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The map label for this gene is acsA-6 [H]

Identifier: 15898848

GI number: 15898848

Start: 1876867

End: 1878735

Strand: Reverse

Name: acsA-6 [H]

Synonym: SSO2059

Alternate gene names: 15898848

Gene position: 1878735-1876867 (Counterclockwise)

Preceding gene: 15898854

Following gene: 15898846

Centisome position: 62.79

GC content: 40.4

Gene sequence:

>1869_bases
ATGAGTTGGAAAATATATTCTCTAGATCAGATTAAAGCACTGGCAAAATTCTCCATGGAAAATCCAGAAGCCTTCTGGCG
GGATAAGGCTAATTACGTAAGTTGGTTTAGGCAACCAGAGAAAATACTTGAGGGAGAACCACCATACGAGAAATGGTTCG
TCGGAGGAACACTTAATATATCCTATAATGCCATAGATAGGCATTTACCAGATAAGAAAGATAAGGTGGCATTTTATTGG
ACCAATGAGAGATTAGATAGTTTTAGGTCAATATCCTTTCAAGATCTTTATCAAGAAGTAAACAAGGCAGCCTATGTCTT
AAGTGAATTGGGCGTGAAAAAAGGCGATACGGTATCCATGCTAATGCCTAATATACCAGAAGCTGTATACTTCTCCTTAG
CAACACACAGACTGGGGGCAATTCTAATAATACATTATGTAGGTTTGAGCGAGGAAACAGTGGCATATAGGTTTAATGAT
TGCGGTTCAAAAGTATTGATTGTTGCTTCAAAGACGTTTAGGAATGGAAATGAGATAAGAATTAAGGATTTTGTGGATAA
AGTTTTGGAATCTCATACTACACCCATACAGAAAGTCTTGACAGTGCCGAGGGGATATTCAGATTTTAATGTTAATGGGA
AAAGGGATGTTGTGTATGATGGTGTGAAACCTAAAGGGAAAGTTTACGTTAAACCAGTGGAAGTTGAGGCTAACGAGCCA
GCGACAGTTTATTACACGTCTGGAACTACGGGAAGACCTAAGGGATTATACCATAGTAATGGAGGGTATGTGATAGCACT
CAATTGGGCTTTTAAGGCAATATTTAACCCAACAGAGAATGACGTTTGGTGGACTGTTTCAGAATTAGGTTGGCCAGTAT
GGCCAATGGCAAATTTATACACGATACCAGTAATGGGAATACCTGGTGTGCTTTTTGAGGGATATGTTGGTTATAAAAGG
GATCTATTCTCGAGAGTAATTGAGAGATATAATGTAAGCCTAGTTTGGAGTTCTACCACAACTCTTTACACTCTCAAGAG
TTTAGGAGAGGAGTCAGTTAAGAGCGGAGATACATCAAGCTTAAGAATGATTCTTAATACAGGAGAACCTTTAAACGTTG
GAGCGTGGATGTGGTTAAATCAGAATCTTCCTCAAGTTAAGATAGCAGATGCGTACTGGATGACAGAGCATTTATCGCCA
GTTGGTGCAACTCCTTACGGAATCGGCGAAATTCCCTTTAAGGCAGGTTCCGCTGGTATACAATTCCCAGGAGGAACATA
TTTCTTAATTGTTGACGATGAGGGAAAACCATTACCTCCTAAGCAAAAGGGATATATAGTGTTAAAACCGCTTAACCCAG
CCTTAGCTAAAATGTGGAATGATCCCAATTACGAGAAGATAAAGGAGAAGTATTGGTCTAGGTTCCCAGGATACTTCTAC
ACTGGAGATTACGGTTATGTTGATGAGGATGGATATCTGTTCGTGCTGGGAAGAGCTGATGATGTAATAAGAGCTGAAGG
GGAGAGGATAGGAACACTTGAAGTTGAAAGTGTAATAGTAACTCATCCCAACGTGGCCGAAGCTGCCGTAATAGGTCAAG
GCGGTAACATAATAGCGTTTGTAGTCCCAAGACAAGGGGTTGAGGTTGGTGACGCACTCAGAAATGACATTAAGAACTAT
TGTAGGAACGCTGGTTACATAGTTGATAAAGTAGTGTTTGTGAAGAGACTGCCTAAAACCAAAAGCGGGAAGATAATGAG
AAGGCTACTAAAGGCTATCCTAGCTAACGAGAATCCAGGTGATGTATCAACATTGGACGATATAAGGATAATGGAGGAAC
TTAAGGAGGCGTTGAAGAGCCTAAGCTAA

