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The map label for this gene is thsA [H]

Identifier: 15897757

GI number: 15897757

Start: 736622

End: 738301

Strand: Reverse

Name: thsA [H]

Synonym: SSO0862

Alternate gene names: 15897757

Gene position: 738301-736622 (Counterclockwise)

Preceding gene: 15897759

Following gene: 15897753

Centisome position: 24.67

GC content: 38.39

Gene sequence:

>1680_bases
ATGGCAGCTCCAGTCTTATTGCTTAAAGAGGGAACAAGCAGAACTACTGGAAGAGATGCGCTAAGGAATAATATACTTGC
TGCGAAGACATTAGCTGAAATGTTAAGGAGTAGTTTAGGTCCTAAAGGTCTTGATAAAATGCTAATTGATAGCTTCGGTG
ACGTAACCATAACTAATGATGGTGCTACAATAGTAAAGGATATGGAGATTCAGCATCCAGCTGCGAAATTATTAGTAGAA
GCAGCTAAAGCTCAAGATGCTGAAGTAGGTGATGGTACTACAAGTGCTGTAGTATTGGCTGGTGCTCTATTAGAGAAGGC
TGAAAGTTTATTGGATCAAAATATACATCCTACAATAATTATTGAGGGGTATAAGAAGGCATACAACAAGGCCTTAGAGT
TACTTCCGCAGTTAGGAACTAGAATTGATATAAAGGATTTGAATTCTTCAGTAGCTAGAGATACTCTAAGAAAGATAGCA
TTTACTACTTTAGCAAGTAAGTTTATTGCAGAAGGTGCTGAATTAAATAAAATAATTGACATGGTAATAGATGCAATAGT
TAATGTAGCAGAACCTTTACCTAATGGTGGATATAATGTGAGTTTAGACTTAATAAAGATAGATAAGAAGAAAGGCGGAA
GTATAGAGGATAGTGTACTAGTTAAAGGACTAGTGTTAGATAAGGAGGTAGTACATCCTGGAATGCCTAGAAGAGTCACC
AAGGCTAAGATAGCTGTTTTGGATGCAGCATTAGAGGTAGAGAAGCCTGAAATTTCAGCCAAGATAAGCATCACATCACC
TGAGCAAATTAAGGCTTTCTTGGATGAGGAGTCTAAATACCTTAAGGATATGGTTGATAAGTTAGCATCAATAGGTGCTA
ATGTTGTAATATGCCAGAAGGGTATTGATGATATAGCACAGCATTTCTTAGCCAAGAAAGGGATATTGGCTGTAAGAAGA
GTTAAGAGGAGCGATATAGAAAAATTAGAGAAGGCATTAGGTGCAAGAATAATAAGTAGCATTAAAGATGCTACTCCCGA
AGACTTAGGATATGCTGAATTAGTTGAGGAAAGGAGAGTTGGGAACGATAAAATGGTATTTATAGAGGGTGCTAAGAACT
TGAAAGCTGTGAATATCTTGTTAAGAGGTTCAAATGATATGGCATTAGATGAGGCTGAGAGGAGTATAAATGATGCATTG
CATGCTCTAAGGAACATATTATTAGAGCCAGTAATATTACCAGGCGGTGGTGCTATCGAGTTAGAGTTAGCGATGAAATT
AAGAGAGTATGCTAGAAGTGTGGGAGGTAAGGAGCAATTAGCTATAGAAGCATTTGCAGACGCATTAGAGGAGATACCTT
TAATTTTAGCTGAAACTGCAGGGCTAGAGGCTATATCTTCATTGATGGACTTAAGAGCTAGGCACGCTAAGGGCTTGAGT
AATACTGGTGTAGATGTCATAGGCGGGAAGATTGTAGATGATGTATATGCGTTAAACATTATCGAGCCTATTAGAGTAAA
GTCTCAAGTGTTAAAGAGTGCTACAGAGGCAGCCACAGCAATATTAAAGATTGATGATCTAATAGCGGCTGCCCCACTAA
AGAGTGAGAAGAAAGGAGGAGAAGGAAGTAAAGAAGAAAGTGGTGGAGAGGGAGGATCTACTCCATCTTTAGGAGACTAA

Upstream 100 bases:

>100_bases
TGGATTTCCTATTTATTTAAAAAATTACTTCTCGGTTTAGCTGAGAGAAAAATTTTTATATAAGCGATACTAATGTTCTC
ACGGAACGGTGTTGTGAGGT

Downstream 100 bases:

>100_bases
ATATTTTTTATTAACCGAAACTTTAACGTTTGTCTCCTCAGTGTTTTCCGTATATCCGTTTATTTCCTCTAATATCTTAT
CTACTACTTTTTTTATGTCT

Product: thermosome subunit alpha

Products: NA

Alternate protein names: Chaperonin subunit alpha; Ring complex subunit alpha; Thermophilic factor 55 alpha; TF55-alpha; Thermophilic factor 56; Thermosome subunit 1 [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MAAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLVE
AAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIA
FTTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDDIAQHFLAKKGILAVRR
VKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDAL
HALRNILLEPVILPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLS
NTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAAAPLKSEKKGGEGSKEESGGEGGSTPSLGD

