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The map label for this gene is sdhA [H]

Identifier: 15889899

GI number: 15889899

Start: 2628735

End: 2630576

Strand: Reverse

Name: sdhA [H]

Synonym: Atu2643

Alternate gene names: 15889899

Gene position: 2630576-2628735 (Counterclockwise)

Preceding gene: 15889900

Following gene: 15889898

Centisome position: 92.57

GC content: 62.0

Gene sequence:

>1842_bases
ATGGCATCGATCAGTTCACCTTCCCAGAATGGCAAGGCCTACACCTATGTCGATCACTCCTATGACGTGATCGTGGTGGG
CGCCGGTGGCGCCGGTCTACGCGCAACGCTCGGCATGGCGGAACAGGGTTTCCGCACGGCCTGCATCACCAAGGTTTTCC
CGACCCGCTCCCACACGGTCGCGGCGCAGGGCGGCATTGCCGCATCGCTTACCAACATGACGCCCGACTGTTGGCAGTGG
CACCTTTACGACACCGTAAAGGGCTCCGACTGGCTGGGCGACGTCGATGCGATGCAATATCTCGCCATGGAAGCGCCGAA
GGCGGTCTATGAGCTGGAACATTACGGCGTGCCCTTCTCGCGCAATGCCGAGGGCAAGATTTACCAGCGCCCGTTCGGCG
GTCACATGCAGAATTACGGCGAAGGCCCACCGGTACAGCGCACCTGTGCTGCCGCCGACCGTACCGGCCACGCCATTCTG
CACACGCTCTATGGCCAGTCGCTGCGCAACAATGCGGAATTCTTCATCGAATATTTCGCGCTCGACCTCATCATGGCGCC
AGATGGTCGTTGCACGGGCGTCGTTGCCTGGAACCTCGATGACGGCACGATCCATCGATTCTCCGCCAAGATGGTGGTGC
TGGCGACCGGCGGTTACGGCCGCGCCTATTTCTCGGCGACCTCTGCTCACACCTGCACCGGCGACGGCGGCGGCATGATT
GCCCGTGCCGGCCTGCCGCTTCAGGACATGGAATTCGTACAGTTCCATCCAACCGGCATTTATGGCGCAGGCTGCCTCAT
CACCGAAGGCGCGCGTGGCGAAGGCGGTTACCTCGTCAACTCAGAAGGCGAACGCTTCATGGAGCGTTATGCGCCATCGG
CGAAGGACCTTGCCTCCCGTGACGTTGTCTCCCGCTGCATGACGATGGAAATCCGTGAAGGCCGCGGCGTCGGCAAGAAC
AAGGATCACATCTTCCTGCATCTGGATCACCTCGATCCTGCGATCCTGCATGAGCGGCTTCCGGGCATTTCCGAAAGCGC
CAAGATTTTTGCCGGCGTGGACGTGACGCGCGAGCCCATCCCGGTTCTGCCGACGGTTCACTATAATATGGGCGGTATTC
CGACCAACTATTGGGGTGAAGTGCTGAATGCCGATGCCAATAACCCGGAACGTATCGCGCCCGGTCTGATGGCCGTCGGC
GAAGCCGGTTGCGCCTCGGTTCACGGTGCCAACCGCCTCGGCTCCAACTCGCTGATCGACCTCGTGGTCTTCGGCCGCGC
CGCCGCTATTCGTGCAGCACAGGTCATCGACCGCGATGCGCCCGTTCCTGCGCTCGACATTGCGGCCTGCGACAAGATCA
TGGAGCGCTTCGACAGCCTGCGTTACGCCAATGGCTCGACGCCGACGGCGGTGCTGCGCGACAAGATGCAGCGCGCCATG
CAGGACGATGCGGCCGTTTTCCGCACGCAGGAATCGCTGGAGAGCGGTTGCCAGCGTCTTTCCGCCATCTGGAAGGAGCT
GCCGGACGTCAAGGTCACCGACCGTTCGATGGTCTGGAACTCCGATCTGGTCGAGACGCTCGAGCTACACAATCTGATGG
CCAACGCGATCACCACGGTCTATGGCGCTGAAGCGCGCAAGGAAAGCCGCGGTTCACACGCCCGTGAGGATTTCGTCGAT
GGTCCTTTCGGCGGTCGCGACGACGTGAACTGGCGCAAGCACACGCTCGCCTGGGTCAGCCCCGAAGGGGACGTCAAACT
CGATTATCGCCCGGTTCACACCGACCTGATCGCCGACGGCATCGATCCCAAAAAGATCGAGCCGAAGGCGCGCGTCTACT
GA

Upstream 100 bases:

>100_bases
AAGCTCGTTCTTCTGATGCTCAATACGTTTTTCGCGATTCTGATTGGCGGTCTTTCCATCTTCGCCATTCTGAAAATCGC
ATTCGCAGGATAAGTCCGCC

Downstream 100 bases:

>100_bases
TTTGAGGAACTGGATATGGTTGAACTCGCTCTCCCCAAGAATTCCCAGATCAGCGAAGGCAAGGTCTGGCCGAAGCCTGA
CGGTGCCAAGAATGTGCGCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MASISSPSQNGKAYTYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVAAQGGIAASLTNMTPDCWQW
HLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFSRNAEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAIL
HTLYGQSLRNNAEFFIEYFALDLIMAPDGRCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIREGRGVGKN
KDHIFLHLDHLDPAILHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGIPTNYWGEVLNADANNPERIAPGLMAVG
EAGCASVHGANRLGSNSLIDLVVFGRAAAIRAAQVIDRDAPVPALDIAACDKIMERFDSLRYANGSTPTAVLRDKMQRAM
QDDAAVFRTQESLESGCQRLSAIWKELPDVKVTDRSMVWNSDLVETLELHNLMANAITTVYGAEARKESRGSHAREDFVD
GPFGGRDDVNWRKHTLAWVSPEGDVKLDYRPVHTDLIADGIDPKKIEPKARVY

Sequences:

>Translated_613_residues
MASISSPSQNGKAYTYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVAAQGGIAASLTNMTPDCWQW
HLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFSRNAEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAIL
HTLYGQSLRNNAEFFIEYFALDLIMAPDGRCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIREGRGVGKN
KDHIFLHLDHLDPAILHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGIPTNYWGEVLNADANNPERIAPGLMAVG
EAGCASVHGANRLGSNSLIDLVVFGRAAAIRAAQVIDRDAPVPALDIAACDKIMERFDSLRYANGSTPTAVLRDKMQRAM
QDDAAVFRTQESLESGCQRLSAIWKELPDVKVTDRSMVWNSDLVETLELHNLMANAITTVYGAEARKESRGSHAREDFVD
GPFGGRDDVNWRKHTLAWVSPEGDVKLDYRPVHTDLIADGIDPKKIEPKARVY
>Mature_612_residues
ASISSPSQNGKAYTYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVAAQGGIAASLTNMTPDCWQWH
LYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFSRNAEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAILH
TLYGQSLRNNAEFFIEYFALDLIMAPDGRCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMIA
RAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIREGRGVGKNK
DHIFLHLDHLDPAILHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGIPTNYWGEVLNADANNPERIAPGLMAVGE
AGCASVHGANRLGSNSLIDLVVFGRAAAIRAAQVIDRDAPVPALDIAACDKIMERFDSLRYANGSTPTAVLRDKMQRAMQ
DDAAVFRTQESLESGCQRLSAIWKELPDVKVTDRSMVWNSDLVETLELHNLMANAITTVYGAEARKESRGSHAREDFVDG
PFGGRDDVNWRKHTLAWVSPEGDVKLDYRPVHTDLIADGIDPKKIEPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=613, Percent_Identity=61.3376835236542, Blast_Score=729, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=601, Percent_Identity=50.5823627287854, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1790597, Length=586, Percent_Identity=41.296928327645, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788928, Length=560, Percent_Identity=31.9642857142857, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=613, Percent_Identity=60.8482871125612, Blast_Score=722, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=617, Percent_Identity=58.3468395461912, Blast_Score=698, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=611, Percent_Identity=62.6841243862521, Blast_Score=761, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=610, Percent_Identity=61.9672131147541, Blast_Score=760, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=27.0491803278689, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=64.2384105960265, Blast_Score=768, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=64.2384105960265, Blast_Score=768, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=64.2384105960265, Blast_Score=768, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=616, Percent_Identity=56.6558441558442, Blast_Score=694, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66777; Mature: 66646

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASISSPSQNGKAYTYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTV
CCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEE
AAQGGIAASLTNMTPDCWQWHLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFS
EECCCCEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCC
RNAEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAILHTLYGQSLRNNAEFFIEYFA
CCCCCCEEECCCCCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LDLIMAPDGRCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
HHEEECCCCCEEEEEEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCCCCEE
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRCMTMEIREGRGVGKNKDHIFLHLDHLDPAILHERLPGISESAKIFAGVDVTREPI
HHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCC
PVLPTVHYNMGGIPTNYWGEVLNADANNPERIAPGLMAVGEAGCASVHGANRLGSNSLID
CCCCEEECCCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCCCEEE
LVVFGRAAAIRAAQVIDRDAPVPALDIAACDKIMERFDSLRYANGSTPTAVLRDKMQRAM
EEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHH
QDDAAVFRTQESLESGCQRLSAIWKELPDVKVTDRSMVWNSDLVETLELHNLMANAITTV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHHHHHHHHHHHHH
YGAEARKESRGSHAREDFVDGPFGGRDDVNWRKHTLAWVSPEGDVKLDYRPVHTDLIADG
HCCHHHHHHCCCCCHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHCC
IDPKKIEPKARVY
CCCCCCCCCCCCC
>Mature Secondary Structure 
ASISSPSQNGKAYTYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTV
CCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEE
AAQGGIAASLTNMTPDCWQWHLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFS
EECCCCEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCC
RNAEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAILHTLYGQSLRNNAEFFIEYFA
CCCCCCEEECCCCCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LDLIMAPDGRCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
HHEEECCCCCEEEEEEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCCCCEE
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRCMTMEIREGRGVGKNKDHIFLHLDHLDPAILHERLPGISESAKIFAGVDVTREPI
HHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCC
PVLPTVHYNMGGIPTNYWGEVLNADANNPERIAPGLMAVGEAGCASVHGANRLGSNSLID
CCCCEEECCCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCCCEEE
LVVFGRAAAIRAAQVIDRDAPVPALDIAACDKIMERFDSLRYANGSTPTAVLRDKMQRAM
EEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHH
QDDAAVFRTQESLESGCQRLSAIWKELPDVKVTDRSMVWNSDLVETLELHNLMANAITTV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHHHHHHHHHHHHH
YGAEARKESRGSHAREDFVDGPFGGRDDVNWRKHTLAWVSPEGDVKLDYRPVHTDLIADG
HCCHHHHHHCCCCCHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHCC
IDPKKIEPKARVY
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA