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The map label for this gene is xseA

Identifier: 159184239

GI number: 159184239

Start: 265041

End: 266639

Strand: Direct

Name: xseA

Synonym: Atu0269

Alternate gene names: 159184239

Gene position: 265041-266639 (Clockwise)

Preceding gene: 159184238

Following gene: 15887623

Centisome position: 9.33

GC content: 63.1

Gene sequence:

>1599_bases
ATGAGCGATATCTTCTCCCACACCGCCTTGAGCAATCTTGCCGAATTTTCGGTGTCCGAACTGTCGGGTTCCATCAAACG
CACGGTGGAGACGGCTTTCGAGCAGGTGCGGGTGCGCGGCGAGATTTCCGGTTATCGTGGCCCGCATTCTTCCGGCCACG
CCTATTTCTCGCTGAAGGATGATCGTGCCCGTATCGACGCGGTGATCTGGAAGGGCACGTTTTCACGGCTGAAGTTCCGC
CCGGAAGAGGGGATGGAAGTGATCGCCACCGGCAAGATCACCACCTTCCCCGGCTCTTCGAAATACCAGATCGTCATCGA
AAGCCTGGAGCCTGCCGGTGCCGGCGCGCTGATGGCGCTTCTGGAAGATCGCCGCCGGCGGCTGGCGGCAGAGGGGCTTT
TTGATTCGGCCCGCAAGCGTCCCCTGCCATTCATGCCGCGTGTCATCGGCGTCGTCACTTCGCCCACGGGTGCGGTCATT
CGCGATATTCTTCACCGTATCTCGGATCGGTTTCCGGTCCACGTCGTCGTCTGGCCGGTCAAGGTGCAGGGCGAAGGCTC
GGGCGAGGAGGTGGCGAACGCCATTCGCGGTTTTAATGCGCTGAAGCCCGGTGGCGACATTGCCCGTCCCGACGTGCTGA
TCGTCGCGCGCGGGGGCGGCAGCCTGGAAGACCTCTGGAGCTTCAACGACGAAATCGTCGTGCGCGCGGCAGCTGAGAGC
GAAATCCCGCTGATTTCTGCCGTCGGACACGAGACCGATACGACATTGATCGATTATGCCGCTGATGTGCGCGCGCCGAC
GCCGACAGGCGCTGCCGAAATGGCGGTGCCGGTACGGGCGGAACTCGAAGCGCAGCTTTCCGGTCTCGCTGCCCGCCTTT
CCGGTTCGGTCTCGCGGCAAATGGACAATCGCCGCCAGGGCGTGCGCGCTTTGGTGCGCGCTTTGCCGTCGCTCGATCAA
CTTCTGGCCCTGCCGCGCCGCCGTTTCGATGAGGCTGCGAGTGGTCTTGGGCGTGGATTGGAATTGACGACGCTGAACAA
GCGCCGCGCTTTCGAACGTTCCGCCTCGGGACTGAGACCGGAAACCCTGCTGAACGGCCTCAAACACCATAGGCAGCGCA
TCACCGAGCGTATGCACCGGGCCGAGACCCTGGTGGAGCGCCGTCTGTTGCAGGGCAAAGGCCGGGTTGATTCATTCGAT
TCCGCGCTGCGTTCGCTTCCTGCCCGCCTGCTTGGCCAGCTGGAACGGCAGAAGGAACGGGTCGTCACCGCAGCACGCCG
GGCCGATACAGCGGTGCTGCACCGCATGGCGCAGAACCGTTCCGGTCTCGCCGCTCATGATCGTATCCTGCAATCTCTGT
CCTACAAGAACGTGCTGAATCGCGGTTATGCCGTGATCCGTGACGAAGAGAACCGGCCGCTGACCCGTGCCGCCGCCATT
GCCTCAGGCGCTGCGGTCTCGATGGAATTTGCCGATGGTCGCGTTTCTGCCATCACGACGGGAGAGGGGACACCCGCCCC
GGAGACCGCCGCCGCGCCAAAAAAGAAGCCGGCGAAACCGGCTTCTTCTGACCCGGGTAATCAGGGCAACCTGTTCTGA

