Click here to switch to the map view.

The map label for this gene is nuoL [H]

Identifier: 15888610

GI number: 15888610

Start: 1267019

End: 1269016

Strand: Direct

Name: nuoL [H]

Synonym: Atu1281

Alternate gene names: 15888610

Gene position: 1267019-1269016 (Clockwise)

Preceding gene: 15888609

Following gene: 15888611

Centisome position: 44.59

GC content: 59.26

Gene sequence:

>1998_bases
ATGATCTACAAGGCTATCGTCTTTCTTCCACTGATCGGCTTCCTGATCGCCGGCCTGTTCGGCCGCTCTATCGGCGCCAA
GGCCTCGGAATATGTCACCACCGGTCTGATGATCGTGGTCGCCATCCTGTCGTGGATCGTTTTCTTTAACGTGGCACTCG
CCCATGGCGAGCCGGGCGAGGTGATCAAGGTCACTGTTTTGCGCTGGATCCAGTCCGGCGGCATCGACGTCGAATGGGCG
TTCCGCATCGATACACTGACGGCCGTCATGTTCGTCGTCGTCAACACGGTCTCGACGCTGGTGCACCTTTATTCGATCGG
ATACATGCACCACGATCCGCATCGTCCGCGCTTCTTTGCCTATCTGTCGCTCTTCACTTTCGCCATGCTGATGCTGGTCA
CCTCCGACAACCTGCTGCAGATGTTCTTCGGCTGGGAAGGCGTGGGGCTGGCGTCCTATCTGCTGATCGGCTTCTGGTTC
AAGAAGCCTTCCGCATCGGCCGCCGCCATGAAGGCGTTCATCGTCAACCGCGTCGGTGACTTCGGCTTCATCCTCGGCAT
CTCGGGCGTCTTCGTGCTGTTCGGCTCGATCAACCTCGAAACTGTCTTCGCTGCCGCCAGCACCTATCTGCCGGCCGAAG
GTGCCGCTTCCACCGGAACCGTCATCAACCTGTTCGGCATGCAGCTGGACAAGGCCAATGCGATAACGGGCGTCTGCCTG
CTGCTCTTCATGGGCGCCATGGGTAAGTCGGCGCAGTTCCTGCTGCACACCTGGCTGCCGGACGCGATGGAAGGCCCGAC
CCCGGTTTCGGCCCTCATTCATGCCGCAACCATGGTCACCGCCGGCGTCTTCCTTGTCGCCCGCATGTCGCCTTTGTTCG
AACTGTCGCCGGATGCGCTCACCGTCGTGACGCTGATCGGTGCGATCACCGCCTTCTTCGCGGCGACTGTGGGTCTGGTG
CAGAACGACATCAAACGCGTGATTGCCTATTCGACCTGCTCGCAGCTCGGTTACATGTTCGTGGCGCTTGGCGTCGGCGC
TTATGGTGCTGCCGTGTTCCACCTCTTCACGCACGCCTTCTTCAAGGCCCTGTTGTTCCTGTGCGCCGGCTCGGTCATCC
ATGCCGTCGATGGCGAGCAGGACATGCGGTACATGGGAGGCCTGCGCAAGCATATCCCCATCACCTTCTGGACCATGACC
GTTGGCACGCTGGCGCTCACCGGCGTCGGTATTCCGGGCACGATGATCGGTTTTGCCGGCTTCTTCTCGAAGGACGTCAT
CATCGAATCCGCTTATGCGTCCCATTCGGTTCTCTCCGGTTTCGCCTTCACGCTGCTGGTCATCGCCGCGCTGTTCACCA
GCTTCTATTCCTGGCGCCTGGCCTTCATGACCTTCTTCGGCAAGCCGCGCGCTTCGGCTGACGTGATGCACCACGTGCAT
GAATCGCCGATGGTCATGCTGATCCCGCTTTTCATCCTCACGGTTGGCGCGATCTTTGCCGGCGTCCTTTTCGAAGGTCA
TTTCTTCGGTGAAGAATATGTCGAATTCTGGAAGGGCGCGCTGTTCATGCTTCCGGAAAACGAGATCCTCGAGGAGTTCC
ACCACGTTCCGCTGTGGGTGAAATGGAGCCCGTTCTTTGCGATGGCGCTTGGTTTCGTGACCGCATGGTACATGTACATC
AAGTCGCCGGAGACCCCGAAGCGTCTGGCGGCGACCCATCGTGGCCTCTACCAGTTCCTCTTGAACAAGTGGTACTTCGA
CGAACTCTATGACTTCCTCTTCGTGCGTTCCGCAAAGGCGCTTGGCCGCTTCCTGTGGAAGAAGGGTGACGTGGCCGTCA
TCGACCATTATGGACCGAACGGCATTGCAGCGCGTGTGGTTGACGTGACCAACCGCATGGTCCGCCTGCAATCCGGTTAC
CTTTATCATTATGCCTTTGCGATGCTGATCGGCATCGCGGCGCTTGTCACCTGGATGATGCTCGGGAGTGCCCTCTGA

