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The map label for this gene is acsA-8 [C]

Identifier: 15898991

GI number: 15898991

Start: 2038638

End: 2040353

Strand: Reverse

Name: acsA-8 [C]

Synonym: SSO2216

Alternate gene names: 15898991

Gene position: 2040353-2038638 (Counterclockwise)

Preceding gene: 15898992

Following gene: 15898990

Centisome position: 68.19

GC content: 35.02

Gene sequence:

>1716_bases
ATGGACTACTACACACTTTACGACCTTTCCTTAGAAAAACCAGAAACCTACTGGGAAACGTTTGCTAATAGGTTATCATT
CTTTAAGAAATGGGAAAAAGTCATAGAAAAAAATAAACAATTACCCATAGCTAAATGGTTCATTAACGGTACTACAAATA
TTGCATATAACGCCCTTAATCACGGTGGTAAGGCCCTTATATTTTACCAAGAGAATAAACATAAAGGAGATGAAATTACA
TTCGATGAGTTAAATAATATGAGTTCAATGATTGCTGGATTATTACTAGATAAAGGGGTAAGAAGAGGAGATAGAATTGC
GATTTATATGCCTAACTCAATATGTACGATAGCTACGATACTAGCTGCGGCTAGACTAGGAGCAATTTATACGCTCATTT
TTGCAGGATTAGGAATAAATGCTATAGTAAGTAGGATTTCAAATCTGGAACCTAAATTAGTAATCTCCATAGATAAGACA
TTCAGAAGGGGAAAGGAAATAAAACTATATACTAACTTAGCCAATATAGTATTTCCGAGGGACTCCTCGCAATTTGACTA
TACAAGAGAATATAAAGAATTTGAGAAAATAGAAAGTAATGAACCATTGAAAATAATGTATACTTCTGGAACAACGGGTA
AACCTAAAGGTGTAATCTTACCACATGGAGCTTGGATGGTAGGAGATTATACAGTATTTGACTTAATGTTTTCATTAAAG
AGTGACGATATAGTTCTAACAACTGCAGATGTGGGATGGATAACGTTCTCAAGAATAATGTATGGAACTCTAATGCATGG
CTCCACGTTGGCATTTATGGAAGGAGCGCCAGACTATCCATCGGATAGATTGCCAAAAATTATTGACGAGTTACAGCCTA
AAGTATTATTTACATCCCCTACACTCCTTAGAACTTTACAAAAGTTAGATGTGAAACTTCCAAGAGTGGAGTTTATAGCC
ACAGCAGGAGAGATAATGGATGAAACTGCATGGAAATACGCATTAAGGTTTTCTGATAGAGTTGCAGATGTATATGGGCA
AACTGAGTTAGGTTATGTAATAGGCTATCCTTATGCGTTAGATGGTGTAGAACCAAAAATAGGATATGCTGGATTGCCAT
TTCCAGCTGCAGTTATAGACACAGTAGACGAAAATGGGAAAAGTTTAAGAGGACATATTGGTCATCTAGTCGCAAGAGAA
CCATTTCCTACCCAATTTATTGGAATTTGGAAAGATGAAGACAAATTTTTAAGCTATTTTGAAAAATTCAACAGCCACGA
TACTGGGGATCTAGCCATAATTGATGAGAAAGGTTATGTTAAAATAGTTGGTAGAGATGACGATATGATAAAGATAGCTG
GACATAGAATAACTAGTGGAGAAGTAGAAAGTGTAATAAATTCCTTGCAAGGAATAATTGAATCAGCTGCTGTAGGAATA
CCGGATGAGATAAAGGGTGAAAAATTAGTAGTATTTTATGTGGGAAACGTAGACGAAAGAATAGTAGCAACAAAGGTTAG
GGAAATGTTGGGGCCTATATATGTCATTGACAAAATATATAAGGTTGAAAGACTACCGAAGTCTCGAAGTGGTAAAATAG
TTAGAAGAGTTTTGAGAGATTTATTATTGGGAAAAGAAATAGATGAAACTATATTGGAAGACCCAGAAATATTAAAGGAG
ATCAAAAATGAGATTAAGAGATCCGAGAGAATTTAG

Upstream 100 bases:

>100_bases
ATATTGTGGTGGAAAAGTAGTAAAGAGAAGAATAATGGAGTGATTGCAATGCTTCTTCTAATCATAAAAACAAATTAAAA
AGTTATAAGAAGTAAAAGAT

Downstream 100 bases:

>100_bases
GGAAAACGTACCCGTTACCAGAAAATACGTATATTTAAATCATGCATCAGTGTCACCCACACCTTTACCGTCGTTATTTG
AGGCTTACAGATATTTATAT

Product: Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8)

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA synthetase [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MDYYTLYDLSLEKPETYWETFANRLSFFKKWEKVIEKNKQLPIAKWFINGTTNIAYNALNHGGKALIFYQENKHKGDEIT
FDELNNMSSMIAGLLLDKGVRRGDRIAIYMPNSICTIATILAAARLGAIYTLIFAGLGINAIVSRISNLEPKLVISIDKT
FRRGKEIKLYTNLANIVFPRDSSQFDYTREYKEFEKIESNEPLKIMYTSGTTGKPKGVILPHGAWMVGDYTVFDLMFSLK
SDDIVLTTADVGWITFSRIMYGTLMHGSTLAFMEGAPDYPSDRLPKIIDELQPKVLFTSPTLLRTLQKLDVKLPRVEFIA
TAGEIMDETAWKYALRFSDRVADVYGQTELGYVIGYPYALDGVEPKIGYAGLPFPAAVIDTVDENGKSLRGHIGHLVARE
PFPTQFIGIWKDEDKFLSYFEKFNSHDTGDLAIIDEKGYVKIVGRDDDMIKIAGHRITSGEVESVINSLQGIIESAAVGI
PDEIKGEKLVVFYVGNVDERIVATKVREMLGPIYVIDKIYKVERLPKSRSGKIVRRVLRDLLLGKEIDETILEDPEILKE
IKNEIKRSERI

Sequences:

>Translated_571_residues
MDYYTLYDLSLEKPETYWETFANRLSFFKKWEKVIEKNKQLPIAKWFINGTTNIAYNALNHGGKALIFYQENKHKGDEIT
FDELNNMSSMIAGLLLDKGVRRGDRIAIYMPNSICTIATILAAARLGAIYTLIFAGLGINAIVSRISNLEPKLVISIDKT
FRRGKEIKLYTNLANIVFPRDSSQFDYTREYKEFEKIESNEPLKIMYTSGTTGKPKGVILPHGAWMVGDYTVFDLMFSLK
SDDIVLTTADVGWITFSRIMYGTLMHGSTLAFMEGAPDYPSDRLPKIIDELQPKVLFTSPTLLRTLQKLDVKLPRVEFIA
TAGEIMDETAWKYALRFSDRVADVYGQTELGYVIGYPYALDGVEPKIGYAGLPFPAAVIDTVDENGKSLRGHIGHLVARE
PFPTQFIGIWKDEDKFLSYFEKFNSHDTGDLAIIDEKGYVKIVGRDDDMIKIAGHRITSGEVESVINSLQGIIESAAVGI
PDEIKGEKLVVFYVGNVDERIVATKVREMLGPIYVIDKIYKVERLPKSRSGKIVRRVLRDLLLGKEIDETILEDPEILKE
IKNEIKRSERI
>Mature_571_residues
MDYYTLYDLSLEKPETYWETFANRLSFFKKWEKVIEKNKQLPIAKWFINGTTNIAYNALNHGGKALIFYQENKHKGDEIT
FDELNNMSSMIAGLLLDKGVRRGDRIAIYMPNSICTIATILAAARLGAIYTLIFAGLGINAIVSRISNLEPKLVISIDKT
FRRGKEIKLYTNLANIVFPRDSSQFDYTREYKEFEKIESNEPLKIMYTSGTTGKPKGVILPHGAWMVGDYTVFDLMFSLK
SDDIVLTTADVGWITFSRIMYGTLMHGSTLAFMEGAPDYPSDRLPKIIDELQPKVLFTSPTLLRTLQKLDVKLPRVEFIA
TAGEIMDETAWKYALRFSDRVADVYGQTELGYVIGYPYALDGVEPKIGYAGLPFPAAVIDTVDENGKSLRGHIGHLVARE
PFPTQFIGIWKDEDKFLSYFEKFNSHDTGDLAIIDEKGYVKIVGRDDDMIKIAGHRITSGEVESVINSLQGIIESAAVGI
PDEIKGEKLVVFYVGNVDERIVATKVREMLGPIYVIDKIYKVERLPKSRSGKIVRRVLRDLLLGKEIDETILEDPEILKE
IKNEIKRSERI

