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The map label for this gene is nuoF [H]

Identifier: 15888604

GI number: 15888604

Start: 1260798

End: 1262102

Strand: Direct

Name: nuoF [H]

Synonym: Atu1275

Alternate gene names: 15888604

Gene position: 1260798-1262102 (Clockwise)

Preceding gene: 15888603

Following gene: 159184690

Centisome position: 44.37

GC content: 60.23

Gene sequence:

>1305_bases
ATGTTAAAAGATCAGGATCGCATCTTTACCAATCTCTACGGCCTCAAGGACAAGTCCCTGAAGGGCGTGATGGCGCGCGG
CCACTGGGACGGCACCAAGCAGATCATCGAAAAGGGCCGTGACTGGATCATCAACGAGATGAAGGCTTCCGGCCTTCGCG
GTCGCGGCGGCGCTGGCTTCCCGACGGGTCTCAAATGGTCCTTCATGCCGAAGGAAAATGACGGCCGTCCGCATTACCTC
GTCGTCAACGCCGACGAATCCGAACCCGGCACCTGCAAGGACCGCGAAATCCTGCGCAACGATCCGCATACGCTGATCGA
AGGCTGCGTGATCGCCGGTTTCGCCATGGGCGCGCACACCGCTTACATTTATGTGCGCGGCGAATATATGCGCGAACGTG
AAGCGCTGCAGGCAGCTATCGACGAATGTTACGATGCCGGCCTGCTCGGCAAGAACAACAAGAACGGCTGGGACTACGAC
ATCTACGTCCATCATGGCGCGGGTGCCTATATCTGCGGCGAAGAGACGGCGCTGCTCGAAAGCCTCGAGGGCAAGAAGGG
CCAGCCACGTCTGAAACCGCCGTTCCCGGCCAATATGGGTCTCTATGGCTGCCCGACGACCGTCAACAACGTCGAATCGA
TCGCCGTTGCGCCAACCATCCTGCGCCGCGGTGCATCCTGGTTCTCGTCCATCGGCCGTCCGAACAATGTCGGCACCAAG
CTGTTCATGGTGTCCGGTCATGTCGAGCGTCCATGCACCTTCGAAGATGCGCTGGGCCTGTCCTTCCGCGAGCTGATCGA
GCACCATTGCGGTGGCATTCGCGGCGGCTGGGACAATCTGCTCGGCGTCATCCCGGGCGGCGCTTCCTGCCCCATCGTTC
GCGGTGAGGACATGAAGGACGCCATCATGGACTTTGACGGCATGCGCGAAGTGAAGTCTTCCTTCGGCACCGGCGGCATG
ATCGTCATGGACAAGTCCACTGACGTCATCAAGGCGATTGCGCGCATCGCGGCCTTCTTCAAGCACGAAAGCTGTGGCCA
GTGCACGCCGTGCCGTGAAGGCACCGGCTGGATGTGGCGCGTGCTGGAACGCATGGTCAAGGGTAACGCCCAGAAGCGTG
AAATCGACATGCTGTTCGAGGTGACCAAGCAGATCGAGGGCCACACCATCTGTGCGCTCGGCGACGCCGCCGCATGGCCG
GTACAGGCGCTGATCCGCAATTTCCGTCCGGAAATCGAAAAGCGCATCGACCAATATACCTACAGGGCCATGGATGATGG
CGCTGTTCTGGAAGCCGCTGAATAA

Upstream 100 bases:

>100_bases
GGCCGTGATGACTGGGTCAAACAGGCCGAGGCGCTCGCCAAGGGTGGTGAAGCCGAGTATATCAGGGTCTTCGGCAAGAA
GCCGCGGTAAAGGGTGAAGC

Downstream 100 bases:

>100_bases
GCATTGAAGGCTTCGAGCGGAGCCGGGAGTTTCCGGCCCCGCAACACCATGAAGCGCCTGGCGAAACTCTGGATGCCTGG
CGTGATTAAGGATTTGTTGC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLKDQDRIFTNLYGLKDKSLKGVMARGHWDGTKQIIEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKENDGRPHYL
VVNADESEPGTCKDREILRNDPHTLIEGCVIAGFAMGAHTAYIYVRGEYMREREALQAAIDECYDAGLLGKNNKNGWDYD
IYVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGASWFSSIGRPNNVGTK
LFMVSGHVERPCTFEDALGLSFRELIEHHCGGIRGGWDNLLGVIPGGASCPIVRGEDMKDAIMDFDGMREVKSSFGTGGM
IVMDKSTDVIKAIARIAAFFKHESCGQCTPCREGTGWMWRVLERMVKGNAQKREIDMLFEVTKQIEGHTICALGDAAAWP
VQALIRNFRPEIEKRIDQYTYRAMDDGAVLEAAE

Sequences:

>Translated_434_residues
MLKDQDRIFTNLYGLKDKSLKGVMARGHWDGTKQIIEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKENDGRPHYL
VVNADESEPGTCKDREILRNDPHTLIEGCVIAGFAMGAHTAYIYVRGEYMREREALQAAIDECYDAGLLGKNNKNGWDYD
IYVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGASWFSSIGRPNNVGTK
LFMVSGHVERPCTFEDALGLSFRELIEHHCGGIRGGWDNLLGVIPGGASCPIVRGEDMKDAIMDFDGMREVKSSFGTGGM
IVMDKSTDVIKAIARIAAFFKHESCGQCTPCREGTGWMWRVLERMVKGNAQKREIDMLFEVTKQIEGHTICALGDAAAWP
VQALIRNFRPEIEKRIDQYTYRAMDDGAVLEAAE
>Mature_434_residues
MLKDQDRIFTNLYGLKDKSLKGVMARGHWDGTKQIIEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKENDGRPHYL
VVNADESEPGTCKDREILRNDPHTLIEGCVIAGFAMGAHTAYIYVRGEYMREREALQAAIDECYDAGLLGKNNKNGWDYD
IYVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGASWFSSIGRPNNVGTK
LFMVSGHVERPCTFEDALGLSFRELIEHHCGGIRGGWDNLLGVIPGGASCPIVRGEDMKDAIMDFDGMREVKSSFGTGGM
IVMDKSTDVIKAIARIAAFFKHESCGQCTPCREGTGWMWRVLERMVKGNAQKREIDMLFEVTKQIEGHTICALGDAAAWP
VQALIRNFRPEIEKRIDQYTYRAMDDGAVLEAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=63.9618138424821, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=63.9618138424821, Blast_Score=584, Evalue=1e-167,
Organism=Escherichia coli, GI1788620, Length=380, Percent_Identity=43.421052631579, Blast_Score=318, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI17531727, Length=426, Percent_Identity=62.9107981220657, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI19920794, Length=425, Percent_Identity=67.2941176470588, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI45550452, Length=434, Percent_Identity=64.9769585253456, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24653819, Length=422, Percent_Identity=43.3649289099526, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24653817, Length=421, Percent_Identity=40.1425178147268, Blast_Score=330, Evalue=8e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48062; Mature: 48062

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDQDRIFTNLYGLKDKSLKGVMARGHWDGTKQIIEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKENDGRPHYLVVNADESEPGTCKDREILRNDPHTLIEGCVIAGFAMGAHT
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEYMREREALQAAIDECYDAGLLGKNNKNGWDYDIYVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGASWFSSIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCE
LFMVSGHVERPCTFEDALGLSFRELIEHHCGGIRGGWDNLLGVIPGGASCPIVRGEDMKD
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCHHHHHEECCCCCCCCEECCCCHHH
AIMDFDGMREVKSSFGTGGMIVMDKSTDVIKAIARIAAFFKHESCGQCTPCREGTGWMWR
HHHCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VLERMVKGNAQKREIDMLFEVTKQIEGHTICALGDAAAWPVQALIRNFRPEIEKRIDQYT
HHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHH
YRAMDDGAVLEAAE
HHHCCCCCEEECCC
>Mature Secondary Structure
MLKDQDRIFTNLYGLKDKSLKGVMARGHWDGTKQIIEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKENDGRPHYLVVNADESEPGTCKDREILRNDPHTLIEGCVIAGFAMGAHT
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEYMREREALQAAIDECYDAGLLGKNNKNGWDYDIYVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGASWFSSIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCE
LFMVSGHVERPCTFEDALGLSFRELIEHHCGGIRGGWDNLLGVIPGGASCPIVRGEDMKD
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCHHHHHEECCCCCCCCEECCCCHHH
AIMDFDGMREVKSSFGTGGMIVMDKSTDVIKAIARIAAFFKHESCGQCTPCREGTGWMWR
HHHCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VLERMVKGNAQKREIDMLFEVTKQIEGHTICALGDAAAWPVQALIRNFRPEIEKRIDQYT
HHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHH
YRAMDDGAVLEAAE
HHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]