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The map label for this gene is nuoM [H]

Identifier: 15888611

GI number: 15888611

Start: 1269016

End: 1270527

Strand: Direct

Name: nuoM [H]

Synonym: Atu1282

Alternate gene names: 15888611

Gene position: 1269016-1270527 (Clockwise)

Preceding gene: 15888610

Following gene: 159184691

Centisome position: 44.66

GC content: 57.8

Gene sequence:

>1512_bases
ATGACCGATTGGCCTATTCTTTCAACGGTCACCTTTCTGCCGCTCGTCGGCGTGGTGCTCCTGCTTCTGACAAATGAGAA
CGGCCCCTATGGTCGCCGCAACATTCTCAACGTCTCGCTGCTGACGACCGTCTTCACTTTCATCGTGTCGCTGTTCGTCT
GGATCGGTTTCGACAACTCGAACCCCGGCTTCCAGATGGTCGAAAAACACGCCTGGTTTGGCAAGATCGCCGCCTATCAT
CTCGGCGTCGACGGCATCTCCATGCTGTTCGTCATCCTCACCACTTTCCTCATGCCGTTCTGCGTGCTGGCAAGCTGGAA
TTCGATTGAAAAGCGCGTCAAGGAATACATGATTGCCTTCCTGCTTCTGGAAGTCGTCATGGTCGGCGTCTTCGTGGCGC
TGGATACGGTTCTTTTCTACGTCTTCTTCGAAGCGACGCTGATCCCGATGTTCATCATCATCGGCGTCTGGGGCGGCAAG
GATCGCGTCTACGCATCCTACAAGTTCTTCCTCTACACGCTGCTCGGCTCGGTCCTGACCATGCTCGCCATCATGGCGAT
GTACTGGCAGTCCGGCACGACCGACATGACCGAACTGCTGAAATACGGCTTCCCGGCCGGCATGCAGACCTGGCTCTGGC
TTGCCTGTTTCGCCGCCTTCTCGGTCAAGATGCCGATGTGGCCGGTGCACACCTGGCTGCCGGATGCGCACGTTCAGGCG
CCAACCGCAGGCTCCGTCATTCTTGCCGGCGTCATGCTGAAGCTCGGCGGTTACGGTTTCATCCGTTTCTCGCTGTCGAT
GTTCCCGCTGGCGTCGGATTATTTCGCACCCTTCGTCTTCACCCTGTCGGTTCTCGCCATCATCTACACCTCGCTGGTGG
CGATGATGCAGGACGACATCAAGAAGCTGATCGCCTATTCGTCGGTCGCCCACATGGGTTACGTGACCATGGGCATCTTC
GCCGCCAATGTGCAGGGCGTGCAGGGCGCAATCTTCCAGATGCTGTCGCACGGCATCGTGTCGGGCGCGCTGTTCCTTTG
CGTCGGCGTTGTCTATGACCGGCTGCACACCCGCGAGATTTCCGCCTATGGCGGTCTCGTCAACAACATGCCGAAATATG
CCGTCGCCTTCATGATTTTCACCATGGCCAATGTCGGTCTGCCCGGCACCTCAGGCTTCGTCGGTGAATTCCTGACGTTG
ATCGGCGTCTTCCGCGCCAACACGTTGGTCGCCCTGTTTGCGGCAACCGGCGTCATCCTCTCGGCCGCTTATGCGCTGTG
GCTTTACCGCCGCGTGATCTTCGGCGCGCTCGAGAAGGAAAGCCTGAAATCGATGCTCGATCTGTCGACCCGCGAAAAGG
TCATCCTTTATCCGCTGGTTGCACTGACGATCTTCTTCGGCGTCTATCCGGCTCCGGTGTTCGATGCGACAGCCGCATCG
GTCGATCTTCTGGTAAACAACTATACGGCTGCATTGCAGGCGGCGCAAAATGTTGCGCTCACTATGAATTGA

Upstream 100 bases:

>100_bases
TGGTCCGCCTGCAATCCGGTTACCTTTATCATTATGCCTTTGCGATGCTGATCGGCATCGCGGCGCTTGTCACCTGGATG
ATGCTCGGGAGTGCCCTCTG

Downstream 100 bases:

