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The map label for this gene is hmuU [H]

Identifier: 15889730

GI number: 15889730

Start: 2428999

End: 2430087

Strand: Reverse

Name: hmuU [H]

Synonym: Atu2459

Alternate gene names: 15889730

Gene position: 2430087-2428999 (Counterclockwise)

Preceding gene: 159185225

Following gene: 15889729

Centisome position: 85.52

GC content: 66.21

Gene sequence:

>1089_bases
GTGAGCCTTGCGGTCTTGAGTTCCACCGGGGGCGGGGTTGCAGGCGACAGGTCCCGTCAGGGGGCCGTCACCCTTGCCGT
GCTAGTCGGCATCCTGCTGTTTGCCTGTGGCGTATCGCTGGTCAGCGGGCCCACCGGTGTCGGCGTTTCCGAACTTTTTG
CCTATCTCAGCGGCGGCGCGGATCAGCTCGATGCGCGCGACAGGGTCATTCTCGAAGCCGTGCGTCTGCCGCGCACGGCG
CTTGGCATGCTGATCGGCGCAGGGCTAGGCGTCTCGGGCGCTATGATGCAGGGCCTGTTCCGCAATCCGCTGGCCGATCC
AGGCATTGTCGGCGTCACCTCGGGGGCAGCACTGTTTGCGGTCGCAGCCATTTCGCTGGGGGAAGGCTCGCTTGCCGCGG
TTGCCGTGTTTTTCGGCCCGCATTTCCTGCCGCTGATGGCGTTTTTCGGCGGGCTGCTGAACACCTGGGTTCTTTATGTA
ATCGCCACCAAGGACGGTGCGACTTCCACCACCACGCTCATTCTGGCCGGTATCGCAGTGGCCGCCATCAGCGGCGCGCT
GACCGGGCTGATGATCTTCGTGGCCGATGACCGGGCGCTGCGCGACATCACCTTCTGGTCGCTCGGTTCGCTGGGTGGGG
CAACGCCGGCCAAGGTGCTCGCGACGCTGCCTTTCATCATCGTCGTGCTTGCCATCATTCCTTTCGTCGCCCGTGGGCTG
GATGCGCTGATCCTTGGGGATGCGGCTGCCTTTCACATGGGCATTCCGGTGCAGCGGCTGAAGCGGGTCGTCATTCTGGC
GGTTGCCGCCGCCTGTGGGGCAAGCGTGGCTGCGGCCGGCTCCATCGGTTTCGTCGGCATCGTCGTGCCGCATCTGCTTC
GCCTCGCCATTGGCCCGTCGCATCGTTTCCTGCTGCCGGCTTCGGCGCTGGGTGGCGCGGCGCTGCTGCTGCTGGCCGAC
AGTTTCGCCCGCACGGTGGCGTCGCCGGCGGAACTGCCGATCGGCGTGGTGACCGCGCTCATCGGCGCGCCGGTCTTCCT
GTTCCTGCTGCTTGGCCGCGGCGGATTTTCCATGCGGAACATGCCATGA

Upstream 100 bases:

>100_bases
TCATCAGCATGGACGGGCTTTATCTCATTGGTTTCGGCCCGCGCACACCGGCCGCCGGCCGCGAACTGGCGCACAAGCTT
TACCCTGACGTGGTGAAGCC

Downstream 100 bases:

>100_bases
TCCGGGCTGAAAACATCACTCTCATCCGCACCGGCCGTCGCCTGCTGGACGATGTCAGCGTCGATCTGAAACCGGGAAAG
GTCAATGTCATCATCGGCCC

Product: ABC transporter, membrane spanning protein (hemin)

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSLAVLSSTGGGVAGDRSRQGAVTLAVLVGILLFACGVSLVSGPTGVGVSELFAYLSGGADQLDARDRVILEAVRLPRTA
LGMLIGAGLGVSGAMMQGLFRNPLADPGIVGVTSGAALFAVAAISLGEGSLAAVAVFFGPHFLPLMAFFGGLLNTWVLYV
IATKDGATSTTTLILAGIAVAAISGALTGLMIFVADDRALRDITFWSLGSLGGATPAKVLATLPFIIVVLAIIPFVARGL
DALILGDAAAFHMGIPVQRLKRVVILAVAAACGASVAAAGSIGFVGIVVPHLLRLAIGPSHRFLLPASALGGAALLLLAD
SFARTVASPAELPIGVVTALIGAPVFLFLLLGRGGFSMRNMP

Sequences:

>Translated_362_residues
MSLAVLSSTGGGVAGDRSRQGAVTLAVLVGILLFACGVSLVSGPTGVGVSELFAYLSGGADQLDARDRVILEAVRLPRTA
LGMLIGAGLGVSGAMMQGLFRNPLADPGIVGVTSGAALFAVAAISLGEGSLAAVAVFFGPHFLPLMAFFGGLLNTWVLYV
IATKDGATSTTTLILAGIAVAAISGALTGLMIFVADDRALRDITFWSLGSLGGATPAKVLATLPFIIVVLAIIPFVARGL
DALILGDAAAFHMGIPVQRLKRVVILAVAAACGASVAAAGSIGFVGIVVPHLLRLAIGPSHRFLLPASALGGAALLLLAD
SFARTVASPAELPIGVVTALIGAPVFLFLLLGRGGFSMRNMP
>Mature_361_residues
SLAVLSSTGGGVAGDRSRQGAVTLAVLVGILLFACGVSLVSGPTGVGVSELFAYLSGGADQLDARDRVILEAVRLPRTAL
GMLIGAGLGVSGAMMQGLFRNPLADPGIVGVTSGAALFAVAAISLGEGSLAAVAVFFGPHFLPLMAFFGGLLNTWVLYVI
ATKDGATSTTTLILAGIAVAAISGALTGLMIFVADDRALRDITFWSLGSLGGATPAKVLATLPFIIVVLAIIPFVARGLD
ALILGDAAAFHMGIPVQRLKRVVILAVAAACGASVAAAGSIGFVGIVVPHLLRLAIGPSHRFLLPASALGGAALLLLADS
FARTVASPAELPIGVVTALIGAPVFLFLLLGRGGFSMRNMP

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=301, Percent_Identity=42.1926910299003, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1790740, Length=328, Percent_Identity=36.890243902439, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1790741, Length=293, Percent_Identity=36.1774744027304, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786805, Length=313, Percent_Identity=36.1022364217252, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1786804, Length=334, Percent_Identity=34.7305389221557, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786347, Length=281, Percent_Identity=32.3843416370107, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36301; Mature: 36169

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAVLSSTGGGVAGDRSRQGAVTLAVLVGILLFACGVSLVSGPTGVGVSELFAYLSGGA
CCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
DQLDARDRVILEAVRLPRTALGMLIGAGLGVSGAMMQGLFRNPLADPGIVGVTSGAALFA
HHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHH
VAAISLGEGSLAAVAVFFGPHFLPLMAFFGGLLNTWVLYVIATKDGATSTTTLILAGIAV
HHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHH
AAISGALTGLMIFVADDRALRDITFWSLGSLGGATPAKVLATLPFIIVVLAIIPFVARGL
HHHHHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DALILGDAAAFHMGIPVQRLKRVVILAVAAACGASVAAAGSIGFVGIVVPHLLRLAIGPS
CEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCC
HRFLLPASALGGAALLLLADSFARTVASPAELPIGVVTALIGAPVFLFLLLGRGGFSMRN
CCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MP
CC
>Mature Secondary Structure 
SLAVLSSTGGGVAGDRSRQGAVTLAVLVGILLFACGVSLVSGPTGVGVSELFAYLSGGA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
DQLDARDRVILEAVRLPRTALGMLIGAGLGVSGAMMQGLFRNPLADPGIVGVTSGAALFA
HHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHH
VAAISLGEGSLAAVAVFFGPHFLPLMAFFGGLLNTWVLYVIATKDGATSTTTLILAGIAV
HHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHH
AAISGALTGLMIFVADDRALRDITFWSLGSLGGATPAKVLATLPFIIVVLAIIPFVARGL
HHHHHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DALILGDAAAFHMGIPVQRLKRVVILAVAAACGASVAAAGSIGFVGIVVPHLLRLAIGPS
CEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCC
HRFLLPASALGGAALLLLADSFARTVASPAELPIGVVTALIGAPVFLFLLLGRGGFSMRN
CCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]