Click here to switch to the map view.

The map label for this gene is huyA-1

Identifier: 15898480

GI number: 15898480

Start: 1516989

End: 1519040

Strand: Reverse

Name: huyA-1

Synonym: SSO1663

Alternate gene names: NA

Gene position: 1519040-1516989 (Counterclockwise)

Preceding gene: 15898486

Following gene: 15898479

Centisome position: 50.77

GC content: 36.7

Gene sequence:

>2052_bases
ATGATAAGAGTGGGCATAGATATAGGAGGCGCTTTCACTGACGTAGTGGTCTATAACGAAGAAAACGGAGAAATAAGTTG
GGCAAAGGTAGAAACCACGCCAGATGACCCGTCAAACGGCGTTCTGGAGGCAATAGATGAAGCCAAAGTAAATTTAGGTT
ATGTAAATACTATAATTCACGGTCAGACATTAGCCATAAACACAATAGTAGAAAGGAAAGGAGCAAAGGTTGGTCTAATC
ACAACTAAGGGCTTTAGAGATATCCTAGAAATCCAAAGGGCTAATAGAAGAGATATGTACAATTTCAGATATAAGAAACC
TACTCCCTTTGTTCCGAGGTATTTAAGACTAGAGGTCACCGAGAGGATAAAGAGTAATGGCGATATTTTGACGTCTCTAA
ACGAAAACGAGGTTGTTGAGGCGATTAAAAAACTAAAAGCGGAAAACGTAGAAGCCATTGCTGTAAGTTTTATCAATTCT
TACGTTAATCCCATACATGAACTTAAGGTAGGAGAGATTATTAAGAGAGTTGATCCTAATATTATAGTAACGTTATCTCA
TGAGGTCACTAGAGAGTGGAGAGAGTACGAGAGAACTAGTACCGCTGTACTTAACGCATACGTTATGCCAAAAATGAGTA
AATACTTAAGTAAACTTGAAAATGAATTTAAAAATAGAGGTTTTAAAGGGAATTATTTCGCTATGCTTTCCAACGGAGGT
ATGGCCACATTCGACTACGCTAAAAGATTTCCAATATATACCTTAGAATCTGGTCCAGTAGCAGGAGTTATTGGGGCAAT
TAAGATAAGCGACATATTAGGAGAAAAAAACATTATAGCAATGGATGGTGGAAGTACAACAACTAAGGCTAGTCTAGTGA
GAAATCTGGAACCCAATATAAATACTGATTACTATGTTGGAAGAGATAAGTACAACCCAGGGTATCCAGTAAAAGTTCCA
ACATTGGATATAGTAGAAATAGGTAATGGTGGAACGAGTATTGCTCGGATTGATGAAACAAGTAACTTAAAAGTAGGACC
CAGAGCAGCTGGTGCTTACCCAGGTCCAGTAGCTTATGGGAAAGGAGGTAAAGATGTTACTGTGACAGATGCTTACATAG
TATGTGGATTTCTAAATCAAGAGGAACTACTTGGAGGGAAAATAAAGGTTAATAAAAGACTTGCTGAGGAGGCTATTTCA
AATATTGCTAAATACTATAACATGTCTATTGAAGAAGTCTCCTATGGTATAGTTAAAATTGCTAATGATAATGCTGTAAA
TGCAGTTAGGTTAATATCAGTTCAAAGAGGATATGATCCAAGAGAGTTTACGCTAGTAGCATACGGTGGCTCTGGCCCTA
TGTTTGCTCCATTTGTTGCAGAAGAATTAGACATAAAGAAGATAATAGTACCATTTCTCCCAGCAGGAGTATTCTCCGCA
TGGGGTATGCTTGTTTCAGACATTAGGCATGACCTTGTTTTATCCTATCCTTTGAGGATTGATAAGGAAAGTAGTGTAGA
TTTGATAAATGAAAAATTTAATGAATTAGAGAGCAAAATAAGGTCCATATTAATATCGGAGGGATTCAAAGAGAAAGATA
TCATAATGCTAAGATACGCTGAGATGAGATATTATGGCCAAGAACATACTGTAAAAGTGAGTGTAATGCCAGGGGAAATT
GGGAATAGGGAATTGGAGGAGATAGAAAGAAGGTTCCATGAAGCTCACGAAATCGCATATGCGTTTACCTTAGATAGTCC
AATCGAAATAGTAAACTTTCATGTGAGTGGTATAGTAAAAGCTAAGACTATTGTATTAAAGAGGATAGAGAGGGATAATT
CAAGTATTGATAAGGCGTTGGTCGGAAAAAGAAAGGTATTCTATGATGGAAAATATGAGGAGTGGAATGTGTATAATAAA
GAATATTTACCTATTAATTATCAAATAGTTGGTCCAGCAATTATAGAAGATCCTACTTCTACATCGTTAGTATTAGAAGG
GCAAACGGGAATGTTAGATAGTTATGGCAATCTAATTATTGAGAGGGATTAA

Upstream 100 bases:

>100_bases
AAAGGATATCGTCATGTGTTATTTAGTCTTTTAAAAATATCTTGCTGACACAGAAGACTATTAGACTGCTTAATATCTTT
AAAACAATACAACTTAATCA

Downstream 100 bases:

>100_bases
TAATGGTAGACCCATTTACATTGGAAATTATAAAGAATGGCCTTGTAGTGGCGTCTGAGGAAATGTTTTACGCTTTCGGA
AGAACCGCTAAAAGTCCGGT

Product: N-methylhydantoinase A (huyA-1)

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MIRVGIDIGGAFTDVVVYNEENGEISWAKVETTPDDPSNGVLEAIDEAKVNLGYVNTIIHGQTLAINTIVERKGAKVGLI
TTKGFRDILEIQRANRRDMYNFRYKKPTPFVPRYLRLEVTERIKSNGDILTSLNENEVVEAIKKLKAENVEAIAVSFINS
YVNPIHELKVGEIIKRVDPNIIVTLSHEVTREWREYERTSTAVLNAYVMPKMSKYLSKLENEFKNRGFKGNYFAMLSNGG
MATFDYAKRFPIYTLESGPVAGVIGAIKISDILGEKNIIAMDGGSTTTKASLVRNLEPNINTDYYVGRDKYNPGYPVKVP
TLDIVEIGNGGTSIARIDETSNLKVGPRAAGAYPGPVAYGKGGKDVTVTDAYIVCGFLNQEELLGGKIKVNKRLAEEAIS
NIAKYYNMSIEEVSYGIVKIANDNAVNAVRLISVQRGYDPREFTLVAYGGSGPMFAPFVAEELDIKKIIVPFLPAGVFSA
WGMLVSDIRHDLVLSYPLRIDKESSVDLINEKFNELESKIRSILISEGFKEKDIIMLRYAEMRYYGQEHTVKVSVMPGEI
GNRELEEIERRFHEAHEIAYAFTLDSPIEIVNFHVSGIVKAKTIVLKRIERDNSSIDKALVGKRKVFYDGKYEEWNVYNK
EYLPINYQIVGPAIIEDPTSTSLVLEGQTGMLDSYGNLIIERD

Sequences:

>Translated_683_residues
MIRVGIDIGGAFTDVVVYNEENGEISWAKVETTPDDPSNGVLEAIDEAKVNLGYVNTIIHGQTLAINTIVERKGAKVGLI
TTKGFRDILEIQRANRRDMYNFRYKKPTPFVPRYLRLEVTERIKSNGDILTSLNENEVVEAIKKLKAENVEAIAVSFINS
YVNPIHELKVGEIIKRVDPNIIVTLSHEVTREWREYERTSTAVLNAYVMPKMSKYLSKLENEFKNRGFKGNYFAMLSNGG
MATFDYAKRFPIYTLESGPVAGVIGAIKISDILGEKNIIAMDGGSTTTKASLVRNLEPNINTDYYVGRDKYNPGYPVKVP
TLDIVEIGNGGTSIARIDETSNLKVGPRAAGAYPGPVAYGKGGKDVTVTDAYIVCGFLNQEELLGGKIKVNKRLAEEAIS
NIAKYYNMSIEEVSYGIVKIANDNAVNAVRLISVQRGYDPREFTLVAYGGSGPMFAPFVAEELDIKKIIVPFLPAGVFSA
WGMLVSDIRHDLVLSYPLRIDKESSVDLINEKFNELESKIRSILISEGFKEKDIIMLRYAEMRYYGQEHTVKVSVMPGEI
GNRELEEIERRFHEAHEIAYAFTLDSPIEIVNFHVSGIVKAKTIVLKRIERDNSSIDKALVGKRKVFYDGKYEEWNVYNK
EYLPINYQIVGPAIIEDPTSTSLVLEGQTGMLDSYGNLIIERD
>Mature_683_residues
MIRVGIDIGGAFTDVVVYNEENGEISWAKVETTPDDPSNGVLEAIDEAKVNLGYVNTIIHGQTLAINTIVERKGAKVGLI
TTKGFRDILEIQRANRRDMYNFRYKKPTPFVPRYLRLEVTERIKSNGDILTSLNENEVVEAIKKLKAENVEAIAVSFINS
YVNPIHELKVGEIIKRVDPNIIVTLSHEVTREWREYERTSTAVLNAYVMPKMSKYLSKLENEFKNRGFKGNYFAMLSNGG
MATFDYAKRFPIYTLESGPVAGVIGAIKISDILGEKNIIAMDGGSTTTKASLVRNLEPNINTDYYVGRDKYNPGYPVKVP
TLDIVEIGNGGTSIARIDETSNLKVGPRAAGAYPGPVAYGKGGKDVTVTDAYIVCGFLNQEELLGGKIKVNKRLAEEAIS
NIAKYYNMSIEEVSYGIVKIANDNAVNAVRLISVQRGYDPREFTLVAYGGSGPMFAPFVAEELDIKKIIVPFLPAGVFSA
WGMLVSDIRHDLVLSYPLRIDKESSVDLINEKFNELESKIRSILISEGFKEKDIIMLRYAEMRYYGQEHTVKVSVMPGEI
GNRELEEIERRFHEAHEIAYAFTLDSPIEIVNFHVSGIVKAKTIVLKRIERDNSSIDKALVGKRKVFYDGKYEEWNVYNK
EYLPINYQIVGPAIIEDPTSTSLVLEGQTGMLDSYGNLIIERD

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=743, Percent_Identity=26.6487213997308, Blast_Score=189, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI133901900, Length=721, Percent_Identity=27.1844660194175, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322634, Length=749, Percent_Identity=29.1054739652871, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI45550492, Length=742, Percent_Identity=26.8194070080863, Blast_Score=204, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 76407; Mature: 76407

