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The map label for this gene is cueR [H]

Identifier: 15888533

GI number: 15888533

Start: 1190024

End: 1190512

Strand: Direct

Name: cueR [H]

Synonym: Atu1197

Alternate gene names: 15888533

Gene position: 1190024-1190512 (Clockwise)

Preceding gene: 159184661

Following gene: 15888534

Centisome position: 41.88

GC content: 57.06

Gene sequence:

>489_bases
ATGAACATTGGCACAGCCGCCACCGCCTCCGGTGTTTCTGCAAAGATGATTAGGCATTACGAGATGATCGGCCTGATCAA
ATCGGCAAATCGCACGGATTCCGGCTACAGGGTCTATACGGCCAATGATCTGGAAACGCTGCGCTTTATCCGGCGCGGAC
GCGATCTCGGTTTTTCCATCGAAAAGATCAGGCAACTCATGACCCTCTGGCGCGATCCGGGCGGCGCCTCCTGCGATGTC
AAACGCATCGTCATGGAACATGTCATCGACCTGGAAGCGAAGATGGATACGCTGCGGGAAATGGCCGATACGCTCCGGAA
CCTCGCGACCTATTGCCCTGACAATGGTGAGCCGGAGTGCCCGATCATTCATGACCTCGCCCATGCGGAAGACCTCGAAT
TTTCGGCGGTTGCCGTCGTGCCCAAACGCACCGGCATGCTGAAGGGGACATCAGGCCCGGCGATGGATTTACAGCGCCAG
GCGAAATAA

Upstream 100 bases:

>100_bases
TGATCGAGGCAACGGTGCCGCAGCTGCTGGCGCGCGGCATGCGGACGGCCGACATTCATGCGGATGTATTTTTCACCCCG
GAAAGATAGGAGCAGGATCG

Downstream 100 bases:

>100_bases
GCCGCCGGTTCCCTTTTGGGGAGCGGGCACCGAATGCAGTGTAAACTGCCAATCTTGATGAAGGAGAGCAGGCCATGTGG
ATACAGATAATACAGCGCTT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MNIGTAATASGVSAKMIRHYEMIGLIKSANRTDSGYRVYTANDLETLRFIRRGRDLGFSIEKIRQLMTLWRDPGGASCDV
KRIVMEHVIDLEAKMDTLREMADTLRNLATYCPDNGEPECPIIHDLAHAEDLEFSAVAVVPKRTGMLKGTSGPAMDLQRQ
AK

Sequences:

>Translated_162_residues
MNIGTAATASGVSAKMIRHYEMIGLIKSANRTDSGYRVYTANDLETLRFIRRGRDLGFSIEKIRQLMTLWRDPGGASCDV
KRIVMEHVIDLEAKMDTLREMADTLRNLATYCPDNGEPECPIIHDLAHAEDLEFSAVAVVPKRTGMLKGTSGPAMDLQRQ
AK
>Mature_162_residues
MNIGTAATASGVSAKMIRHYEMIGLIKSANRTDSGYRVYTANDLETLRFIRRGRDLGFSIEKIRQLMTLWRDPGGASCDV
KRIVMEHVIDLEAKMDTLREMADTLRNLATYCPDNGEPECPIIHDLAHAEDLEFSAVAVVPKRTGMLKGTSGPAMDLQRQ
AK

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=39.3700787401575, Blast_Score=104, Evalue=3e-24,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=36.2204724409449, Blast_Score=85, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 18012; Mature: 18012

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGTAATASGVSAKMIRHYEMIGLIKSANRTDSGYRVYTANDLETLRFIRRGRDLGFSI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCH
EKIRQLMTLWRDPGGASCDVKRIVMEHVIDLEAKMDTLREMADTLRNLATYCPDNGEPEC
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIIHDLAHAEDLEFSAVAVVPKRTGMLKGTSGPAMDLQRQAK
CHHHHHHCCCCCCCEEEEECCCCCCCEECCCCCCCCHHHCCC
>Mature Secondary Structure
MNIGTAATASGVSAKMIRHYEMIGLIKSANRTDSGYRVYTANDLETLRFIRRGRDLGFSI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCH
EKIRQLMTLWRDPGGASCDVKRIVMEHVIDLEAKMDTLREMADTLRNLATYCPDNGEPEC
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIIHDLAHAEDLEFSAVAVVPKRTGMLKGTSGPAMDLQRQAK
CHHHHHHCCCCCCCEEEEECCCCCCCEECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]