>100_bases
CGACAGGACCCGTTGGACATGACCGCTGAAATCCTTTTTGCCAGTCTGCACATCGCGACGCCCGAGCTGATCCTTGCGGT
CGGCGCGCTGGCGCTGCTCA

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTDWPILSTVTFLPLVGVVLLLLTNENGPYGRRNILNVSLLTTVFTFIVSLFVWIGFDNSNPGFQMVEKHAWFGKIAAYH
LGVDGISMLFVILTTFLMPFCVLASWNSIEKRVKEYMIAFLLLEVVMVGVFVALDTVLFYVFFEATLIPMFIIIGVWGGK
DRVYASYKFFLYTLLGSVLTMLAIMAMYWQSGTTDMTELLKYGFPAGMQTWLWLACFAAFSVKMPMWPVHTWLPDAHVQA
PTAGSVILAGVMLKLGGYGFIRFSLSMFPLASDYFAPFVFTLSVLAIIYTSLVAMMQDDIKKLIAYSSVAHMGYVTMGIF
AANVQGVQGAIFQMLSHGIVSGALFLCVGVVYDRLHTREISAYGGLVNNMPKYAVAFMIFTMANVGLPGTSGFVGEFLTL
IGVFRANTLVALFAATGVILSAAYALWLYRRVIFGALEKESLKSMLDLSTREKVILYPLVALTIFFGVYPAPVFDATAAS
VDLLVNNYTAALQAAQNVALTMN

Sequences:

>Translated_503_residues
MTDWPILSTVTFLPLVGVVLLLLTNENGPYGRRNILNVSLLTTVFTFIVSLFVWIGFDNSNPGFQMVEKHAWFGKIAAYH
LGVDGISMLFVILTTFLMPFCVLASWNSIEKRVKEYMIAFLLLEVVMVGVFVALDTVLFYVFFEATLIPMFIIIGVWGGK
DRVYASYKFFLYTLLGSVLTMLAIMAMYWQSGTTDMTELLKYGFPAGMQTWLWLACFAAFSVKMPMWPVHTWLPDAHVQA
PTAGSVILAGVMLKLGGYGFIRFSLSMFPLASDYFAPFVFTLSVLAIIYTSLVAMMQDDIKKLIAYSSVAHMGYVTMGIF
AANVQGVQGAIFQMLSHGIVSGALFLCVGVVYDRLHTREISAYGGLVNNMPKYAVAFMIFTMANVGLPGTSGFVGEFLTL
IGVFRANTLVALFAATGVILSAAYALWLYRRVIFGALEKESLKSMLDLSTREKVILYPLVALTIFFGVYPAPVFDATAAS
VDLLVNNYTAALQAAQNVALTMN
>Mature_502_residues
TDWPILSTVTFLPLVGVVLLLLTNENGPYGRRNILNVSLLTTVFTFIVSLFVWIGFDNSNPGFQMVEKHAWFGKIAAYHL
GVDGISMLFVILTTFLMPFCVLASWNSIEKRVKEYMIAFLLLEVVMVGVFVALDTVLFYVFFEATLIPMFIIIGVWGGKD
RVYASYKFFLYTLLGSVLTMLAIMAMYWQSGTTDMTELLKYGFPAGMQTWLWLACFAAFSVKMPMWPVHTWLPDAHVQAP
TAGSVILAGVMLKLGGYGFIRFSLSMFPLASDYFAPFVFTLSVLAIIYTSLVAMMQDDIKKLIAYSSVAHMGYVTMGIFA
ANVQGVQGAIFQMLSHGIVSGALFLCVGVVYDRLHTREISAYGGLVNNMPKYAVAFMIFTMANVGLPGTSGFVGEFLTLI
GVFRANTLVALFAATGVILSAAYALWLYRRVIFGALEKESLKSMLDLSTREKVILYPLVALTIFFGVYPAPVFDATAASV
DLLVNNYTAALQAAQNVALTMN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=352, Percent_Identity=34.6590909090909, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI251831117, Length=333, Percent_Identity=24.024024024024, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788613, Length=495, Percent_Identity=36.3636363636364, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1788827, Length=294, Percent_Identity=29.2517006802721, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1788831, Length=308, Percent_Identity=26.9480519480519, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788614, Length=484, Percent_Identity=25.6198347107438, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788829, Length=348, Percent_Identity=25.8620689655172, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=389, Percent_Identity=25.706940874036, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI2367154, Length=286, Percent_Identity=25.8741258741259, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55481; Mature: 55349

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCEEEECC
>Mature Secondary Structure 
TDWPILSTVTFLPLVGVVLLLLTNENGPYGRRNILNVSLLTTVFTFIVSLFVWIGFDNS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC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HHHHHHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]