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The map label for this gene is flhA [H]

Identifier: 159184372

GI number: 159184372

Start: 564582

End: 566669

Strand: Direct

Name: flhA [H]

Synonym: Atu0581

Alternate gene names: 159184372

Gene position: 564582-566669 (Clockwise)

Preceding gene: 15887925

Following gene: 159184373

Centisome position: 19.87

GC content: 59.2

Gene sequence:

>2088_bases
ATGGCGCAGCCACCAGTCATCTCCTTGCCCAAGGTCAGTCCGAGCATGCGGGATATCGGTTTCGCATTGGGCATCATTTC
GATCCTTTGCGTTCTGTTTCTGCCTATTCCGGTCATGCTGGTGGACATCGGTCTGGCGTTCTCGATTGCGCTTTCGGTCC
TCATCCTCATGGTGGCGCTCTGGATCCAGCGCCCGCTGGACTTCTCGTCATTCCCGACCGTGCTGCTGATTGCCACAATG
ATCCGTCTGTCGCTGAACATTGCGACGACGCGTGTCATCCTTTCGCATGGTAACGAGGGGCCGACGGCGGCAGGTGGCGT
GATCGCGGGTTTCTCCAGCCTCGTCATGTCCGGTGACTTCGTCATCGGTCTCATCGTCTTCCTGATCCTGATCACGGTCA
ACTTCATCGTCATCACCAAGGGTGCGACGCGTATCGCCGAAGTCGGCGCGCGCTTCACCCTAGACGCCATCCCCGGCAAG
CAGATGTCGATCGATGCGGATCTGTCCGCCGGCATCATCGATGAAAAGGAAGCGCAGCGTCGCCGCCGGGAACTGGAAGA
AGAAAGCTCTTTCTTCGGTTCGATGGACGGTGCCTCGAAATTCGTCCGCGGCGACGCGATCGCCGGCCTCATCATCACCG
CGATCAACGTTTTCGGCGGCATCATCATCGGTTATTTCCGCCACGGCATGCCGATCGGCGAAGCGGCCGATGTTTTCGTC
AAGCTTTCGGTCGGTGATGGTATCGTCTCGCAGATCCCGGCCCTGATCGTATCGCTGGCGGCCGGCCTTCTGGTGTCGCG
CGGTGGCACAGCCGGATCGACGGATCAGGCCGTCATCAATCAGCTGAGCGGTTATCCCCGCGCTTTGATGGTCTCGGCCA
TGCTGATGGGTCTGCTCGCCGTCATTCCGGGCCTTCCCTTCGTGCCCTTCATTTTCCTCGGCGGCATCATGGCCTTTGGC
AGCTGGTATATTCCGCGCCAGGCCGAAGCCGAAAGCGCGCTTCGCCGCCAGGAAGAGGAAAACAAGGTTCTCCAGACCAC
CGAGGCGGAAAAGGATTCCGTCAAGCAGGTGCTGAAGACCGCCGAGATCGAGCTCGCGCTCGGCAAGCAGGTTTCCACCC
GCCTTCTCGGCGCGCATCAGGAACTGGCCTTCCGCGTCGGCAAGATGCGCAAGAAATTCGCCACGCAATATGGCTTTGTG
GTGCCGGAGATCAAGGTCTCCGACGACATCATGATCCCGGAAAAGGCCTATCAGATCCGCGTCCACGGCACGACGATCGC
GTCCAGCAACCTGCGCGTCGGCGATGTGCTGGTCGTGACGGGGGCAGGGCGCAAGCCGAGCATCCCAGGTGATGAAATCC
GCGAACCCGCTTTCGGCATGCCGGCCGTCTCGATCCTCGAGACCTTTACCGAGGATCTGAAGCGCGAAGGCTTCCACCCG
ATCGATAACGTCTCTGTCGTGCTGACGCATCTGAGCGAGGTTATCCGCAACAATCTGCCGCAGCTTCTGTCCTACAAGGA
CGTCAAGATCCTCATCGACAGGCTTGATCCCGAATACAAGAAGCTGGCTGACGAGATTTGTTCGTCGCACATGTCCTATT
CCGGCCTGCAGGCGGTGCTGAAGTTGCTGCTGGCCGAGCGCGTATCGATCCGCAACCTGCATCTCATTTTGGAAGCGGTG
GCAGAACTCGCACCGCATGTGCGCAAGACCGAGCAGATCGTCGAACATGTCCGCGTTCGCATGTCGCAGCAGCTCTGCGG
CGACCTTGCCGACAATGGCGTGCTGCGCGTCCTGCGACTCGGCAACAAGTGGGACATGGTCTTCCATCAGGCGCTGAAAC
GCGACCAGAAGGGCGAAATCGTCGAATTTGACATCGATCCGCGCCATCTCGAGGAGTTTTCCGAGCAGGCATCGAAAGTT
ATCCGTGAATTCATGGATCGCGGGCTGCCCTTTGTCCTTGTAACCTCGCCGGAAACGCGGTCCTATGTGCGCATGATTAT
CGAGCGACTCTTTGCGACCCTGCCGGTTCTTTCACATGTGGAACTGGCCAAGGGTCTCGAGATCAAGATTCTGGGCGCCA
TTTCATGA

