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The map label for this gene is gntZ [H]

Identifier: 15888851

GI number: 15888851

Start: 1517611

End: 1519041

Strand: Reverse

Name: gntZ [H]

Synonym: Atu1526

Alternate gene names: 15888851

Gene position: 1519041-1517611 (Counterclockwise)

Preceding gene: 159184801

Following gene: 159184798

Centisome position: 53.46

GC content: 59.19

Gene sequence:

>1431_bases
GTGGAACAGGCAGAAATCGGTTTGATCGGTCTCGGCGTCATGGGCTCGAACCTGGCGTTGAACATCGCAGAAAAGGGCAA
CAAGATTGCCGTATTCAACCGAACCCCGGAAGTTACACGAAAATTCTACGCTGATGCGGGCGAACTGCAGGGTCAGATCA
TTCCCTGCGAAACCATCGAGGAATTCGTCGCCGCCATTCGTCCTCCGCGCCCGATCATCATCATGATCAAGGCAGGCGAT
CCGGTCGACCAGCAGATGGAAATCCTGAAACCGCATCTGGCCAACGGCGACATCATGATCGATGCCGGCAATGCCAACTT
CCGCGATACGATCCGCCGTTTCGATAACCTCAAGGATAGCGGCCTGACCTTTATCGGCATGGGCGTTTCCGGCGGTGAAG
AAGGTGCGCGCCATGGACCGTCGATCATGGTTGGCGGCACCGAGGATAGCTGGAAGCGCGTCGAAAAGGTTCTGACCTCC
ATTTCCGCCAAGTATAATGACGATCCGTGCGTGGCATGGCTCGGCAATGACGGTGCTGGTCATTTCGTCAAGACCATCCA
TAACGGCATCGAATATGCCGACATGCAGATGATTGCCGAAATCTACGGCATCCTGCGTGATGGCCTGAAAATGAGCGCCG
TCGAGATCGCCGACGTGTTTGCCGAATGGAACAAGGGCCGCCTGAATTCCTACCTGATCGAAATCACCGAGAAGGTTCTG
CGCGCTGCCGATCCGATCACCGGCAAGCCGATGGTCGATCTGATCCTCGACAAGGCCGGCCAGAAGGGCACAGGCAAGTG
GTCGGTCATCGAAGCCCAGAACATGGGCGTCGCTGCAACCGCCATCGAGGCGGCCGTGGCTGCCCGTATCCTGTCGTCGC
AGAAGGATGAGCGTGAAGCTGCCGAGAAGATCTTCGGCCTGCCGACCCTCGCAGCGGCCCCCGCCGACAAAAAGGCCTTC
ATCGCCGATCTGGAAAGCGCGCTTCTGGCCGCCAAGGTCGGTGCTTACGCCCAGGGCTTCGCCATCATGTCGGCTGCTTC
GAAGGAGTTCAACTGGAACCTGCCGATGCCGACGATTGCCCGCATCTGGCGCGCCGGCTGCATCATCCGCTCGGAATTCC
TTGATGAGATCACCTCGGCCTTTACCAAGGATCCGCATGTGGCCAACCTCATCGTGACGCCGGCCTTCTCCGCCATCGTC
AAGGATACCGACGCGCCGCTGCGCCGTGTGGTGTCTTACGCCGTGCTCTCCGGTCTGCCGGTTTCGGCGCTTGCTTCGGC
GCTCGGTTATTTCGACGCCTATCGCCGTGGTCGCGGCAGCGCCAACCTCATTCAGGCACAGCGCGATTTCTTCGGTGCAC
ATGGTTTTGAACGCACCGATGGTGTGGACAAGCCGCACGGCCCATGGGGTAGCGGCGCCGATATTTTTTGA

Upstream 100 bases:

>100_bases
GCGTCATCAAAATTTAATCGTTTCAGTCGCCCCTAGCCTTGCCGTTTGCCTATTACAGTGCCACAACACGACCACCTAAA
AGCAAGATGGAGGCACATCC

Downstream 100 bases:

>100_bases
TCGGCTGAAACGACAAACAAAAGGCCCGCGCAAGCGGGCCTTTTTCATTTCGGTTTATGGTTCAACTCAGCGGGCGGCGG
CGAGGCCGACGATCAGGCCG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MEQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTPEVTRKFYADAGELQGQIIPCETIEEFVAAIRPPRPIIIMIKAGD
PVDQQMEILKPHLANGDIMIDAGNANFRDTIRRFDNLKDSGLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTS
ISAKYNDDPCVAWLGNDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAVEIADVFAEWNKGRLNSYLIEITEKVL
RAADPITGKPMVDLILDKAGQKGTGKWSVIEAQNMGVAATAIEAAVAARILSSQKDEREAAEKIFGLPTLAAAPADKKAF
IADLESALLAAKVGAYAQGFAIMSAASKEFNWNLPMPTIARIWRAGCIIRSEFLDEITSAFTKDPHVANLIVTPAFSAIV
KDTDAPLRRVVSYAVLSGLPVSALASALGYFDAYRRGRGSANLIQAQRDFFGAHGFERTDGVDKPHGPWGSGADIF

Sequences:

>Translated_476_residues
MEQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTPEVTRKFYADAGELQGQIIPCETIEEFVAAIRPPRPIIIMIKAGD
PVDQQMEILKPHLANGDIMIDAGNANFRDTIRRFDNLKDSGLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTS
ISAKYNDDPCVAWLGNDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAVEIADVFAEWNKGRLNSYLIEITEKVL
RAADPITGKPMVDLILDKAGQKGTGKWSVIEAQNMGVAATAIEAAVAARILSSQKDEREAAEKIFGLPTLAAAPADKKAF
IADLESALLAAKVGAYAQGFAIMSAASKEFNWNLPMPTIARIWRAGCIIRSEFLDEITSAFTKDPHVANLIVTPAFSAIV
KDTDAPLRRVVSYAVLSGLPVSALASALGYFDAYRRGRGSANLIQAQRDFFGAHGFERTDGVDKPHGPWGSGADIF
>Mature_476_residues
MEQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTPEVTRKFYADAGELQGQIIPCETIEEFVAAIRPPRPIIIMIKAGD
PVDQQMEILKPHLANGDIMIDAGNANFRDTIRRFDNLKDSGLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTS
ISAKYNDDPCVAWLGNDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAVEIADVFAEWNKGRLNSYLIEITEKVL
RAADPITGKPMVDLILDKAGQKGTGKWSVIEAQNMGVAATAIEAAVAARILSSQKDEREAAEKIFGLPTLAAAPADKKAF
IADLESALLAAKVGAYAQGFAIMSAASKEFNWNLPMPTIARIWRAGCIIRSEFLDEITSAFTKDPHVANLIVTPAFSAIV
KDTDAPLRRVVSYAVLSGLPVSALASALGYFDAYRRGRGSANLIQAQRDFFGAHGFERTDGVDKPHGPWGSGADIF

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=459, Percent_Identity=46.6230936819172, Blast_Score=399, Evalue=1e-111,
Organism=Escherichia coli, GI1788341, Length=471, Percent_Identity=47.5583864118896, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17542558, Length=460, Percent_Identity=46.0869565217391, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321695, Length=466, Percent_Identity=46.5665236051502, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=46.3736263736264, Blast_Score=405, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24639279, Length=456, Percent_Identity=45.6140350877193, Blast_Score=390, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51266; Mature: 51266

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTPEVTRKFYADAGELQGQIIPCETIE
CCCCCEEEEEEEEECCCEEEEEECCCCEEEEECCCHHHHHHHHCCHHHCCCCEECHHHHH
EFVAAIRPPRPIIIMIKAGDPVDQQMEILKPHLANGDIMIDAGNANFRDTIRRFDNLKDS
HHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCC
GLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTSISAKYNDDPCVAWLGNDGAG
CCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAVEIADVFAEWNKGRLNSYLIEITEKVL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RAADPITGKPMVDLILDKAGQKGTGKWSVIEAQNMGVAATAIEAAVAARILSSQKDEREA
HHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
AEKIFGLPTLAAAPADKKAFIADLESALLAAKVGAYAQGFAIMSAASKEFNWNLPMPTIA
HHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RIWRAGCIIRSEFLDEITSAFTKDPHVANLIVTPAFSAIVKDTDAPLRRVVSYAVLSGLP
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHCCCC
VSALASALGYFDAYRRGRGSANLIQAQRDFFGAHGFERTDGVDKPHGPWGSGADIF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTPEVTRKFYADAGELQGQIIPCETIE
CCCCCEEEEEEEEECCCEEEEEECCCCEEEEECCCHHHHHHHHCCHHHCCCCEECHHHHH
EFVAAIRPPRPIIIMIKAGDPVDQQMEILKPHLANGDIMIDAGNANFRDTIRRFDNLKDS
HHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCC
GLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTSISAKYNDDPCVAWLGNDGAG
CCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAVEIADVFAEWNKGRLNSYLIEITEKVL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RAADPITGKPMVDLILDKAGQKGTGKWSVIEAQNMGVAATAIEAAVAARILSSQKDEREA
HHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
AEKIFGLPTLAAAPADKKAFIADLESALLAAKVGAYAQGFAIMSAASKEFNWNLPMPTIA
HHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RIWRAGCIIRSEFLDEITSAFTKDPHVANLIVTPAFSAIVKDTDAPLRRVVSYAVLSGLP
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHCCCC
VSALASALGYFDAYRRGRGSANLIQAQRDFFGAHGFERTDGVDKPHGPWGSGADIF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3020045; 7584049; 9384377; 1659648 [H]