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The map label for this gene is rio1 [H]

Identifier: 15899130

GI number: 15899130

Start: 2165372

End: 2166136

Strand: Reverse

Name: rio1 [H]

Synonym: SSO2374

Alternate gene names: 15899130

Gene position: 2166136-2165372 (Counterclockwise)

Preceding gene: 15899131

Following gene: 15899129

Centisome position: 72.39

GC content: 32.55

Gene sequence:

>765_bases
TTGACAGAATTACCGAAGAAAACTAAAGATGAAAAAAGACGCAAAGATGAAGATCTTTTTAAAGTAGTAGATTCTACAAT
AGATTATAGGACATATCTAAATTTGATTCAAATAGCTAGACGATTAAACATTAAGGAGTATTTAGGTGCAATATCGTCTG
GGAAAGAAGCTAGGATATATCCTGCTAGGACTTTTGATGATACGTATTATGCAGTAAAGATATACTATACATCTACAGCT
CAAAGTAAAAGAGCTATTAAGAAGTATACTATTGGTGATATAAGGTTCGAAGACATAAAAGTAACTAACACTAAACAACT
TATTAATACTTGGGCAAAAAAGGAATTCAAAAATCTTAGTAGACTATATGAGGCTGGAACCAGAGTACCAAAACCTATTC
TGGTTTTCGAGAACGTTCTCGTGATGGAATTTATTGGGGAAAATGGTATAAGAGCTCCCCTTTTGAAGGAGCTAAGTGAC
GAGGAGATTACACAAGGATTGTATGAGGACTTAATTCAACAAGTGGAAATTATGGTAAAAGGAGCTAAATTGATTCACGG
AGACTTAAGTGAATATAACGTAATAGTTTATGATAATAAATGTTATATAATCGATGTAGGTCAAGCAGTTCCAATAGATT
ACGAAGATGCAATCACATTACTGAAAAGGGACCTAGATAACATAAATAGATTTTTTGAGAATAAAGGAATAAATATAAGG
CCTACAGAAGAGTTATTGATAAAATACGGAGTTACTGGGGATTGA

Upstream 100 bases:

>100_bases
GTTGTGATATATTGTATAAGTATGGAAACGATGAAATAAAAAGACTTGTAAACGAGAATATCATAAGTAGAGAAGTAATT
GACCAGTTAAGAGGATAAAT

Downstream 100 bases:

>100_bases
TAATCTTGTTCATCACGGTAGAAGATGAAAAATTAGAAGTAGTTAAAAAAGTGATTGGGAAACTAGAACAATTTACTGAT
ACTAAAATTATATATGATGA

Product: hypothetical protein

Products: NA

Alternate protein names: AfRio1 [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTELPKKTKDEKRRKDEDLFKVVDSTIDYRTYLNLIQIARRLNIKEYLGAISSGKEARIYPARTFDDTYYAVKIYYTSTA
QSKRAIKKYTIGDIRFEDIKVTNTKQLINTWAKKEFKNLSRLYEAGTRVPKPILVFENVLVMEFIGENGIRAPLLKELSD
EEITQGLYEDLIQQVEIMVKGAKLIHGDLSEYNVIVYDNKCYIIDVGQAVPIDYEDAITLLKRDLDNINRFFENKGINIR
PTEELLIKYGVTGD

Sequences:

>Translated_254_residues
MTELPKKTKDEKRRKDEDLFKVVDSTIDYRTYLNLIQIARRLNIKEYLGAISSGKEARIYPARTFDDTYYAVKIYYTSTA
QSKRAIKKYTIGDIRFEDIKVTNTKQLINTWAKKEFKNLSRLYEAGTRVPKPILVFENVLVMEFIGENGIRAPLLKELSD
EEITQGLYEDLIQQVEIMVKGAKLIHGDLSEYNVIVYDNKCYIIDVGQAVPIDYEDAITLLKRDLDNINRFFENKGINIR
PTEELLIKYGVTGD
>Mature_253_residues
TELPKKTKDEKRRKDEDLFKVVDSTIDYRTYLNLIQIARRLNIKEYLGAISSGKEARIYPARTFDDTYYAVKIYYTSTAQ
SKRAIKKYTIGDIRFEDIKVTNTKQLINTWAKKEFKNLSRLYEAGTRVPKPILVFENVLVMEFIGENGIRAPLLKELSDE
EITQGLYEDLIQQVEIMVKGAKLIHGDLSEYNVIVYDNKCYIIDVGQAVPIDYEDAITLLKRDLDNINRFFENKGINIRP
TEELLIKYGVTGD

Specific function: Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis [H]

COG id: COG1718

COG function: function code TD; Serine/threonine protein kinase involved in cell cycle control

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI23510356, Length=250, Percent_Identity=36.4, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI22325377, Length=230, Percent_Identity=31.304347826087, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI23510358, Length=141, Percent_Identity=39.7163120567376, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI115532073, Length=230, Percent_Identity=38.2608695652174, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17556977, Length=241, Percent_Identity=34.0248962655602, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71989043, Length=155, Percent_Identity=40, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324693, Length=270, Percent_Identity=34.4444444444444, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324122, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24662811, Length=242, Percent_Identity=35.1239669421488, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21356879, Length=242, Percent_Identity=35.1239669421488, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI19920700, Length=252, Percent_Identity=34.5238095238095, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24649986, Length=235, Percent_Identity=24.6808510638298, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 29471; Mature: 29340

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00109 PROTEIN_KINASE_TYR ; PS50011 PROTEIN_KINASE_DOM ; PS01245 RIO1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELPKKTKDEKRRKDEDLFKVVDSTIDYRTYLNLIQIARRLNIKEYLGAISSGKEARIY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
PARTFDDTYYAVKIYYTSTAQSKRAIKKYTIGDIRFEDIKVTNTKQLINTWAKKEFKNLS
ECCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
RLYEAGTRVPKPILVFENVLVMEFIGENGIRAPLLKELSDEEITQGLYEDLIQQVEIMVK
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
GAKLIHGDLSEYNVIVYDNKCYIIDVGQAVPIDYEDAITLLKRDLDNINRFFENKGINIR
HHHHEECCCCCCEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PTEELLIKYGVTGD
CHHHHHEECCCCCC
>Mature Secondary Structure 
TELPKKTKDEKRRKDEDLFKVVDSTIDYRTYLNLIQIARRLNIKEYLGAISSGKEARIY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
PARTFDDTYYAVKIYYTSTAQSKRAIKKYTIGDIRFEDIKVTNTKQLINTWAKKEFKNLS
ECCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
RLYEAGTRVPKPILVFENVLVMEFIGENGIRAPLLKELSDEEITQGLYEDLIQQVEIMVK
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
GAKLIHGDLSEYNVIVYDNKCYIIDVGQAVPIDYEDAITLLKRDLDNINRFFENKGINIR
HHHHEECCCCCCEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PTEELLIKYGVTGD
CHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]