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The map label for this gene is livM [H]

Identifier: 15889683

GI number: 15889683

Start: 2381092

End: 2382270

Strand: Reverse

Name: livM [H]

Synonym: Atu2412

Alternate gene names: 15889683

Gene position: 2382270-2381092 (Counterclockwise)

Preceding gene: 159185205

Following gene: 159185204

Centisome position: 83.84

GC content: 62.6

Gene sequence:

>1179_bases
ATGATTACCGGCTTCCTCCTGCGCGCGCTCGATCGCCGCATTTCCATCGCCATCGGCATCATCCTGGCCATCGCCGTCCT
GGTGCCCGCCTCCAACCTGCTTTTGCCGGAGGGCAGCGCGTTCCGCATCCCGACCTATATCATGTCGATGCTGGGCAAAT
ATCTGGCCTATGCGCTGCTGGCCCTGGCGCTTGACCTGGTCTGGGGTTATTGCGGCATTCTTTCGCTCGGCCACGCCGCC
TTCTTCGCGCTTGGCGGTTATGCCATGGGCATGTATCTGATGCGGCAGATCGGCACGCGCGGCGTGTACGGCCATCCGGT
GCTGCCTGACTTCATGGTGTTCCTCAACTGGAAGGAGTTGCCGTGGTTCTGGCACGGCTTCGACATGTTCTGGTTTGCGG
CGCTGATGGTGCTTGTCGTGCCGGGGCTGCTCGCCTTCGTGTTCGGCTGGTTCGCCTTCCGCTCGCGCGTCAACGGCGTT
TACCTCTCGATCATCACCCAGGCCATGACCTACGCTCTGCTGCTTGCCTTCTTCCGCAACGACATGGGTTTCGGCGGCAA
TAACGGCCTCACCGATTTCAAGGATATCCTCGGCTTTTCCGTGCAGGCGGATGGCACCCGCGCCATGCTGTTTGCAATGA
CGGCCGCGATGCTGGCGCTTTCTCTGCTGATTGCGTCGGGTATCGTCAATTCCAAATTCGGCAAGGTGCTGGTGGGCGTG
CGGGACGCCGAAAGCCGGGTGCGCTTCCTCGGTTTCCGGGTGGAAAACATCAAGCTCTTCACCTTCGTCGTGTCGGCGAT
GATGGCGGGTGTTGCCGGTGCGTTGTTCGTGCCGCAGGTGGGCATCATCAACCCCGGCGAATTTTCTCCCGCCAACTCCA
TCGAGGTGGTGGTATGGACGGCAGTCGGCGGGCGCGGCACGCTGATCGGGCCGATCATCGGCGCGCTGCTGGTGAATGGC
GGCAAGAGCTATTTCACCGGCGCTTTTCCCGAATTCTGGCTGTTTGCGCTGGGTGGGCTGTTCATCGCGGTGACGCTGTT
CTTCCCCAAGGGCATCGTCGGCACAATCCAGCATTATCTGGCCGGGCGGCGCGAGAAGCGTGTCGCGCGGGCAGCGGCGG
CGGCCAAGCAGCCGGGCAACGACAGTGCGGCAACGGCCGCGCAACAGGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
GCGCCGTGCTCGGCAAGATCCTCGTGCTCGTTCTCATCATCCTGTTCATCCAGAAGCGGCCGCGCGGTCTCTTCGCACTC
AAGGGAAGGGCGATCGAAGC

Downstream 100 bases:

>100_bases
GCCCATGAACACGGTTTCCGAAAACAGAACCAAAAGCCTGCTTTATCTCGATGGCGTCTCGGTCTCCTTCGATGGCTTCA
AGGCGCTGAACTCGCTTTCT

Product: ABC transporter, membrane spanning protein (urea/amide)

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MITGFLLRALDRRISIAIGIILAIAVLVPASNLLLPEGSAFRIPTYIMSMLGKYLAYALLALALDLVWGYCGILSLGHAA
FFALGGYAMGMYLMRQIGTRGVYGHPVLPDFMVFLNWKELPWFWHGFDMFWFAALMVLVVPGLLAFVFGWFAFRSRVNGV
YLSIITQAMTYALLLAFFRNDMGFGGNNGLTDFKDILGFSVQADGTRAMLFAMTAAMLALSLLIASGIVNSKFGKVLVGV
RDAESRVRFLGFRVENIKLFTFVVSAMMAGVAGALFVPQVGIINPGEFSPANSIEVVVWTAVGGRGTLIGPIIGALLVNG
GKSYFTGAFPEFWLFALGGLFIAVTLFFPKGIVGTIQHYLAGRREKRVARAAAAAKQPGNDSAATAAQQAAE

Sequences:

>Translated_392_residues
MITGFLLRALDRRISIAIGIILAIAVLVPASNLLLPEGSAFRIPTYIMSMLGKYLAYALLALALDLVWGYCGILSLGHAA
FFALGGYAMGMYLMRQIGTRGVYGHPVLPDFMVFLNWKELPWFWHGFDMFWFAALMVLVVPGLLAFVFGWFAFRSRVNGV
YLSIITQAMTYALLLAFFRNDMGFGGNNGLTDFKDILGFSVQADGTRAMLFAMTAAMLALSLLIASGIVNSKFGKVLVGV
RDAESRVRFLGFRVENIKLFTFVVSAMMAGVAGALFVPQVGIINPGEFSPANSIEVVVWTAVGGRGTLIGPIIGALLVNG
GKSYFTGAFPEFWLFALGGLFIAVTLFFPKGIVGTIQHYLAGRREKRVARAAAAAKQPGNDSAATAAQQAAE
>Mature_392_residues
MITGFLLRALDRRISIAIGIILAIAVLVPASNLLLPEGSAFRIPTYIMSMLGKYLAYALLALALDLVWGYCGILSLGHAA
FFALGGYAMGMYLMRQIGTRGVYGHPVLPDFMVFLNWKELPWFWHGFDMFWFAALMVLVVPGLLAFVFGWFAFRSRVNGV
YLSIITQAMTYALLLAFFRNDMGFGGNNGLTDFKDILGFSVQADGTRAMLFAMTAAMLALSLLIASGIVNSKFGKVLVGV
RDAESRVRFLGFRVENIKLFTFVVSAMMAGVAGALFVPQVGIINPGEFSPANSIEVVVWTAVGGRGTLIGPIIGALLVNG
GKSYFTGAFPEFWLFALGGLFIAVTLFFPKGIVGTIQHYLAGRREKRVARAAAAAKQPGNDSAATAAQQAAE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=347, Percent_Identity=24.4956772334294, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 42294; Mature: 42294

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]