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVGIDIGGAFTDVVVYNEENGEISWAKVETTPDDPSNGVLEAIDEAKVNLGYVNTIIH
CEEEEEECCCCEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEC
GQTLAINTIVERKGAKVGLITTKGFRDILEIQRANRRDMYNFRYKKPTPFVPRYLRLEVT
CCEEEEEEHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHH
ERIKSNGDILTSLNENEVVEAIKKLKAENVEAIAVSFINSYVNPIHELKVGEIIKRVDPN
HHHCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IIVTLSHEVTREWREYERTSTAVLNAYVMPKMSKYLSKLENEFKNRGFKGNYFAMLSNGG
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
MATFDYAKRFPIYTLESGPVAGVIGAIKISDILGEKNIIAMDGGSTTTKASLVRNLEPNI
EEEEHHHHCCCEEEECCCCCEEEEEHEEEHHHCCCCCEEEECCCCCCHHHHHHHCCCCCC
NTDYYVGRDKYNPGYPVKVPTLDIVEIGNGGTSIARIDETSNLKVGPRAAGAYPGPVAYG
CCCEEECCCCCCCCCCEEECCEEEEEECCCCCEEEEECCCCCCEECCCCCCCCCCCCCCC
KGGKDVTVTDAYIVCGFLNQEELLGGKIKVNKRLAEEAISNIAKYYNMSIEEVSYGIVKI
CCCCEEEEEEEEEEEEECCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCHHHCCEEEEEE
ANDNAVNAVRLISVQRGYDPREFTLVAYGGSGPMFAPFVAEELDIKKIIVPFLPAGVFSA
ECCCCCCEEEEEEEECCCCCCEEEEEEECCCCCEECCHHHHHCCHHHHHHHHCCHHHHHH
WGMLVSDIRHDLVLSYPLRIDKESSVDLINEKFNELESKIRSILISEGFKEKDIIMLRYA
HHHHHHHHHHHEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
EMRYYGQEHTVKVSVMPGEIGNRELEEIERRFHEAHEIAYAFTLDSPIEIVNFHVSGIVK
HHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEEHHHHHH
AKTIVLKRIERDNSSIDKALVGKRKVFYDGKYEEWNVYNKEYLPINYQIVGPAIIEDPTS
HHHHHHHHHHCCCCHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEEEEECCEEECCCCC
TSLVLEGQTGMLDSYGNLIIERD
CEEEEECCCCCCCCCCCEEEECC
>Mature Secondary Structure
MIRVGIDIGGAFTDVVVYNEENGEISWAKVETTPDDPSNGVLEAIDEAKVNLGYVNTIIH
CEEEEEECCCCEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEC
GQTLAINTIVERKGAKVGLITTKGFRDILEIQRANRRDMYNFRYKKPTPFVPRYLRLEVT
CCEEEEEEHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHH
ERIKSNGDILTSLNENEVVEAIKKLKAENVEAIAVSFINSYVNPIHELKVGEIIKRVDPN
HHHCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IIVTLSHEVTREWREYERTSTAVLNAYVMPKMSKYLSKLENEFKNRGFKGNYFAMLSNGG
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
MATFDYAKRFPIYTLESGPVAGVIGAIKISDILGEKNIIAMDGGSTTTKASLVRNLEPNI
EEEEHHHHCCCEEEECCCCCEEEEEHEEEHHHCCCCCEEEECCCCCCHHHHHHHCCCCCC
NTDYYVGRDKYNPGYPVKVPTLDIVEIGNGGTSIARIDETSNLKVGPRAAGAYPGPVAYG
CCCEEECCCCCCCCCCEEECCEEEEEECCCCCEEEEECCCCCCEECCCCCCCCCCCCCCC
KGGKDVTVTDAYIVCGFLNQEELLGGKIKVNKRLAEEAISNIAKYYNMSIEEVSYGIVKI
CCCCEEEEEEEEEEEEECCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCHHHCCEEEEEE
ANDNAVNAVRLISVQRGYDPREFTLVAYGGSGPMFAPFVAEELDIKKIIVPFLPAGVFSA
ECCCCCCEEEEEEEECCCCCCEEEEEEECCCCCEECCHHHHHCCHHHHHHHHCCHHHHHH
WGMLVSDIRHDLVLSYPLRIDKESSVDLINEKFNELESKIRSILISEGFKEKDIIMLRYA
HHHHHHHHHHHEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
EMRYYGQEHTVKVSVMPGEIGNRELEEIERRFHEAHEIAYAFTLDSPIEIVNFHVSGIVK
HHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEEHHHHHH
AKTIVLKRIERDNSSIDKALVGKRKVFYDGKYEEWNVYNKEYLPINYQIVGPAIIEDPTS
HHHHHHHHHHCCCCHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEEEEECCEEECCCCC
TSLVLEGQTGMLDSYGNLIIERD
CEEEEECCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]