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The map label for this gene is adhC [H]

Identifier: 15888975

GI number: 15888975

Start: 1655875

End: 1657002

Strand: Direct

Name: adhC [H]

Synonym: Atu1670

Alternate gene names: 15888975

Gene position: 1655875-1657002 (Clockwise)

Preceding gene: 159184867

Following gene: 15888976

Centisome position: 58.27

GC content: 61.79

Gene sequence:

>1128_bases
ATGGACGTTCGCGCCGCCGTTGCCATTCAGGCAGGAAAACCGCTCGAGGTCATGACCGTTCAGCTTGAAGGTCCCCGCGC
CGGTGAAGTGCTGATCGAAGTCAAGGCGACCGGCATCTGCCACACCGACGATTTCACCCTCTCTGGCGCTGACCCGGAAG
GCCTGTTCCCGGCAATCCTCGGCCATGAAGGTGCGGGCATCGTCGTGGATGTCGGCCCCGGCGTCACCTCGGTCAAGAAG
GGCGACCACGTCATTCCGCTCTACACGCCGGAATGCCGCGAATGCTACTCCTGCACCTCGCGCAAGACCAATCTCTGCAC
CTCCATCCGCGCCACCCAGGGCCAGGGCGTGATGCCTGACGGCACCTCGCGCTTCTCGATCGGCAAGGACAAGATTCACC
ACTATATGGGTTGCTCGACCTTCTCGAATTTCACCGTCCTGCCGGAAATCGCGCTGGCCAAGATCAACCCGGACGCGCCC
TTCGACAAGGTCTGCTACATCGGCTGCGGCGTCACGACCGGTATCGGCGCCGTCATCAACACCGCCAAGGTCGAGATTGG
CTCCACGGCGATCGTCTTCGGTCTCGGCGGCATCGGTCTCAACGTGCTGCAGGGCCTGCGTCTTGCCGGTGCGGACATGA
TCATCGGCGTCGATATCAACAACGACCGCAAGGCCTGGGGCGAAAAATTCGGCATGACCCACTTCGTCAATCCGAAGGAA
GTCGGCGACGACATCGTGCCCTATCTCGTCAACATGACGAAGCGTAATGGCGACCTCATCGGCGGCGCAGACTATACGTT
CGACTGCACCGGCAATACCAAGGTCATGCGCCAGGCGCTGGAAGCCTCGCATCGCGGTTGGGGCAAGTCGGTCATCATCG
GCGTCGCCGGCGCCGGCCAGGAAATCTCCACCCGTCCGTTCCAGCTGGTCACCGGCCGTAACTGGATGGGCACCGCCTTC
GGCGGCGCGCGCGGCCGCACCGATGTGCCGAAGATTGTCGACTGGTACATGGAAGGCAAGATCCAGATCGACCCGATGAT
CACCCACACCATGCCGCTCGAAGACATCAACAAGGGCTTCGAGCTGATGCACAAGGGTGAATCGATCCGCGGCGTCGTTG
TTTATTGA

Upstream 100 bases:

>100_bases
CCCTTTTTCCATTCCGGGTCACCGGATTTTGCCTTGCCCGGCCAGCCGCGCTCGGGCAAAACCTTTTTACTTTGATATTA
AAAGACTGAGGAGATCGAAT

Downstream 100 bases:

>100_bases
TTCCAGACGAAGGTGGGCGCGCCTGACGGTGCGCCCGCCATTCATGCAAATGTGATCGCCGCCGGCCTCCTGCAGCCATG
GCGATTAACGGCACGGTAAA

Product: alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MDVRAAVAIQAGKPLEVMTVQLEGPRAGEVLIEVKATGICHTDDFTLSGADPEGLFPAILGHEGAGIVVDVGPGVTSVKK
GDHVIPLYTPECRECYSCTSRKTNLCTSIRATQGQGVMPDGTSRFSIGKDKIHHYMGCSTFSNFTVLPEIALAKINPDAP
FDKVCYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINNDRKAWGEKFGMTHFVNPKE
VGDDIVPYLVNMTKRNGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQEISTRPFQLVTGRNWMGTAF
GGARGRTDVPKIVDWYMEGKIQIDPMITHTMPLEDINKGFELMHKGESIRGVVVY

Sequences:

>Translated_375_residues
MDVRAAVAIQAGKPLEVMTVQLEGPRAGEVLIEVKATGICHTDDFTLSGADPEGLFPAILGHEGAGIVVDVGPGVTSVKK
GDHVIPLYTPECRECYSCTSRKTNLCTSIRATQGQGVMPDGTSRFSIGKDKIHHYMGCSTFSNFTVLPEIALAKINPDAP
FDKVCYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINNDRKAWGEKFGMTHFVNPKE
VGDDIVPYLVNMTKRNGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQEISTRPFQLVTGRNWMGTAF
GGARGRTDVPKIVDWYMEGKIQIDPMITHTMPLEDINKGFELMHKGESIRGVVVY
>Mature_375_residues
MDVRAAVAIQAGKPLEVMTVQLEGPRAGEVLIEVKATGICHTDDFTLSGADPEGLFPAILGHEGAGIVVDVGPGVTSVKK
GDHVIPLYTPECRECYSCTSRKTNLCTSIRATQGQGVMPDGTSRFSIGKDKIHHYMGCSTFSNFTVLPEIALAKINPDAP
FDKVCYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINNDRKAWGEKFGMTHFVNPKE
VGDDIVPYLVNMTKRNGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQEISTRPFQLVTGRNWMGTAF
GGARGRTDVPKIVDWYMEGKIQIDPMITHTMPLEDINKGFELMHKGESIRGVVVY

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=57.6407506702413, Blast_Score=430, Evalue=1e-121,
Organism=Homo sapiens, GI71565152, Length=380, Percent_Identity=43.421052631579, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI34577061, Length=375, Percent_Identity=44.5333333333333, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI4501929, Length=375, Percent_Identity=44.2666666666667, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI71743840, Length=375, Percent_Identity=42.6666666666667, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI262073058, Length=375, Percent_Identity=42.6666666666667, Blast_Score=317, Evalue=8e-87,
Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=43.4666666666667, Blast_Score=314, Evalue=8e-86,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=42.0485175202156, Blast_Score=305, Evalue=3e-83,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=42.3076923076923, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=58.9333333333333, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1787863, Length=365, Percent_Identity=23.2876712328767, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788073, Length=378, Percent_Identity=26.984126984127, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082125, Length=388, Percent_Identity=25.2577319587629, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510992, Length=369, Percent_Identity=25.7452574525745, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790045, Length=353, Percent_Identity=26.0623229461756, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=24.2819843342037, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=373, Percent_Identity=26.0053619302949, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=53.0343007915567, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71997431, Length=381, Percent_Identity=52.755905511811, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=53.935860058309, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562584, Length=373, Percent_Identity=25.7372654155496, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=374, Percent_Identity=24.8663101604278, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=382, Percent_Identity=24.869109947644, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=55.7640750670241, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=27.2980501392758, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=27.2980501392758, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=377, Percent_Identity=28.1167108753316, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=375, Percent_Identity=25.3333333333333, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=379, Percent_Identity=26.6490765171504, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=280, Percent_Identity=27.8571428571429, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=367, Percent_Identity=25.6130790190736, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=364, Percent_Identity=25.2747252747253, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=372, Percent_Identity=25.5376344086022, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=374, Percent_Identity=58.5561497326203, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 40062; Mature: 40062

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRAAVAIQAGKPLEVMTVQLEGPRAGEVLIEVKATGICHTDDFTLSGADPEGLFPAIL
CCCEEEEEEECCCCEEEEEEEECCCCCCEEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGIVVDVGPGVTSVKKGDHVIPLYTPECRECYSCTSRKTNLCTSIRATQGQGVMPD
CCCCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCHHEEEEEECCCCCCCCC
GTSRFSIGKDKIHHYMGCSTFSNFTVLPEIALAKINPDAPFDKVCYIGCGVTTGIGAVIN
CCCEEECCHHHHHHHHCCCCCCCCEECCCEEEEEECCCCCCCCEEEEECCHHHHHHHHEE
TAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINNDRKAWGEKFGMTHFVNPKE
EEEEEECCEEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCEECCCHHH
VGDDIVPYLVNMTKRNGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQ
HCCHHHHHHHHHHCCCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
EISTRPFQLVTGRNWMGTAFGGARGRTDVPKIVDWYMEGKIQIDPMITHTMPLEDINKGF
CCCCCCEEEEECCCEEEECCCCCCCCCCCHHHHHHHHCCEEEECCEEEECCCHHHHHHHH
ELMHKGESIRGVVVY
HHHHCCCCCEEEEEC
>Mature Secondary Structure
MDVRAAVAIQAGKPLEVMTVQLEGPRAGEVLIEVKATGICHTDDFTLSGADPEGLFPAIL
CCCEEEEEEECCCCEEEEEEEECCCCCCEEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGIVVDVGPGVTSVKKGDHVIPLYTPECRECYSCTSRKTNLCTSIRATQGQGVMPD
CCCCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCHHEEEEEECCCCCCCCC
GTSRFSIGKDKIHHYMGCSTFSNFTVLPEIALAKINPDAPFDKVCYIGCGVTTGIGAVIN
CCCEEECCHHHHHHHHCCCCCCCCEECCCEEEEEECCCCCCCCEEEEECCHHHHHHHHEE
TAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINNDRKAWGEKFGMTHFVNPKE
EEEEEECCEEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCEECCCHHH
VGDDIVPYLVNMTKRNGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQ
HCCHHHHHHHHHHCCCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
EISTRPFQLVTGRNWMGTAFGGARGRTDVPKIVDWYMEGKIQIDPMITHTMPLEDINKGF
CCCCCCEEEEECCCEEEECCCCCCCCCCCHHHHHHHHCCEEEECCEEEECCCHHHHHHHH
ELMHKGESIRGVVVY
HHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]