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The map label for this gene is parC [H]

Identifier: 15888496

GI number: 15888496

Start: 1151840

End: 1154092

Strand: Direct

Name: parC [H]

Synonym: Atu1158

Alternate gene names: 15888496

Gene position: 1151840-1154092 (Clockwise)

Preceding gene: 159184641

Following gene: 159184644

Centisome position: 40.54

GC content: 61.25

Gene sequence:

>2253_bases
ATGGGAAAAGATCTTGTACCTCCGTCCGGCGGAGACGATAACATTCATCCGGTCGATTTGAAGGCGGCGCTTGAAGAGCG
CTACCTCGCTTATGCCTTGTCCACGATCATGCATCGTGCGCTGCCGGATGTGCGCGACGGCCTGAAGCCGGTGCACCGCC
GCATCATTCACGCCATGAGTGAAATGGGTATTCGTCCCAACTCGGCCTTCAAGAAATGCGCGCGTATCGTCGGCGATGTG
ATCGGTAAGTTCCACCCGCATGGCGACCAGTCGGTCTATGATGCGCTGGTGCGTCTCGCGCAGGATTTCTCGCAGCGTTA
TCCGATTGTCGACGGGCAGGGCAACTTCGGCAACATCGATGGCGACGGCGCCGCCGCCTATCGTTACACCGAAGCGCGCA
TGACCGATGTGGCGGCACTGCTGCTGGAAGGCATCGGCGAGGACGCGGTGGATTTCCGCGCCACCTATAATGAGGAAGAC
GAAGAACCGGTGGTCCTGCCGGGCGCTTTCCCGAACCTCCTGGCAAACGGTGCCTCTGGTATTGCCGTGGGCATGGCGAC
ATCGATCCCGCCGCACAATGCCCACGAACTTTGCGACGCCGCGCTGCATCTCATCAAGCACCCCGATGCGACGGTGGAAA
AGCTGGTGGAGTTCATTCCTGGCCCCGACCTGCCAACCGGTGGCGTGATCATCGAAAGCCGCGAGAATATTCTCGATGCC
TATAAAACGGGCCGCGGCGGTTTCCGCGTGCGCGCCAAATGGGAAACGGAAGATCTCGGCCGTGGCGGCTACCAGATCGT
CATCACCGAAATTCCCTTCCAGGTGCAGAAATCGCGGCTGATCGAAAAGATCGCCGAGCTGCTGATCGCCCGCAAGCTGC
CTTTGCTCGAAGACGTCAGAGACGAATCCGCCGAAGACGTGCGTATCGTTCTGGTGCCGAAAAACCGCACCGTCGACGCG
ACGCTGCTGATGGAATCGCTGTTCCGCCTGTCCGATCTCGAAAGCCGCCTGCCGCTCAACATGAATGTGCTGTCGCTTGG
CAAGGTGCCGAAGGTCATGGCGCTGAACGAGGTACTGAGCGAGTGGCTGGCGCACCGCAAGGACGTGCTGGTCCGCCGCT
CCCGCCACCGTCTGGCAGCTATCGACCGCAGGCTCGAAATTCTGGGCGGCTTACTTATTGCCTACCTCAATCTCGACGAG
GTGATCCGCATCATCCGCGAGGAGGACGAGCCGAAACAGGTGATGATGGCCAGGTGGTCGCTCACCGACAATCAGGCCGA
AGCCATCCTCAACATGCGGTTGCGCAATCTGCGCAAGCTCGAGGAATTCGAGATCCGCAAGGAACACGACGACCTCAGCA
AGGAAAAGTCAGAGATCGAAGGGCTGCTCGCCTCCGATGACAAGCAGTGGCAGACAGTCGCCTGGGAAATCGGCGAGGTC
AAAAAGAAATACGCCAAGGCAACCGAAATCGGCCGCCGCCGCACGCAGTTCGCGGATGCGCCGGATGCTGACATCGAGGC
CATCCAGCAGGCGATGATCGAAAAGGAACCGGTCACCATCGTCATCTCGCAGAAGGGCTGGATCAGGGCGCTGAAGGGGC
ACATGTCCGACACGTCGGCCCTGACCTTCAAGGAAGGCGACGGACCGAAGCTCGCCTTCCCGGCGCAGACCACCGACAAG
CTGTTGCTGCTGACGACAGGCGGCAAGGCCTATACGCTCGGCGCCGACAAGCTGCCGGGCGGGCGTGGCCATGGCGAGCC
GATCCGCATCATGGTCGATATGGAGAACGATCAGGATATCCTGACAGCCTTCGTACACGATCCGTCGCGCAAGCTGCTGC
TGGTCTCGACTGGCGGCAACGGCTTCATCGTCGCCGAAAGCGAAATGATCGCGAATACCCGCAAGGGCAAGCAGATCATG
AACGTCTCGATGCCCGATGAAGCAAAGCTCGCGGTGCCGGTGACGGGCGACCATGTCGCCGTCGTTGGCGAGAACCGCAA
GCTGCTTGCCTTCCCGTTGTCGCAGGTGCCGGAAATGTCACGCGGCAAGGGCGTGCGCCTGCAACGCTACAAGGATGGCG
GCGTGGTGGACGTGAAGTGCTTTGCGCTGGCGGATGGCCTCAGCTGGTCCGATACGGCCGGCCGCGCTTTCACCAAGGTC
GGCGAAGAGTTGCGTGAATGGCTGGCTGACCGCGCAACGGTGGGCCGCACCGTGCCGAAGGGCTTTCCGCGCAGCGGGAA
GTTTGGCGGGTGA

