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The map label for this gene is mscS [H]

Identifier: 15888392

GI number: 15888392

Start: 1043852

End: 1044673

Strand: Reverse

Name: mscS [H]

Synonym: Atu1050

Alternate gene names: 15888392

Gene position: 1044673-1043852 (Counterclockwise)

Preceding gene: 15888393

Following gene: 15888391

Centisome position: 36.76

GC content: 59.98

Gene sequence:

>822_bases
ATGGAACAACAGGCAACCGATATCCTCGTCGCATCGCAGACAGCCGTGCGGCAGGCGAGCGCGCTGGCGGTGCAATATTC
CTTTTCGGTCATTGGTGCGCTGCTGCTGCTGATCATTGGCTGGCTGGCCGCCGCCTTCCTGCAACGCTGGGCGTTTCAGG
GCCTGTCACGCATTCGCGGTTTCGATGCAACGCTCGCCGGTTTCTTCGCGGGCGGCATCCGTTACGTCGTGCTCATTCTG
GTCATCGTTATGGTGCTTGGCCAGTTCGGGGTGCAGACGGCCTCGATTCTCGCCGCCCTCGGCGCTGCCGGCCTCGCCAT
CGGTCTTGCGCTACAAGGCACGCTGCAGAACATCGCCGCCGGCATCATGTTGCTTGTGTTGCGCCCTTTCCGGGTTGGCG
AATATATCGAGACCAGCACGGTCAGCGGCACGATCATCGAAATCGGGCTTTTCGCCACCGAACTCAAGACCAGTGACGGA
CTTTACCGGCTTGCGCCGAATTCCACACTCTGGAACGTGCCTATCACCAATTACAGCCGCTTTCCTTCACGCCGCCACGA
ACTCAGCCTGACTGTCAAGAACGACGAGGATATGGCTGCCGCGCAGGATATGCTGATGACCGTGGTGCGCTCGGAAAGTC
GTATCCTGCTCGACCCCGCCCCGGTCACATTCGTGGATTCCGTTACCGCCGACAGCGCCACCGTTAAATTGCGGTATTGG
GTGCGCAGCGACAACTATTTCGTAACGACGCGCGACGTGACAAAAGCCATGCGGCTCGCTTTTGACGAACGCAAGGCCGA
GGTAAACGCACAGCCTGCCTGA

Upstream 100 bases:

>100_bases
TCGTGCTGCCGCTTGCCGGCTGAGGCCCGATTTTGGGCGGAACCGCTGCGGCACCCATTCGTTACCAAATCTGAACGGCA
ATAGAATCACGGGATAATTC

Downstream 100 bases:

>100_bases
GGCCTGACGGTTAATCCTGCCCGCATATTTTAAGCGCGGTGGCTGAACAGCCATCGCGTTTTTCATGACCCGACGTCAAC
ACCCACCCTTGCATCCTGCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEQQATDILVASQTAVRQASALAVQYSFSVIGALLLLIIGWLAAAFLQRWAFQGLSRIRGFDATLAGFFAGGIRYVVLIL
VIVMVLGQFGVQTASILAALGAAGLAIGLALQGTLQNIAAGIMLLVLRPFRVGEYIETSTVSGTIIEIGLFATELKTSDG
LYRLAPNSTLWNVPITNYSRFPSRRHELSLTVKNDEDMAAAQDMLMTVVRSESRILLDPAPVTFVDSVTADSATVKLRYW
VRSDNYFVTTRDVTKAMRLAFDERKAEVNAQPA

Sequences:

>Translated_273_residues
MEQQATDILVASQTAVRQASALAVQYSFSVIGALLLLIIGWLAAAFLQRWAFQGLSRIRGFDATLAGFFAGGIRYVVLIL
VIVMVLGQFGVQTASILAALGAAGLAIGLALQGTLQNIAAGIMLLVLRPFRVGEYIETSTVSGTIIEIGLFATELKTSDG
LYRLAPNSTLWNVPITNYSRFPSRRHELSLTVKNDEDMAAAQDMLMTVVRSESRILLDPAPVTFVDSVTADSATVKLRYW
VRSDNYFVTTRDVTKAMRLAFDERKAEVNAQPA
>Mature_273_residues
MEQQATDILVASQTAVRQASALAVQYSFSVIGALLLLIIGWLAAAFLQRWAFQGLSRIRGFDATLAGFFAGGIRYVVLIL
VIVMVLGQFGVQTASILAALGAAGLAIGLALQGTLQNIAAGIMLLVLRPFRVGEYIETSTVSGTIIEIGLFATELKTSDG
LYRLAPNSTLWNVPITNYSRFPSRRHELSLTVKNDEDMAAAQDMLMTVVRSESRILLDPAPVTFVDSVTADSATVKLRYW
VRSDNYFVTTRDVTKAMRLAFDERKAEVNAQPA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=254, Percent_Identity=37.007874015748, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1787591, Length=155, Percent_Identity=28.3870967741935, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786670, Length=172, Percent_Identity=23.8372093023256, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29681; Mature: 29681

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQQATDILVASQTAVRQASALAVQYSFSVIGALLLLIIGWLAAAFLQRWAFQGLSRIRG
CCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FDATLAGFFAGGIRYVVLILVIVMVLGQFGVQTASILAALGAAGLAIGLALQGTLQNIAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIMLLVLRPFRVGEYIETSTVSGTIIEIGLFATELKTSDGLYRLAPNSTLWNVPITNYSR
HHHHHHHCCHHCCCHHHHCCCCCEEEEEEHHHHHHCCCCCEEEECCCCEEEECCCCCCCC
FPSRRHELSLTVKNDEDMAAAQDMLMTVVRSESRILLDPAPVTFVDSVTADSATVKLRYW
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCEEEEEEEE
VRSDNYFVTTRDVTKAMRLAFDERKAEVNAQPA
EECCCEEEEHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEQQATDILVASQTAVRQASALAVQYSFSVIGALLLLIIGWLAAAFLQRWAFQGLSRIRG
CCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FDATLAGFFAGGIRYVVLILVIVMVLGQFGVQTASILAALGAAGLAIGLALQGTLQNIAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIMLLVLRPFRVGEYIETSTVSGTIIEIGLFATELKTSDGLYRLAPNSTLWNVPITNYSR
HHHHHHHCCHHCCCHHHHCCCCCEEEEEEHHHHHHCCCCCEEEECCCCEEEECCCCCCCC
FPSRRHELSLTVKNDEDMAAAQDMLMTVVRSESRILLDPAPVTFVDSVTADSATVKLRYW
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCEEEEEEEE
VRSDNYFVTTRDVTKAMRLAFDERKAEVNAQPA
EECCCEEEEHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]