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The map label for this gene is moeA [H]

Identifier: 15888995

GI number: 15888995

Start: 1673988

End: 1675205

Strand: Direct

Name: moeA [H]

Synonym: Atu1690

Alternate gene names: 15888995

Gene position: 1673988-1675205 (Clockwise)

Preceding gene: 15888994

Following gene: 159184874

Centisome position: 58.91

GC content: 65.76

Gene sequence:

>1218_bases
ATGAACCCGTTGCTGCCCGTGGACGAGGCCATTAAACGCCTTCTGGAAGCTGCAGTTCCGGTCACGGACAGCGAAACCCT
GCCGCTTGCCGAATGTGATGGCCGCGTTCTCGCGACCGATCTGGCGGCCCGCCTTACCCAGCCTCCCTTCGATGCCTCAG
CCATGGATGGTTATGCGCTGCGTAGCGCCGACGCGGCGGAGATCGGCTCGGTCCTCACCCTCATCGGTCAGGCGGCTGCC
GGCCATGCTTTCGCGGGCACGGTGGGCAAAGGCGAAGCCGTACGCATCTTCACCGGCGCACCCGTGCCTGATGGCGCCGA
TACGATCCTCATTCAGGAAGACGCCGAACTGCTGGACGACGGAAAAATCCGCACCACCTTCGCTGTCACCGCCGGGCGAC
ACATCCGTCCGCGCGGGCAGGATTTCACTGAAGGCGAAACGGCTCTGGAAGCCGGCCGGGAACTCGGCTTCACCGACCTG
ACGCTGGCGGCGGCGATGAACCACGCGGCACTCTCCGTCTATCGCAGGCCACGCATCGCCATTCTCGCCACCGGTGACGA
ATTGCTGCCGCCGGGGAGCGCGCCTGAACCCGCGCAGATCATCGCCTCCAACACATTTGGCGTTGCTGCACTGGCCCGGC
AGGCAGGCGCTGAGGTTATCGATCTCGGTATCATCGCCGATGATGACAGCCTTATCCGCGCCGCCATCCGCAGGGCCGTT
GCGGCCGGGGTGGACGTGTTGGTGACGCTTGGCGGCGCCTCGGTCGGCGACCATGATCTCGTGCAGGCGGCCCTGAAGGC
GGAAGGCATGCAGCTCGATTTCTGGCGCATCGCCATGCGTCCGGGAAAACCGCTGATGGTCGGCGCGATCGGCAGCACGC
AGGTTCTCGGCCTGCCCGGAAACCCGGTCGCAAGCCTCGTCTGCGGCCTGCTCTTCCTGGAGCCGCTGATCCGCAGGATC
GCCCGTCGTGCGCCGCTGCAGCGCAGCACGTCGGCCCGCACCGCGACGCCGCTGAAAGCCAATGACCAGCGGCAGGACTA
TCTGCGCGCCCGTTTCAGCGCGGACGAAAACGGTGCGCTGGTGGCGGAAGCCTATGCGAAGCAGGATTCATCCATGATGA
AGATATTGGCCCATTCTGATGGCCTGATCGTGCGCCCGCCACACGCGCCGGAGGCAGCGCCCGGGGCGATATGCCCGGTT
ATAAGGCTGAAGCCCTGA

Upstream 100 bases:

>100_bases
CATGGCCAAAGCCGCCGACAAAGGCATGGAAATCGTCAATATCCGTCTTCTCGAAAAGAGCGGCGGCAAATCCGGTGATT
TCCGCCGCCAGGAGAGCTGA

Downstream 100 bases:

>100_bases
CAGGCTGCGGGCCGGATTTCGGCCCGCAATGAGCAGGCCCTTTCCCAATCTTGCCGATTGGTCGCCTCGCCTTCACAAAA
TGGTGCCAGCGCCAGCCGCG

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MNPLLPVDEAIKRLLEAAVPVTDSETLPLAECDGRVLATDLAARLTQPPFDASAMDGYALRSADAAEIGSVLTLIGQAAA
GHAFAGTVGKGEAVRIFTGAPVPDGADTILIQEDAELLDDGKIRTTFAVTAGRHIRPRGQDFTEGETALEAGRELGFTDL
TLAAAMNHAALSVYRRPRIAILATGDELLPPGSAPEPAQIIASNTFGVAALARQAGAEVIDLGIIADDDSLIRAAIRRAV
AAGVDVLVTLGGASVGDHDLVQAALKAEGMQLDFWRIAMRPGKPLMVGAIGSTQVLGLPGNPVASLVCGLLFLEPLIRRI
ARRAPLQRSTSARTATPLKANDQRQDYLRARFSADENGALVAEAYAKQDSSMMKILAHSDGLIVRPPHAPEAAPGAICPV
IRLKP