Upstream 100 bases:

>100_bases
GCCGAAGCGGCCATCGGTCTTGCAATACTCGTTGTCTTCTACCGCAACCGCGGATCGATCGCCGTCGAAGACGTCAATAT
GATGAAGGGCTGATAAGGCT

Downstream 100 bases:

>100_bases
TGACCGATTGGCCTATTCTTTCAACGGTCACCTTTCTGCCGCTCGTCGGCGTGGTGCTCCTGCTTCTGACAAATGAGAAC
GGCCCCTATGGTCGCCGCAA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 12; NDH-1, chain 12 [H]

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MIYKAIVFLPLIGFLIAGLFGRSIGAKASEYVTTGLMIVVAILSWIVFFNVALAHGEPGEVIKVTVLRWIQSGGIDVEWA
FRIDTLTAVMFVVVNTVSTLVHLYSIGYMHHDPHRPRFFAYLSLFTFAMLMLVTSDNLLQMFFGWEGVGLASYLLIGFWF
KKPSASAAAMKAFIVNRVGDFGFILGISGVFVLFGSINLETVFAAASTYLPAEGAASTGTVINLFGMQLDKANAITGVCL
LLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDALTVVTLIGAITAFFAATVGLV
QNDIKRVIAYSTCSQLGYMFVALGVGAYGAAVFHLFTHAFFKALLFLCAGSVIHAVDGEQDMRYMGGLRKHIPITFWTMT
VGTLALTGVGIPGTMIGFAGFFSKDVIIESAYASHSVLSGFAFTLLVIAALFTSFYSWRLAFMTFFGKPRASADVMHHVH
ESPMVMLIPLFILTVGAIFAGVLFEGHFFGEEYVEFWKGALFMLPENEILEEFHHVPLWVKWSPFFAMALGFVTAWYMYI
KSPETPKRLAATHRGLYQFLLNKWYFDELYDFLFVRSAKALGRFLWKKGDVAVIDHYGPNGIAARVVDVTNRMVRLQSGY
LYHYAFAMLIGIAALVTWMMLGSAL

Sequences:

>Translated_665_residues
MIYKAIVFLPLIGFLIAGLFGRSIGAKASEYVTTGLMIVVAILSWIVFFNVALAHGEPGEVIKVTVLRWIQSGGIDVEWA
FRIDTLTAVMFVVVNTVSTLVHLYSIGYMHHDPHRPRFFAYLSLFTFAMLMLVTSDNLLQMFFGWEGVGLASYLLIGFWF
KKPSASAAAMKAFIVNRVGDFGFILGISGVFVLFGSINLETVFAAASTYLPAEGAASTGTVINLFGMQLDKANAITGVCL
LLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDALTVVTLIGAITAFFAATVGLV
QNDIKRVIAYSTCSQLGYMFVALGVGAYGAAVFHLFTHAFFKALLFLCAGSVIHAVDGEQDMRYMGGLRKHIPITFWTMT
VGTLALTGVGIPGTMIGFAGFFSKDVIIESAYASHSVLSGFAFTLLVIAALFTSFYSWRLAFMTFFGKPRASADVMHHVH
ESPMVMLIPLFILTVGAIFAGVLFEGHFFGEEYVEFWKGALFMLPENEILEEFHHVPLWVKWSPFFAMALGFVTAWYMYI
KSPETPKRLAATHRGLYQFLLNKWYFDELYDFLFVRSAKALGRFLWKKGDVAVIDHYGPNGIAARVVDVTNRMVRLQSGY
LYHYAFAMLIGIAALVTWMMLGSAL
>Mature_665_residues
MIYKAIVFLPLIGFLIAGLFGRSIGAKASEYVTTGLMIVVAILSWIVFFNVALAHGEPGEVIKVTVLRWIQSGGIDVEWA
FRIDTLTAVMFVVVNTVSTLVHLYSIGYMHHDPHRPRFFAYLSLFTFAMLMLVTSDNLLQMFFGWEGVGLASYLLIGFWF
KKPSASAAAMKAFIVNRVGDFGFILGISGVFVLFGSINLETVFAAASTYLPAEGAASTGTVINLFGMQLDKANAITGVCL
LLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDALTVVTLIGAITAFFAATVGLV
QNDIKRVIAYSTCSQLGYMFVALGVGAYGAAVFHLFTHAFFKALLFLCAGSVIHAVDGEQDMRYMGGLRKHIPITFWTMT
VGTLALTGVGIPGTMIGFAGFFSKDVIIESAYASHSVLSGFAFTLLVIAALFTSFYSWRLAFMTFFGKPRASADVMHHVH
ESPMVMLIPLFILTVGAIFAGVLFEGHFFGEEYVEFWKGALFMLPENEILEEFHHVPLWVKWSPFFAMALGFVTAWYMYI
KSPETPKRLAATHRGLYQFLLNKWYFDELYDFLFVRSAKALGRFLWKKGDVAVIDHYGPNGIAARVVDVTNRMVRLQSGY
LYHYAFAMLIGIAALVTWMMLGSAL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=448, Percent_Identity=41.0714285714286, Blast_Score=318, Evalue=8e-87,
Organism=Escherichia coli, GI1788614, Length=602, Percent_Identity=39.5348837209302, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1788829, Length=439, Percent_Identity=29.6127562642369, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1788831, Length=353, Percent_Identity=30.8781869688385, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI1788827, Length=442, Percent_Identity=28.0542986425339, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788613, Length=490, Percent_Identity=25.5102040816327, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI2367154, Length=216, Percent_Identity=27.3148148148148, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693160, Length=372, Percent_Identity=26.6129032258064, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73220; Mature: 73220

