGNVATADGTKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLAAVMAAVEAASLADIPVIADGGIKFSGDLAKAIA
AGASAVMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVL
HQLAGGLKAAMGYVGGSNIKEFQERATFVRISSAGLRESHAHDVTITRESPNYPGAV

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=425, Percent_Identity=40, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI217035146, Length=423, Percent_Identity=40.4255319148936, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI34328930, Length=423, Percent_Identity=40.4255319148936, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI34328928, Length=423, Percent_Identity=40.4255319148936, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI217035152, Length=423, Percent_Identity=40.4255319148936, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI156616279, Length=423, Percent_Identity=40.4255319148936, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI217035148, Length=423, Percent_Identity=39.4799054373522, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI217035150, Length=423, Percent_Identity=36.6430260047281, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=39.8373983739837, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=39.8373983739837, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=39.8373983739837, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=39.8373983739837, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI156104880, Length=257, Percent_Identity=37.7431906614786, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1788855, Length=458, Percent_Identity=57.4235807860262, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786293, Length=237, Percent_Identity=39.662447257384, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=443, Percent_Identity=36.117381489842, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI71994389, Length=393, Percent_Identity=37.9134860050891, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17560440, Length=247, Percent_Identity=39.6761133603239, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=433, Percent_Identity=39.4919168591224, Blast_Score=299, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6322012, Length=458, Percent_Identity=38.646288209607, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6323464, Length=432, Percent_Identity=40.9722222222222, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6319352, Length=312, Percent_Identity=39.4230769230769, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=41.025641025641, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=427, Percent_Identity=40.5152224824356, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24641073, Length=427, Percent_Identity=40.5152224824356, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=38.963963963964, Blast_Score=285, Evalue=5e-77,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 47593; Mature: 47593

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPILSSAMDTVTEGRLAIAMAQAGGIGVIHRNLTPIEQAEEVRQVKKFESGMVVNPVT
CCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEE
IGPDATLAEAQALMKAHGISGIPVVENGGAGGHKNGRLVGILTNRDVRFASDPQQKIYEL
ECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCCEEECCCHHHHHHHH
MTRENLVTVKESSVDQQEARRLLHKHRIEKLLVVDGKGNCVGLITVKDIEKSQLNPNATK
HHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCHHHCCCCCCCC
DAQGRLRAAAAISVGADAIERAERLIDAGVDLLVVDTAHGHSQRVLDAVAQVKKMSNSVR
CHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEE
IIAGNVATADGTKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLAAVMAAVEAASLAD
EEECCEECCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
IPVIADGGIKFSGDLAKAIAAGASAVMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGSVG
CCEEECCCEEECCHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCC
AMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVLHQLAGGLKAAMGYVGGSNIK
HHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
EFQERATFVRISSAGLRESHAHDVTITRESPNYPGAV
HHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MNLPILSSAMDTVTEGRLAIAMAQAGGIGVIHRNLTPIEQAEEVRQVKKFESGMVVNPVT
CCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEE
IGPDATLAEAQALMKAHGISGIPVVENGGAGGHKNGRLVGILTNRDVRFASDPQQKIYEL
ECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCCEEECCCHHHHHHHH
MTRENLVTVKESSVDQQEARRLLHKHRIEKLLVVDGKGNCVGLITVKDIEKSQLNPNATK
HHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCHHHCCCCCCCC
DAQGRLRAAAAISVGADAIERAERLIDAGVDLLVVDTAHGHSQRVLDAVAQVKKMSNSVR
CHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEE
IIAGNVATADGTKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLAAVMAAVEAASLAD
EEECCEECCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
IPVIADGGIKFSGDLAKAIAAGASAVMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGSVG
CCEEECCCEEECCHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCC
AMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVLHQLAGGLKAAMGYVGGSNIK
HHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
EFQERATFVRISSAGLRESHAHDVTITRESPNYPGAV
HHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA