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The map label for this gene is alr

Identifier: 15888423

GI number: 15888423

Start: 1071353

End: 1072528

Strand: Reverse

Name: alr

Synonym: Atu1080

Alternate gene names: 15888423

Gene position: 1072528-1071353 (Counterclockwise)

Preceding gene: 15888427

Following gene: 15888422

Centisome position: 37.74

GC content: 62.76

Gene sequence:

>1176_bases
ATGACAGACGACTTCGAAGACAGCTTTCCCGACAACGAAACCGATGCGTTCGAGCAAGCCCCGCTGCGATTGACCGTCGA
TCTCGGCGCTCTCGCCGACAATTGGCGGGACATGAAGAAGCGGTCCGGAAGAGCCCGCACGGCCGCCGTCGTCAAGGCCG
ATGCCTATGGTCTCGGCATCGAGGATTGTGGTGCGACGCTTTACCATGCCGGCGCGCGGGACTTCTTCGTGGCGACGGTG
GCCGAGGGCGCGACCCTTCGCTCCTATGCTCCGGAAGCGCGCATCTTCGTATTGTCAGGCATCTGGCAGGGCCAGGAACG
GCAGGTGTTCGACAATGATCTGGTGCCGGTGCTGGCCTCCGAGGAGCAACTGTCCTTCTGGATGGCGACGGTCGCCGAGC
GGGGTGACCACCCCTGCGCGCTGCATGTGGACACCGGCTTCAATCGCCTCGGCCTGCCGCTTGATGACGCGCTGTTTCTG
GCCGACGACGTGACACGGCCGGCGAGTTTCGACCCGGTTCTGGTGCTGTCGCATCTCGCCTGCGCCGATACACCGTCCTC
CCCCATGAACAGGGCGCAGCTCGAATCATTCCGAAGGGTTAGCGCCGCCTTCGAAGGTATCGAATCAAGCCTTTCGGCAT
CCGCCGGTATCTTTCTCGGTCCCGACTATCATTTCGACCTCACCCGCCCCGGCATCGCCCTTTATGGCGGCGAGGCGGTC
AACGATGTGGCCAACCCGATGCGGCCCGTCGCCAAGGCCGAGGCCCGGATCATCCAGATACGCGAAGCAGGCGAAGGCCA
GACGGTGAGCTATGGCAGCAGCTTCCTGCTCAAGCGCGCAAGCCGGCTTGCCATCGCATCCGTCGGTTATGCGGATGGCT
ATCAGCGTTCGCTGTCCGGCTCGGGCATTCCCTTACGTGAAATGGGCCATGGCGGTGCATATGGCGTCGTCAACGGCCAC
AAGGTGCCCGTGGCCGGGCGCGTGACCATGGACCTGACTATTTTCGACGTCACGGATGTGCCGGCAAATGCCATTCGCGC
TGGCGACTATATCGAGCTTTTTGGCCCCAACGTTCCAGTCGATGAAACCGCACGGGCGGCCGGCACGATCGGTTATGAGA
TGCTGACGGGGCTCGGCCTGCGTTACGAACGGCAATATCTGGTAGCGGATGACTGA

Upstream 100 bases:

>100_bases
GAAACATTGTGCATGAGTCAAGTTTAAAGCATTCGATCCTTACCGTCTTGAACAAAAGTGCTAGGGTCTGGCCGGTTCCA
AATCAACCGGACGCAATGGC

Downstream 100 bases:

>100_bases
GGGCGGCCTTTAGCTCTTGGAAAGCCGACGCGACCTGTGCTAAAAGAGAACAAAAGGAGATCGAAATGCCCGAAATCCAT
TTGAGCGAGCAGGACGAGAA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTDDFEDSFPDNETDAFEQAPLRLTVDLGALADNWRDMKKRSGRARTAAVVKADAYGLGIEDCGATLYHAGARDFFVATV
AEGATLRSYAPEARIFVLSGIWQGQERQVFDNDLVPVLASEEQLSFWMATVAERGDHPCALHVDTGFNRLGLPLDDALFL
ADDVTRPASFDPVLVLSHLACADTPSSPMNRAQLESFRRVSAAFEGIESSLSASAGIFLGPDYHFDLTRPGIALYGGEAV
NDVANPMRPVAKAEARIIQIREAGEGQTVSYGSSFLLKRASRLAIASVGYADGYQRSLSGSGIPLREMGHGGAYGVVNGH
KVPVAGRVTMDLTIFDVTDVPANAIRAGDYIELFGPNVPVDETARAAGTIGYEMLTGLGLRYERQYLVADD

Sequences:

>Translated_391_residues
MTDDFEDSFPDNETDAFEQAPLRLTVDLGALADNWRDMKKRSGRARTAAVVKADAYGLGIEDCGATLYHAGARDFFVATV
AEGATLRSYAPEARIFVLSGIWQGQERQVFDNDLVPVLASEEQLSFWMATVAERGDHPCALHVDTGFNRLGLPLDDALFL
ADDVTRPASFDPVLVLSHLACADTPSSPMNRAQLESFRRVSAAFEGIESSLSASAGIFLGPDYHFDLTRPGIALYGGEAV
NDVANPMRPVAKAEARIIQIREAGEGQTVSYGSSFLLKRASRLAIASVGYADGYQRSLSGSGIPLREMGHGGAYGVVNGH
KVPVAGRVTMDLTIFDVTDVPANAIRAGDYIELFGPNVPVDETARAAGTIGYEMLTGLGLRYERQYLVADD
>Mature_390_residues
TDDFEDSFPDNETDAFEQAPLRLTVDLGALADNWRDMKKRSGRARTAAVVKADAYGLGIEDCGATLYHAGARDFFVATVA
EGATLRSYAPEARIFVLSGIWQGQERQVFDNDLVPVLASEEQLSFWMATVAERGDHPCALHVDTGFNRLGLPLDDALFLA
DDVTRPASFDPVLVLSHLACADTPSSPMNRAQLESFRRVSAAFEGIESSLSASAGIFLGPDYHFDLTRPGIALYGGEAVN
DVANPMRPVAKAEARIIQIREAGEGQTVSYGSSFLLKRASRLAIASVGYADGYQRSLSGSGIPLREMGHGGAYGVVNGHK
VPVAGRVTMDLTIFDVTDVPANAIRAGDYIELFGPNVPVDETARAAGTIGYEMLTGLGLRYERQYLVADD

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=369, Percent_Identity=32.520325203252, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1790487, Length=372, Percent_Identity=31.1827956989247, Blast_Score=156, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR1_AGRT5 (P58736)

Other databases:

- EMBL:   AE007869
- PIR:   AG2709
- PIR:   H97491
- RefSeq:   NP_354104.1
- ProteinModelPortal:   P58736
- SMR:   P58736
- STRING:   P58736
- GeneID:   1133118
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1080
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   YGGEAVN
- PhylomeDB:   P58736
- ProtClustDB:   CLSK800293
- BioCyc:   ATUM176299-1:ATU1080-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 42092; Mature: 41960

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 52-52 ACT_SITE 271-271

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDFEDSFPDNETDAFEQAPLRLTVDLGALADNWRDMKKRSGRARTAAVVKADAYGLGI
CCCCCCCCCCCCCCCHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCH
EDCGATLYHAGARDFFVATVAEGATLRSYAPEARIFVLSGIWQGQERQVFDNDLVPVLAS
HHHCCHHHCCCCCCEEEEEECCCCCHHHCCCCCEEEEEECCCCCCCCEECCCCCEEEEEC
EEQLSFWMATVAERGDHPCALHVDTGFNRLGLPLDDALFLADDVTRPASFDPVLVLSHLA
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
CADTPSSPMNRAQLESFRRVSAAFEGIESSLSASAGIFLGPDYHFDLTRPGIALYGGEAV
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCEEEECCCHH
NDVANPMRPVAKAEARIIQIREAGEGQTVSYGSSFLLKRASRLAIASVGYADGYQRSLSG
HHHHHHHHHHHHHHEEEEEEEECCCCCEEECCHHHHHHHHHHHEEEECCCCCCHHHHCCC
SGIPLREMGHGGAYGVVNGHKVPVAGRVTMDLTIFDVTDVPANAIRAGDYIELFGPNVPV
CCCCHHHCCCCCCEEECCCCCCCEECEEEEEEEEEEECCCCHHHHCCCCEEEECCCCCCC
DETARAAGTIGYEMLTGLGLRYERQYLVADD
CHHHHHHHHHHHHHHHCCCCEEECEEEEECC
>Mature Secondary Structure 
TDDFEDSFPDNETDAFEQAPLRLTVDLGALADNWRDMKKRSGRARTAAVVKADAYGLGI
CCCCCCCCCCCCCCHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCH
EDCGATLYHAGARDFFVATVAEGATLRSYAPEARIFVLSGIWQGQERQVFDNDLVPVLAS
HHHCCHHHCCCCCCEEEEEECCCCCHHHCCCCCEEEEEECCCCCCCCEECCCCCEEEEEC
EEQLSFWMATVAERGDHPCALHVDTGFNRLGLPLDDALFLADDVTRPASFDPVLVLSHLA
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
CADTPSSPMNRAQLESFRRVSAAFEGIESSLSASAGIFLGPDYHFDLTRPGIALYGGEAV
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCEEEECCCHH
NDVANPMRPVAKAEARIIQIREAGEGQTVSYGSSFLLKRASRLAIASVGYADGYQRSLSG
HHHHHHHHHHHHHHEEEEEEEECCCCCEEECCHHHHHHHHHHHEEEECCCCCCHHHHCCC
SGIPLREMGHGGAYGVVNGHKVPVAGRVTMDLTIFDVTDVPANAIRAGDYIELFGPNVPV
CCCCHHHCCCCCCEEECCCCCCCEECEEEEEEEEEEECCCCHHHHCCCCEEEECCCCCCC
DETARAAGTIGYEMLTGLGLRYERQYLVADD
CHHHHHHHHHHHHHHHCCCCEEECEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194