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The map label for this gene is adk

Identifier: 15889221

GI number: 15889221

Start: 1903630

End: 1904220

Strand: Reverse

Name: adk

Synonym: Atu1926

Alternate gene names: 15889221

Gene position: 1904220-1903630 (Counterclockwise)

Preceding gene: 159184982

Following gene: 159184981

Centisome position: 67.01

GC content: 59.05

Gene sequence:

>591_bases
ATGAGACTGATATTTTTGGGTCCGCCGGGTGCGGGCAAGGGAACCCAGGCCAAGCGGCTGACTGACAAGTACGGGATCCC
GCAGCTTTCCACCGGTGACATGCTTCGCGCTGCGGTCAGCGCGGGCACCGAAATCGGCAAGCGCGCCAAAGCCGTCATGG
ACGCCGGCGGGCTCGTTTCCGACGATATCGTCAATCAGATCGTTTCCGAACGCATCGAAGCACCGGACTGTGCCAAGGGC
TTTATTCTCGACGGCTATCCGCGCACCGTTCCGCAGGCCAAGGCGCTTGCGGACAATATGCGCAAGAAGAATCAGGTCCT
GGATGCCGTCATCGAACTGAAGGTGGATGAAGAGGCGTTGATTCGCCGAATCGAAAACCGCGTAGCTGAAACCATTGCCG
CTGGCGGCACGGTTCGCTCGGATGACAATCCGGAAGCTTTCCGCAAGCGTCTGACAGAATATCGCGAAAAGACCGCGCCG
CTGTCTGCCTATTACAGCGAACAGGGCGAGCTGGTGACGCTTGATGGCATGGCTGATGTCGATGCCGTCACTGAGGCCAT
TGAGCGCGTTCTCGAGAAAGCCTCTGCCTGA

Upstream 100 bases:

>100_bases
TAACTCTGGATACGGTTGCGCAGATTCAGGGTCACCTGATCGCCCAGCAATATGAAGGTCTGATCAAGAAGTCGAAGTTG
CGTGGAGGAAAGAGGGGACG

Downstream 100 bases:

>100_bases
TCGACGGAGCGGATGGGCAGGCGCTGTTGCGTTCTTGCCCATATCGCGCTTCCGCATGACGGCTGATCCTCTGGATCGCA
AAAGAATCTTGGCGGAGCCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MRLIFLGPPGAGKGTQAKRLTDKYGIPQLSTGDMLRAAVSAGTEIGKRAKAVMDAGGLVSDDIVNQIVSERIEAPDCAKG
FILDGYPRTVPQAKALADNMRKKNQVLDAVIELKVDEEALIRRIENRVAETIAAGGTVRSDDNPEAFRKRLTEYREKTAP
LSAYYSEQGELVTLDGMADVDAVTEAIERVLEKASA

Sequences:

>Translated_196_residues
MRLIFLGPPGAGKGTQAKRLTDKYGIPQLSTGDMLRAAVSAGTEIGKRAKAVMDAGGLVSDDIVNQIVSERIEAPDCAKG
FILDGYPRTVPQAKALADNMRKKNQVLDAVIELKVDEEALIRRIENRVAETIAAGGTVRSDDNPEAFRKRLTEYREKTAP
LSAYYSEQGELVTLDGMADVDAVTEAIERVLEKASA
>Mature_196_residues
MRLIFLGPPGAGKGTQAKRLTDKYGIPQLSTGDMLRAAVSAGTEIGKRAKAVMDAGGLVSDDIVNQIVSERIEAPDCAKG
FILDGYPRTVPQAKALADNMRKKNQVLDAVIELKVDEEALIRRIENRVAETIAAGGTVRSDDNPEAFRKRLTEYREKTAP
LSAYYSEQGELVTLDGMADVDAVTEAIERVLEKASA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=217, Percent_Identity=41.0138248847926, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI4502013, Length=217, Percent_Identity=41.0138248847926, Blast_Score=167, Evalue=4e-42,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=34.1708542713568, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=34.7368421052632, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=29.9492385786802, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=29.9492385786802, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=29.9492385786802, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=29.9492385786802, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI28144897, Length=176, Percent_Identity=30.6818181818182, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144899, Length=172, Percent_Identity=31.3953488372093, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706497, Length=202, Percent_Identity=28.2178217821782, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22749187, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI1786680, Length=219, Percent_Identity=44.7488584474886, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17552384, Length=217, Percent_Identity=40.5529953917051, Blast_Score=169, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17567503, Length=196, Percent_Identity=34.6938775510204, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=200, Percent_Identity=29.5, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=195, Percent_Identity=29.2307692307692, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17537943, Length=218, Percent_Identity=28.8990825688073, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25147457, Length=195, Percent_Identity=25.6410256410256, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=198, Percent_Identity=41.9191919191919, Blast_Score=157, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=34.3434343434343, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322828, Length=176, Percent_Identity=30.1136363636364, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=41.0377358490566, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24663208, Length=196, Percent_Identity=34.6938775510204, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17647141, Length=196, Percent_Identity=34.6938775510204, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=34.1708542713568, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=34.1708542713568, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI221459597, Length=192, Percent_Identity=26.5625, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21356893, Length=192, Percent_Identity=26.5625, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_AGRT5 (Q8UE38)

Other databases:

- EMBL:   AE007869
- PIR:   AD2813
- PIR:   F97591
- RefSeq:   NP_354902.1
- ProteinModelPortal:   Q8UE38
- SMR:   Q8UE38
- STRING:   Q8UE38
- GeneID:   1133964
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1926
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   ATUM176299-1:ATU1926-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21177; Mature: 21177

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIFLGPPGAGKGTQAKRLTDKYGIPQLSTGDMLRAAVSAGTEIGKRAKAVMDAGGLVS
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDIVNQIVSERIEAPDCAKGFILDGYPRTVPQAKALADNMRKKNQVLDAVIELKVDEEAL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IRRIENRVAETIAAGGTVRSDDNPEAFRKRLTEYREKTAPLSAYYSEQGELVTLDGMADV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCH
DAVTEAIERVLEKASA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLIFLGPPGAGKGTQAKRLTDKYGIPQLSTGDMLRAAVSAGTEIGKRAKAVMDAGGLVS
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDIVNQIVSERIEAPDCAKGFILDGYPRTVPQAKALADNMRKKNQVLDAVIELKVDEEAL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IRRIENRVAETIAAGGTVRSDDNPEAFRKRLTEYREKTAPLSAYYSEQGELVTLDGMADV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCH
DAVTEAIERVLEKASA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194