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The map label for this gene is fumC [H]

Identifier: 15897944

GI number: 15897944

Start: 934340

End: 935677

Strand: Reverse

Name: fumC [H]

Synonym: SSO1077

Alternate gene names: 15897944

Gene position: 935677-934340 (Counterclockwise)

Preceding gene: 15897948

Following gene: 15897940

Centisome position: 31.27

GC content: 36.55

Gene sequence:

>1338_bases
ATGGATTACGTTCAATTAATTATGAAATATACCGATACTGCGCCCAAGCTTTTTATGAATACTGGAACCAAATTTCCTAG
AAGAATTATCTGGTCTATGGGAGTTTTAAAGAAGTCCTGTGCTAAAGTCAACGCAGATCTTGGATTATTAGATAAAAAAA
TTGCGGATTCAATTATTAAGGCATCTGACGATTTAATTGATGGAAAATTAGATGATAAGATAGTGCTTGATGTATTTCAA
ACGGGTTCAGGGACCGGACTTAATATGAACGTAAATGAGGTTATAGCAGAAGTAGCTTCTAGCTATTCTAATCTTAAAGT
ACATCCAAATGATCATGTAAATTTTGGTCAGTCCTCAAACGATACTGTGCCAACAGCTATAAGAATTGCAGCAGTAGCTG
AGGTAACAAATAGGCTACTGCCTGCATTACAGCAAATAATATCCTCTTTAAATAAGAAGGCTGAGGAGTACAAGGATGTT
ATAAAGGCTGGTAGAACCCATTTAAGAGACGCATTACCAGTAACTTTAGGTCAAGAACTTTCAGCCTACGCAGACGCTTT
CCAGCATGAACATGAACAAGTTATGAATATTTTGGAATATGTGAAGGAATTGCCAATTGGAGGTACTGCGACTGGTACTG
GGCTAAATAGCCACCCAGAATTCCAAGAAAGAGTTATAAACGAAATAAACAGAATTACCGGTTTAGGATTTAAGCCAGCT
AATAGGTTTAGAGCAATGAGATTGCTCACCGATCTCTTATTATTAAGCGGAGCACTGAGGAATATTGCAGTAGACCTATA
TAGATTAGGGCAAGATATAAGGTTAATGTTTTCCGGTCCCTTAACTGGGTTAAATGAAATTGATTTACCTACACAAGAGG
AGATAGCTGGTAGCTCAATAATGCCTGGTAAAACTAATCCAGTTACGGTTGAGGCTACTTTACTAATCTCAGCACAAGTT
GTGGGATTAGATCATGCAAACCAATTCGCATCAATGTTAGGCGAATTTGAGTTATCAATGGGAATTCCATTAGTTGGTTA
TAATATCGTAACCCAAGTTAATTTCATCTCAGAGGCTTTAGAGAAGATGTCAAGATTAGTGATTGATGGAATGGTAGCAA
ATGTAGAGAAGATGAAGAGATATGCTGAATCCTCTCCTTCACTTATAACCATAGTATCTCCAGTAATAGGCTATGATAAA
GCAACAGAAATAGGAAAGAAGTTAAATAAGGGAATGTCCATACGTGAAGCATTAAGGGAATTAGGATATAGCGATAATGA
GATAAATAAAATATTAGACTTAAGCAAACTAGTTAAACCAGGGTTCACAGCTAAATGA

Upstream 100 bases:

>100_bases
TTGGTAACATTTTCAAGTCTTATTACGGACATATATTGGGTATTACGTAAAGTGGGTTAAAGATTTTTTCAAAGATAATT
CCTTGTAAAGATTTAATATA

Downstream 100 bases:

>100_bases
GAAAAGATAAACGTCCCAAGGGTAGGTTACCTCTTTTTAACACCTTCTATTATCCAAAATCCTTCCTTCTCCTTTACCAT
GGCCACTTTAAATTTACTGG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MDYVQLIMKYTDTAPKLFMNTGTKFPRRIIWSMGVLKKSCAKVNADLGLLDKKIADSIIKASDDLIDGKLDDKIVLDVFQ
TGSGTGLNMNVNEVIAEVASSYSNLKVHPNDHVNFGQSSNDTVPTAIRIAAVAEVTNRLLPALQQIISSLNKKAEEYKDV
IKAGRTHLRDALPVTLGQELSAYADAFQHEHEQVMNILEYVKELPIGGTATGTGLNSHPEFQERVINEINRITGLGFKPA
NRFRAMRLLTDLLLLSGALRNIAVDLYRLGQDIRLMFSGPLTGLNEIDLPTQEEIAGSSIMPGKTNPVTVEATLLISAQV
VGLDHANQFASMLGEFELSMGIPLVGYNIVTQVNFISEALEKMSRLVIDGMVANVEKMKRYAESSPSLITIVSPVIGYDK
ATEIGKKLNKGMSIREALRELGYSDNEINKILDLSKLVKPGFTAK

Sequences:

>Translated_445_residues
MDYVQLIMKYTDTAPKLFMNTGTKFPRRIIWSMGVLKKSCAKVNADLGLLDKKIADSIIKASDDLIDGKLDDKIVLDVFQ
TGSGTGLNMNVNEVIAEVASSYSNLKVHPNDHVNFGQSSNDTVPTAIRIAAVAEVTNRLLPALQQIISSLNKKAEEYKDV
IKAGRTHLRDALPVTLGQELSAYADAFQHEHEQVMNILEYVKELPIGGTATGTGLNSHPEFQERVINEINRITGLGFKPA
NRFRAMRLLTDLLLLSGALRNIAVDLYRLGQDIRLMFSGPLTGLNEIDLPTQEEIAGSSIMPGKTNPVTVEATLLISAQV
VGLDHANQFASMLGEFELSMGIPLVGYNIVTQVNFISEALEKMSRLVIDGMVANVEKMKRYAESSPSLITIVSPVIGYDK
ATEIGKKLNKGMSIREALRELGYSDNEINKILDLSKLVKPGFTAK
>Mature_445_residues
MDYVQLIMKYTDTAPKLFMNTGTKFPRRIIWSMGVLKKSCAKVNADLGLLDKKIADSIIKASDDLIDGKLDDKIVLDVFQ
TGSGTGLNMNVNEVIAEVASSYSNLKVHPNDHVNFGQSSNDTVPTAIRIAAVAEVTNRLLPALQQIISSLNKKAEEYKDV
IKAGRTHLRDALPVTLGQELSAYADAFQHEHEQVMNILEYVKELPIGGTATGTGLNSHPEFQERVINEINRITGLGFKPA
NRFRAMRLLTDLLLLSGALRNIAVDLYRLGQDIRLMFSGPLTGLNEIDLPTQEEIAGSSIMPGKTNPVTVEATLLISAQV
VGLDHANQFASMLGEFELSMGIPLVGYNIVTQVNFISEALEKMSRLVIDGMVANVEKMKRYAESSPSLITIVSPVIGYDK
ATEIGKKLNKGMSIREALRELGYSDNEINKILDLSKLVKPGFTAK

Specific function: May function as an auxiliary aerobic enzyme in the citric acid cycle [H]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=425, Percent_Identity=42.1176470588235, Blast_Score=305, Evalue=6e-83,
Organism=Escherichia coli, GI1787896, Length=400, Percent_Identity=40.75, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI87082375, Length=430, Percent_Identity=34.6511627906977, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1790398, Length=322, Percent_Identity=27.639751552795, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17553882, Length=425, Percent_Identity=42.8235294117647, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=40.7975460122699, Blast_Score=235, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324993, Length=406, Percent_Identity=41.1330049261084, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6321806, Length=260, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640179, Length=427, Percent_Identity=41.92037470726, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24640177, Length=427, Percent_Identity=41.92037470726, Blast_Score=317, Evalue=7e-87,
Organism=Drosophila melanogaster, GI78710009, Length=429, Percent_Identity=41.025641025641, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24662684, Length=427, Percent_Identity=40.2810304449649, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24583245, Length=427, Percent_Identity=34.8946135831382, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48775; Mature: 48775

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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CCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8276121; 8119400; 11427726; 2124611 [H]