Upstream 100 bases:

>100_bases
AAGGCATCGGCCCGAATTGCGTTCGCTTTTCGAAAACCGATGCCCGGAACCGTGCGACGGCTTTTCCGTCGCCCTTCTCA
TGAAGAGACAGGACGAATTC

Downstream 100 bases:

>100_bases
TAACCGACCCGCAGGGAACAATCATTGCATTGTTCCTTGCCATCTGCCGCATAGGCGCCTGCTTCATGACCATGCCGGGC
TTTTCAAGTTCGCGCATCTC

Product: flagellar biosynthesis protein FlhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MAQPPVISLPKVSPSMRDIGFALGIISILCVLFLPIPVMLVDIGLAFSIALSVLILMVALWIQRPLDFSSFPTVLLIATM
IRLSLNIATTRVILSHGNEGPTAAGGVIAGFSSLVMSGDFVIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGIIDEKEAQRRRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
KLSVGDGIVSQIPALIVSLAAGLLVSRGGTAGSTDQAVINQLSGYPRALMVSAMLMGLLAVIPGLPFVPFIFLGGIMAFG
SWYIPRQAEAESALRRQEEENKVLQTTEAEKDSVKQVLKTAEIELALGKQVSTRLLGAHQELAFRVGKMRKKFATQYGFV
VPEIKVSDDIMIPEKAYQIRVHGTTIASSNLRVGDVLVVTGAGRKPSIPGDEIREPAFGMPAVSILETFTEDLKREGFHP
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKILIDRLDPEYKKLADEICSSHMSYSGLQAVLKLLLAERVSIRNLHLILEAV
AELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRLGNKWDMVFHQALKRDQKGEIVEFDIDPRHLEEFSEQASKV
IREFMDRGLPFVLVTSPETRSYVRMIIERLFATLPVLSHVELAKGLEIKILGAIS

Sequences:

>Translated_695_residues
MAQPPVISLPKVSPSMRDIGFALGIISILCVLFLPIPVMLVDIGLAFSIALSVLILMVALWIQRPLDFSSFPTVLLIATM
IRLSLNIATTRVILSHGNEGPTAAGGVIAGFSSLVMSGDFVIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGIIDEKEAQRRRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
KLSVGDGIVSQIPALIVSLAAGLLVSRGGTAGSTDQAVINQLSGYPRALMVSAMLMGLLAVIPGLPFVPFIFLGGIMAFG
SWYIPRQAEAESALRRQEEENKVLQTTEAEKDSVKQVLKTAEIELALGKQVSTRLLGAHQELAFRVGKMRKKFATQYGFV
VPEIKVSDDIMIPEKAYQIRVHGTTIASSNLRVGDVLVVTGAGRKPSIPGDEIREPAFGMPAVSILETFTEDLKREGFHP
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKILIDRLDPEYKKLADEICSSHMSYSGLQAVLKLLLAERVSIRNLHLILEAV
AELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRLGNKWDMVFHQALKRDQKGEIVEFDIDPRHLEEFSEQASKV
IREFMDRGLPFVLVTSPETRSYVRMIIERLFATLPVLSHVELAKGLEIKILGAIS
>Mature_694_residues
AQPPVISLPKVSPSMRDIGFALGIISILCVLFLPIPVMLVDIGLAFSIALSVLILMVALWIQRPLDFSSFPTVLLIATMI
RLSLNIATTRVILSHGNEGPTAAGGVIAGFSSLVMSGDFVIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGKQ
MSIDADLSAGIIDEKEAQRRRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINVFGGIIIGYFRHGMPIGEAADVFVK
LSVGDGIVSQIPALIVSLAAGLLVSRGGTAGSTDQAVINQLSGYPRALMVSAMLMGLLAVIPGLPFVPFIFLGGIMAFGS
WYIPRQAEAESALRRQEEENKVLQTTEAEKDSVKQVLKTAEIELALGKQVSTRLLGAHQELAFRVGKMRKKFATQYGFVV
PEIKVSDDIMIPEKAYQIRVHGTTIASSNLRVGDVLVVTGAGRKPSIPGDEIREPAFGMPAVSILETFTEDLKREGFHPI
DNVSVVLTHLSEVIRNNLPQLLSYKDVKILIDRLDPEYKKLADEICSSHMSYSGLQAVLKLLLAERVSIRNLHLILEAVA
ELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRLGNKWDMVFHQALKRDQKGEIVEFDIDPRHLEEFSEQASKVI
REFMDRGLPFVLVTSPETRSYVRMIIERLFATLPVLSHVELAKGLEIKILGAIS