Upstream 100 bases:

>100_bases
ATATTTATCTTACATTAAATAACTTTTAAATCTTATACAAATCTATCATTGTTGAACGAAAGGTATATATAATTTTTAAT
TTACAAATATATATGATAAC

Downstream 100 bases:

>100_bases
AATGTTTTTTATGGAAAACGCAATTAACTTCCTTTGGGCATTTCTCAAATGATAGAGGAACGTTACTTTACTTATTCCTA
ATAGCTTAGCTAATTCATCG

Product: Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-6)

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSWKIYSLDQIKALAKFSMENPEAFWRDKANYVSWFRQPEKILEGEPPYEKWFVGGTLNISYNAIDRHLPDKKDKVAFYW
TNERLDSFRSISFQDLYQEVNKAAYVLSELGVKKGDTVSMLMPNIPEAVYFSLATHRLGAILIIHYVGLSEETVAYRFND
CGSKVLIVASKTFRNGNEIRIKDFVDKVLESHTTPIQKVLTVPRGYSDFNVNGKRDVVYDGVKPKGKVYVKPVEVEANEP
ATVYYTSGTTGRPKGLYHSNGGYVIALNWAFKAIFNPTENDVWWTVSELGWPVWPMANLYTIPVMGIPGVLFEGYVGYKR
DLFSRVIERYNVSLVWSSTTTLYTLKSLGEESVKSGDTSSLRMILNTGEPLNVGAWMWLNQNLPQVKIADAYWMTEHLSP
VGATPYGIGEIPFKAGSAGIQFPGGTYFLIVDDEGKPLPPKQKGYIVLKPLNPALAKMWNDPNYEKIKEKYWSRFPGYFY
TGDYGYVDEDGYLFVLGRADDVIRAEGERIGTLEVESVIVTHPNVAEAAVIGQGGNIIAFVVPRQGVEVGDALRNDIKNY
CRNAGYIVDKVVFVKRLPKTKSGKIMRRLLKAILANENPGDVSTLDDIRIMEELKEALKSLS

Sequences:

>Translated_622_residues
MSWKIYSLDQIKALAKFSMENPEAFWRDKANYVSWFRQPEKILEGEPPYEKWFVGGTLNISYNAIDRHLPDKKDKVAFYW
TNERLDSFRSISFQDLYQEVNKAAYVLSELGVKKGDTVSMLMPNIPEAVYFSLATHRLGAILIIHYVGLSEETVAYRFND
CGSKVLIVASKTFRNGNEIRIKDFVDKVLESHTTPIQKVLTVPRGYSDFNVNGKRDVVYDGVKPKGKVYVKPVEVEANEP
ATVYYTSGTTGRPKGLYHSNGGYVIALNWAFKAIFNPTENDVWWTVSELGWPVWPMANLYTIPVMGIPGVLFEGYVGYKR
DLFSRVIERYNVSLVWSSTTTLYTLKSLGEESVKSGDTSSLRMILNTGEPLNVGAWMWLNQNLPQVKIADAYWMTEHLSP
VGATPYGIGEIPFKAGSAGIQFPGGTYFLIVDDEGKPLPPKQKGYIVLKPLNPALAKMWNDPNYEKIKEKYWSRFPGYFY
TGDYGYVDEDGYLFVLGRADDVIRAEGERIGTLEVESVIVTHPNVAEAAVIGQGGNIIAFVVPRQGVEVGDALRNDIKNY
CRNAGYIVDKVVFVKRLPKTKSGKIMRRLLKAILANENPGDVSTLDDIRIMEELKEALKSLS
>Mature_621_residues
SWKIYSLDQIKALAKFSMENPEAFWRDKANYVSWFRQPEKILEGEPPYEKWFVGGTLNISYNAIDRHLPDKKDKVAFYWT
NERLDSFRSISFQDLYQEVNKAAYVLSELGVKKGDTVSMLMPNIPEAVYFSLATHRLGAILIIHYVGLSEETVAYRFNDC
GSKVLIVASKTFRNGNEIRIKDFVDKVLESHTTPIQKVLTVPRGYSDFNVNGKRDVVYDGVKPKGKVYVKPVEVEANEPA
TVYYTSGTTGRPKGLYHSNGGYVIALNWAFKAIFNPTENDVWWTVSELGWPVWPMANLYTIPVMGIPGVLFEGYVGYKRD
LFSRVIERYNVSLVWSSTTTLYTLKSLGEESVKSGDTSSLRMILNTGEPLNVGAWMWLNQNLPQVKIADAYWMTEHLSPV
GATPYGIGEIPFKAGSAGIQFPGGTYFLIVDDEGKPLPPKQKGYIVLKPLNPALAKMWNDPNYEKIKEKYWSRFPGYFYT
GDYGYVDEDGYLFVLGRADDVIRAEGERIGTLEVESVIVTHPNVAEAAVIGQGGNIIAFVVPRQGVEVGDALRNDIKNYC
RNAGYIVDKVVFVKRLPKTKSGKIMRRLLKAILANENPGDVSTLDDIRIMEELKEALKSLS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI13375727, Length=623, Percent_Identity=33.3868378812199, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI8923896, Length=664, Percent_Identity=30.8734939759036, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI253970489, Length=677, Percent_Identity=30.7237813884786, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI28416953, Length=628, Percent_Identity=30.8917197452229, Blast_Score=285, Evalue=1e-76,
Organism=Homo sapiens, GI38505220, Length=539, Percent_Identity=28.9424860853432, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI122937307, Length=537, Percent_Identity=27.7467411545624, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI42544132, Length=529, Percent_Identity=28.3553875236295, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI31982927, Length=645, Percent_Identity=24.9612403100775, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI115511026, Length=539, Percent_Identity=27.6437847866419, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI157311624, Length=545, Percent_Identity=26.4220183486239, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI157311622, Length=545, Percent_Identity=26.4220183486239, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI58082049, Length=548, Percent_Identity=26.2773722627737, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI227499619, Length=476, Percent_Identity=24.1596638655462, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790505, Length=632, Percent_Identity=32.753164556962, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1786529, Length=626, Percent_Identity=32.7476038338658, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1788107, Length=526, Percent_Identity=26.615969581749, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI221142682, Length=520, Percent_Identity=24.2307692307692, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI145693145, Length=538, Percent_Identity=23.0483271375465, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786810, Length=539, Percent_Identity=23.0055658627087, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=652, Percent_Identity=30.521472392638, Blast_Score=258, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI71982997, Length=652, Percent_Identity=30.521472392638, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17558820, Length=535, Percent_Identity=25.981308411215, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17531443, Length=553, Percent_Identity=24.5931283905967, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=552, Percent_Identity=24.4565217391304, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17569507, Length=626, Percent_Identity=22.5239616613419, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=557, Percent_Identity=24.7755834829443, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17557194, Length=523, Percent_Identity=24.4741873804971, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=543, Percent_Identity=24.4935543278085, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=524, Percent_Identity=23.0916030534351, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=374, Percent_Identity=25.1336898395722, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319264, Length=647, Percent_Identity=32.6120556414219, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6323182, Length=649, Percent_Identity=31.4329738058552, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6319699, Length=535, Percent_Identity=25.981308411215, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667955, Length=647, Percent_Identity=31.3755795981453, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI62472339, Length=565, Percent_Identity=32.212389380531, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21355225, Length=629, Percent_Identity=30.8426073131955, Blast_Score=272, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=31.9230769230769, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI21355181, Length=522, Percent_Identity=23.9463601532567, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648260, Length=508, Percent_Identity=25, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656500, Length=505, Percent_Identity=24.5544554455446, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI18859661, Length=514, Percent_Identity=24.5136186770428, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281365686, Length=312, Percent_Identity=26.2820512820513, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356441, Length=398, Percent_Identity=24.1206030150754, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648253, Length=376, Percent_Identity=24.2021276595745, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358303, Length=474, Percent_Identity=23.6286919831224, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648255, Length=376, Percent_Identity=24.2021276595745, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648257, Length=361, Percent_Identity=25.207756232687, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161076582, Length=386, Percent_Identity=25.1295336787565, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=387, Percent_Identity=25.8397932816537, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24653035, Length=377, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 70116; Mature: 69985