Sequences:

>Translated_405_residues
MNPLLPVDEAIKRLLEAAVPVTDSETLPLAECDGRVLATDLAARLTQPPFDASAMDGYALRSADAAEIGSVLTLIGQAAA
GHAFAGTVGKGEAVRIFTGAPVPDGADTILIQEDAELLDDGKIRTTFAVTAGRHIRPRGQDFTEGETALEAGRELGFTDL
TLAAAMNHAALSVYRRPRIAILATGDELLPPGSAPEPAQIIASNTFGVAALARQAGAEVIDLGIIADDDSLIRAAIRRAV
AAGVDVLVTLGGASVGDHDLVQAALKAEGMQLDFWRIAMRPGKPLMVGAIGSTQVLGLPGNPVASLVCGLLFLEPLIRRI
ARRAPLQRSTSARTATPLKANDQRQDYLRARFSADENGALVAEAYAKQDSSMMKILAHSDGLIVRPPHAPEAAPGAICPV
IRLKP
>Mature_405_residues
MNPLLPVDEAIKRLLEAAVPVTDSETLPLAECDGRVLATDLAARLTQPPFDASAMDGYALRSADAAEIGSVLTLIGQAAA
GHAFAGTVGKGEAVRIFTGAPVPDGADTILIQEDAELLDDGKIRTTFAVTAGRHIRPRGQDFTEGETALEAGRELGFTDL
TLAAAMNHAALSVYRRPRIAILATGDELLPPGSAPEPAQIIASNTFGVAALARQAGAEVIDLGIIADDDSLIRAAIRRAV
AAGVDVLVTLGGASVGDHDLVQAALKAEGMQLDFWRIAMRPGKPLMVGAIGSTQVLGLPGNPVASLVCGLLFLEPLIRRI
ARRAPLQRSTSARTATPLKANDQRQDYLRARFSADENGALVAEAYAKQDSSMMKILAHSDGLIVRPPHAPEAAPGAICPV
IRLKP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=399, Percent_Identity=32.8320802005013, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI66932975, Length=399, Percent_Identity=32.8320802005013, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=36.8146214099217, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25147659, Length=355, Percent_Identity=31.2676056338028, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=360, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17136978, Length=409, Percent_Identity=28.1173594132029, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24638841, Length=409, Percent_Identity=28.1173594132029, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42317; Mature: 42317

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLLPVDEAIKRLLEAAVPVTDSETLPLAECDGRVLATDLAARLTQPPFDASAMDGYAL
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEHHHHHHHHCCCCCCCCCCCCCCC
RSADAAEIGSVLTLIGQAAAGHAFAGTVGKGEAVRIFTGAPVPDGADTILIQEDAELLDD
CCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCCCCCEEEEECCHHHHCC
GKIRTTFAVTAGRHIRPRGQDFTEGETALEAGRELGFTDLTLAAAMNHAALSVYRRPRIA
CCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEE
ILATGDELLPPGSAPEPAQIIASNTFGVAALARQAGAEVIDLGIIADDDSLIRAAIRRAV
EEECCCCCCCCCCCCCCHHEEECCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHH
AAGVDVLVTLGGASVGDHDLVQAALKAEGMQLDFWRIAMRPGKPLMVGAIGSTQVLGLPG
HCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCEEEECCC
NPVASLVCGLLFLEPLIRRIARRAPLQRSTSARTATPLKANDQRQDYLRARFSADENGAL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCE
VAEAYAKQDSSMMKILAHSDGLIVRPPHAPEAAPGAICPVIRLKP
EEHHHHHCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MNPLLPVDEAIKRLLEAAVPVTDSETLPLAECDGRVLATDLAARLTQPPFDASAMDGYAL
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEHHHHHHHHCCCCCCCCCCCCCCC
RSADAAEIGSVLTLIGQAAAGHAFAGTVGKGEAVRIFTGAPVPDGADTILIQEDAELLDD
CCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCCCCCEEEEECCHHHHCC
GKIRTTFAVTAGRHIRPRGQDFTEGETALEAGRELGFTDLTLAAAMNHAALSVYRRPRIA
CCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEE
ILATGDELLPPGSAPEPAQIIASNTFGVAALARQAGAEVIDLGIIADDDSLIRAAIRRAV
EEECCCCCCCCCCCCCCHHEEECCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHH
AAGVDVLVTLGGASVGDHDLVQAALKAEGMQLDFWRIAMRPGKPLMVGAIGSTQVLGLPG
HCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCEEEECCC
NPVASLVCGLLFLEPLIRRIARRAPLQRSTSARTATPLKANDQRQDYLRARFSADENGAL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCE
VAEAYAKQDSSMMKILAHSDGLIVRPPHAPEAAPGAICPVIRLKP
EEHHHHHCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]