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The map label for this gene is hisE

Identifier: 159184135

GI number: 159184135

Start: 40779

End: 41102

Strand: Reverse

Name: hisE

Synonym: Atu0038

Alternate gene names: 159184135

Gene position: 41102-40779 (Counterclockwise)

Preceding gene: 15887397

Following gene: 159184134

Centisome position: 1.45

GC content: 59.88

Gene sequence:

>324_bases
ATGAGCGCATTTTCCCTTTCCGATCTGGAACGCATCGTCGCGAAGCGTGCCGCTGCATCCCCTGATGAATCCTGGACGGC
CAAGCTGGTTGCTGCCGGCCAGGAGCGCGCAGCAAAGAAGCTGGGCGAAGAAGCGGTTGAAGCCGTCATCGCTGCCATCG
CACAGGATCGCGACGGGCTTAAAAACGAAGCAGCCGACCTGCTTTACCATCTGCTGGTGGTGCTGAAGATCGCCGACATT
CCCTTGAGCGATGTTTTTGCCGAACTGGAGCGTCGCACAGGTCAGACCGGCCTTGCGGAAAAGGCGGCGAGGCCGACACC
ATGA

Upstream 100 bases:

>100_bases
TTCCATCTTCCACTTCGGCACCTATTCGATCGGTGAAGCCAAGAGCTACATGGCCGAACATGGCATTGCCATGCGTCTCG
ACTGATTGCAGGAACATCCC

Downstream 100 bases:

>100_bases
AGATTGAGGCGGGCAGCGGGGAGAGAGGCATGCCAGGCACACTCGATCATTTTCGTGCGGACGAATATTCGCCCTATCAC
TTCTTCAGTTCCGAAGAATG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSAFSLSDLERIVAKRAAASPDESWTAKLVAAGQERAAKKLGEEAVEAVIAAIAQDRDGLKNEAADLLYHLLVVLKIADI
PLSDVFAELERRTGQTGLAEKAARPTP

Sequences:

>Translated_107_residues
MSAFSLSDLERIVAKRAAASPDESWTAKLVAAGQERAAKKLGEEAVEAVIAAIAQDRDGLKNEAADLLYHLLVVLKIADI
PLSDVFAELERRTGQTGLAEKAARPTP
>Mature_106_residues
SAFSLSDLERIVAKRAAASPDESWTAKLVAAGQERAAKKLGEEAVEAVIAAIAQDRDGLKNEAADLLYHLLVVLKIADIP
LSDVFAELERRTGQTGLAEKAARPTP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=87, Percent_Identity=48.2758620689655, Blast_Score=86, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_AGRT5 (Q8UJ91)

Other databases:

- EMBL:   AE007869
- PIR:   AG2581
- PIR:   E97363
- RefSeq:   NP_353077.2
- ProteinModelPortal:   Q8UJ91
- SMR:   Q8UJ91
- STRING:   Q8UJ91
- GeneID:   1132076
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0038
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   ATUM176299-1:ATU0038-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11411; Mature: 11280

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFSLSDLERIVAKRAAASPDESWTAKLVAAGQERAAKKLGEEAVEAVIAAIAQDRDGL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KNEAADLLYHLLVVLKIADIPLSDVFAELERRTGQTGLAEKAARPTP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure 
SAFSLSDLERIVAKRAAASPDESWTAKLVAAGQERAAKKLGEEAVEAVIAAIAQDRDGL
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KNEAADLLYHLLVVLKIADIPLSDVFAELERRTGQTGLAEKAARPTP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194