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The map label for this gene is pip [H]

Identifier: 15888412

GI number: 15888412

Start: 1061975

End: 1062931

Strand: Reverse

Name: pip [H]

Synonym: Atu1069

Alternate gene names: 15888412

Gene position: 1062931-1061975 (Counterclockwise)

Preceding gene: 15888413

Following gene: 159184603

Centisome position: 37.41

GC content: 60.19

Gene sequence:

>957_bases
ATGACTGAAGAACTGCGCGGCTTTTACCCCGAGATCGAACCTTTCGAAACCGGCATGCTGGATGTCGGCGACGGGCATGT
GATCTATTGGGAGCGGGTGGGCACCCGTGGCGCGAAACCGGCGGTTTTCCTGCATGGTGGGCCGGGTGGCGGGGTAAACC
CCACCCATCGGCGGGTTTTCGATCCCGCACTTTACGATGTCATCCTGTTCGATCAGCGCGGCTGCGGCCGCTCCACGCCG
CATGCGGCGCTTGAGGCCAACACCACGTGGCATCTGGTTGCCGATATCGAAAGGCTACGTGAACTCTGCGGCTTCGAAAA
ATGGCTTGTTTTCGGCGGCTCCTGGGGTTCGACGCTGGCGCTCGCTTATGCCGAGACCCATCCCGACCGCGTCAGCGAAC
TCGTCCTGCGCGGCATCTACACCGTCACCAGGCCGGAGCTGGACTGGTATTATCAGTTCGGCGTTTCCGAAATGTATCCG
GACCACTGGGAGAGATTCATCGCGCCCATTCCGGAGGGGGAGCGCGGTGAGATGATGCAGGCCTATAATCGCTATCTTAC
CGGCGCCGACGAAGCGAAAAAGCTGGAATGCGCCAAGGCCTGGAGCCAGTGGGAGGGTGCAACCATTGCGCTCGTCACCG
ACCCCAGCCGTGTGGATGATTTCGGTGAGGATAAATACGCCATCGCCTTTGCACGCATCGAGAACCATTTCTTCGTCAAT
GACTGCTGGCTGGAAGAAGAGCAACTGCTGCGGAACGCCGGCAGGCTGAAAGATATTCCCGGCGCCATCGTGCACGGGCG
TTATGACATGCCCTGCCCGCTGAAATATGCCTGGCAGTTGGCCAAGGCCTGGCCGAAGGCGGATTTCCACATCATCGAAG
CGGCCGGGCATGCGCTGAGCGAACCCGGCATTCTTGACCAGCTGATCCGCGCAAACGATCGCTTTGCCGGGAAATGA

Upstream 100 bases:

>100_bases
CAAACCGGCAATCGAGCAGAGCGTCGACGAGGCGGAGATCACCTCCTACCAGCACCCGGATCACGACACGGCCACGTGGC
CGCCCGAAGGACCATAAGAC

Downstream 100 bases:

>100_bases
GAGTCTTTTCAGATGCTTGAGGCGTCCTGATGAGACATTGATTCACACGTGATTTAAAGCAGGGTTCCTGGGAAGATCAG
CCGGCGTATTGCGACGTGAG

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTEELRGFYPEIEPFETGMLDVGDGHVIYWERVGTRGAKPAVFLHGGPGGGVNPTHRRVFDPALYDVILFDQRGCGRSTP
HAALEANTTWHLVADIERLRELCGFEKWLVFGGSWGSTLALAYAETHPDRVSELVLRGIYTVTRPELDWYYQFGVSEMYP
DHWERFIAPIPEGERGEMMQAYNRYLTGADEAKKLECAKAWSQWEGATIALVTDPSRVDDFGEDKYAIAFARIENHFFVN
DCWLEEEQLLRNAGRLKDIPGAIVHGRYDMPCPLKYAWQLAKAWPKADFHIIEAAGHALSEPGILDQLIRANDRFAGK

Sequences:

>Translated_318_residues
MTEELRGFYPEIEPFETGMLDVGDGHVIYWERVGTRGAKPAVFLHGGPGGGVNPTHRRVFDPALYDVILFDQRGCGRSTP
HAALEANTTWHLVADIERLRELCGFEKWLVFGGSWGSTLALAYAETHPDRVSELVLRGIYTVTRPELDWYYQFGVSEMYP
DHWERFIAPIPEGERGEMMQAYNRYLTGADEAKKLECAKAWSQWEGATIALVTDPSRVDDFGEDKYAIAFARIENHFFVN
DCWLEEEQLLRNAGRLKDIPGAIVHGRYDMPCPLKYAWQLAKAWPKADFHIIEAAGHALSEPGILDQLIRANDRFAGK
>Mature_317_residues
TEELRGFYPEIEPFETGMLDVGDGHVIYWERVGTRGAKPAVFLHGGPGGGVNPTHRRVFDPALYDVILFDQRGCGRSTPH
AALEANTTWHLVADIERLRELCGFEKWLVFGGSWGSTLALAYAETHPDRVSELVLRGIYTVTRPELDWYYQFGVSEMYPD
HWERFIAPIPEGERGEMMQAYNRYLTGADEAKKLECAKAWSQWEGATIALVTDPSRVDDFGEDKYAIAFARIENHFFVND
CWLEEEQLLRNAGRLKDIPGAIVHGRYDMPCPLKYAWQLAKAWPKADFHIIEAAGHALSEPGILDQLIRANDRFAGK

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 36063; Mature: 35932

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEELRGFYPEIEPFETGMLDVGDGHVIYWERVGTRGAKPAVFLHGGPGGGVNPTHRRVF
CCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHC
DPALYDVILFDQRGCGRSTPHAALEANTTWHLVADIERLRELCGFEKWLVFGGSWGSTLA
CHHHEEEEEECCCCCCCCCCCCEEECCCEEEHHHHHHHHHHHHCCCEEEEECCCCCCEEE
LAYAETHPDRVSELVLRGIYTVTRPELDWYYQFGVSEMYPDHWERFIAPIPEGERGEMMQ
EEEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHCCHHHHHHHHCCCCCCCCCHHHH
AYNRYLTGADEAKKLECAKAWSQWEGATIALVTDPSRVDDFGEDKYAIAFARIENHFFVN
HHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCCEEEEEEEECCEEEEE
DCWLEEEQLLRNAGRLKDIPGAIVHGRYDMPCPLKYAWQLAKAWPKADFHIIEAAGHALS
HHCCCHHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCC
EPGILDQLIRANDRFAGK
CCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEELRGFYPEIEPFETGMLDVGDGHVIYWERVGTRGAKPAVFLHGGPGGGVNPTHRRVF
CCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHC
DPALYDVILFDQRGCGRSTPHAALEANTTWHLVADIERLRELCGFEKWLVFGGSWGSTLA
CHHHEEEEEECCCCCCCCCCCCEEECCCEEEHHHHHHHHHHHHCCCEEEEECCCCCCEEE
LAYAETHPDRVSELVLRGIYTVTRPELDWYYQFGVSEMYPDHWERFIAPIPEGERGEMMQ
EEEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHCCHHHHHHHHCCCCCCCCCHHHH
AYNRYLTGADEAKKLECAKAWSQWEGATIALVTDPSRVDDFGEDKYAIAFARIENHFFVN
HHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCCEEEEEEEECCEEEEE
DCWLEEEQLLRNAGRLKDIPGAIVHGRYDMPCPLKYAWQLAKAWPKADFHIIEAAGHALS
HHCCCHHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCC
EPGILDQLIRANDRFAGK
CCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]