Upstream 100 bases:

>100_bases
TTTTGCTAACTCGTTAGTTGAGGATATGGTTTCATCGACGTTAAAATCGGTGAGCCGATGTCGGCATTTCCGAATCGACG
GCTTTTGGTTACAAACGGTC

Downstream 100 bases:

>100_bases
TCAGATCGACGCCGCATCCGAAAAACGGCGGCTGACGGTGAAGGTCTTTTCGATATCTGGATGCAGCTCCATGCCGAGGC
CAGCACCCGGCGGCACGGTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSDIFSHTALSNLAEFSVSELSGSIKRTVETAFEQVRVRGEISGYRGPHSSGHAYFSLKDDRARIDAVIWKGTFSRLKFR
PEEGMEVIATGKITTFPGSSKYQIVIESLEPAGAGALMALLEDRRRRLAAEGLFDSARKRPLPFMPRVIGVVTSPTGAVI
RDILHRISDRFPVHVVVWPVKVQGEGSGEEVANAIRGFNALKPGGDIARPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
EIPLISAVGHETDTTLIDYAADVRAPTPTGAAEMAVPVRAELEAQLSGLAARLSGSVSRQMDNRRQGVRALVRALPSLDQ
LLALPRRRFDEAASGLGRGLELTTLNKRRAFERSASGLRPETLLNGLKHHRQRITERMHRAETLVERRLLQGKGRVDSFD
SALRSLPARLLGQLERQKERVVTAARRADTAVLHRMAQNRSGLAAHDRILQSLSYKNVLNRGYAVIRDEENRPLTRAAAI
ASGAAVSMEFADGRVSAITTGEGTPAPETAAAPKKKPAKPASSDPGNQGNLF

Sequences:

>Translated_532_residues
MSDIFSHTALSNLAEFSVSELSGSIKRTVETAFEQVRVRGEISGYRGPHSSGHAYFSLKDDRARIDAVIWKGTFSRLKFR
PEEGMEVIATGKITTFPGSSKYQIVIESLEPAGAGALMALLEDRRRRLAAEGLFDSARKRPLPFMPRVIGVVTSPTGAVI
RDILHRISDRFPVHVVVWPVKVQGEGSGEEVANAIRGFNALKPGGDIARPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
EIPLISAVGHETDTTLIDYAADVRAPTPTGAAEMAVPVRAELEAQLSGLAARLSGSVSRQMDNRRQGVRALVRALPSLDQ
LLALPRRRFDEAASGLGRGLELTTLNKRRAFERSASGLRPETLLNGLKHHRQRITERMHRAETLVERRLLQGKGRVDSFD
SALRSLPARLLGQLERQKERVVTAARRADTAVLHRMAQNRSGLAAHDRILQSLSYKNVLNRGYAVIRDEENRPLTRAAAI
ASGAAVSMEFADGRVSAITTGEGTPAPETAAAPKKKPAKPASSDPGNQGNLF
>Mature_531_residues
SDIFSHTALSNLAEFSVSELSGSIKRTVETAFEQVRVRGEISGYRGPHSSGHAYFSLKDDRARIDAVIWKGTFSRLKFRP
EEGMEVIATGKITTFPGSSKYQIVIESLEPAGAGALMALLEDRRRRLAAEGLFDSARKRPLPFMPRVIGVVTSPTGAVIR
DILHRISDRFPVHVVVWPVKVQGEGSGEEVANAIRGFNALKPGGDIARPDVLIVARGGGSLEDLWSFNDEIVVRAAAESE
IPLISAVGHETDTTLIDYAADVRAPTPTGAAEMAVPVRAELEAQLSGLAARLSGSVSRQMDNRRQGVRALVRALPSLDQL
LALPRRRFDEAASGLGRGLELTTLNKRRAFERSASGLRPETLLNGLKHHRQRITERMHRAETLVERRLLQGKGRVDSFDS
ALRSLPARLLGQLERQKERVVTAARRADTAVLHRMAQNRSGLAAHDRILQSLSYKNVLNRGYAVIRDEENRPLTRAAAIA
SGAAVSMEFADGRVSAITTGEGTPAPETAAAPKKKPAKPASSDPGNQGNLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=487, Percent_Identity=34.2915811088296, Blast_Score=244, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_AGRT5 (Q8UIM4)

