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The map label for this gene is hmrR2 [H]

Identifier: 15888228

GI number: 15888228

Start: 880625

End: 881038

Strand: Reverse

Name: hmrR2 [H]

Synonym: Atu0888

Alternate gene names: 15888228

Gene position: 881038-880625 (Counterclockwise)

Preceding gene: 15888232

Following gene: 15888227

Centisome position: 31.01

GC content: 60.87

Gene sequence:

>414_bases
ATGCTGTCCATCGGTGAACTGTCGAAACGCACCGGCGTGAAGGTGCCGACGATCCGCTATTACGAGCAGATGGGCCTCAT
CCGCGAGGCGGACCGTTCGGACGGCAACCAGCGCCGTTACGAAAAATCCGACCTCGAAAGGCTGGCCTTCATCCGCCATG
CGCGCGATCTCGGCCTGAATATCGAGGCCATCCGCGAGCTGCTTGCGCTCAGCCAGCACCGGCAGATGCCTTGCGAAGGT
GCCGACCGCATCGCCGCCGAGCATCTTGCCCATGTGCGCGAAAAGATTGCCAGCCTGAAGAAGCTGGAACACGAGCTGGA
ACGCATCGTCTCCCATTGCCACGGCCATTCGATCGAGGATTGTTACGTCATCCGCGCGCTTTCCAACCACGGTATGTGCG
AGGGCGAGCATTGA

Upstream 100 bases:

>100_bases
GGCACTGGCCCAGGCGCTTGGCGTCAACGATGCCGCTTGAGGCCATTGAATCGGTCGTGAAAAAGCCATATCTCTAGAGA
CTGGAGATATGGAGAAAGCC

Downstream 100 bases:

>100_bases
ACCGCTAAAGCGGGCTTGACAGAATATGGATTCGGGCGCATTGCATTCCCCATGATCAACGAACGCGCACCCATCTCCTG
CTCGTATTTTTGGGCCTTCC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MLSIGELSKRTGVKVPTIRYYEQMGLIREADRSDGNQRRYEKSDLERLAFIRHARDLGLNIEAIRELLALSQHRQMPCEG
ADRIAAEHLAHVREKIASLKKLEHELERIVSHCHGHSIEDCYVIRALSNHGMCEGEH

Sequences:

>Translated_137_residues
MLSIGELSKRTGVKVPTIRYYEQMGLIREADRSDGNQRRYEKSDLERLAFIRHARDLGLNIEAIRELLALSQHRQMPCEG
ADRIAAEHLAHVREKIASLKKLEHELERIVSHCHGHSIEDCYVIRALSNHGMCEGEH
>Mature_137_residues
MLSIGELSKRTGVKVPTIRYYEQMGLIREADRSDGNQRRYEKSDLERLAFIRHARDLGLNIEAIRELLALSQHRQMPCEG
ADRIAAEHLAHVREKIASLKKLEHELERIVSHCHGHSIEDCYVIRALSNHGMCEGEH

Specific function: Transcriptional regulator involved in acid tolerance. Binds copper [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=132, Percent_Identity=40.9090909090909, Blast_Score=90, Evalue=6e-20,
Organism=Escherichia coli, GI1786695, Length=132, Percent_Identity=31.0606060606061, Blast_Score=70, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15763; Mature: 15763

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIGELSKRTGVKVPTIRYYEQMGLIREADRSDGNQRRYEKSDLERLAFIRHARDLGLN
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
IEAIRELLALSQHRQMPCEGADRIAAEHLAHVREKIASLKKLEHELERIVSHCHGHSIED
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
CYVIRALSNHGMCEGEH
HHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLSIGELSKRTGVKVPTIRYYEQMGLIREADRSDGNQRRYEKSDLERLAFIRHARDLGLN
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
IEAIRELLALSQHRQMPCEGADRIAAEHLAHVREKIASLKKLEHELERIVSHCHGHSIED
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
CYVIRALSNHGMCEGEH
HHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]