Specific function: Required for formation of the rod structure of the flagellar apparatus. May constitute the export apparatus of flagellin. The flagellum is required to cause a persistent disease in a murine model of infection [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=679, Percent_Identity=37.260677466863, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006301
- InterPro:   IPR001712 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 75921; Mature: 75790

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPPVISLPKVSPSMRDIGFALGIISILCVLFLPIPVMLVDIGLAFSIALSVLILMVAL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIQRPLDFSSFPTVLLIATMIRLSLNIATTRVILSHGNEGPTAAGGVIAGFSSLVMSGDF
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCH
VIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGIIDEKEAQR
HHHHHHHHHHHHHHHHEEECCHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCHHHHHH
RRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
KLSVGDGIVSQIPALIVSLAAGLLVSRGGTAGSTDQAVINQLSGYPRALMVSAMLMGLLA
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VIPGLPFVPFIFLGGIMAFGSWYIPRQAEAESALRRQEEENKVLQTTEAEKDSVKQVLKT
HHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEIELALGKQVSTRLLGAHQELAFRVGKMRKKFATQYGFVVPEIKVSDDIMIPEKAYQIR
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEECCCCCEEEE
VHGTTIASSNLRVGDVLVVTGAGRKPSIPGDEIREPAFGMPAVSILETFTEDLKREGFHP
EEEEEEECCCCEECCEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKILIDRLDPEYKKLADEICSSHMSYSGLQAVL
CCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHH
KLLLAERVSIRNLHLILEAVAELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GNKWDMVFHQALKRDQKGEIVEFDIDPRHLEEFSEQASKVIREFMDRGLPFVLVTSPETR
CCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHH
SYVRMIIERLFATLPVLSHVELAKGLEIKILGAIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
AQPPVISLPKVSPSMRDIGFALGIISILCVLFLPIPVMLVDIGLAFSIALSVLILMVAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIQRPLDFSSFPTVLLIATMIRLSLNIATTRVILSHGNEGPTAAGGVIAGFSSLVMSGDF
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCH
VIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGIIDEKEAQR
HHHHHHHHHHHHHHHHEEECCHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCHHHHHH
RRRELEEESSFFGSMDGASKFVRGDAIAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
KLSVGDGIVSQIPALIVSLAAGLLVSRGGTAGSTDQAVINQLSGYPRALMVSAMLMGLLA
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VIPGLPFVPFIFLGGIMAFGSWYIPRQAEAESALRRQEEENKVLQTTEAEKDSVKQVLKT
HHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEIELALGKQVSTRLLGAHQELAFRVGKMRKKFATQYGFVVPEIKVSDDIMIPEKAYQIR
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEECCCCCEEEE
VHGTTIASSNLRVGDVLVVTGAGRKPSIPGDEIREPAFGMPAVSILETFTEDLKREGFHP
EEEEEEECCCCEECCEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKILIDRLDPEYKKLADEICSSHMSYSGLQAVL
CCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHH
KLLLAERVSIRNLHLILEAVAELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GNKWDMVFHQALKRDQKGEIVEFDIDPRHLEEFSEQASKVIREFMDRGLPFVLVTSPETR
CCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHH
SYVRMIIERLFATLPVLSHVELAKGLEIKILGAIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]