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYKAIVFLPLIGFLIAGLFGRSIGAKASEYVTTGLMIVVAILSWIVFFNVALAHGEPGE
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VIKVTVLRWIQSGGIDVEWAFRIDTLTAVMFVVVNTVSTLVHLYSIGYMHHDPHRPRFFA
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
YLSLFTFAMLMLVTSDNLLQMFFGWEGVGLASYLLIGFWFKKPSASAAAMKAFIVNRVGD
HHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
FGFILGISGVFVLFGSINLETVFAAASTYLPAEGAASTGTVINLFGMQLDKANAITGVCL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHCCCHHHHHHHH
LLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDAL
HHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHH
TVVTLIGAITAFFAATVGLVQNDIKRVIAYSTCSQLGYMFVALGVGAYGAAVFHLFTHAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKALLFLCAGSVIHAVDGEQDMRYMGGLRKHIPITFWTMTVGTLALTGVGIPGTMIGFAG
HHHHHHHHCCCHHEECCCCHHHHHHCCHHHCCCEEEHHHHHHHHHHHCCCCCHHHHHHHH
FFSKDVIIESAYASHSVLSGFAFTLLVIAALFTSFYSWRLAFMTFFGKPRASADVMHHVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
ESPMVMLIPLFILTVGAIFAGVLFEGHFFGEEYVEFWKGALFMLPENEILEEFHHVPLWV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEECCCHHHHHHHCCCCEEE
KWSPFFAMALGFVTAWYMYIKSPETPKRLAATHRGLYQFLLNKWYFDELYDFLFVRSAKA
EECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGRFLWKKGDVAVIDHYGPNGIAARVVDVTNRMVRLQSGYLYHYAFAMLIGIAALVTWMM
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGSAL
HHCCC
>Mature Secondary Structure
MIYKAIVFLPLIGFLIAGLFGRSIGAKASEYVTTGLMIVVAILSWIVFFNVALAHGEPGE
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VIKVTVLRWIQSGGIDVEWAFRIDTLTAVMFVVVNTVSTLVHLYSIGYMHHDPHRPRFFA
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
YLSLFTFAMLMLVTSDNLLQMFFGWEGVGLASYLLIGFWFKKPSASAAAMKAFIVNRVGD
HHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
FGFILGISGVFVLFGSINLETVFAAASTYLPAEGAASTGTVINLFGMQLDKANAITGVCL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHCCCHHHHHHHH
LLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDAL
HHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHH
TVVTLIGAITAFFAATVGLVQNDIKRVIAYSTCSQLGYMFVALGVGAYGAAVFHLFTHAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKALLFLCAGSVIHAVDGEQDMRYMGGLRKHIPITFWTMTVGTLALTGVGIPGTMIGFAG
HHHHHHHHCCCHHEECCCCHHHHHHCCHHHCCCEEEHHHHHHHHHHHCCCCCHHHHHHHH
FFSKDVIIESAYASHSVLSGFAFTLLVIAALFTSFYSWRLAFMTFFGKPRASADVMHHVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
ESPMVMLIPLFILTVGAIFAGVLFEGHFFGEEYVEFWKGALFMLPENEILEEFHHVPLWV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEECCCHHHHHHHCCCCEEE
KWSPFFAMALGFVTAWYMYIKSPETPKRLAATHRGLYQFLLNKWYFDELYDFLFVRSAKA
EECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGRFLWKKGDVAVIDHYGPNGIAARVVDVTNRMVRLQSGYLYHYAFAMLIGIAALVTWMM
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGSAL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]