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWKIYSLDQIKALAKFSMENPEAFWRDKANYVSWFRQPEKILEGEPPYEKWFVGGTLNI
CCEEEECHHHHHHHHHHCCCCCHHHHHCCHHHHHHHCCHHHHHCCCCCHHHEEECCEEEE
SYNAIDRHLPDKKDKVAFYWTNERLDSFRSISFQDLYQEVNKAAYVLSELGVKKGDTVSM
EEHHHHHCCCCCCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LMPNIPEAVYFSLATHRLGAILIIHYVGLSEETVAYRFNDCGSKVLIVASKTFRNGNEIR
ECCCCCHHHHHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCEEEEEEEECCCCCCEEE
IKDFVDKVLESHTTPIQKVLTVPRGYSDFNVNGKRDVVYDGVKPKGKVYVKPVEVEANEP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEEECCCC
ATVYYTSGTTGRPKGLYHSNGGYVIALNWAFKAIFNPTENDVWWTVSELGWPVWPMANLY
EEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEECCCCCCCEEEEHHHCCCCCCCCCCEE
TIPVMGIPGVLFEGYVGYKRDLFSRVIERYNVSLVWSSTTTLYTLKSLGEESVKSGDTSS
EEECCCCCHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCHHHHCCCCCCE
LRMILNTGEPLNVGAWMWLNQNLPQVKIADAYWMTEHLSPVGATPYGIGEIPFKAGSAGI
EEEEEECCCCCCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
QFPGGTYFLIVDDEGKPLPPKQKGYIVLKPLNPALAKMWNDPNYEKIKEKYWSRFPGYFY
ECCCCEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCEE
TGDYGYVDEDGYLFVLGRADDVIRAEGERIGTLEVESVIVTHPNVAEAAVIGQGGNIIAF
ECCCCEECCCCEEEEEECCCCHHHCCCCEEEEEEEEEEEEECCCCCCEEEEECCCCEEEE
VVPRQGVEVGDALRNDIKNYCRNAGYIVDKVVFVKRLPKTKSGKIMRRLLKAILANENPG
EECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
DVSTLDDIRIMEELKEALKSLS
CCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWKIYSLDQIKALAKFSMENPEAFWRDKANYVSWFRQPEKILEGEPPYEKWFVGGTLNI
CEEEECHHHHHHHHHHCCCCCHHHHHCCHHHHHHHCCHHHHHCCCCCHHHEEECCEEEE
SYNAIDRHLPDKKDKVAFYWTNERLDSFRSISFQDLYQEVNKAAYVLSELGVKKGDTVSM
EEHHHHHCCCCCCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LMPNIPEAVYFSLATHRLGAILIIHYVGLSEETVAYRFNDCGSKVLIVASKTFRNGNEIR
ECCCCCHHHHHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCEEEEEEEECCCCCCEEE
IKDFVDKVLESHTTPIQKVLTVPRGYSDFNVNGKRDVVYDGVKPKGKVYVKPVEVEANEP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEEECCCC
ATVYYTSGTTGRPKGLYHSNGGYVIALNWAFKAIFNPTENDVWWTVSELGWPVWPMANLY
EEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEECCCCCCCEEEEHHHCCCCCCCCCCEE
TIPVMGIPGVLFEGYVGYKRDLFSRVIERYNVSLVWSSTTTLYTLKSLGEESVKSGDTSS
EEECCCCCHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCHHHHCCCCCCE
LRMILNTGEPLNVGAWMWLNQNLPQVKIADAYWMTEHLSPVGATPYGIGEIPFKAGSAGI
EEEEEECCCCCCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
QFPGGTYFLIVDDEGKPLPPKQKGYIVLKPLNPALAKMWNDPNYEKIKEKYWSRFPGYFY
ECCCCEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCEE
TGDYGYVDEDGYLFVLGRADDVIRAEGERIGTLEVESVIVTHPNVAEAAVIGQGGNIIAF
ECCCCEECCCCEEEEEECCCCHHHCCCCEEEEEEEEEEEEECCCCCCEEEEECCCCEEEE
VVPRQGVEVGDALRNDIKNYCRNAGYIVDKVVFVKRLPKTKSGKIMRRLLKAILANENPG
EECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
DVSTLDDIRIMEELKEALKSLS
CCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]