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The map label for this gene is hem4

Identifier: 15889909

GI number: 15889909

Start: 2636615

End: 2637355

Strand: Direct

Name: hem4

Synonym: Atu2653

Alternate gene names: NA

Gene position: 2636615-2637355 (Clockwise)

Preceding gene: 15889908

Following gene: 159185309

Centisome position: 92.79

GC content: 60.46

Gene sequence:

>741_bases
GTGCGGATCGTCGTCACCCGGCCGCAGCGTTCGGGCGAAAGGACGGCTGCAAAGCTTGAAGCGCTTGGCCATGCGCCGGT
GCTTCTGCCGCTGTTTCATCCCATCCATCATGGCGAACGCGCCACCTCGGCGCTGTCCGATCCGGCGGGCGCTATCGCGG
TGACCAGCGCTGAAGCCTTGCGGGCGCTGGCAACGTGCGAAGAACAGCTTGCCCCCTATCTGTCGAAACCGCTTTTCGCC
GTCGGCGGGGCAACGGCGGAAGCAGCGCAAGAAACCGGCTTCGAGCAGATATTCACCGCCTCCGGAGATGCTCTGGGTCT
GACCGTGCTGGTGAAACAGCACCGCGCTTTTTTGACTGAAGAAGAACCCTTGCTCTATCTCGCCGGCAGGCCACGTGGCT
CCGTCTTCGAAGAGGGCCTTGCCGCCGCGGGCATTCCCTTCAGAACGGTCGACTGTTACGAGATGCTGCCCTCGGATATC
TCCGAAAACACGCTCGAAACGACGCTTCTCGACACGACCGCCGATATGGTCCTGCTCTATTCCTCTGAAGCGGCGCGGGC
CTTTTTCCATCATGTATCGGCGGATAAATACGTGACGGCGCTGGCGGCGACAAAATTCATCTGCATCAGCCGCAACGTGC
TGTTTCTGGTTCCGGAAATCTTCCGCGCAAATGCCAAGGCCGCCGAAGAGCCGAGCGAAGCCGCGATGTTCGAACTTCTG
CACCATAACTCTGGAACCTAA

Upstream 100 bases:

>100_bases
TCCGGCAACCGCAGGGACGCCTTGATACTGGGGAAAAAGGCCGGCGAAGAGGTGCGCGCCAAAGCGGGCAGCAATTTCTT
CGAAGGCTGGAGCTGAGCCG

Downstream 100 bases:

>100_bases
TTCGACCTCACCTCTTTCCTTTGCCGCCGTCACTGACTAGGTTTAGAGTATTGCAGGCAGAAATGAGGTTGTCATGGTAT
CGGGAAAGCCGCCACGCCAC

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen-III Synthase Protein

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MRIVVTRPQRSGERTAAKLEALGHAPVLLPLFHPIHHGERATSALSDPAGAIAVTSAEALRALATCEEQLAPYLSKPLFA
VGGATAEAAQETGFEQIFTASGDALGLTVLVKQHRAFLTEEEPLLYLAGRPRGSVFEEGLAAAGIPFRTVDCYEMLPSDI
SENTLETTLLDTTADMVLLYSSEAARAFFHHVSADKYVTALAATKFICISRNVLFLVPEIFRANAKAAEEPSEAAMFELL
HHNSGT

Sequences:

>Translated_246_residues
MRIVVTRPQRSGERTAAKLEALGHAPVLLPLFHPIHHGERATSALSDPAGAIAVTSAEALRALATCEEQLAPYLSKPLFA
VGGATAEAAQETGFEQIFTASGDALGLTVLVKQHRAFLTEEEPLLYLAGRPRGSVFEEGLAAAGIPFRTVDCYEMLPSDI
SENTLETTLLDTTADMVLLYSSEAARAFFHHVSADKYVTALAATKFICISRNVLFLVPEIFRANAKAAEEPSEAAMFELL
HHNSGT
>Mature_246_residues
MRIVVTRPQRSGERTAAKLEALGHAPVLLPLFHPIHHGERATSALSDPAGAIAVTSAEALRALATCEEQLAPYLSKPLFA
VGGATAEAAQETGFEQIFTASGDALGLTVLVKQHRAFLTEEEPLLYLAGRPRGSVFEEGLAAAGIPFRTVDCYEMLPSDI
SENTLETTLLDTTADMVLLYSSEAARAFFHHVSADKYVTALAATKFICISRNVLFLVPEIFRANAKAAEEPSEAAMFELL
HHNSGT

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 26420; Mature: 26420

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVVTRPQRSGERTAAKLEALGHAPVLLPLFHPIHHGERATSALSDPAGAIAVTSAEAL
CEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCCCEEEEEHHHHH
RALATCEEQLAPYLSKPLFAVGGATAEAAQETGFEQIFTASGDALGLTVLVKQHRAFLTE
HHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCC
EEPLLYLAGRPRGSVFEEGLAAAGIPFRTVDCYEMLPSDISENTLETTLLDTTADMVLLY
CCCEEEEECCCCCHHHHHHHHHCCCCCEEHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEE
SSEAARAFFHHVSADKYVTALAATKFICISRNVLFLVPEIFRANAKAAEEPSEAAMFELL
CCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHEEEHHHHHCCCCCCCCCHHHHHHHHH
HHNSGT
HCCCCC
>Mature Secondary Structure
MRIVVTRPQRSGERTAAKLEALGHAPVLLPLFHPIHHGERATSALSDPAGAIAVTSAEAL
CEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCCCEEEEEHHHHH
RALATCEEQLAPYLSKPLFAVGGATAEAAQETGFEQIFTASGDALGLTVLVKQHRAFLTE
HHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCC
EEPLLYLAGRPRGSVFEEGLAAAGIPFRTVDCYEMLPSDISENTLETTLLDTTADMVLLY
CCCEEEEECCCCCHHHHHHHHHCCCCCEEHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEE
SSEAARAFFHHVSADKYVTALAATKFICISRNVLFLVPEIFRANAKAAEEPSEAAMFELL
CCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHEEEHHHHHCCCCCCCCCHHHHHHHHH
HHNSGT
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA