Click here to switch to the map view.

The map label for this gene is lpiA [H]

Identifier: 15889786

GI number: 15889786

Start: 2490048

End: 2492648

Strand: Direct

Name: lpiA [H]

Synonym: Atu2521

Alternate gene names: 15889786

Gene position: 2490048-2492648 (Clockwise)

Preceding gene: 159185252

Following gene: 15889787

Centisome position: 87.63

GC content: 60.36

Gene sequence:

>2601_bases
ATGGCAGACAAGAGCGAAGTTACAGAGACGGATATTATCGAATCCCCGGTTGAAAGCTTTTTTGCCAGAAACCGGCCCTA
TCTGACGGCCATTGCCATCACGCTCATCTTCGTGATGATGACGTTTGCAATTTACCGTCTCACCTCGGAAGTACGATATG
ACGATGTGATCGCCGCTCTTCTTGGTACGTCCTTTTCCGCTGTACTGCTCGCCATCGTCTTTACGGCGCTGAGCTTTCTG
GCGCTGATCTTTTACGATGCGAATGCCATCGAATATGTCGGCAAGAAAGTCCGGTTTCCCTCAATGGCGGCCACCGCCTT
CGCGGCCTATGCCATCGGCAATACGGCCGGCTTCGGTCCGCTGAGCGGCGGCGCCATCCGCTTCCGCGCCTATTCCCGGC
TCGGCCTCTCGCCGGGAGACATCGCCCGCGTCATCGCCTTCGTCACTCTGTCGTTCGGCCTCGGGCTTCTTTCCGTCAGC
GCGCTTTCAACCTTCATCGTCGCGCCGCGCATCGCCGCGATCATCGGTTTTGACCCGCTTGTCCTGAGGGGCGGCGCACT
CGCCGTCATCGCCATTCTCGTGATCACCGCTTATGTCGGCCGTAACGGCAAGGCGATCCGGCTCGGCAAATGGCGGCTGC
GCCTTCCCGACAGCCGCACATCGTCGCGTCAGTTTCTGGTGTCGGCCTTCGATATCGCCGCATCGGCCTCCGTTCTCTAT
GTGTTATTGCCGGAAACCCATCTCGGCTGGCCGACCTTCTTCGCGATCTATGCCACGGCCGTCGGCCTCGGTGTGCTCAG
CCATGTCCCCGCAGGCCTCGGCGTCTTCGAAACCGTCATGGTCGCGGGTCTCGGCAACGCCATCAGCGTCGATCAGCTGC
TTGGCAGCCTCGTTCTTTATCGCGTCATCTACCACGTCCTGCCGCTGGTGGTCGCCATTCTGGTCATGATCGTTTCCGAA
ACGAAGCAGTTCGCGGCCAAGCCGGTGGTGTCGGATATCAGCCAGCTTGCCGTCAGGCTCGCCCCACCGCTGCTCTCCAC
CTTCGCCATCATTCTCGGCACCATGCTGATTTTTTCGAGCGTGACGCCGACGCCTGATAGCAACCTCGATTTCCTCTCGA
ATTTTGTGCCGTTACCGATTATCGAAGCGGCACACTTTCTGACCAGCATTCTCGGCCTCGGCCTCGTTGTCGCTTCCCGC
GGCCTCGGGCAGAGGCTGGACGGCGCCTGGTGGATCGCCCTCATTGCGGCTTCCCTCGCCCTTATCCTTTCCATCCTCAA
GGCCATCGCGGTCTTCGAGGCGGTGTTCCTCGGCATCTTTATCGCGGCACTCGCCCTGAATATGCGCAGCTTCAACCGGC
ACGCCTCCCTGGTCAAACAGGCGCTGGGTCCAAGCTGGCTCGCGGCAATGGCCGTCATCATTGCCGGCGCGGCAACGATC
CTCCTGTTCGTCTATCGTGATACCGATTACAGCCACGCATTGTGGTGGGAATTCGAGTTCTCCGAAGAAGCCCCCCGCGG
GCTGCGCGCCCTGCTCGGTCTGGTGCTTGCTTCCTCGACCATCGCAATTTTCAGCCTGATGCGGCCGGTTACCTTCAAGC
CCGACTCCATTCAGCCTGAGGACGTAGAACGGGCCACCGACATCGTCATGCGACAGGATTCGGCCGACGCCAATCTGGTG
CGCATGGGCGACAAGCATGTGATGTTCTCCGAAAGCGGCAATGCCTTCATCATGTACGGTATCCAGGGCCGCTCGTGGAT
CGCCTTTGCCGACCCCGTCGGCGACGAAGAGGATTTTCCCGACCTCGTCTGGCAATTCGTGGAAGCCGCCCGTGGAGCCG
GCGCCCGCGCCGCTTTCTACCAGATTTCGCCCTTCCTTCTCTCCCATTGTGCCGATGCGGGCCTGCGCGCCTTCAAGCTC
GGCGAACTGGCGTTGGTTGATCTCACCGCATTCGAACTGAAGGGCGGCAAGCTTGCGACCCTTCGCCAGTCGCTGAGCCG
CGGCGCGCGCGACGGCCTCACCTTCGAGGTTGTCGAGCAATCGCAGGTGCCCGATATCATGGATGAGTTGCAGCAGGTCT
CCGATGGCTGGCTTGCGCACCACAATACGCGGGAAAAGCGCTTCTCGCTTGGCGCTTTCGAACCGGACTATATTCTGTCG
CAACCCGTCGCCGTGCTGCGCAAGGATGGAAAAATCACCGCCTTCGCCAATCTGATGGTGACGGAGACGAAAAAGGAAGC
CACCATCGACCTCATGCGCTTTTCGGCGGATGCGCCGCGCGGCTCGATGGATTTCCTCTTCGTCAGCATCATGCAGCATC
TGCGCGAGGCGGGATATGAAAGCTTCAATCTCGGCATGGCGCCCATGTCCGGCATGTCGAAGCGCGATGCCGCGCCGGTC
TGGGACCGTATCGGCAGCACGCTGTTCGAGCACGGCGAACGTTTCTACAACTTCAAGGGACTTCGCGCCTTCAAGGCAAA
GTTCCACCCGAAATGGGAACCCCGTTACCTTGCTGTGCAGAACGGCGCTGACGCCGCTCTGGCACTGATGGATGCGACGG
TTCTGATCAGCGGCGGTGTCAGAGGAGTGATCGGAAAATGA

Upstream 100 bases:

>100_bases
ACGTCATGCATTTCTGCTAAGCAAATTTCCTCAACCGAAACGAATTAGCGACACAATCCTGTGGTTCGCCAACCAACGGT
ACTGGCGCTGGAAAAAGTAA

Downstream 100 bases:

>100_bases
TGAAACGCAATCTGATAGGGGCATTCATTGCCGCTTCGACGCTACTCTCCTCGTCTGTCGCCTTTTCCCAGGATAAGCCG
GCCTATGAAACCGGTATGAT

Product: protein regulated by acid pH

Products: NA

Alternate protein names: Lysylphosphatidylglycerol synthase; LPG synthase; Multiple peptide resistance factor [H]

Number of amino acids: Translated: 866; Mature: 865

Protein sequence:

>866_residues
MADKSEVTETDIIESPVESFFARNRPYLTAIAITLIFVMMTFAIYRLTSEVRYDDVIAALLGTSFSAVLLAIVFTALSFL
ALIFYDANAIEYVGKKVRFPSMAATAFAAYAIGNTAGFGPLSGGAIRFRAYSRLGLSPGDIARVIAFVTLSFGLGLLSVS
ALSTFIVAPRIAAIIGFDPLVLRGGALAVIAILVITAYVGRNGKAIRLGKWRLRLPDSRTSSRQFLVSAFDIAASASVLY
VLLPETHLGWPTFFAIYATAVGLGVLSHVPAGLGVFETVMVAGLGNAISVDQLLGSLVLYRVIYHVLPLVVAILVMIVSE
TKQFAAKPVVSDISQLAVRLAPPLLSTFAIILGTMLIFSSVTPTPDSNLDFLSNFVPLPIIEAAHFLTSILGLGLVVASR
GLGQRLDGAWWIALIAASLALILSILKAIAVFEAVFLGIFIAALALNMRSFNRHASLVKQALGPSWLAAMAVIIAGAATI
LLFVYRDTDYSHALWWEFEFSEEAPRGLRALLGLVLASSTIAIFSLMRPVTFKPDSIQPEDVERATDIVMRQDSADANLV
RMGDKHVMFSESGNAFIMYGIQGRSWIAFADPVGDEEDFPDLVWQFVEAARGAGARAAFYQISPFLLSHCADAGLRAFKL
GELALVDLTAFELKGGKLATLRQSLSRGARDGLTFEVVEQSQVPDIMDELQQVSDGWLAHHNTREKRFSLGAFEPDYILS
QPVAVLRKDGKITAFANLMVTETKKEATIDLMRFSADAPRGSMDFLFVSIMQHLREAGYESFNLGMAPMSGMSKRDAAPV
WDRIGSTLFEHGERFYNFKGLRAFKAKFHPKWEPRYLAVQNGADAALALMDATVLISGGVRGVIGK

Sequences:

>Translated_866_residues
MADKSEVTETDIIESPVESFFARNRPYLTAIAITLIFVMMTFAIYRLTSEVRYDDVIAALLGTSFSAVLLAIVFTALSFL
ALIFYDANAIEYVGKKVRFPSMAATAFAAYAIGNTAGFGPLSGGAIRFRAYSRLGLSPGDIARVIAFVTLSFGLGLLSVS
ALSTFIVAPRIAAIIGFDPLVLRGGALAVIAILVITAYVGRNGKAIRLGKWRLRLPDSRTSSRQFLVSAFDIAASASVLY
VLLPETHLGWPTFFAIYATAVGLGVLSHVPAGLGVFETVMVAGLGNAISVDQLLGSLVLYRVIYHVLPLVVAILVMIVSE
TKQFAAKPVVSDISQLAVRLAPPLLSTFAIILGTMLIFSSVTPTPDSNLDFLSNFVPLPIIEAAHFLTSILGLGLVVASR
GLGQRLDGAWWIALIAASLALILSILKAIAVFEAVFLGIFIAALALNMRSFNRHASLVKQALGPSWLAAMAVIIAGAATI
LLFVYRDTDYSHALWWEFEFSEEAPRGLRALLGLVLASSTIAIFSLMRPVTFKPDSIQPEDVERATDIVMRQDSADANLV
RMGDKHVMFSESGNAFIMYGIQGRSWIAFADPVGDEEDFPDLVWQFVEAARGAGARAAFYQISPFLLSHCADAGLRAFKL
GELALVDLTAFELKGGKLATLRQSLSRGARDGLTFEVVEQSQVPDIMDELQQVSDGWLAHHNTREKRFSLGAFEPDYILS
QPVAVLRKDGKITAFANLMVTETKKEATIDLMRFSADAPRGSMDFLFVSIMQHLREAGYESFNLGMAPMSGMSKRDAAPV
WDRIGSTLFEHGERFYNFKGLRAFKAKFHPKWEPRYLAVQNGADAALALMDATVLISGGVRGVIGK
>Mature_865_residues
ADKSEVTETDIIESPVESFFARNRPYLTAIAITLIFVMMTFAIYRLTSEVRYDDVIAALLGTSFSAVLLAIVFTALSFLA
LIFYDANAIEYVGKKVRFPSMAATAFAAYAIGNTAGFGPLSGGAIRFRAYSRLGLSPGDIARVIAFVTLSFGLGLLSVSA
LSTFIVAPRIAAIIGFDPLVLRGGALAVIAILVITAYVGRNGKAIRLGKWRLRLPDSRTSSRQFLVSAFDIAASASVLYV
LLPETHLGWPTFFAIYATAVGLGVLSHVPAGLGVFETVMVAGLGNAISVDQLLGSLVLYRVIYHVLPLVVAILVMIVSET
KQFAAKPVVSDISQLAVRLAPPLLSTFAIILGTMLIFSSVTPTPDSNLDFLSNFVPLPIIEAAHFLTSILGLGLVVASRG
LGQRLDGAWWIALIAASLALILSILKAIAVFEAVFLGIFIAALALNMRSFNRHASLVKQALGPSWLAAMAVIIAGAATIL
LFVYRDTDYSHALWWEFEFSEEAPRGLRALLGLVLASSTIAIFSLMRPVTFKPDSIQPEDVERATDIVMRQDSADANLVR
MGDKHVMFSESGNAFIMYGIQGRSWIAFADPVGDEEDFPDLVWQFVEAARGAGARAAFYQISPFLLSHCADAGLRAFKLG
ELALVDLTAFELKGGKLATLRQSLSRGARDGLTFEVVEQSQVPDIMDELQQVSDGWLAHHNTREKRFSLGAFEPDYILSQ
PVAVLRKDGKITAFANLMVTETKKEATIDLMRFSADAPRGSMDFLFVSIMQHLREAGYESFNLGMAPMSGMSKRDAAPVW
DRIGSTLFEHGERFYNFKGLRAFKAKFHPKWEPRYLAVQNGADAALALMDATVLISGGVRGVIGK

Specific function: Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes

COG id: COG2898

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LPG synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787006, Length=281, Percent_Identity=25.9786476868327, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR022791 [H]

Pfam domain/function: PF03706 UPF0104 [H]

EC number: =2.3.2.3 [H]

Molecular weight: Translated: 93878; Mature: 93746

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKSEVTETDIIESPVESFFARNRPYLTAIAITLIFVMMTFAIYRLTSEVRYDDVIAAL
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGTSFSAVLLAIVFTALSFLALIFYDANAIEYVGKKVRFPSMAATAFAAYAIGNTAGFGP
HCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
LSGGAIRFRAYSRLGLSPGDIARVIAFVTLSFGLGLLSVSALSTFIVAPRIAAIIGFDPL
CCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VLRGGALAVIAILVITAYVGRNGKAIRLGKWRLRLPDSRTSSRQFLVSAFDIAASASVLY
HHCCCHHHHHHHHHHHHHHCCCCCEEEEECEEEECCCCCCCHHHHHHHHHHHHHCCCEEE
VLLPETHLGWPTFFAIYATAVGLGVLSHVPAGLGVFETVMVAGLGNAISVDQLLGSLVLY
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
RVIYHVLPLVVAILVMIVSETKQFAAKPVVSDISQLAVRLAPPLLSTFAIILGTMLIFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTPTPDSNLDFLSNFVPLPIIEAAHFLTSILGLGLVVASRGLGQRLDGAWWIALIAASLA
CCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LILSILKAIAVFEAVFLGIFIAALALNMRSFNRHASLVKQALGPSWLAAMAVIIAGAATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LLFVYRDTDYSHALWWEFEFSEEAPRGLRALLGLVLASSTIAIFSLMRPVTFKPDSIQPE
EEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
DVERATDIVMRQDSADANLVRMGDKHVMFSESGNAFIMYGIQGRSWIAFADPVGDEEDFP
HHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEEEECCCEEEEEECCCCCCCCCH
DLVWQFVEAARGAGARAAFYQISPFLLSHCADAGLRAFKLGELALVDLTAFELKGGKLAT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHEECCCEEEEEEEEEEECCCCHHH
LRQSLSRGARDGLTFEVVEQSQVPDIMDELQQVSDGWLAHHNTREKRFSLGAFEPDYILS
HHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHCCCCHHHHCCCCCCCCCHHHH
QPVAVLRKDGKITAFANLMVTETKKEATIDLMRFSADAPRGSMDFLFVSIMQHLREAGYE
CCHHHHHCCCCEEEEEHEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
SFNLGMAPMSGMSKRDAAPVWDRIGSTLFEHGERFYNFKGLRAFKAKFHPKWEPRYLAVQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHCCCCCCCCEEEEE
NGADAALALMDATVLISGGVRGVIGK
CCCCHHHHHHHHHHHEECCCCCCCCC
>Mature Secondary Structure 
ADKSEVTETDIIESPVESFFARNRPYLTAIAITLIFVMMTFAIYRLTSEVRYDDVIAAL
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGTSFSAVLLAIVFTALSFLALIFYDANAIEYVGKKVRFPSMAATAFAAYAIGNTAGFGP
HCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
LSGGAIRFRAYSRLGLSPGDIARVIAFVTLSFGLGLLSVSALSTFIVAPRIAAIIGFDPL
CCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VLRGGALAVIAILVITAYVGRNGKAIRLGKWRLRLPDSRTSSRQFLVSAFDIAASASVLY
HHCCCHHHHHHHHHHHHHHCCCCCEEEEECEEEECCCCCCCHHHHHHHHHHHHHCCCEEE
VLLPETHLGWPTFFAIYATAVGLGVLSHVPAGLGVFETVMVAGLGNAISVDQLLGSLVLY
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
RVIYHVLPLVVAILVMIVSETKQFAAKPVVSDISQLAVRLAPPLLSTFAIILGTMLIFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTPTPDSNLDFLSNFVPLPIIEAAHFLTSILGLGLVVASRGLGQRLDGAWWIALIAASLA
CCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LILSILKAIAVFEAVFLGIFIAALALNMRSFNRHASLVKQALGPSWLAAMAVIIAGAATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LLFVYRDTDYSHALWWEFEFSEEAPRGLRALLGLVLASSTIAIFSLMRPVTFKPDSIQPE
EEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
DVERATDIVMRQDSADANLVRMGDKHVMFSESGNAFIMYGIQGRSWIAFADPVGDEEDFP
HHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEEEECCCEEEEEECCCCCCCCCH
DLVWQFVEAARGAGARAAFYQISPFLLSHCADAGLRAFKLGELALVDLTAFELKGGKLAT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHEECCCEEEEEEEEEEECCCCHHH
LRQSLSRGARDGLTFEVVEQSQVPDIMDELQQVSDGWLAHHNTREKRFSLGAFEPDYILS
HHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHCCCCHHHHCCCCCCCCCHHHH
QPVAVLRKDGKITAFANLMVTETKKEATIDLMRFSADAPRGSMDFLFVSIMQHLREAGYE
CCHHHHHCCCCEEEEEHEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
SFNLGMAPMSGMSKRDAAPVWDRIGSTLFEHGERFYNFKGLRAFKAKFHPKWEPRYLAVQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHCCCCCCCCEEEEE
NGADAALALMDATVLISGGVRGVIGK
CCCCHHHHHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11342591; 12496209 [H]