Sequences:

>Translated_559_residues
MAAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLVE
AAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIA
FTTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDDIAQHFLAKKGILAVRR
VKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDAL
HALRNILLEPVILPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLS
NTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAAAPLKSEKKGGEGSKEESGGEGGSTPSLGD
>Mature_558_residues
AAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLVEA
AKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAF
TTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVTK
AKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDDIAQHFLAKKGILAVRRV
KRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALH
ALRNILLEPVILPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLSN
TGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAAAPLKSEKKGGEGSKEESGGEGGSTPSLGD

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, stimulates protein folding and has ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI24307939, Length=531, Percent_Identity=41.6195856873823, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI63162572, Length=550, Percent_Identity=37.2727272727273, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI38455427, Length=513, Percent_Identity=42.495126705653, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI57863257, Length=542, Percent_Identity=39.6678966789668, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI5453607, Length=531, Percent_Identity=36.7231638418079, Blast_Score=344, Evalue=2e-94,
Organism=Homo sapiens, GI58761484, Length=550, Percent_Identity=34.1818181818182, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI58331173, Length=516, Percent_Identity=36.8217054263566, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI4502643, Length=524, Percent_Identity=36.2595419847328, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI261399877, Length=488, Percent_Identity=35.655737704918, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI5453603, Length=535, Percent_Identity=34.9532710280374, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI302058290, Length=509, Percent_Identity=34.3811394891945, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI261399875, Length=443, Percent_Identity=33.4085778781038, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI48762932, Length=531, Percent_Identity=33.8983050847458, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI302058292, Length=516, Percent_Identity=32.7519379844961, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI58331171, Length=524, Percent_Identity=32.2519083969466, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI57863259, Length=375, Percent_Identity=36.8, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI58331185, Length=315, Percent_Identity=34.6031746031746, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI7657253, Length=517, Percent_Identity=25.9187620889749, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI25914754, Length=447, Percent_Identity=24.1610738255034, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI9055272, Length=447, Percent_Identity=24.1610738255034, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI1790586, Length=127, Percent_Identity=35.4330708661417, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144674, Length=530, Percent_Identity=42.4528301886792, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17532603, Length=520, Percent_Identity=41.5384615384615, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17532601, Length=534, Percent_Identity=39.8876404494382, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI25148561, Length=550, Percent_Identity=34.7272727272727, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17564182, Length=531, Percent_Identity=34.8399246704331, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI25147750, Length=536, Percent_Identity=36.9402985074627, Blast_Score=308, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI25144678, Length=526, Percent_Identity=35.171102661597, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32566944, Length=453, Percent_Identity=34.2163355408389, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI25144680, Length=403, Percent_Identity=36.4764267990074, Blast_Score=247, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI71998178, Length=559, Percent_Identity=30.5903398926655, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI71981457, Length=328, Percent_Identity=41.4634146341463, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17555558, Length=578, Percent_Identity=24.3944636678201, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=537, Percent_Identity=36.8715083798883, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322524, Length=539, Percent_Identity=38.0333951762523, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6320418, Length=543, Percent_Identity=37.3848987108656, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6320058, Length=513, Percent_Identity=37.4269005847953, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6322350, Length=527, Percent_Identity=35.8633776091082, Blast_Score=322, Evalue=9e-89,
Organism=Saccharomyces cerevisiae, GI6322049, Length=517, Percent_Identity=34.2359767891683, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6320393, Length=529, Percent_Identity=32.1361058601134, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322452, Length=541, Percent_Identity=30.8687615526802, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323288, Length=123, Percent_Identity=34.1463414634146, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17647245, Length=543, Percent_Identity=41.0681399631676, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24583944, Length=518, Percent_Identity=41.3127413127413, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652903, Length=522, Percent_Identity=41.1877394636015, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24647512, Length=546, Percent_Identity=36.996336996337, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI24647510, Length=546, Percent_Identity=36.996336996337, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI24649027, Length=553, Percent_Identity=38.1555153707052, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24649029, Length=553, Percent_Identity=38.1555153707052, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24645179, Length=542, Percent_Identity=37.4538745387454, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI18858175, Length=539, Percent_Identity=35.2504638218924, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI28571140, Length=539, Percent_Identity=35.2504638218924, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI18859933, Length=537, Percent_Identity=34.4506517690875, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI19921848, Length=550, Percent_Identity=34, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI20130093, Length=332, Percent_Identity=26.8072289156627, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45552711, Length=332, Percent_Identity=26.8072289156627, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59676; Mature: 59545

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00750 TCP1_1 ; PS00751 TCP1_2 ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITND
CCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECC
GATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTII
CCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIID
EECHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
HHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQK
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIE
CCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEE
LELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCC
NTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAAAPLKSEKKGG
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EGSKEESGGEGGSTPSLGD
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITND
CCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECC
GATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTII
CCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIID
EECHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
HHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQK
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIE
CCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEE
LELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCC
NTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAAAPLKSEKKGG
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EGSKEESGGEGGSTPSLGD
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7473746 [H]