Specific function: Plays a role in the autotrophic CO(2) fixation pathway. Activates 3-hydroxypropionate to its CoA ester. Can also activate propionate, and to a lesser extent acrylate, acetate and butyrate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI13375727, Length=629, Percent_Identity=31.3195548489666, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI28416953, Length=622, Percent_Identity=30.5466237942122, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI8923896, Length=653, Percent_Identity=28.6370597243492, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI253970489, Length=397, Percent_Identity=35.0125944584383, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI31982927, Length=619, Percent_Identity=25.5250403877221, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI42544132, Length=521, Percent_Identity=25.9117082533589, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI122937307, Length=498, Percent_Identity=27.3092369477912, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI115511026, Length=504, Percent_Identity=24.6031746031746, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI38505220, Length=546, Percent_Identity=25.2747252747253, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI157311624, Length=552, Percent_Identity=25.5434782608696, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI157311622, Length=552, Percent_Identity=25.5434782608696, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI58082049, Length=546, Percent_Identity=25.4578754578755, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI42544134, Length=342, Percent_Identity=23.0994152046784, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790505, Length=624, Percent_Identity=31.4102564102564, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1786529, Length=629, Percent_Identity=29.7297297297297, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI145693145, Length=524, Percent_Identity=23.2824427480916, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788107, Length=531, Percent_Identity=26.1770244821092, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI221142682, Length=505, Percent_Identity=22.7722772277228, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786810, Length=495, Percent_Identity=22.8282828282828, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1789201, Length=437, Percent_Identity=22.4256292906178, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983001, Length=636, Percent_Identity=30.9748427672956, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI71982997, Length=636, Percent_Identity=30.6603773584906, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17569507, Length=623, Percent_Identity=20.8667736757624, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71996755, Length=510, Percent_Identity=22.7450980392157, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=483, Percent_Identity=25.0517598343685, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=487, Percent_Identity=23.8193018480493, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=382, Percent_Identity=25.9162303664921, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=532, Percent_Identity=22.9323308270677, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=232, Percent_Identity=30.1724137931034, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=260, Percent_Identity=27.3076923076923, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560140, Length=498, Percent_Identity=21.4859437751004, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319264, Length=647, Percent_Identity=30.4482225656878, Blast_Score=267, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6323182, Length=640, Percent_Identity=30.46875, Blast_Score=253, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6319699, Length=349, Percent_Identity=23.2091690544413, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667955, Length=644, Percent_Identity=31.2111801242236, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=31.8505338078292, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21355225, Length=634, Percent_Identity=28.7066246056782, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24667959, Length=509, Percent_Identity=31.8271119842829, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24648260, Length=510, Percent_Identity=22.9411764705882, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581924, Length=528, Percent_Identity=23.1060606060606, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18859661, Length=513, Percent_Identity=24.7563352826511, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922652, Length=517, Percent_Identity=22.2437137330754, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356947, Length=503, Percent_Identity=21.4711729622266, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24656500, Length=506, Percent_Identity=21.9367588932806, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356441, Length=364, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.36 [H]

Molecular weight: Translated: 64643; Mature: 64643

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYYTLYDLSLEKPETYWETFANRLSFFKKWEKVIEKNKQLPIAKWFINGTTNIAYNALN
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCC
HGGKALIFYQENKHKGDEITFDELNNMSSMIAGLLLDKGVRRGDRIAIYMPNSICTIATI
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
LAAARLGAIYTLIFAGLGINAIVSRISNLEPKLVISIDKTFRRGKEIKLYTNLANIVFPR
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHCCCEEEEEEEHHHEEECC
DSSQFDYTREYKEFEKIESNEPLKIMYTSGTTGKPKGVILPHGAWMVGDYTVFDLMFSLK
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCEEECCHHHHHHHHHCC
SDDIVLTTADVGWITFSRIMYGTLMHGSTLAFMEGAPDYPSDRLPKIIDELQPKVLFTSP
CCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEECCC
TLLRTLQKLDVKLPRVEFIATAGEIMDETAWKYALRFSDRVADVYGQTELGYVIGYPYAL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEE
DGVEPKIGYAGLPFPAAVIDTVDENGKSLRGHIGHLVAREPFPTQFIGIWKDEDKFLSYF
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHH
EKFNSHDTGDLAIIDEKGYVKIVGRDDDMIKIAGHRITSGEVESVINSLQGIIESAAVGI
HHHCCCCCCCEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
PDEIKGEKLVVFYVGNVDERIVATKVREMLGPIYVIDKIYKVERLPKSRSGKIVRRVLRD
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LLLGKEIDETILEDPEILKEIKNEIKRSERI
HHCCCHHHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYYTLYDLSLEKPETYWETFANRLSFFKKWEKVIEKNKQLPIAKWFINGTTNIAYNALN
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCC
HGGKALIFYQENKHKGDEITFDELNNMSSMIAGLLLDKGVRRGDRIAIYMPNSICTIATI
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
LAAARLGAIYTLIFAGLGINAIVSRISNLEPKLVISIDKTFRRGKEIKLYTNLANIVFPR
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHCCCEEEEEEEHHHEEECC
DSSQFDYTREYKEFEKIESNEPLKIMYTSGTTGKPKGVILPHGAWMVGDYTVFDLMFSLK
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCEEECCHHHHHHHHHCC
SDDIVLTTADVGWITFSRIMYGTLMHGSTLAFMEGAPDYPSDRLPKIIDELQPKVLFTSP
CCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEECCC
TLLRTLQKLDVKLPRVEFIATAGEIMDETAWKYALRFSDRVADVYGQTELGYVIGYPYAL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEE
DGVEPKIGYAGLPFPAAVIDTVDENGKSLRGHIGHLVAREPFPTQFIGIWKDEDKFLSYF
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHH
EKFNSHDTGDLAIIDEKGYVKIVGRDDDMIKIAGHRITSGEVESVINSLQGIIESAAVGI
HHHCCCCCCCEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
PDEIKGEKLVVFYVGNVDERIVATKVREMLGPIYVIDKIYKVERLPKSRSGKIVRRVLRD
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LLLGKEIDETILEDPEILKEIKNEIKRSERI
HHCCCHHHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA