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The map label for this gene is virB11 [H]

Identifier: 159046522

GI number: 159046522

Start: 41929

End: 42915

Strand: Direct

Name: virB11 [H]

Synonym: Dshi_3983

Alternate gene names: 159046522

Gene position: 41929-42915 (Clockwise)

Preceding gene: 159046521

Following gene: 159046523

Centisome position: 33.2

GC content: 61.5

Gene sequence:

>987_bases
ATGTCGCTGAGCTATCTCGAAACCTCCCTCGACCGGATCGAAGCCGCCGCCCGCGACGATGTCATCGAGATCTGCATCAA
CCCCGACGGGACCTGCTGGGGCGAATTCCAGGGCGATCACTTCATGCGCGCGCTGGATCAAAGGCTGACGGGCGTTCAGG
TCAGGGACCTCGGCAACCAGATCGCCTCCTCGGCCAATACCACGATGAGCAAGGACCGCCCCATCGTCTCGGTATCGATC
ACCTACAAGGGTCGCCCGATCCGGGCACAGGTCATCACCCCGCCCGCCGTGCTCTCGGCCATGTCGATCAGCTTGCGGTT
CTTCTCGAGCCTGCCGCTCGAGGGCATTGCGCTCGACTTTCTCTTTGGCAAAGAGCGCAAGCTCGAAGACCTGCGCGTCG
AAAAAAAGCGCGCCTTGCGCGCCGTGGTGGCCGCGGGTTTGATCGATGATGCGCTGGCCTTCTGCGTCGAGAACAAACTC
AACATGATCGTCTCGGGTGGCACCTCCACCGGCAAGACCGTCGCCGCGCGCAAGATCCTCTCTCACGTACCGGCCGAGGA
ACGCATCGTCACCATCGAAGAAGCGGCCGAGCTGCTGCCGACCCAGCCAAATGCAGTGACCCTCATCGCCAATCGCGACG
CGGAATTCCAGACCGCCGATGTGCTTCTCACCGCCACGCTGCGCATGCGCCCCGACCGGATCATCCTGGGCGAAGTGCGC
GGCAAGGAGGCCATGACCTTTCTGGAAGCCATCAACACCGGCCACGGCGGGTCCATGACCACGCTGCATGCCGAAACACC
GCAACTGGCCGTGCAGCGGCTTGCGATCGCAGCACTGAAAACCGAGATCCCGATGACCTATGCCGACATGATCCAGTACA
TCGAAAATTCCATCGATGTGATCATCCAGGCCGGTCGCCATGACGGAAAACGCGGCATCACGGAATTCTACCTCCCCGGA
GCAACTGAGATTGGAATTTCCCCATGA

Upstream 100 bases:

>100_bases
GTCATCGGCGATTACCTCTCCATCGGCCCCGTCATCTATGTCGACCAAGGCGCGCGCGTCACTGTCATGGTCGACCGCGA
TCTGGAGATATTCTGAGCCC

Downstream 100 bases:

>100_bases
AGACCTTTGAATACAATATCCTGTCTTTTCCCATGACCCGCAAAACCAGCCTTGCCGACATGCAGGCCAGCCTGAACGAG
AAGGGCGCAGACGGGTGGGA

Product: type II secretion system protein E

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSLSYLETSLDRIEAAARDDVIEICINPDGTCWGEFQGDHFMRALDQRLTGVQVRDLGNQIASSANTTMSKDRPIVSVSI
TYKGRPIRAQVITPPAVLSAMSISLRFFSSLPLEGIALDFLFGKERKLEDLRVEKKRALRAVVAAGLIDDALAFCVENKL
NMIVSGGTSTGKTVAARKILSHVPAEERIVTIEEAAELLPTQPNAVTLIANRDAEFQTADVLLTATLRMRPDRIILGEVR
GKEAMTFLEAINTGHGGSMTTLHAETPQLAVQRLAIAALKTEIPMTYADMIQYIENSIDVIIQAGRHDGKRGITEFYLPG
ATEIGISP

Sequences:

>Translated_328_residues
MSLSYLETSLDRIEAAARDDVIEICINPDGTCWGEFQGDHFMRALDQRLTGVQVRDLGNQIASSANTTMSKDRPIVSVSI
TYKGRPIRAQVITPPAVLSAMSISLRFFSSLPLEGIALDFLFGKERKLEDLRVEKKRALRAVVAAGLIDDALAFCVENKL
NMIVSGGTSTGKTVAARKILSHVPAEERIVTIEEAAELLPTQPNAVTLIANRDAEFQTADVLLTATLRMRPDRIILGEVR
GKEAMTFLEAINTGHGGSMTTLHAETPQLAVQRLAIAALKTEIPMTYADMIQYIENSIDVIIQAGRHDGKRGITEFYLPG
ATEIGISP
>Mature_327_residues
SLSYLETSLDRIEAAARDDVIEICINPDGTCWGEFQGDHFMRALDQRLTGVQVRDLGNQIASSANTTMSKDRPIVSVSIT
YKGRPIRAQVITPPAVLSAMSISLRFFSSLPLEGIALDFLFGKERKLEDLRVEKKRALRAVVAAGLIDDALAFCVENKLN
MIVSGGTSTGKTVAARKILSHVPAEERIVTIEEAAELLPTQPNAVTLIANRDAEFQTADVLLTATLRMRPDRIILGEVRG
KEAMTFLEAINTGHGGSMTTLHAETPQLAVQRLAIAALKTEIPMTYADMIQYIENSIDVIIQAGRHDGKRGITEFYLPGA
TEIGISP

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 35762; Mature: 35631

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSYLETSLDRIEAAARDDVIEICINPDGTCWGEFQGDHFMRALDQRLTGVQVRDLGNQ
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHH
IASSANTTMSKDRPIVSVSITYKGRPIRAQVITPPAVLSAMSISLRFFSSLPLEGIALDF
HHHCCCCCCCCCCCEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEE
LFGKERKLEDLRVEKKRALRAVVAAGLIDDALAFCVENKLNMIVSGGTSTGKTVAARKIL
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
SHVPAEERIVTIEEAAELLPTQPNAVTLIANRDAEFQTADVLLTATLRMRPDRIILGEVR
HHCCCCCEEEEHHHHHHHCCCCCCEEEEEECCCCCCCHHHEEEEEEEEECCCEEEEEECC
GKEAMTFLEAINTGHGGSMTTLHAETPQLAVQRLAIAALKTEIPMTYADMIQYIENSIDV
CHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEE
IIQAGRHDGKRGITEFYLPGATEIGISP
EEECCCCCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
SLSYLETSLDRIEAAARDDVIEICINPDGTCWGEFQGDHFMRALDQRLTGVQVRDLGNQ
CCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHH
IASSANTTMSKDRPIVSVSITYKGRPIRAQVITPPAVLSAMSISLRFFSSLPLEGIALDF
HHHCCCCCCCCCCCEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEE
LFGKERKLEDLRVEKKRALRAVVAAGLIDDALAFCVENKLNMIVSGGTSTGKTVAARKIL
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
SHVPAEERIVTIEEAAELLPTQPNAVTLIANRDAEFQTADVLLTATLRMRPDRIILGEVR
HHCCCCCEEEEHHHHHHHCCCCCCEEEEEECCCCCCCHHHEEEEEEEEECCCEEEEEECC
GKEAMTFLEAINTGHGGSMTTLHAETPQLAVQRLAIAALKTEIPMTYADMIQYIENSIDV
CHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEE
IIQAGRHDGKRGITEFYLPGATEIGISP
EEECCCCCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]