Upstream 100 bases:

>100_bases
AACGCGGTTAACAAAAAACCTTGCTTGGCATGTGTTTTCATCCACAGCGCAGACCCCTTGGTTTCTTGCCGGTTATCGGC
ATTTCCGCTAGTCAAGCACC

Downstream 100 bases:

>100_bases
AATTTGAGCTGCGTCCCGGGAGATCATTCGGGACGTCTTTCATAGCGCCTGTCTCGCTATTCCAACTGAGTATTTTGTTT
CAGGGCTACGCGACGCTTAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MGKDLVPPSGGDDNIHPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGIRPNSAFKKCARIVGDV
IGKFHPHGDQSVYDALVRLAQDFSQRYPIVDGQGNFGNIDGDGAAAYRYTEARMTDVAALLLEGIGEDAVDFRATYNEED
EEPVVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALHLIKHPDATVEKLVEFIPGPDLPTGGVIIESRENILDA
YKTGRGGFRVRAKWETEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDVRDESAEDVRIVLVPKNRTVDA
TLLMESLFRLSDLESRLPLNMNVLSLGKVPKVMALNEVLSEWLAHRKDVLVRRSRHRLAAIDRRLEILGGLLIAYLNLDE
VIRIIREEDEPKQVMMARWSLTDNQAEAILNMRLRNLRKLEEFEIRKEHDDLSKEKSEIEGLLASDDKQWQTVAWEIGEV
KKKYAKATEIGRRRTQFADAPDADIEAIQQAMIEKEPVTIVISQKGWIRALKGHMSDTSALTFKEGDGPKLAFPAQTTDK
LLLLTTGGKAYTLGADKLPGGRGHGEPIRIMVDMENDQDILTAFVHDPSRKLLLVSTGGNGFIVAESEMIANTRKGKQIM
NVSMPDEAKLAVPVTGDHVAVVGENRKLLAFPLSQVPEMSRGKGVRLQRYKDGGVVDVKCFALADGLSWSDTAGRAFTKV
GEELREWLADRATVGRTVPKGFPRSGKFGG

Sequences:

>Translated_750_residues
MGKDLVPPSGGDDNIHPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGIRPNSAFKKCARIVGDV
IGKFHPHGDQSVYDALVRLAQDFSQRYPIVDGQGNFGNIDGDGAAAYRYTEARMTDVAALLLEGIGEDAVDFRATYNEED
EEPVVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALHLIKHPDATVEKLVEFIPGPDLPTGGVIIESRENILDA
YKTGRGGFRVRAKWETEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDVRDESAEDVRIVLVPKNRTVDA
TLLMESLFRLSDLESRLPLNMNVLSLGKVPKVMALNEVLSEWLAHRKDVLVRRSRHRLAAIDRRLEILGGLLIAYLNLDE
VIRIIREEDEPKQVMMARWSLTDNQAEAILNMRLRNLRKLEEFEIRKEHDDLSKEKSEIEGLLASDDKQWQTVAWEIGEV
KKKYAKATEIGRRRTQFADAPDADIEAIQQAMIEKEPVTIVISQKGWIRALKGHMSDTSALTFKEGDGPKLAFPAQTTDK
LLLLTTGGKAYTLGADKLPGGRGHGEPIRIMVDMENDQDILTAFVHDPSRKLLLVSTGGNGFIVAESEMIANTRKGKQIM
NVSMPDEAKLAVPVTGDHVAVVGENRKLLAFPLSQVPEMSRGKGVRLQRYKDGGVVDVKCFALADGLSWSDTAGRAFTKV
GEELREWLADRATVGRTVPKGFPRSGKFGG
>Mature_749_residues
GKDLVPPSGGDDNIHPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGIRPNSAFKKCARIVGDVI
GKFHPHGDQSVYDALVRLAQDFSQRYPIVDGQGNFGNIDGDGAAAYRYTEARMTDVAALLLEGIGEDAVDFRATYNEEDE
EPVVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALHLIKHPDATVEKLVEFIPGPDLPTGGVIIESRENILDAY
KTGRGGFRVRAKWETEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDVRDESAEDVRIVLVPKNRTVDAT
LLMESLFRLSDLESRLPLNMNVLSLGKVPKVMALNEVLSEWLAHRKDVLVRRSRHRLAAIDRRLEILGGLLIAYLNLDEV
IRIIREEDEPKQVMMARWSLTDNQAEAILNMRLRNLRKLEEFEIRKEHDDLSKEKSEIEGLLASDDKQWQTVAWEIGEVK
KKYAKATEIGRRRTQFADAPDADIEAIQQAMIEKEPVTIVISQKGWIRALKGHMSDTSALTFKEGDGPKLAFPAQTTDKL
LLLTTGGKAYTLGADKLPGGRGHGEPIRIMVDMENDQDILTAFVHDPSRKLLLVSTGGNGFIVAESEMIANTRKGKQIMN
VSMPDEAKLAVPVTGDHVAVVGENRKLLAFPLSQVPEMSRGKGVRLQRYKDGGVVDVKCFALADGLSWSDTAGRAFTKVG
EELREWLADRATVGRTVPKGFPRSGKFGG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=449, Percent_Identity=23.162583518931, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789396, Length=670, Percent_Identity=41.4925373134328, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1788562, Length=634, Percent_Identity=38.1703470031546, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212645657, Length=172, Percent_Identity=31.3953488372093, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=354, Percent_Identity=27.1186440677966, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82933; Mature: 82802