Other databases:

- EMBL:   AE007869
- PIR:   AE2609
- PIR:   D97391
- RefSeq:   NP_353300.2
- STRING:   Q8UIM4
- GeneID:   1132307
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0269
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   LVWPVKV
- PhylomeDB:   Q8UIM4
- ProtClustDB:   PRK00286
- BioCyc:   ATUM176299-1:ATU0269-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 57792; Mature: 57660

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIFSHTALSNLAEFSVSELSGSIKRTVETAFEQVRVRGEISGYRGPHSSGHAYFSLKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECC
DRARIDAVIWKGTFSRLKFRPEEGMEVIATGKITTFPGSSKYQIVIESLEPAGAGALMAL
CCHHHHHEEECCHHHHHEECCCCCCEEEEECEEEECCCCCCEEEEEECCCCCCHHHHHHH
LEDRRRRLAAEGLFDSARKRPLPFMPRVIGVVTSPTGAVIRDILHRISDRFPVHVVVWPV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEE
KVQGEGSGEEVANAIRGFNALKPGGDIARPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
EEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCEEEEECCCC
EIPLISAVGHETDTTLIDYAADVRAPTPTGAAEMAVPVRAELEAQLSGLAARLSGSVSRQ
CCCEEEECCCCCCCHHHHHHHHCCCCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHHHH
MDNRRQGVRALVRALPSLDQLLALPRRRFDEAASGLGRGLELTTLNKRRAFERSASGLRP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCH
ETLLNGLKHHRQRITERMHRAETLVERRLLQGKGRVDSFDSALRSLPARLLGQLERQKER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVTAARRADTAVLHRMAQNRSGLAAHDRILQSLSYKNVLNRGYAVIRDEENRPLTRAAAI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
ASGAAVSMEFADGRVSAITTGEGTPAPETAAAPKKKPAKPASSDPGNQGNLF
HCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDIFSHTALSNLAEFSVSELSGSIKRTVETAFEQVRVRGEISGYRGPHSSGHAYFSLKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECC
DRARIDAVIWKGTFSRLKFRPEEGMEVIATGKITTFPGSSKYQIVIESLEPAGAGALMAL
CCHHHHHEEECCHHHHHEECCCCCCEEEEECEEEECCCCCCEEEEEECCCCCCHHHHHHH
LEDRRRRLAAEGLFDSARKRPLPFMPRVIGVVTSPTGAVIRDILHRISDRFPVHVVVWPV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEE
KVQGEGSGEEVANAIRGFNALKPGGDIARPDVLIVARGGGSLEDLWSFNDEIVVRAAAES
EEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCEEEEECCCC
EIPLISAVGHETDTTLIDYAADVRAPTPTGAAEMAVPVRAELEAQLSGLAARLSGSVSRQ
CCCEEEECCCCCCCHHHHHHHHCCCCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHHHH
MDNRRQGVRALVRALPSLDQLLALPRRRFDEAASGLGRGLELTTLNKRRAFERSASGLRP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCH
ETLLNGLKHHRQRITERMHRAETLVERRLLQGKGRVDSFDSALRSLPARLLGQLERQKER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVTAARRADTAVLHRMAQNRSGLAAHDRILQSLSYKNVLNRGYAVIRDEENRPLTRAAAI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
ASGAAVSMEFADGRVSAITTGEGTPAPETAAAPKKKPAKPASSDPGNQGNLF
HCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194