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKDLVPPSGGDDNIHPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
EMGIRPNSAFKKCARIVGDVIGKFHPHGDQSVYDALVRLAQDFSQRYPIVDGQGNFGNID
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GDGAAAYRYTEARMTDVAALLLEGIGEDAVDFRATYNEEDEEPVVLPGAFPNLLANGASG
CCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCEEECCCCHHHHHCCCCC
IAVGMATSIPPHNAHELCDAALHLIKHPDATVEKLVEFIPGPDLPTGGVIIESRENILDA
EEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHH
YKTGRGGFRVRAKWETEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDVR
HHCCCCCEEEEEEECHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DESAEDVRIVLVPKNRTVDATLLMESLFRLSDLESRLPLNMNVLSLGKVPKVMALNEVLS
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHH
EWLAHRKDVLVRRSRHRLAAIDRRLEILGGLLIAYLNLDEVIRIIREEDEPKQVMMARWS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHC
LTDNQAEAILNMRLRNLRKLEEFEIRKEHDDLSKEKSEIEGLLASDDKQWQTVAWEIGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KKKYAKATEIGRRRTQFADAPDADIEAIQQAMIEKEPVTIVISQKGWIRALKGHMSDTSA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCE
LTFKEGDGPKLAFPAQTTDKLLLLTTGGKAYTLGADKLPGGRGHGEPIRIMVDMENDQDI
EEEECCCCCEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCH
LTAFVHDPSRKLLLVSTGGNGFIVAESEMIANTRKGKQIMNVSMPDEAKLAVPVTGDHVA
HHHEEECCCCEEEEEEECCCEEEEECHHHHHHHHCCCEEEECCCCCCCEEEEEECCCEEE
VVGENRKLLAFPLSQVPEMSRGKGVRLQRYKDGGVVDVKCFALADGLSWSDTAGRAFTKV
EEECCCEEEEECHHHCCCCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHH
GEELREWLADRATVGRTVPKGFPRSGKFGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKDLVPPSGGDDNIHPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
EMGIRPNSAFKKCARIVGDVIGKFHPHGDQSVYDALVRLAQDFSQRYPIVDGQGNFGNID
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GDGAAAYRYTEARMTDVAALLLEGIGEDAVDFRATYNEEDEEPVVLPGAFPNLLANGASG
CCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCEEECCCCHHHHHCCCCC
IAVGMATSIPPHNAHELCDAALHLIKHPDATVEKLVEFIPGPDLPTGGVIIESRENILDA
EEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHH
YKTGRGGFRVRAKWETEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDVR
HHCCCCCEEEEEEECHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DESAEDVRIVLVPKNRTVDATLLMESLFRLSDLESRLPLNMNVLSLGKVPKVMALNEVLS
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHH
EWLAHRKDVLVRRSRHRLAAIDRRLEILGGLLIAYLNLDEVIRIIREEDEPKQVMMARWS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHC
LTDNQAEAILNMRLRNLRKLEEFEIRKEHDDLSKEKSEIEGLLASDDKQWQTVAWEIGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KKKYAKATEIGRRRTQFADAPDADIEAIQQAMIEKEPVTIVISQKGWIRALKGHMSDTSA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCE
LTFKEGDGPKLAFPAQTTDKLLLLTTGGKAYTLGADKLPGGRGHGEPIRIMVDMENDQDI
EEEECCCCCEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCH
LTAFVHDPSRKLLLVSTGGNGFIVAESEMIANTRKGKQIMNVSMPDEAKLAVPVTGDHVA
HHHEEECCCCEEEEEEECCCEEEEECHHHHHHHHCCCEEEECCCCCCCEEEEEECCCEEE
VVGENRKLLAFPLSQVPEMSRGKGVRLQRYKDGGVVDVKCFALADGLSWSDTAGRAFTKV
EEECCCEEEEECHHHCCCCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHH
GEELREWLADRATVGRTVPKGFPRSGKFGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]